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Jeffrey A. Bluestone
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Journal Articles

Chimeric cytokine receptor provides IL-2 signaling for engineered regulatory T cell therapy

Jessica T Cortez, Han Ly, Eleonora Trotta, James F Matthaei, Peter Kegler, Brian Phong, Benjamin M Fiebiger, Josue Torres, Jack Chase, Trevor Mileur, Joshua N Beilke, Jeffrey A Bluestone, Fred Ramsdell, Brent S McKenzie, Frédéric Van Gool
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 166.10.
https://doi.org/10.4049/jimmunol.210.Supp.166.10
Published: 01 May 2023
View article titled, Chimeric cytokine receptor provides IL-2 signaling for engineered regulatory T cell therapy
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Journal Articles

Elucidating Inflammation-induced Cell Fate Decisions in Primary Human Tregs

Patrick Ho, Jeffrey A Bluestone, Qizhi Tang
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 238.01.
https://doi.org/10.4049/jimmunol.210.Supp.238.01
Published: 01 May 2023
View article titled, Elucidating Inflammation-induced Cell Fate Decisions in Primary Human Tregs
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Journal Articles

The Role of Aire in the selection of Regulatory T cells in Type 1 Diabetes

Jennifer Anne Bridge, Jared Balolong, Julia Belk, Shen Dong, Nathan Cramer, Cody Mowery, Frances Crawford, Jimmy Ye, Ansuman Satpathy, John W Kappler, Jeffrey A Bluestone, Mark S Anderson
Journal: The Journal of Immunology
J Immunol (2021) 206 (1_Supplement): 51.07.
https://doi.org/10.4049/jimmunol.206.Supp.51.07
Published: 01 May 2021
View article titled, The Role of Aire in the selection of Regulatory T cells in Type 1 Diabetes
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Journal Articles

Chimeric antigen receptor signaling confers antitumor activity to human regulatory T cells

Leonardo Ferreira, Yannick D. Muller, Anupurna M. Kaul, Hashim Shaikh, Ryan Guerrero-Moreno, Lilian E. Yao, Daniel B. Goodman, Jeffrey A Bluestone, Qizhi Tang
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 238.1.
https://doi.org/10.4049/jimmunol.204.Supp.238.1
Published: 01 May 2020
View article titled, Chimeric antigen receptor signaling confers antitumor activity to human regulatory T cells
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Journal Articles

Effect of combined low dose IL-2 and polyclonal Tregs infusion in Type 1 Diabetes patients

Shen Dong, Cody Mowery, Kamir Hiam, Kevan C Herold, Stephen Gitelman, Jonathan Esensten, Weihong Liu, Angela Lares, Vinh Nguyen, Michael Lee, Ashley Leinbach, Jimmie Ye, Qizhi Tang, Jeffrey A Bluestone
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 224.49.
https://doi.org/10.4049/jimmunol.204.Supp.224.49
Published: 01 May 2020
View article titled, Effect of combined low dose IL-2 and polyclonal Tregs infusion in Type 1 Diabetes patients
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Journal Articles

Regulatory T cell control of systemic tumor-specific immunity and response to checkpoint immunotherapy response in liver metastasis

James Lee, Sadaf Mehdizadeh, Jennifer Anne Bridge, Arabella Young, Ilgiz A. Mufazalov, Adil Daud, Jeffrey A Bluestone
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 244.7.
https://doi.org/10.4049/jimmunol.204.Supp.244.7
Published: 01 May 2020
View article titled, Regulatory T cell control of systemic tumor-specific immunity and response to checkpoint immunotherapy response in liver metastasis
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Journal Articles

The Role of Aire in the selection of Regulatory T cells in Diabetes

Jennifer Anne Bridge, Jared Balolong, Shen Dong, Nathan Cramer, Cody Mowery, Frances Crawford, Jimmie Ye, John W Kappler, Jeffrey A Bluestone, Mark S Anderson
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 143.9.
https://doi.org/10.4049/jimmunol.204.Supp.143.9
Published: 01 May 2020
View article titled, The Role of Aire in the selection of Regulatory T cells in Diabetes
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Journal Articles

Cutting Edge: IL-6–Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression

Ilgiz A. Mufazalov, David Andruszewski, Carsten Schelmbauer, Sylvia Heink, Michaela Blanfeld, Joumana Masri, Yilang Tang, Rebecca Schüler, Christina Eich, F. Thomas Wunderlich, Susanne H. Karbach, Jeffrey A. Bluestone, Thomas Korn, Ari Waisman
Journal: The Journal of Immunology
J Immunol (2020) 204 (4): 747–751.
https://doi.org/10.4049/jimmunol.1900876
Published: 15 February 2020
View article titled, Cutting Edge: IL-6–Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression
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Includes: Supplementary data
Journal Articles

Development of citrullinated-vimentin-specific CAR for targeting Tregs to treat autoimmune rheumatoid arthritis

Caroline Raffin, Yannick Muller, Jessica Barragan, Yu Zhou, Luca Piccoli, Antonio Lanzavecchia, Semih U Tareen, Jason D Fontenot, Jeffrey A Bluestone
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 133.2.
https://doi.org/10.4049/jimmunol.202.Supp.133.2
Published: 01 May 2019
View article titled, Development of citrullinated-vimentin-specific CAR for targeting Tregs to treat autoimmune rheumatoid arthritis
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Journal Articles

Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy

Jamie B. Spangler, Eleonora Trotta, Jakub Tomala, Ariana Peck, Tracy A. Young, Christina S. Savvides, Stephanie Silveria, Petra Votavova, Joshua Salafsky, Vijay S. Pande, Marek Kovar, Jeffrey A. Bluestone, K. Christopher Garcia
Journal: The Journal of Immunology
J Immunol (2018) 201 (7): 2094–2106.
https://doi.org/10.4049/jimmunol.1800578
Published: 01 October 2018
View article titled, Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy
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Includes: Multimedia, Supplementary data
Journal Articles

Immunological Insights Into Liver Metastasis Associated Resistance To Checkpoint Blockade Cancer Immunotherapy

James Lee, Sadaf Mehdizadeh, Katy Tsai, Alain Algazi, Michael Rosenblum, Adil Daud, Jeffrey A. Bluestone
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 122.26.
https://doi.org/10.4049/jimmunol.200.Supp.122.26
Published: 01 May 2018
View article titled, Immunological Insights Into Liver Metastasis Associated Resistance To Checkpoint Blockade Cancer Immunotherapy
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Journal Articles

Targeting EZH2 Selectively Alters Intratumoral Regulatory T Cells to Enhance Cancer Immunity

Michel DuPage, David Wang, Jason Quiros, Kelly Mahuron, Chien-Chun Pai, Valeria Ranzani, Arabella Young, Stephanie Silveria, Tory Harwin, Arbi Abnousian, Massimiliano Pagani, Michael Rosenblum, Frederic Van Gool, Lawrence Fong, Jeffrey A. Bluestone
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 57.39.
https://doi.org/10.4049/jimmunol.200.Supp.57.39
Published: 01 May 2018
View article titled, Targeting EZH2 Selectively Alters Intratumoral Regulatory T Cells to Enhance Cancer Immunity
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Journal Articles

Discovery of a novel human anti-IL-2 antibody that potentiates Regulatory T cells by a structure-based mechanism

Eleonora Trotta, Paul H. Bessette, Stephanie L. Silveria, Lauren K. Ely, Kevin Jude, Charles R. Holst, Anthony Coyle, Christopher K. Garcia, Natasha K. Crellin, Isaac J. Rondon, Jeffrey A. Bluestone
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 176.4.
https://doi.org/10.4049/jimmunol.200.Supp.176.4
Published: 01 May 2018
View article titled, Discovery of a novel human anti-IL-2 antibody that potentiates Regulatory T cells by a structure-based mechanism
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Journal Articles

Development of citrullinated-vimentin-specific CAR for targeting Tregs to treat autoimmune rheumatoid arthritis

Caroline Raffin, Yu Zhou, Luca Piccoli, Antonio Lanzavecchia, Michel Sadelain, Semih U. Tareen, Jason D. Fontenot, Jeffrey A. Bluestone
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 176.17.
https://doi.org/10.4049/jimmunol.200.Supp.176.17
Published: 01 May 2018
View article titled, Development of citrullinated-vimentin-specific CAR for targeting Tregs to treat autoimmune rheumatoid arthritis
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Journal Articles

Development of syngeneic NOD tumor models to study tumor immunity in autoimmune-prone mice.

Arabella Young, Vinh Nguyen, Sadaf Mehdizadeh, Kathleen C. F. Sheehan, David V. Serreze, Robert D. Schreiber, Jeffrey A. Bluestone
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 178.19.
https://doi.org/10.4049/jimmunol.200.Supp.178.19
Published: 01 May 2018
View article titled, Development of syngeneic NOD tumor models to study tumor immunity in autoimmune-prone mice.
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Journal Articles

Antigen discovery for regulatory T cells (Tregs) in type-1 diabetes (T1D)

Shen Dong, Daqi Xu, Jennifer Anne Bridge, Whitney Purtha, Allyson Spence, Danny Wells, Xiao hua Wang, Qizhi Tang, Mark S. Anderson, Jeffrey A. Bluestone
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 101.12.
https://doi.org/10.4049/jimmunol.200.Supp.101.12
Published: 01 May 2018
View article titled, Antigen discovery for regulatory T cells (Tregs) in type-1 diabetes (T1D)
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Journal Articles

Foxp3 domain-swap interface is required to suppress T helper type 2 transcriptional program in Regulatory T cells.

Frederic Van Gool, Michelle L. Nguyen, Maxwell R. Mumbach, Ansuman T. Satpathy, Mark S. Anderson, Alexander Marson, Howard Y. Chang, Jeffrey A. Bluestone
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 101.9.
https://doi.org/10.4049/jimmunol.200.Supp.101.9
Published: 01 May 2018
View article titled, Foxp3 domain-swap interface is required to suppress T helper type 2 transcriptional program in Regulatory T cells.
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Journal Articles

Tailoring a new generation of chimeric antigen receptors for regulatory T cells

Leonardo Ferreira, Anupurna Kaul, Ryan Guerrero-Moreno, Jason D. Fontenot, Jeffrey A. Bluestone, Qizhi Tang
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 176.15.
https://doi.org/10.4049/jimmunol.200.Supp.176.15
Published: 01 May 2018
View article titled, Tailoring a new generation of chimeric antigen receptors for regulatory T cells
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Journal Articles

Aire-dependent thymic FoxP3+ regulatory T cells in Type 1 Diabetes

Jennifer Anne Bridge, Benjamin Yuen, Shen Dong, Jimmy Ye, John W. Kappler, Jeffrey A. Bluestone, Mark S. Anderson
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 101.10.
https://doi.org/10.4049/jimmunol.200.Supp.101.10
Published: 01 May 2018
View article titled, Aire-dependent thymic FoxP3<sup>+</sup> regulatory T cells in Type 1 Diabetes
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Journal Articles

Engineering antigen-specific T cells from human pluripotent stem cells

Linda Thuy Vo, David H. Nguyen, Theodore Roth, Alexander Marson, George Q. Daley, Jeffrey A. Bluestone
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 103.12.
https://doi.org/10.4049/jimmunol.200.Supp.103.12
Published: 01 May 2018
View article titled, Engineering antigen-specific T cells from human pluripotent stem cells
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