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Kenji Nakanishi
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Journal Articles

IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation.

Tomohiro Yoshimoto, Takayuki Yoshimoto, Koubun Yasuda, Junichiro Mizuguchi, Kenji Nakanishi
Journal: The Journal of Immunology
J Immunol (2010) 184 (6): 3298.
https://doi.org/10.4049/jimmunol.1090006
Published: 15 March 2010
View article titled, IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation.
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Protective Effect of IL-18 on Kainate- and IL-1β-Induced Cerebellar Ataxia in Mice

Tsugunobu Andoh, Hiroyuki Kishi, Kazumi Motoki, Kenji Nakanishi, Yasushi Kuraishi, Atsushi Muraguchi
Journal: The Journal of Immunology
J Immunol (2008) 180 (4): 2322–2328.
https://doi.org/10.4049/jimmunol.180.4.2322
Published: 15 February 2008
View article titled, Protective Effect of IL-18 on Kainate- and IL-1β-Induced Cerebellar Ataxia in Mice
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IL-27 Suppresses Th2 Cell Development and Th2 Cytokines Production from Polarized Th2 Cells: A Novel Therapeutic Way for Th2-Mediated Allergic Inflammation

Tomohiro Yoshimoto, Takayuki Yoshimoto, Koubun Yasuda, Junichiro Mizuguchi, Kenji Nakanishi
Journal: The Journal of Immunology
J Immunol (2007) 179 (7): 4415–4423.
https://doi.org/10.4049/jimmunol.179.7.4415
Published: 01 October 2007
View article titled, IL-27 Suppresses Th2 Cell Development and Th2 Cytokines Production from Polarized Th2 Cells: A Novel Therapeutic Way for Th2-Mediated Allergic Inflammation
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Human Mast Cell Chymase Cleaves Pro-IL-18 and Generates a Novel and Biologically Active IL-18 Fragment

Youichi Omoto, Kazuya Tokime, Keiichi Yamanaka, Koji Habe, Tatsuhiko Morioka, Ichiro Kurokawa, Hiroko Tsutsui, Kiyofumi Yamanishi, Kenji Nakanishi, Hitoshi Mizutani
Journal: The Journal of Immunology
J Immunol (2006) 177 (12): 8315–8319.
https://doi.org/10.4049/jimmunol.177.12.8315
Published: 15 December 2006
View article titled, Human Mast Cell Chymase Cleaves Pro-IL-18 and Generates a Novel and Biologically Active IL-18 Fragment
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IL-1 Receptor-Associated Kinase 4 Is Essential for IL-18-Mediated NK and Th1 Cell Responses

Nobutaka Suzuki, Nien-Jung Chen, Douglas G. Millar, Shinobu Suzuki, Thomas Horacek, Hiromitsu Hara, Denis Bouchard, Kenji Nakanishi, Josef M. Penninger, Pamela S. Ohashi, Wen-Chen Yeh
Journal: The Journal of Immunology
J Immunol (2003) 170 (8): 4031–4035.
https://doi.org/10.4049/jimmunol.170.8.4031
Published: 15 April 2003
View article titled, IL-1 Receptor-Associated Kinase 4 Is Essential for IL-18-Mediated NK and Th1 Cell Responses
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Critical Roles of Myeloid Differentiation Factor 88-Dependent Proinflammatory Cytokine Release in Early Phase Clearance of Listeria monocytogenes in Mice

Ekihiro Seki, Hiroko Tsutsui, Noriko M. Tsuji, Nobuki Hayashi, Keishi Adachi, Hiroki Nakano, Shizue Futatsugi-Yumikura, Osamu Takeuchi, Katsuaki Hoshino, Shizuo Akira, Jiro Fujimoto, Kenji Nakanishi
Journal: The Journal of Immunology
J Immunol (2002) 169 (7): 3863–3868.
https://doi.org/10.4049/jimmunol.169.7.3863
Published: 01 October 2002
View article titled, Critical Roles of Myeloid Differentiation Factor 88-Dependent Proinflammatory Cytokine Release in Early Phase Clearance of <em>Listeria monocytogenes</em> in Mice
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Plasmodium berghei Infection in Mice Induces Liver Injury by an IL-12- and Toll-Like Receptor/Myeloid Differentiation Factor 88-Dependent Mechanism

Keishi Adachi, Hiroko Tsutsui, Shin-Ichiro Kashiwamura, Ekihiro Seki, Hiroki Nakano, Osamu Takeuchi, Kazuyoshi Takeda, Ko Okumura, Luc Van Kaer, Haruki Okamura, Shizuo Akira, Kenji Nakanishi
Journal: The Journal of Immunology
J Immunol (2001) 167 (10): 5928–5934.
https://doi.org/10.4049/jimmunol.167.10.5928
Published: 15 November 2001
View article titled, <em>Plasmodium</em> <em>berghei</em> Infection in Mice Induces Liver Injury by an IL-12- and Toll-Like Receptor/Myeloid Differentiation Factor 88-Dependent Mechanism
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Journal Articles

Lipopolysaccharide-Induced IL-18 Secretion from Murine Kupffer Cells Independently of Myeloid Differentiation Factor 88 That Is Critically Involved in Induction of Production of IL-12 and IL-1β

Ekihiro Seki, Hiroko Tsutsui, Hiroki Nakano, Noriko M. Tsuji, Katsuaki Hoshino, Osamu Adachi, Keishi Adachi, Shizue Futatsugi, Keisuke Kuida, Osamu Takeuchi, Haruki Okamura, Jiro Fujimoto, Shizuo Akira, Kenji Nakanishi
Journal: The Journal of Immunology
J Immunol (2001) 166 (4): 2651–2657.
https://doi.org/10.4049/jimmunol.166.4.2651
Published: 15 February 2001
View article titled, Lipopolysaccharide-Induced IL-18 Secretion from Murine Kupffer Cells Independently of Myeloid Differentiation Factor 88 That Is Critically Involved in Induction of Production of IL-12 and IL-1β
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Journal Articles

Skin-Specific Caspase-1-Transgenic Mice Show Cutaneous Apoptosis and Pre-Endotoxin Shock Condition with a High Serum Level of IL-18

Kei-ichi Yamanaka, Minoru Tanaka, Hiroko Tsutsui, Thomas S. Kupper, Kunihiko Asahi, Haruki Okamura, Kenji Nakanishi, Misao Suzuki, Nobuhiko Kayagaki, Roy A. Black, Douglas K. Miller, Kunio Nakashima, Masayuki Shimizu, Hitoshi Mizutani
Journal: The Journal of Immunology
J Immunol (2000) 165 (2): 997–1003.
https://doi.org/10.4049/jimmunol.165.2.997
Published: 15 July 2000
View article titled, Skin-Specific Caspase-1-Transgenic Mice Show Cutaneous Apoptosis and Pre-Endotoxin Shock Condition with a High Serum Level of IL-18
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Cutting Edge: Endotoxin Tolerance in Mouse Peritoneal Macrophages Correlates with Down-Regulation of Surface Toll-Like Receptor 4 Expression

Fumiko Nomura, Sachiko Akashi, Yoshimitsu Sakao, Shintaro Sato, Taro Kawai, Makoto Matsumoto, Kenji Nakanishi, Masao Kimoto, Kensuke Miyake, Kiyoshi Takeda, Shizuo Akira
Journal: The Journal of Immunology
J Immunol (2000) 164 (7): 3476–3479.
https://doi.org/10.4049/jimmunol.164.7.3476
Published: 01 April 2000
View article titled, Cutting Edge: Endotoxin Tolerance in Mouse Peritoneal Macrophages Correlates with Down-Regulation of Surface Toll-Like Receptor 4 Expression
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Journal Articles

Expression and Function of TNF-Related Apoptosis-Inducing Ligand on Murine Activated NK Cells

Nobuhiko Kayagaki, Noriko Yamaguchi, Masafumi Nakayama, Kazuyoshi Takeda, Hisaya Akiba, Hiroko Tsutsui, Haruki Okamura, Kenji Nakanishi, Ko Okumura, Hideo Yagita
Journal: The Journal of Immunology
J Immunol (1999) 163 (4): 1906–1913.
https://doi.org/10.4049/jimmunol.163.4.1906
Published: 15 August 1999
View article titled, Expression and Function of TNF-Related Apoptosis-Inducing Ligand on Murine Activated NK Cells
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Cutting Edge: Generation of IL-18 Receptor-Deficient Mice: Evidence for IL-1 Receptor-Related Protein as an Essential IL-18 Binding Receptor

Katsuaki Hoshino, Hiroko Tsutsui, Taro Kawai, Kiyoshi Takeda, Kenji Nakanishi, Yoshifumi Takeda, Shizuo Akira
Journal: The Journal of Immunology
J Immunol (1999) 162 (9): 5041–5044.
https://doi.org/10.4049/jimmunol.162.9.5041
Published: 01 May 1999
View article titled, Cutting Edge: Generation of IL-18 Receptor-Deficient Mice: Evidence for IL-1 Receptor-Related Protein as an Essential IL-18 Binding Receptor
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Alleviation of Lipopolysaccharide-Induced Acute Liver Injury in Propionibacterium acnes-Primed IFN-γ-Deficient Mice by a Concomitant Reduction of TNF-α, IL-12, and IL-18 Production

Hirokazu Tsuji, Naofumi Mukaida, Akihisa Harada, Shuichi Kaneko, Eiki Matsushita, Yasuni Nakanuma, Hiroko Tsutsui, Haruki Okamura, Kenji Nakanishi, Yoh-ichi Tagawa, Yoichiro Iwakura, Ken-ichi Kobayashi, Kouji Matsushima
Journal: The Journal of Immunology
J Immunol (1999) 162 (2): 1049–1055.
https://doi.org/10.4049/jimmunol.162.2.1049
Published: 15 January 1999
View article titled, Alleviation of Lipopolysaccharide-Induced Acute Liver Injury in <em>Propionibacterium acnes</em>-Primed IFN-γ-Deficient Mice by a Concomitant Reduction of TNF-α, IL-12, and IL-18 Production
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Journal Articles

IL-12 Up-Regulates IL-18 Receptor Expression on T Cells, Th1 Cells, and B Cells: Synergism with IL-18 for IFN-γ Production

Tomohiro Yoshimoto, Kiyoshi Takeda, Takashi Tanaka, Kazunobu Ohkusu, Shin-ichiro Kashiwamura, Haruki Okamura, Shizuo Akira, Kenji Nakanishi
Journal: The Journal of Immunology
J Immunol (1998) 161 (7): 3400–3407.
https://doi.org/10.4049/jimmunol.161.7.3400
Published: 01 October 1998
View article titled, IL-12 Up-Regulates IL-18 Receptor Expression on T Cells, Th1 Cells, and B Cells: Synergism with IL-18 for IFN-γ Production
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LPS-Stimulated SJL Macrophages Produce IL-12 and IL-18 That Inhibit IgE Production In Vitro by Induction of IFN-γ Production from CD3intIL-2Rβ+ T Cells

Tomohiro Yoshimoto, Nobuhiko Nagai, Kazunobu Ohkusu, Haruyasu Ueda, Haruki Okamura, Kenji Nakanishi
Journal: The Journal of Immunology
J Immunol (1998) 161 (3): 1483–1492.
https://doi.org/10.4049/jimmunol.161.3.1483
Published: 01 August 1998
View article titled, LPS-Stimulated SJL Macrophages Produce IL-12 and IL-18 That Inhibit IgE Production In Vitro by Induction of IFN-γ Production from CD3<sup>int</sup>IL-2Rβ<sup>+ </sup>T Cells
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A Critical Role for IL-18 in the Proliferation and Activation of NK1.1+CD3− Cells

Michio Tomura, Xu-Yu Zhou, Seiji Maruo, Hyun-Jong Ahn, Toshiyuki Hamaoka, Haruki Okamura, Kenji Nakanishi, Tadao Tanimoto, Masashi Kurimoto, Hiromi Fujiwara
Journal: The Journal of Immunology
J Immunol (1998) 160 (10): 4738–4746.
https://doi.org/10.4049/jimmunol.160.10.4738
Published: 15 May 1998
View article titled, A Critical Role for IL-18 in the Proliferation and Activation of NK1.1<sup>+</sup>CD3<sup>−</sup> Cells
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Differential Capacities of CD4+, CD8+, and CD4−CD8− T Cell Subsets to Express IL-18 Receptor and Produce IFN-γ in Response to IL-18

Michio Tomura, Seiji Maruo, Jie Mu, Xu-Yu Zhou, Hyun-Jong Ahn, Toshiyuki Hamaoka, Haruki Okamura, Kenji Nakanishi, Steven Clark, Masashi Kurimoto, Hiromi Fujiwara
Journal: The Journal of Immunology
J Immunol (1998) 160 (8): 3759–3765.
https://doi.org/10.4049/jimmunol.160.8.3759
Published: 15 April 1998
View article titled, Differential Capacities of CD4<sup>+</sup>, CD8<sup>+</sup>, and CD4<sup>−</sup>CD8<sup>−</sup> T Cell Subsets to Express IL-18 Receptor and Produce IFN-γ in Response to IL-18
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Regulation of Antibody Response in Different Immunoglobulin Classes: VI. Selective Suppression of IgE Response by Administration of Antigen-Conjugated Muramylpeptides

Tadamitsu Kishimoto, Yoshikatsu Hirai, Kenji Nakanishi, Ichiro Azuma, Atsuo Nagamatsu, Yuichi Yamamura
Journal: The Journal of Immunology
J Immunol (1979) 123 (6): 2709–2715.
https://doi.org/10.4049/jimmunol.123.6.2709
Published: 01 December 1979
View article titled, Regulation of Antibody Response in Different Immunoglobulin Classes: <subtitle>VI. Selective Suppression of IgE Response by Administration of Antigen-Conjugated Muramylpeptides</subtitle>
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Regulation of Antibody Response in Different Immunoglobulin Classes: IV. Properties and Functions of “IgE Class-Specific” Suppressor Factor(s) Released from DNP-Mycobacterium-Primed T Cells

Tadamitsu Kishimoto, Yoshikatsu Hirai, Masaki Suemura, Kenji Nakanishi, Yuichi Yamamura
Journal: The Journal of Immunology
J Immunol (1978) 121 (5): 2106–2112.
https://doi.org/10.4049/jimmunol.121.5.2106
Published: 01 November 1978
View article titled, Regulation of Antibody Response in Different Immunoglobulin Classes: <subtitle>IV. Properties and Functions of “IgE Class-Specific” Suppressor Factor(s) Released from DNP-Mycobacterium-Primed T Cells</subtitle>
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