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Journal Articles

The xenobiotic transporter Mdr1 permits T cell adaptation to mucosa-associated bile acids in the ileum

Mark S Sundrud, Wei Cao, Hisako Kayama, Mei Lan Chen, Amber Delmas, Amy Sun, Sang Yong Kim, Kelly McKevitt, Erumbi S. Rangarajan, Amanda P. Beck, Angelos Oikonomopoulos, Precious N. Lacey, Gustavo J Martinez, Tina Izard, Robin G Lorenz, Alex Rodriguez-Palacios, Fabio Cominelli, Maria T Abreu, Daniel W. Hommes, Sergei B Koralov, Kiyoshi Takeda
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 65.14.
https://doi.org/10.4049/jimmunol.198.Supp.65.14
Published: 01 May 2017
View article titled, The xenobiotic transporter Mdr1 permits T cell adaptation to mucosa-associated bile acids in the ileum
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Pillars Article: Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product. J. Immunol. 1999. 162: 3749–3752

Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai, Hideki Sanjo, Tomohiko Ogawa, Yoshifumi Takeda, Kiyoshi Takeda, Shizuo Akira
Journal: The Journal of Immunology
J Immunol (2016) 197 (7): 2563–2566.
Published: 01 October 2016
View article titled, Pillars Article: Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <em>Lps</em> Gene Product. <em>J. Immunol.</em> 1999. 162: 3749–3752
Open the PDF for Pillars Article: Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <em>Lps</em> Gene Product. <em>J. Immunol.</em> 1999. 162: 3749–3752 in another window
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Journal Articles

Correction: Stat3 Activation Is Responsible for IL-6–Dependent T Cell Proliferation through Preventing Apoptosis: Generation and Characterization of T Cell–Specific Stat3-Deficient Mice

Kiyoshi Takeda, Tsuneyasu Kaisho, Nobuaki Yoshida, Junji Takeda, Tadamitsu Kishimoto, Shizuo Akira
Journal: The Journal of Immunology
J Immunol (2015) 194 (7): 3526.
https://doi.org/10.4049/jimmunol.1500168
Published: 01 April 2015
View article titled, Correction: Stat3 Activation Is Responsible for IL-6–Dependent T Cell Proliferation through Preventing Apoptosis: Generation and Characterization of T Cell–Specific Stat3-Deficient Mice
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Role of Mouse and Human Autophagy Proteins in IFN-γ–Induced Cell-Autonomous Responses against Toxoplasma gondii

Jun Ohshima, Youngae Lee, Miwa Sasai, Tatsuya Saitoh, Ji Su Ma, Naganori Kamiyama, Yoshiharu Matsuura, Suh Pann-Ghill, Mikako Hayashi, Shigeyuki Ebisu, Kiyoshi Takeda, Shizuo Akira, Masahiro Yamamoto
Journal: The Journal of Immunology
J Immunol (2014) 192 (7): 3328–3335.
https://doi.org/10.4049/jimmunol.1302822
Published: 01 April 2014
View article titled, Role of Mouse and Human Autophagy Proteins in IFN-γ–Induced Cell-Autonomous Responses against <em>Toxoplasma gondii</em>
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Includes: Supplementary data
Journal Articles

Ecto-Nucleoside Triphosphate Diphosphohydrolase 7 Controls Th17 Cell Responses through Regulation of Luminal ATP in the Small Intestine

Takashi Kusu, Hisako Kayama, Makoto Kinoshita, Seong Gyu Jeon, Yoshiyasu Ueda, Yoshiyuki Goto, Ryu Okumura, Hiroyuki Saiga, Takashi Kurakawa, Kayo Ikeda, Yuichi Maeda, Jun-ichi Nishimura, Yasunobu Arima, Koji Atarashi, Kenya Honda, Masaaki Murakami, Jun Kunisawa, Hiroshi Kiyono, Meinoshin Okumura, Masahiro Yamamoto, Kiyoshi Takeda
Journal: The Journal of Immunology
J Immunol (2013) 190 (2): 774–783.
https://doi.org/10.4049/jimmunol.1103067
Published: 15 January 2013
View article titled, Ecto-Nucleoside Triphosphate Diphosphohydrolase 7 Controls Th17 Cell Responses through Regulation of Luminal ATP in the Small Intestine
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Includes: Supplementary data
Journal Articles

Dietary Folic Acid Promotes Survival of Foxp3+ Regulatory T Cells in the Colon

Makoto Kinoshita, Hisako Kayama, Takashi Kusu, Tomoyuki Yamaguchi, Jun Kunisawa, Hiroshi Kiyono, Shimon Sakaguchi, Kiyoshi Takeda
Journal: The Journal of Immunology
J Immunol (2012) 189 (6): 2869–2878.
https://doi.org/10.4049/jimmunol.1200420
Published: 15 September 2012
View article titled, Dietary Folic Acid Promotes Survival of Foxp3<sup>+</sup> Regulatory T Cells in the Colon
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Includes: Supplementary data
Journal Articles

Enhanced Cancer Immunotherapy Using STAT3-Depleted Dendritic Cells with High Th1-Inducing Ability and Resistance to Cancer Cell-Derived Inhibitory Factors

Tomoko Iwata-Kajihara, Hidetoshi Sumimoto, Naoshi Kawamura, Ryo Ueda, Tomomi Takahashi, Hiroyuki Mizuguchi, Makoto Miyagishi, Kiyoshi Takeda, Yutaka Kawakami
Journal: The Journal of Immunology
J Immunol (2011) 187 (1): 27–36.
https://doi.org/10.4049/jimmunol.1002067
Published: 01 July 2011
View article titled, Enhanced Cancer Immunotherapy Using STAT3-Depleted Dendritic Cells with High Th1-Inducing Ability and Resistance to Cancer Cell-Derived Inhibitory Factors
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Journal Articles

Lipocalin 2-Dependent Inhibition of Mycobacterial Growth in Alveolar Epithelium

Hiroyuki Saiga, Junichi Nishimura, Hirotaka Kuwata, Megumi Okuyama, Sohkichi Matsumoto, Shintaro Sato, Makoto Matsumoto, Shizuo Akira, Yasunobu Yoshikai, Kenya Honda, Masahiro Yamamoto, Kiyoshi Takeda
Journal: The Journal of Immunology
J Immunol (2008) 181 (12): 8521–8527.
https://doi.org/10.4049/jimmunol.181.12.8521
Published: 15 December 2008
View article titled, Lipocalin 2-Dependent Inhibition of Mycobacterial Growth in Alveolar Epithelium
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Journal Articles

Potent Antimycobacterial Activity of Mouse Secretory Leukocyte Protease Inhibitor

Junichi Nishimura, Hiroyuki Saiga, Shintaro Sato, Megumi Okuyama, Hisako Kayama, Hirotaka Kuwata, Sohkichi Matsumoto, Toshirou Nishida, Yoshiki Sawa, Shizuo Akira, Yasunobu Yoshikai, Masahiro Yamamoto, Kiyoshi Takeda
Journal: The Journal of Immunology
J Immunol (2008) 180 (6): 4032–4039.
https://doi.org/10.4049/jimmunol.180.6.4032
Published: 15 March 2008
View article titled, Potent Antimycobacterial Activity of Mouse Secretory Leukocyte Protease Inhibitor
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Deoxynucleic Acids from Cryptococcus neoformans Activate Myeloid Dendritic Cells via a TLR9-Dependent Pathway

Kiwamu Nakamura, Akiko Miyazato, Gang Xiao, Masumitsu Hatta, Ken Inden, Tetsuji Aoyagi, Kohei Shiratori, Kiyoshi Takeda, Shizuo Akira, Shinobu Saijo, Yoichiro Iwakura, Yoshiyuki Adachi, Naohito Ohno, Kazuo Suzuki, Jiro Fujita, Mitsuo Kaku, Kazuyoshi Kawakami
Journal: The Journal of Immunology
J Immunol (2008) 180 (6): 4067–4074.
https://doi.org/10.4049/jimmunol.180.6.4067
Published: 15 March 2008
View article titled, Deoxynucleic Acids from <em>Cryptococcus neoformans</em> Activate Myeloid Dendritic Cells via a TLR9-Dependent Pathway
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STAT3 Is Indispensable to IL-27-Mediated Cell Proliferation but Not to IL-27-Induced Th1 Differentiation and Suppression of Proinflammatory Cytokine Production

Toshiyuki Owaki, Masayuki Asakawa, Noriko Morishima, Izuru Mizoguchi, Fumio Fukai, Kiyoshi Takeda, Junichiro Mizuguchi, Takayuki Yoshimoto
Journal: The Journal of Immunology
J Immunol (2008) 180 (5): 2903–2911.
https://doi.org/10.4049/jimmunol.180.5.2903
Published: 01 March 2008
View article titled, STAT3 Is Indispensable to IL-27-Mediated Cell Proliferation but Not to IL-27-Induced Th1 Differentiation and Suppression of Proinflammatory Cytokine Production
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Journal Articles

Malaria Parasites Require TLR9 Signaling for Immune Evasion by Activating Regulatory T Cells

Hajime Hisaeda, Kohhei Tetsutani, Takashi Imai, Chikako Moriya, Liping Tu, Shinjiro Hamano, Xuefeng Duan, Bin Chou, Hidekazu Ishida, Akiko Aramaki, Jianying Shen, Ken J. Ishii, Cevayir Coban, Shizuo Akira, Kiyoshi Takeda, Koji Yasutomo, Motomi Torii, Kunisuke Himeno
Journal: The Journal of Immunology
J Immunol (2008) 180 (4): 2496–2503.
https://doi.org/10.4049/jimmunol.180.4.2496
Published: 15 February 2008
View article titled, Malaria Parasites Require TLR9 Signaling for Immune Evasion by Activating Regulatory T Cells
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TLR-Dependent Induction of IFN-β Mediates Host Defense against Trypanosoma cruzi

Ritsuko Koga, Shinjiro Hamano, Hirotaka Kuwata, Koji Atarashi, Masahiro Ogawa, Hajime Hisaeda, Masahiro Yamamoto, Shizuo Akira, Kunisuke Himeno, Makoto Matsumoto, Kiyoshi Takeda
Journal: The Journal of Immunology
J Immunol (2006) 177 (10): 7059–7066.
https://doi.org/10.4049/jimmunol.177.10.7059
Published: 15 November 2006
View article titled, TLR-Dependent Induction of IFN-β Mediates Host Defense against <em>Trypanosoma cruzi</em>
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Journal Articles

MyD88-Dependent Signaling for IL-15 Production Plays an Important Role in Maintenance of CD8αα TCRαβ and TCRγδ Intestinal Intraepithelial Lymphocytes

Qingsheng Yu, Ce Tang, Sun Xun, Toshiki Yajima, Kiyoshi Takeda, Yasunobu Yoshikai
Journal: The Journal of Immunology
J Immunol (2006) 176 (10): 6180–6185.
https://doi.org/10.4049/jimmunol.176.10.6180
Published: 15 May 2006
View article titled, MyD88-Dependent Signaling for IL-15 Production Plays an Important Role in Maintenance of CD8αα TCRαβ and TCRγδ Intestinal Intraepithelial Lymphocytes
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Essential Role of IκB Kinase α in Thymic Organogenesis Required for the Establishment of Self-Tolerance

Dan Kinoshita, Fumiko Hirota, Tsuneyasu Kaisho, Michiyuki Kasai, Keisuke Izumi, Yoshimi Bando, Yasuhiro Mouri, Akemi Matsushima, Shino Niki, Hongwei Han, Kiyotaka Oshikawa, Noriyuki Kuroda, Masahiko Maegawa, Minoru Irahara, Kiyoshi Takeda, Shizuo Akira, Mitsuru Matsumoto
Journal: The Journal of Immunology
J Immunol (2006) 176 (7): 3995–4002.
https://doi.org/10.4049/jimmunol.176.7.3995
Published: 01 April 2006
View article titled, Essential Role of IκB Kinase α in Thymic Organogenesis Required for the Establishment of Self-Tolerance
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Journal Articles

IL-27 Suppresses CD28-Medicated IL-2 Production through Suppressor of Cytokine Signaling 3

Toshiyuki Owaki, Masayuki Asakawa, Sadahiro Kamiya, Kiyoshi Takeda, Fumio Fukai, Junichiro Mizuguchi, Takayuki Yoshimoto
Journal: The Journal of Immunology
J Immunol (2006) 176 (5): 2773–2780.
https://doi.org/10.4049/jimmunol.176.5.2773
Published: 01 March 2006
View article titled, IL-27 Suppresses CD28-Medicated IL-2 Production through Suppressor of Cytokine Signaling 3
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The MyD88-Dependent, but Not the MyD88-Independent, Pathway of TLR4 Signaling Is Important in Clearing Nontypeable Haemophilus influenzae from the Mouse Lung

Catharina W. Wieland, Sandrine Florquin, Nico A. Maris, Kasper Hoebe, Bruce Beutler, Kiyoshi Takeda, Shizuo Akira, Tom van der Poll
Journal: The Journal of Immunology
J Immunol (2005) 175 (9): 6042–6049.
https://doi.org/10.4049/jimmunol.175.9.6042
Published: 01 November 2005
View article titled, The MyD88-Dependent, but Not the MyD88-Independent, Pathway of TLR4 Signaling Is Important in Clearing Nontypeable <em>Haemophilus influenzae</em> from the Mouse Lung
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Stat3 in Resident Macrophages as a Repressor Protein of Inflammatory Response

Akihiro Matsukawa, Shinji Kudo, Takako Maeda, Kousuke Numata, Hiroyuki Watanabe, Kiyoshi Takeda, Shizuo Akira, Takaaki Ito
Journal: The Journal of Immunology
J Immunol (2005) 175 (5): 3354–3359.
https://doi.org/10.4049/jimmunol.175.5.3354
Published: 01 September 2005
View article titled, Stat3 in Resident Macrophages as a Repressor Protein of Inflammatory Response
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Muramyl Dipeptide Enhances Osteoclast Formation Induced by Lipopolysaccharide, IL-1α, and TNF-α through Nucleotide-Binding Oligomerization Domain 2-Mediated Signaling in Osteoblasts

Shuhua Yang, Naoyuki Takahashi, Teruhito Yamashita, Nobuaki Sato, Masahiro Takahashi, Makio Mogi, Takashi Uematsu, Yasuhiro Kobayashi, Yuko Nakamichi, Kiyoshi Takeda, Shizuo Akira, Haruhiko Takada, Nobuyuki Udagawa, Kiyofumi Furusawa
Journal: The Journal of Immunology
J Immunol (2005) 175 (3): 1956–1964.
https://doi.org/10.4049/jimmunol.175.3.1956
Published: 01 August 2005
View article titled, Muramyl Dipeptide Enhances Osteoclast Formation Induced by Lipopolysaccharide, IL-1α, and TNF-α through Nucleotide-Binding Oligomerization Domain 2-Mediated Signaling in Osteoblasts
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Priming Effect of Lipopolysaccharide on Acetyl-Coenzyme A:Lyso-Platelet-Activating Factor Acetyltransferase Is MyD88 and TRIF Independent

Hideo Shindou, Satoshi Ishii, Masahiro Yamamoto, Kiyoshi Takeda, Shizuo Akira, Takao Shimizu
Journal: The Journal of Immunology
J Immunol (2005) 175 (2): 1177–1183.
https://doi.org/10.4049/jimmunol.175.2.1177
Published: 15 July 2005
View article titled, Priming Effect of Lipopolysaccharide on Acetyl-Coenzyme A:Lyso-Platelet-Activating Factor Acetyltransferase Is MyD88 and TRIF Independent
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