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Journal Articles

Differential Role of CTLA-4 in Regulation of Resting Memory Versus Naive CD4 T Cell Activation

D. P. Metz, D. L. Farber, T. Taylor, K. Bottomly
Journal: The Journal of Immunology
J Immunol (1998) 161 (11): 5855–5861.
DOI: https://doi.org/10.4049/jimmunol.161.11.5855
Published: 01 December 1998
View article titled, Differential Role of CTLA-4 in Regulation of Resting Memory Versus Naive CD4 T Cell Activation
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Journal Articles

Distinct biochemical signals characterize agonist- and altered peptide ligand-induced differentiation of naive CD4+ T cells into Th1 and Th2 subsets.

Y Boutin, D Leitenberg, X Tao, K Bottomly
Journal: The Journal of Immunology
J Immunol (1997) 159 (12): 5802–5809.
DOI: https://doi.org/10.4049/jimmunol.159.12.5802
Published: 15 December 1997
View article titled, Distinct biochemical signals characterize agonist- and altered peptide ligand-induced differentiation of naive CD4+ T cells into Th1 and Th2 subsets.
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Journal Articles

Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation.

X Tao, S Constant, P Jorritsma, K Bottomly
Journal: The Journal of Immunology
J Immunol (1997) 159 (12): 5956–5963.
DOI: https://doi.org/10.4049/jimmunol.159.12.5956
Published: 15 December 1997
View article titled, Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation.
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Journal Articles

Regulation of memory CD4 T cell adhesion by CD4-MHC class II interaction.

D P Metz, D L Farber, R Konig, K Bottomly
Journal: The Journal of Immunology
J Immunol (1997) 159 (6): 2567–2573.
DOI: https://doi.org/10.4049/jimmunol.159.6.2567
Published: 15 September 1997
View article titled, Regulation of memory CD4 T cell adhesion by CD4-MHC class II interaction.
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Journal Articles

Induction of IL-4-producing CD4+ T cells by antigenic peptides altered for TCR binding.

X Tao, C Grant, S Constant, K Bottomly
Journal: The Journal of Immunology
J Immunol (1997) 158 (9): 4237–4244.
DOI: https://doi.org/10.4049/jimmunol.158.9.4237
Published: 01 May 1997
View article titled, Induction of IL-4-producing CD4+ T cells by antigenic peptides altered for TCR binding.
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Journal Articles

Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype.

T Nakamura, R K Lee, S Y Nam, E R Podack, K Bottomly, R A Flavell
Journal: The Journal of Immunology
J Immunol (1997) 158 (6): 2648–2653.
DOI: https://doi.org/10.4049/jimmunol.158.6.2648
Published: 15 March 1997
View article titled, Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype.
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Journal Articles

Reciprocal regulation of CD30 expression on CD4+ T cells by IL-4 and IFN-gamma.

T Nakamura, R K Lee, S Y Nam, B K Al-Ramadi, P A Koni, K Bottomly, E R Podack, R A Flavell
Journal: The Journal of Immunology
J Immunol (1997) 158 (5): 2090–2098.
DOI: https://doi.org/10.4049/jimmunol.158.5.2090
Published: 01 March 1997
View article titled, Reciprocal regulation of CD30 expression on CD4+ T cells by IL-4 and IFN-gamma.
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Journal Articles

Polarization of IL-4- and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells.

T Nakamura, Y Kamogawa, K Bottomly, R A Flavell
Journal: The Journal of Immunology
J Immunol (1997) 158 (3): 1085–1094.
DOI: https://doi.org/10.4049/jimmunol.158.3.1085
Published: 01 February 1997
View article titled, Polarization of IL-4- and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells.
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Journal Articles

Bias in the gamma delta T cell response to Listeria monocytogenes. V delta 6.3+ cells are a major component of the gamma delta T cell response to Listeria monocytogenes.

C Belles, A K Kuhl, A J Donoghue, Y Sano, R L O'Brien, W Born, K Bottomly, S R Carding
Journal: The Journal of Immunology
J Immunol (1996) 156 (11): 4280–4289.
DOI: https://doi.org/10.4049/jimmunol.156.11.4280
Published: 01 June 1996
View article titled, Bias in the gamma delta T cell response to Listeria monocytogenes. V delta 6.3+ cells are a major component of the gamma delta T cell response to Listeria monocytogenes.
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Journal Articles

B lymphocytes can be competent antigen-presenting cells for priming CD4+ T cells to protein antigens in vivo.

S Constant, N Schweitzer, J West, P Ranney, K Bottomly
Journal: The Journal of Immunology
J Immunol (1995) 155 (8): 3734–3741.
DOI: https://doi.org/10.4049/jimmunol.155.8.3734
Published: 15 October 1995
View article titled, B lymphocytes can be competent antigen-presenting cells for priming CD4+ T cells to protein antigens in vivo.
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Journal Articles

Peptide and protein antigens require distinct antigen-presenting cell subsets for the priming of CD4+ T cells.

S Constant, D Sant'Angelo, T Pasqualini, T Taylor, D Levin, R Flavell, K Bottomly
Journal: The Journal of Immunology
J Immunol (1995) 154 (10): 4915–4923.
DOI: https://doi.org/10.4049/jimmunol.154.10.4915
Published: 15 May 1995
View article titled, Peptide and protein antigens require distinct antigen-presenting cell subsets for the priming of CD4+ T cells.
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Journal Articles

Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo.

D Levin, S Constant, T Pasqualini, R Flavell, K Bottomly
Journal: The Journal of Immunology
J Immunol (1993) 151 (12): 6742–6750.
DOI: https://doi.org/10.4049/jimmunol.151.12.6742
Published: 15 December 1993
View article titled, Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo.
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Journal Articles

Functional CD4 T cell subset interplay in an intact immune system.

J S Murray, J Madri, T Pasqualini, K Bottomly
Journal: The Journal of Immunology
J Immunol (1993) 150 (10): 4270–4276.
DOI: https://doi.org/10.4049/jimmunol.150.10.4270
Published: 15 May 1993
View article titled, Functional CD4 T cell subset interplay in an intact immune system.
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Journal Articles

Activation requirements for CD4+ T cells differing in CD45R expression.

M Luqman, K Bottomly
Journal: The Journal of Immunology
J Immunol (1992) 149 (7): 2300–2306.
DOI: https://doi.org/10.4049/jimmunol.149.7.2300
Published: 01 October 1992
View article titled, Activation requirements for CD4+ T cells differing in CD45R expression.
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Journal Articles

Activation status of the CD4-8- gamma delta-T cells recovered from mice with influenza pneumonia.

M Eichelberger, W Allan, S R Carding, K Bottomly, P C Doherty
Journal: The Journal of Immunology
J Immunol (1991) 147 (7): 2069–2074.
DOI: https://doi.org/10.4049/jimmunol.147.7.2069
Published: 01 October 1991
View article titled, Activation status of the CD4-8- gamma delta-T cells recovered from mice with influenza pneumonia.
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Journal Articles

Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice.

D N Ernst, M V Hobbs, B E Torbett, A L Glasebrook, M A Rehse, K Bottomly, K Hayakawa, R R Hardy, W O Weigle
Journal: The Journal of Immunology
J Immunol (1990) 145 (5): 1295–1302.
DOI: https://doi.org/10.4049/jimmunol.145.5.1295
Published: 01 September 1990
View article titled, Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice.
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Journal Articles

Monoclonal antibodies to murine CD3 epsilon define distinct epitopes, one of which may interact with CD4 during T cell activation.

P Portoles, J Rojo, A Golby, M Bonneville, S Gromkowski, L Greenbaum, C A Janeway, Jr, D B Murphy, K Bottomly
Journal: The Journal of Immunology
J Immunol (1989) 142 (12): 4169–4175.
DOI: https://doi.org/10.4049/jimmunol.142.12.4169
Published: 15 June 1989
View article titled, Monoclonal antibodies to murine CD3 epsilon define distinct epitopes, one of which may interact with CD4 during T cell activation.
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Journal Articles

Antigen-specific activation of effector macrophages by IFN-gamma producing (TH1) T cell clones. Failure of IL-4-producing (TH2) T cell clones to activate effector function in macrophages.

R D Stout, K Bottomly
Journal: The Journal of Immunology
J Immunol (1989) 142 (3): 760–765.
DOI: https://doi.org/10.4049/jimmunol.142.3.760
Published: 01 February 1989
View article titled, Antigen-specific activation of effector macrophages by IFN-gamma producing (TH1) T cell clones. Failure of IL-4-producing (TH2) T cell clones to activate effector function in macrophages.
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Journal Articles

Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells.

L A Greenbaum, J B Horowitz, A Woods, T Pasqualini, E P Reich, K Bottomly
Journal: The Journal of Immunology
J Immunol (1988) 140 (5): 1555–1560.
DOI: https://doi.org/10.4049/jimmunol.140.5.1555
Published: 01 March 1988
View article titled, Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells.
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Journal Articles

IL-4 (B cell stimulatory factor 1) exhibits thymocyte growth factor activity in the presence of IL-2.

S R Carding, K Bottomly
Journal: The Journal of Immunology
J Immunol (1988) 140 (5): 1519–1526.
DOI: https://doi.org/10.4049/jimmunol.140.5.1519
Published: 01 March 1988
View article titled, IL-4 (B cell stimulatory factor 1) exhibits thymocyte growth factor activity in the presence of IL-2.
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