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John J. O'Shea
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Journal Articles

STAT1 gain of function mutation impairs immune response to viral infections

Rachael Laura Philips, Yi-Chu Liao, Tasha Morrison, Vijender Chaitankar, Chen Yao, Vasileios Oikonomou, Joshua Milner, Michail S Lionakis, John J O’Shea
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 243.25.
https://doi.org/10.4049/jimmunol.210.Supp.243.25
Published: 01 May 2023
View article titled, STAT1 gain of function mutation impairs immune response to viral infections
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Journal Articles

Distinct 3D remodeling of Il4-Il13-Il5loci mediates differential type 2 responses in innate versus adaptive lymphocytes

Hiroyuki Nagashima, Justin Shayne, Yuka Kanno, John J O’Shea
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 243.10.
https://doi.org/10.4049/jimmunol.210.Supp.243.10
Published: 01 May 2023
View article titled, Distinct 3D remodeling of <em>Il4-Il13-Il5</em>loci mediates differential type 2 responses in innate versus adaptive lymphocytes
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Journal Articles

PI3Kdelta coordinates transcriptional, epigenetic and metabolic changes to promote effector CD8 T cells differentiation.

Jennifer Leigh Cannons, Andrea C Pichler, Alejandro Villarino, Senta Kapnick, Han-Yu Shih, Gulbu Uzel, Helen Su, Peter McGuire, John J O'Shea, Dorian B McGavern, Pamela Schwartzberg
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 233.01.
https://doi.org/10.4049/jimmunol.210.Supp.233.01
Published: 01 May 2023
View article titled, PI3Kdelta coordinates transcriptional, epigenetic and metabolic changes to promote effector CD8 T cells differentiation.
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Journal Articles

PAXBP1 SERVES AS A NOVEL REGULATOR OF T HELPER SPECIFICATION BY RESTRAINING THE TYPE 1 PROGRAM

Danielle Alexandria Chisolm, Yuki Morimoto, Rachael Laura Philips, Hiroyuki Nagashima, Ijeoma Meremikwu, Francoise Meylan, Chen Yao, Vijender Chaitankar, John J O’Shea, Yuka Kanno
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 76.13.
https://doi.org/10.4049/jimmunol.210.Supp.76.13
Published: 01 May 2023
View article titled, PAXBP1 SERVES AS A NOVEL REGULATOR OF T HELPER SPECIFICATION BY RESTRAINING THE TYPE 1 PROGRAM
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Journal Articles

TGF-β promotes glycolysis through PFKL in activated macrophages and exacerbates sepsis by disrupting blood coagulation

Thierry Gauthier, Chen Yao, Wenwen Jin, Yun-Ji Lim, Liliana C Patino, Na Liu, Mladen Mitrovic, Roxane Tussiwand, John J O’Shea, Wanjun Chen
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 161.02.
https://doi.org/10.4049/jimmunol.210.Supp.161.02
Published: 01 May 2023
View article titled, TGF-β promotes glycolysis through PFKL in activated macrophages and exacerbates sepsis by disrupting blood coagulation
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Journal Articles

Cutting Edge: Steroid Responsiveness in Foxp3+ Regulatory T Cells Determines Steroid Sensitivity during Allergic Airway Inflammation in Mice

Quang Tam Nguyen, Dongkyun Kim, Supinya Iamsawat, Hongnga T. Le, Sohee Kim, Kevin T. Qiu, Terry D. Hinds, Peter Bazeley, John J. O’Shea, Jaehyuk Choi, Kewal Asosingh, Serpil C. Erzurum, Booki Min
Journal: The Journal of Immunology
J Immunol (2021) 207 (3): 765–770.
https://doi.org/10.4049/jimmunol.2100251
Published: 01 August 2021
View article titled, Cutting Edge: Steroid Responsiveness in Foxp3<sup>+</sup> Regulatory T Cells Determines Steroid Sensitivity during Allergic Airway Inflammation in Mice
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Includes: Supplementary data
Journal Articles

A critical CTCF binding site of the Ifng-Il22 locus specifies cytokine expression and finetunes immune response

Han-Yu Shih, Chunhong Liu, ping wang, Sadie Signorella, William Montgomery, Dragana Jankovic, Hiroyuki Nagashima, Chen Yao, Yuka Kanno, Yijun Ryan, John J O’Shea
Journal: The Journal of Immunology
J Immunol (2021) 206 (1_Supplement): 53.13.
https://doi.org/10.4049/jimmunol.206.Supp.53.13
Published: 01 May 2021
View article titled, A critical CTCF binding site of the <em>Ifng-Il22</em> locus specifies cytokine expression and finetunes immune response
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Journal Articles

PI3Kd coordinates transcriptional, epigenetic and metabolic changes to promote effector CD8 T cells at the expense of memory

Jennifer Leigh Cannons, Alejandro V Villarino, Senta M Kapnick, Silvia Preite, Han-Yu Shih, Julio Washington Gomez-Rodriguez, Julie Reilley, Bonnie Huang, Ian McBain, Tuoqi Wu, Helen C Su, Dorian B McGavern, John J O’Shea, Peter J McGuire, Gulbu Uzel, Pamela L Schwartzberg
Journal: The Journal of Immunology
J Immunol (2021) 206 (1_Supplement): 52.18.
https://doi.org/10.4049/jimmunol.206.Supp.52.18
Published: 01 May 2021
View article titled, PI3Kd coordinates transcriptional, epigenetic and metabolic changes to promote effector CD8 T cells at the expense of memory
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Journal Articles

STAT1 gain of function mutation impairs immune response to viral infections

Rachael Laura Philips, Chen Yao, Joshua D Milner, Michail S Lionakis, John J O’Shea
Journal: The Journal of Immunology
J Immunol (2021) 206 (1_Supplement): 103.38.
https://doi.org/10.4049/jimmunol.206.Supp.103.38
Published: 01 May 2021
View article titled, STAT1 gain of function mutation impairs immune response to viral infections
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Journal Articles

Translating JAKs to Jakinibs

In Special Collection:
Translating Immunology
Massimo Gadina, Danielle A. Chisolm, Rachael L. Philips, Iain B. McInness, Paul S. Changelian, John J. O’Shea
Journal: The Journal of Immunology
J Immunol (2020) 204 (8): 2011–2020.
https://doi.org/10.4049/jimmunol.1901477
Published: 15 April 2020
View article titled, Translating JAKs to Jakinibs
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Journal Articles

Single-Cell Transcriptomics Identifies TOX as a Key Transcriptional Regulator of Stem- Like CD8 T Cells in Chronic Infection

Tuoqi Wu, Chen Yao, Hongwei Sun, Neal Lacey, Luca Gattinoni, Dorian B McGavern, John J O'Shea, Pamela L Schwartzberg
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 140.2.
https://doi.org/10.4049/jimmunol.202.Supp.140.2
Published: 01 May 2019
View article titled, Single-Cell Transcriptomics Identifies TOX as a Key Transcriptional Regulator of Stem- Like CD8 T Cells in Chronic Infection
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Journal Articles

STAT5B: A Differential Regulator of the Life and Death of CD4+ Effector Memory T Cells

Sonia S. Majri, Jill M. Fritz, Alejandro V. Villarino, Lixin Zheng, Chrysi Kanellopoulou, Benjamin Chaigne-Delalande, Juha Grönholm, Julie E. Niemela, Behdad Afzali, Matthew Biancalana, Stefania Pittaluga, Ashleigh Sun, José L. Cohen, Steven M. Holland, John J. O’Shea, Gulbu Uzel, Michael J. Lenardo
Journal: The Journal of Immunology
J Immunol (2018) 200 (1): 110–118.
https://doi.org/10.4049/jimmunol.1701133
Published: 01 January 2018
View article titled, STAT5B: A Differential Regulator of the Life and Death of CD4<sup>+</sup> Effector Memory T Cells
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Includes: Supplementary data
Journal Articles

IL-7-dependent STAT1 activation limits homeostatic CD4 T cell expansion

Marta Catalfamo, Cecile Le Saout, Megan A. Luckey, Alejandro Villarino, Mindy Smith, Rebecca B. Hasley, Timothy G. Myers, Hiromi Imamichi, Jung-Hyun Park, John J O’Shea, H. Clifford Lane
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 212.4.
https://doi.org/10.4049/jimmunol.198.Supp.212.4
Published: 01 May 2017
View article titled, IL-7-dependent STAT1 activation limits homeostatic CD4 T cell expansion
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Journal Articles

An Nlrc4 mutation associated with systemic hyperinflammation drives spontaneous non-hematopoietic IL-18 hyperproduction

Zeshan Tariq, Dorian B McGavern, John J O’Shea, Scott Canna
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 62.10.
https://doi.org/10.4049/jimmunol.196.Supp.62.10
Published: 01 May 2016
View article titled, An Nlrc4 mutation associated with systemic hyperinflammation drives spontaneous non-hematopoietic IL-18 hyperproduction
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Journal Articles

Correction: The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell–Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9–Producing T Cells

Arianne C. Richard, Cuiyan Tan, Eric T. Hawley, Julio Gomez-Rodriguez, Ritobrata Goswami, Xiang-Ping Yang, Anthony C. Cruz, Pallavi Penumetcha, Erika T. Hayes, Martin Pelletier, Odile Gabay, Matthew Walsh, John R. Ferdinand, Andrea Keane-Myers, Yongwon Choi, John J. O’Shea, Aymen Al-Shamkhani, Mark H. Kaplan, Igal Gery, Richard M. Siegel, FranÇoise Meylan
Journal: The Journal of Immunology
J Immunol (2015) 195 (12): 5839–5840.
https://doi.org/10.4049/jimmunol.1502026
Published: 15 December 2015
View article titled, Correction: The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell–Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9–Producing T Cells
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Journal Articles

The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell–Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9–Producing T Cells

Arianne C. Richard, Cuiyan Tan, Eric T. Hawley, Julio Gomez-Rodriguez, Ritobrata Goswami, Xiang-Ping Yang, Anthony C. Cruz, Pallavi Penumetcha, Erika T. Hayes, Martin Pelletier, Odile Gabay, Matthew Walsh, John R. Ferdinand, Andrea Keane-Myers, Yongwon Choi, John J. O’Shea, Aymen Al-Shamkhani, Mark H. Kaplan, Igal Gery, Richard M. Siegel, Françoise Meylan
Journal: The Journal of Immunology
J Immunol (2015) 194 (8): 3567–3582.
https://doi.org/10.4049/jimmunol.1401220
Published: 15 April 2015
View article titled, The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell–Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9–Producing T Cells
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Includes: Supplementary data
Journal Articles

Mechanisms of Jak/STAT Signaling in Immunity and Disease

In Special Collection:
Brief Reviews
Alejandro V. Villarino, Yuka Kanno, John R. Ferdinand, John J. O’Shea
Journal: The Journal of Immunology
J Immunol (2015) 194 (1): 21–27.
https://doi.org/10.4049/jimmunol.1401867
Published: 01 January 2015
View article titled, Mechanisms of Jak/STAT Signaling in Immunity and Disease
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Journal Articles

Proprotein Convertase FURIN Constrains Th2 Differentiation and Is Critical for Host Resistance against Toxoplasma gondii

Anna Oksanen, Saara Aittomäki, Dragana Jankovic, Zsuzsanna Ortutay, Kati Pulkkinen, Sanna Hämäläinen, Anne Rokka, Garry L. Corthals, Wendy T. Watford, Ilkka Junttila, John J. O’Shea, Marko Pesu
Journal: The Journal of Immunology
J Immunol (2014) 193 (11): 5470–5479.
https://doi.org/10.4049/jimmunol.1401629
Published: 01 December 2014
View article titled, Proprotein Convertase FURIN Constrains Th2 Differentiation and Is Critical for Host Resistance against <em>Toxoplasma gondii</em>
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Includes: Supplementary data
Journal Articles

Tofacitinib Suppresses Antibody Responses to Protein Therapeutics in Murine Hosts

Masanori Onda, Kamran Ghoreschi, Scott Steward-Tharp, Craig Thomas, John J. O’Shea, Ira H. Pastan, David J. FitzGerald
Journal: The Journal of Immunology
J Immunol (2014) 193 (1): 48–55.
https://doi.org/10.4049/jimmunol.1400063
Published: 01 July 2014
View article titled, Tofacitinib Suppresses Antibody Responses to Protein Therapeutics in Murine Hosts
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Includes: Supplementary data
Journal Articles

Proliferation Conditions Promote Intrinsic Changes in NK Cells for an IL-10 Response

Margarite L. Tarrio, Seung-Hwan Lee, Maria F. Fragoso, Hong-Wei Sun, Yuka Kanno, John J. O’Shea, Christine A. Biron
Journal: The Journal of Immunology
J Immunol (2014) 193 (1): 354–363.
https://doi.org/10.4049/jimmunol.1302999
Published: 01 July 2014
View article titled, Proliferation Conditions Promote Intrinsic Changes in NK Cells for an IL-10 Response
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Includes: Supplementary data