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John D. Lambris
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Journal Articles

The Complement-Targeted Inhibitor Mini-FH Protects against Experimental Periodontitis via Both C3-Dependent and C3-Independent Mechanisms

Xiaofei Li, Hui Wang, Christoph Q. Schmidt, Viviana P. Ferreira, Despina Yancopoulou, Dimitrios C. Mastellos, John D. Lambris, George Hajishengallis
Journal: The Journal of Immunology
J Immunol (2023) 211 (3): 453–461.
https://doi.org/10.4049/jimmunol.2300242
Published: 12 June 2023
View article titled, The Complement-Targeted Inhibitor Mini-FH Protects against Experimental Periodontitis via Both C3-Dependent and C3-Independent Mechanisms
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Includes: Supplementary data
Journal Articles

Role of complement activation in cellular activation by systemic lupus erythematosus (SLE) immune complexes (ICs)

Sanjay Khandelwal, Sooho S Myoung, John D Lambris, Jennifer L Rogers, David S Pisetsky, Gowthami M Arepally
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 155.13.
https://doi.org/10.4049/jimmunol.210.Supp.155.13
Published: 01 May 2023
View article titled, Role of complement activation in cellular activation by systemic lupus erythematosus (SLE) immune complexes (ICs)
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Journal Articles

Complement Is Required for Microbe-Driven Induction of Th17 and Periodontitis

Hui Wang, Hidetaka Ideguchi, Tetsuhiro Kajikawa, Dimitrios C. Mastellos, John D. Lambris, George Hajishengallis
Journal: The Journal of Immunology
J Immunol (2022) 209 (7): 1370–1378.
https://doi.org/10.4049/jimmunol.2200338
Published: 01 October 2022
View article titled, Complement Is Required for Microbe-Driven Induction of Th17 and Periodontitis
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Includes: Supplementary data
Journal Articles

Air Bubbles Activate Complement and Trigger Hemostasis and C3-Dependent Cytokine Release Ex Vivo in Human Whole Blood

Benjamin S. Storm, Dorte Christiansen, Hilde Fure, Judith K. Ludviksen, Corinna Lau, John D. Lambris, Trent M. Woodruff, Ole-Lars Brekke, Tonje Braaten, Erik W. Nielsen, Tom Eirik Mollnes
Journal: The Journal of Immunology
J Immunol (2021) 207 (11): 2828–2840.
https://doi.org/10.4049/jimmunol.2100308
Published: 01 December 2021
View article titled, Air Bubbles Activate Complement and Trigger Hemostasis and C3-Dependent Cytokine Release Ex Vivo in Human Whole Blood
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Includes: Supplementary data
Journal Articles

Cholesterol Crystals Induce Coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor

Caroline S. Gravastrand, Bjørg Steinkjer, Bente Halvorsen, Anne Landsem, Mona Skjelland, Eva Astrid Jacobsen, Trent M. Woodruff, John D. Lambris, Tom E. Mollnes, Ole-Lars Brekke, Terje Espevik, Anne Mari A. Rokstad
Journal: The Journal of Immunology
J Immunol (2019) 203 (4): 853–863.
https://doi.org/10.4049/jimmunol.1900503
Published: 15 August 2019
View article titled, Cholesterol Crystals Induce Coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor
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Includes: Supplementary data
Journal Articles

Anaphylatoxin receptor C3aR on platelets participates in platelet function and links innate immunity with thrombosis

Reinhard Joerg Sauter, Manuela Sauter, Edimara S. Reis, Frederic Emschermann, Henry Nording, Peter Kraft, Maximilian Mauler, Patrick Muenzer, Johannes Rheinlaender, Frank Edlich, Tilman E Schäffer, Sven G Meuth, Daniel Duerschmied, Oliver Borst, Christoph Kleinschnitz, John D Lambris, Harald Langer
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 126.25.
https://doi.org/10.4049/jimmunol.202.Supp.126.25
Published: 01 May 2019
View article titled, Anaphylatoxin receptor C3aR on platelets participates in platelet function and links innate immunity with thrombosis
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Journal Articles

Short Leucine-Rich Proteoglycans Modulate Complement Activity and Increase Killing of the Respiratory Pathogen Moraxella catarrhalis

Maisem Laabei, Guanghui Liu, David Ermert, John D. Lambris, Kristian Riesbeck, Anna M. Blom
Journal: The Journal of Immunology
J Immunol (2018) 201 (9): 2721–2730.
https://doi.org/10.4049/jimmunol.1800734
Published: 01 November 2018
View article titled, Short Leucine-Rich Proteoglycans Modulate Complement Activity and Increase Killing of the Respiratory Pathogen <em>Moraxella catarrhalis</em>
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Includes: Supplementary data
Journal Articles

Factor H–IgG Chimeric Proteins as a Therapeutic Approach against the Gram-Positive Bacterial Pathogen Streptococcus pyogenes

Anna M. Blom, Michal Magda, Lisa Kohl, Jutamas Shaughnessy, John D. Lambris, Sanjay Ram, David Ermert
Journal: The Journal of Immunology
J Immunol (2017) 199 (11): 3828–3839.
https://doi.org/10.4049/jimmunol.1700426
Published: 01 December 2017
View article titled, Factor H–IgG Chimeric Proteins as a Therapeutic Approach against the Gram-Positive Bacterial Pathogen <em>Streptococcus pyogenes</em>
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Journal Articles

Complement C5a Functions as a Master Switch for the pH Balance in Neutrophils Exerting Fundamental Immunometabolic Effects

Stephanie Denk, Miriam D. Neher, David A. C. Messerer, Rebecca Wiegner, Bo Nilsson, Daniel Rittirsch, Kristina Nilsson-Ekdahl, Sebastian Weckbach, Anita Ignatius, Miriam Kalbitz, Florian Gebhard, Manfred E. Weiss, Josef Vogt, Peter Radermacher, Jörg Köhl, John D. Lambris, Markus S. Huber-Lang
Journal: The Journal of Immunology
J Immunol (2017) 198 (12): 4846–4854.
https://doi.org/10.4049/jimmunol.1700393
Published: 15 June 2017
View article titled, Complement C5a Functions as a Master Switch for the pH Balance in Neutrophils Exerting Fundamental Immunometabolic Effects
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Journal Articles

Structural Implications for the Formation and Function of the Complement Effector Protein iC3b

Malvina Papanastasiou, Sophia Koutsogiannaki, Yiannis Sarigiannis, Brian V. Geisbrecht, Daniel Ricklin, John D. Lambris
Journal: The Journal of Immunology
J Immunol (2017) 198 (8): 3326–3335.
https://doi.org/10.4049/jimmunol.1601864
Published: 15 April 2017
View article titled, Structural Implications for the Formation and Function of the Complement Effector Protein iC3b
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Includes: Supplementary data
Journal Articles

Systems Analysis of the Complement-Induced Priming Phase of Liver Regeneration

Jun S. Min, Robert A. DeAngelis, Edimara S. Reis, Shakti Gupta, Mano R. Maurya, Charles Evans, Arun Das, Charles Burant, John D. Lambris, Shankar Subramaniam
Journal: The Journal of Immunology
J Immunol (2016) 197 (6): 2500–2508.
https://doi.org/10.4049/jimmunol.1600628
Published: 15 September 2016
View article titled, Systems Analysis of the Complement-Induced Priming Phase of Liver Regeneration
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Includes: Supplementary data
Journal Articles

Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole Blood

Adam Z. Blatt, Gurpanna Saggu, Koustubh V. Kulkarni, Claudio Cortes, Joshua M. Thurman, Daniel Ricklin, John D. Lambris, Jesus G. Valenzuela, Viviana P. Ferreira
Journal: The Journal of Immunology
J Immunol (2016) 196 (11): 4671–4680.
https://doi.org/10.4049/jimmunol.1600040
Published: 01 June 2016
View article titled, Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole Blood
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Includes: Supplementary data
Journal Articles

Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H–like Protein 1 Reveal Functional Determinants of Complement Regulation

Markus J. Harder, Markus Anliker, Britta Höchsmann, Thomas Simmet, Markus Huber-Lang, Hubert Schrezenmeier, Daniel Ricklin, John D. Lambris, Paul N. Barlow, Christoph Q. Schmidt
Journal: The Journal of Immunology
J Immunol (2016) 196 (2): 866–876.
https://doi.org/10.4049/jimmunol.1501919
Published: 15 January 2016
View article titled, Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H–like Protein 1 Reveal Functional Determinants of Complement Regulation
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Includes: Supplementary data
Journal Articles

Attenuation of Staphylococcus aureus–Induced Bacteremia by Human Mini-Antibodies Targeting the Complement Inhibitory Protein Efb

Maria Georgoutsou-Spyridonos, Daniel Ricklin, Haris Pratsinis, Eustathia Perivolioti, Ioannis Pirmettis, Brandon L. Garcia, Brian V. Geisbrecht, Periklis G. Foukas, John D. Lambris, Dimitrios C. Mastellos, Georgia Sfyroera
Journal: The Journal of Immunology
J Immunol (2015) 195 (8): 3946–3958.
https://doi.org/10.4049/jimmunol.1500966
Published: 15 October 2015
View article titled, Attenuation of <em>Staphylococcus aureus–</em>Induced Bacteremia by Human Mini-Antibodies Targeting the Complement Inhibitory Protein Efb
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Includes: Supplementary data
Journal Articles

Rare Loss-of-Function Mutation in Complement Component C3 Provides Insight into Molecular and Pathophysiological Determinants of Complement Activity

Georgia Sfyroera, Daniel Ricklin, Edimara S. Reis, Hui Chen, Emilia L. Wu, Yiannis N. Kaznessis, Kristina N. Ekdahl, Bo Nilsson, John D. Lambris
Journal: The Journal of Immunology
J Immunol (2015) 194 (7): 3305–3316.
https://doi.org/10.4049/jimmunol.1402781
Published: 01 April 2015
View article titled, Rare Loss-of-Function Mutation in Complement Component C3 Provides Insight into Molecular and Pathophysiological Determinants of Complement Activity
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Includes: Supplementary data
Journal Articles

Complement Deficiency Promotes Cutaneous Wound Healing in Mice

Stavros Rafail, Ioannis Kourtzelis, Periklis G. Foukas, Maciej M. Markiewski, Robert A. DeAngelis, Mara Guariento, Daniel Ricklin, Elizabeth A. Grice, John D. Lambris
Journal: The Journal of Immunology
J Immunol (2015) 194 (3): 1285–1291.
https://doi.org/10.4049/jimmunol.1402354
Published: 01 February 2015
View article titled, Complement Deficiency Promotes Cutaneous Wound Healing in Mice
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Journal Articles

The Extracellular Adherence Protein from Staphylococcus aureus Inhibits the Classical and Lectin Pathways of Complement by Blocking Formation of the C3 Proconvertase

Jordan L. Woehl, Daphne A. C. Stapels, Brandon L. Garcia, Kasra X. Ramyar, Andrew Keightley, Maartje Ruyken, Maria Syriga, Georgia Sfyroera, Alexander B. Weber, Michal Zolkiewski, Daniel Ricklin, John D. Lambris, Suzan H. M. Rooijakkers, Brian V. Geisbrecht
Journal: The Journal of Immunology
J Immunol (2014) 193 (12): 6161–6171.
https://doi.org/10.4049/jimmunol.1401600
Published: 15 December 2014
View article titled, The Extracellular Adherence Protein from <em>Staphylococcus aureus</em> Inhibits the Classical and Lectin Pathways of Complement by Blocking Formation of the C3 Proconvertase
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Includes: Supplementary data
Journal Articles

Genetic and Intervention Studies Implicating Complement C3 as a Major Target for the Treatment of Periodontitis

Tomoki Maekawa, Toshiharu Abe, Evlambia Hajishengallis, Kavita B. Hosur, Robert A. DeAngelis, Daniel Ricklin, John D. Lambris, George Hajishengallis
Journal: The Journal of Immunology
J Immunol (2014) 192 (12): 6020–6027.
https://doi.org/10.4049/jimmunol.1400569
Published: 15 June 2014
View article titled, Genetic and Intervention Studies Implicating Complement C3 as a Major Target for the Treatment of Periodontitis
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Includes: Supplementary data
Journal Articles

Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release

Eivind O. Samstad, Nathalie Niyonzima, Stig Nymo, Marie H. Aune, Liv Ryan, Siril S. Bakke, Knut T. Lappegård, Ole-Lars Brekke, John D. Lambris, Jan K. Damås, Eicke Latz, Tom E. Mollnes, Terje Espevik
Journal: The Journal of Immunology
J Immunol (2014) 192 (6): 2837–2845.
https://doi.org/10.4049/jimmunol.1302484
Published: 15 March 2014
View article titled, Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release
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Includes: Supplementary data
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The Complement Anaphylatoxin C5a Receptor Contributes to Obese Adipose Tissue Inflammation and Insulin Resistance

Julia Phieler, Kyoung-Jin Chung, Antonios Chatzigeorgiou, Anne Klotzsche-von Ameln, Ruben Garcia-Martin, David Sprott, Maria Moisidou, Theodora Tzanavari, Barbara Ludwig, Elena Baraban, Monika Ehrhart-Bornstein, Stefan R. Bornstein, Hassan Mziaut, Michele Solimena, Katia P. Karalis, Matina Economopoulou, John D. Lambris, Triantafyllos Chavakis
Journal: The Journal of Immunology
J Immunol (2013) 191 (8): 4367–4374.
https://doi.org/10.4049/jimmunol.1300038
Published: 15 October 2013
View article titled, The Complement Anaphylatoxin C5a Receptor Contributes to Obese Adipose Tissue Inflammation and Insulin Resistance
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Includes: Supplementary data