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Ken J. Ishii
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Journal Articles

Identification of RPL15 60S Ribosomal Protein as a Novel Topotecan Target Protein That Correlates with DAMP Secretion and Antitumor Immune Activation

Shunsuke Yamada, Yuichi Kitai, Takashi Tadokoro, Runa Takahashi, Haruka Shoji, Taiga Maemoto, Marie Ishiura, Ryuta Muromoto, Jun-ichi Kashiwakura, Ken J. Ishii, Katsumi Maenaka, Taro Kawai, Tadashi Matsuda
Journal: The Journal of Immunology
J Immunol (2022) 209 (1): 171–179.
DOI: https://doi.org/10.4049/jimmunol.2100963
Published: 01 July 2022
View article titled, Identification of RPL15 60S Ribosomal Protein as a Novel Topotecan Target Protein That Correlates with DAMP Secretion and Antitumor Immune Activation
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Includes: Supplementary data
Journal Articles

Oncolytic Reovirus Inhibits Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in a TLR3-Dependent Manner

Yuki Katayama, Masashi Tachibana, Nozomi Kurisu, Yukako Oya, Yuichi Terasawa, Hiroshi Goda, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi, Fuminori Sakurai
Journal: The Journal of Immunology
J Immunol (2018) 200 (8): 2987–2999.
DOI: https://doi.org/10.4049/jimmunol.1700435
Published: 15 April 2018
View article titled, Oncolytic Reovirus Inhibits Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in a TLR3-Dependent Manner
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Includes: Supplementary data
Journal Articles

An Antigen-Free, Plasmacytoid Dendritic Cell–Targeting Immunotherapy To Bolster Memory CD8+ T Cells in Nonhuman Primates

Yuji Masuta, Takuya Yamamoto, Yayoi Natsume-Kitatani, Tomohiro Kanuma, Eiko Moriishi, Kouji Kobiyama, Kenji Mizuguchi, Yasuhiro Yasutomi, Ken J. Ishii
Journal: The Journal of Immunology
J Immunol (2018) 200 (6): 2067–2075.
DOI: https://doi.org/10.4049/jimmunol.1701183
Published: 15 March 2018
View article titled, An Antigen-Free, Plasmacytoid Dendritic Cell–Targeting Immunotherapy To Bolster Memory CD8<sup>+</sup> T Cells in Nonhuman Primates
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Includes: Supplementary data
Journal Articles

Essential Role of CARD14 in Murine Experimental Psoriasis

Mayuri Tanaka, Kouji Kobiyama, Tetsuya Honda, Kozue Uchio-Yamada, Yayoi Natsume-Kitatani, Kenji Mizuguchi, Kenji Kabashima, Ken J. Ishii
Journal: The Journal of Immunology
J Immunol (2018) 200 (1): 71–81.
DOI: https://doi.org/10.4049/jimmunol.1700995
Published: 01 January 2018
View article titled, Essential Role of CARD14 in Murine Experimental Psoriasis
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Includes: Supplementary data
Journal Articles

Inflammasome and Fas-Mediated IL-1β Contributes to Th17/Th1 Cell Induction in Pathogenic Bacterial Infection In Vivo

Ryosuke Uchiyama, Shin Yonehara, Shun’ichiro Taniguchi, Satoshi Ishido, Ken J. Ishii, Hiroko Tsutsui
Journal: The Journal of Immunology
J Immunol (2017) 199 (3): 1122–1130.
DOI: https://doi.org/10.4049/jimmunol.1601373
Published: 01 August 2017
View article titled, Inflammasome and Fas-Mediated IL-1β Contributes to Th17/Th1 Cell Induction in Pathogenic Bacterial Infection In Vivo
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Includes: Supplementary data
Journal Articles

CD63-Mediated Antigen Delivery into Extracellular Vesicles via DNA Vaccination Results in Robust CD8+ T Cell Responses

Tomohiro Kanuma, Takuya Yamamoto, Kouji Kobiyama, Eiko Moriishi, Yuji Masuta, Takato Kusakabe, Koji Ozasa, Etsushi Kuroda, Nao Jounai, Ken J. Ishii
Journal: The Journal of Immunology
J Immunol (2017) 198 (12): 4707–4715.
DOI: https://doi.org/10.4049/jimmunol.1600731
Published: 15 June 2017
View article titled, CD63-Mediated Antigen Delivery into Extracellular Vesicles via DNA Vaccination Results in Robust CD8<sup>+</sup> T Cell Responses
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Includes: Supplementary data
Journal Articles

DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity

Yuichi Kitai, Takumi Kawasaki, Takuya Sueyoshi, Kouji Kobiyama, Ken J. Ishii, Jian Zou, Shizuo Akira, Tadashi Matsuda, Taro Kawai
Journal: The Journal of Immunology
J Immunol (2017) 198 (4): 1649–1659.
DOI: https://doi.org/10.4049/jimmunol.1601694
Published: 15 February 2017
View article titled, DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity
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Includes: Supplementary data
Journal Articles

Hydroxypropyl-β-Cyclodextrin Spikes Local Inflammation That Induces Th2 Cell and T Follicular Helper Cell Responses to the Coadministered Antigen

Motoyasu Onishi, Koji Ozasa, Kouji Kobiyama, Keiichi Ohata, Mitsutaka Kitano, Keiichi Taniguchi, Tomoyuki Homma, Masanori Kobayashi, Akihiko Sato, Yuko Katakai, Yasuhiro Yasutomi, Edward Wijaya, Yoshinobu Igarashi, Noriyuki Nakatsu, Wataru Ise, Takeshi Inoue, Hiroshi Yamada, Alexis Vandenbon, Daron M. Standley, Tomohiro Kurosaki, Cevayir Coban, Taiki Aoshi, Etsushi Kuroda, Ken J. Ishii
Journal: The Journal of Immunology
J Immunol (2015) 194 (6): 2673–2682.
DOI: https://doi.org/10.4049/jimmunol.1402027
Published: 15 March 2015
View article titled, Hydroxypropyl-β-Cyclodextrin Spikes Local Inflammation That Induces Th2 Cell and T Follicular Helper Cell Responses to the Coadministered Antigen
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Includes: Multimedia, Supplementary data
Journal Articles

A New Subset of CD103+CD8α+ Dendritic Cells in the Small Intestine Expresses TLR3, TLR7, and TLR9 and Induces Th1 Response and CTL Activity

Kosuke Fujimoto, Thangaraj Karuppuchamy, Naoki Takemura, Masaki Shimohigoshi, Tomohisa Machida, Yasunari Haseda, Taiki Aoshi, Ken J. Ishii, Shizuo Akira, Satoshi Uematsu
Journal: The Journal of Immunology
J Immunol (2011) 186 (11): 6287–6295.
DOI: https://doi.org/10.4049/jimmunol.1004036
Published: 01 June 2011
View article titled, A New Subset of CD103<sup>+</sup>CD8α<sup>+</sup> Dendritic Cells in the Small Intestine Expresses TLR3, TLR7, and TLR9 and Induces Th1 Response and CTL Activity
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Includes: Supplementary data
Journal Articles

NLRP4 Negatively Regulates Autophagic Processes through an Association with Beclin1

Nao Jounai, Kouji Kobiyama, Masaaki Shiina, Kazuhiro Ogata, Ken J. Ishii, Fumihiko Takeshita
Journal: The Journal of Immunology
J Immunol (2011) 186 (3): 1646–1655.
DOI: https://doi.org/10.4049/jimmunol.1001654
Published: 01 February 2011
View article titled, NLRP4 Negatively Regulates Autophagic Processes through an Association with Beclin1
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Includes: Supplementary data
Journal Articles

A Signaling Polypeptide Derived from an Innate Immune Adaptor Molecule Can Be Harnessed as a New Class of Vaccine Adjuvant

Kouji Kobiyama, Fumihiko Takeshita, Ken J. Ishii, Shohei Koyama, Taiki Aoshi, Shizuo Akira, Asako Sakaue-Sawano, Atsushi Miyawaki, Yuko Yamanaka, Hisashi Hirano, Koichi Suzuki, Kenji Okuda
Journal: The Journal of Immunology
J Immunol (2009) 182 (3): 1593–1601.
DOI: https://doi.org/10.4049/jimmunol.182.3.1593
Published: 01 February 2009
View article titled, A Signaling Polypeptide Derived from an Innate Immune Adaptor Molecule Can Be Harnessed as a New Class of Vaccine Adjuvant
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Includes: Supplementary data
Journal Articles

Malaria Parasites Require TLR9 Signaling for Immune Evasion by Activating Regulatory T Cells

Hajime Hisaeda, Kohhei Tetsutani, Takashi Imai, Chikako Moriya, Liping Tu, Shinjiro Hamano, Xuefeng Duan, Bin Chou, Hidekazu Ishida, Akiko Aramaki, Jianying Shen, Ken J. Ishii, Cevayir Coban, Shizuo Akira, Kiyoshi Takeda, Koji Yasutomo, Motomi Torii, Kunisuke Himeno
Journal: The Journal of Immunology
J Immunol (2008) 180 (4): 2496–2503.
DOI: https://doi.org/10.4049/jimmunol.180.4.2496
Published: 15 February 2008
View article titled, Malaria Parasites Require TLR9 Signaling for Immune Evasion by Activating Regulatory T Cells
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Journal Articles

Cutting Edge: Cooperation of IPS-1- and TRIF-Dependent Pathways in Poly IC-Enhanced Antibody Production and Cytotoxic T Cell Responses

Himanshu Kumar, Shohei Koyama, Ken J. Ishii, Taro Kawai, Shizuo Akira
Journal: The Journal of Immunology
J Immunol (2008) 180 (2): 683–687.
DOI: https://doi.org/10.4049/jimmunol.180.2.683
Published: 15 January 2008
View article titled, Cutting Edge: Cooperation of IPS-1- and TRIF-Dependent Pathways in Poly IC-Enhanced Antibody Production and Cytotoxic T Cell Responses
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Journal Articles

Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination

Shohei Koyama, Ken J. Ishii, Himanshu Kumar, Takeshi Tanimoto, Cevayir Coban, Satoshi Uematsu, Taro Kawai, Shizuo Akira
Journal: The Journal of Immunology
J Immunol (2007) 179 (7): 4711–4720.
DOI: https://doi.org/10.4049/jimmunol.179.7.4711
Published: 01 October 2007
View article titled, Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination
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Journal Articles

Blocking of the TLR5 Activation Domain Hampers Protective Potential of Flagellin DNA Vaccine

Sukumar Saha, Fumihiko Takeshita, Tomoko Matsuda, Nao Jounai, Kouji Kobiyama, Tetsuya Matsumoto, Shin Sasaki, Atsushi Yoshida, Ke-Qin Xin, Dennis M. Klinman, Satoshi Uematsu, Ken J. Ishii, Shizuo Akira, Kenji Okuda
Journal: The Journal of Immunology
J Immunol (2007) 179 (2): 1147–1154.
DOI: https://doi.org/10.4049/jimmunol.179.2.1147
Published: 15 July 2007
View article titled, Blocking of the TLR5 Activation Domain Hampers Protective Potential of Flagellin DNA Vaccine
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Journal Articles

Cutting Edge: Pivotal Function of Ubc13 in Thymocyte TCR Signaling

Masahiro Yamamoto, Shintaro Sato, Tatsuya Saitoh, Hiroaki Sakurai, Satoshi Uematsu, Taro Kawai, Ken J. Ishii, Osamu Takeuchi, Shizuo Akira
Journal: The Journal of Immunology
J Immunol (2006) 177 (11): 7520–7524.
DOI: https://doi.org/10.4049/jimmunol.177.11.7520
Published: 01 December 2006
View article titled, Cutting Edge: Pivotal Function of Ubc13 in Thymocyte TCR Signaling
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Journal Articles

Th1-Like Cytokine Induction by Heat-Killed Brucella abortus Is Dependent on Triggering of TLR9

Li-Yun Huang, Ken J. Ishii, Shizuo Akira, Julio Aliberti, Basil Golding
Journal: The Journal of Immunology
J Immunol (2005) 175 (6): 3964–3970.
DOI: https://doi.org/10.4049/jimmunol.175.6.3964
Published: 15 September 2005
View article titled, Th1-Like Cytokine Induction by Heat-Killed Brucella abortus Is Dependent on Triggering of TLR9
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Journal Articles

CpG RNA: Identification of Novel Single-Stranded RNA That Stimulates Human CD14+CD11c+ Monocytes

Takahiro Sugiyama, Mayda Gursel, Fumihiko Takeshita, Cevayir Coban, Jacqueline Conover, Tsuneyasu Kaisho, Shizuo Akira, Dennis M. Klinman, Ken J. Ishii
Journal: The Journal of Immunology
J Immunol (2005) 174 (4): 2273–2279.
DOI: https://doi.org/10.4049/jimmunol.174.4.2273
Published: 15 February 2005
View article titled, CpG RNA: Identification of Novel Single-Stranded RNA That Stimulates Human CD14<sup>+</sup>CD11c<sup>+</sup> Monocytes
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Journal Articles

CpG Oligodeoxynucleotides Enhance Neonatal Resistance to Listeria Infection

Shuichi Ito, Ken J. Ishii, Mayda Gursel, Hidekazu Shirotra, Atsushi Ihata, Dennis M. Klinman
Journal: The Journal of Immunology
J Immunol (2005) 174 (2): 777–782.
DOI: https://doi.org/10.4049/jimmunol.174.2.777
Published: 15 January 2005
View article titled, CpG Oligodeoxynucleotides Enhance Neonatal Resistance to Listeria Infection
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Journal Articles

Transcriptional Regulation of the Human TLR9 Gene

Fumihiko Takeshita, Koichi Suzuki, Shin Sasaki, Norihisa Ishii, Dennis M. Klinman, Ken J. Ishii
Journal: The Journal of Immunology
J Immunol (2004) 173 (4): 2552–2561.
DOI: https://doi.org/10.4049/jimmunol.173.4.2552
Published: 15 August 2004
View article titled, Transcriptional Regulation of the Human TLR9 Gene
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