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Klaus Ley
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Journal Articles

Exploring the Biomedical Potential of MXenes in Macrophage Phenotype Identification and Tracking

Giorgia Longo, Linda Giro, Laura Fusco, Natalya Resto-Trujillo, Benjamin Chacon, Christopher Shuck, Martina Pigazzi, Yuri Gogotsi, Klaus Ley, Marco Orecchioni, Lucia Delogu
Journal: The Journal of Immunology
J Immunol (2024) 212 (1_Supplement): 0281_5822.
https://doi.org/10.4049/jimmunol.212.supp.0281.5822
Published: 01 May 2024
View article titled, Exploring the Biomedical Potential of MXenes in Macrophage Phenotype Identification and Tracking
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Journal Articles

ThresholdR: An Automated Method for Thresholding CITE-seq-based Antibody Expression Data for Immune Cells

Mohammad Oliaeimotlagh, Sunil Kumar, Amir Khan, Sujit Silas Armstrong Suthahar, Vasantika Suryawanshi, Jeffrey Makings, Christopher Durant, Fabrizio Drago, Angela Taylor, Coleen McNamara, Lewis Lanier, Catherine Hedrick, Klaus Ley
Journal: The Journal of Immunology
J Immunol (2024) 212 (1_Supplement): 0261_5438.
https://doi.org/10.4049/jimmunol.212.supp.0261.5438
Published: 01 May 2024
View article titled, ThresholdR: An Automated Method for Thresholding CITE-seq-based Antibody Expression Data for Immune Cells
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Journal Articles

Identification of candidate biomarkers for Coronary Artery Disease by Spectral Flow-cytometry

Sunil Kumar, Mohammad Oliaeimotlagh, Klaus Ley
Journal: The Journal of Immunology
J Immunol (2024) 212 (1_Supplement): 0024_5688.
https://doi.org/10.4049/jimmunol.212.supp.0024.5688
Published: 01 May 2024
View article titled, Identification of candidate biomarkers for Coronary Artery Disease by Spectral Flow-cytometry
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Journal Articles

A splice variant of kindlin-3 is functional in β2 integrin activation and neutrophil adhesion

Lai Wen, Serena Lee, Klaus Ley
Journal: The Journal of Immunology
J Immunol (2024) 212 (1_Supplement): 1156_5049.
https://doi.org/10.4049/jimmunol.212.supp.1156.5049
Published: 01 May 2024
View article titled, A splice variant of kindlin-3 is functional in β2 integrin activation and neutrophil adhesion
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Journal Articles

Bimodal single cell RNA sequencing reveals changes in CD4+ T cell transcriptomes with age

Amir Khan, Mohammad Oliaeimotlagh, Sunil Kumar, Catherine Hedrick, Klaus Ley
Journal: The Journal of Immunology
J Immunol (2024) 212 (1_Supplement): 0600_4979.
https://doi.org/10.4049/jimmunol.212.supp.0600.4979
Published: 01 May 2024
View article titled, Bimodal single cell RNA sequencing reveals changes in CD4+ T cell transcriptomes with age
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Journal Articles

PD-1 and CD73 synergistically limit CD4 T cell responses to autoantigens

Felix Nettersheim, Simon Brunel, Robert Sinkovits, Sujit Armstrong, Payel Roy, Monica Billitti, Kouji Kobiyama, Lihui Lu, Chris Benedict, Florin Vaida, Allesandro Sette, Bjoern Peters, Thamotharampillai Dileepan, Marc Jenkins, Klaus Ley
Journal: The Journal of Immunology
J Immunol (2024) 212 (1_Supplement): 1103_6106.
https://doi.org/10.4049/jimmunol.212.supp.1103.6106
Published: 01 May 2024
View article titled, PD-1 and CD73 synergistically limit CD4 T cell responses to autoantigens
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Journal Articles

Functional Phenotype and Ontogeny of Olfr2 Expressing Vascular Macrophages in Atherosclerotic Plaques

Marco Orecchioni, Sujit Armstrong Suthahar, Felix Nettersheim, Ahmad Alimadadi, Erpei Wang, Monica Billitti, Natalya Resto-Trujillo, Payel Roy, Catherine Hedrick, Klaus Ley
Journal: The Journal of Immunology
J Immunol (2024) 212 (1_Supplement): 1325_5021.
https://doi.org/10.4049/jimmunol.212.supp.1325.5021
Published: 01 May 2024
View article titled, Functional Phenotype and Ontogeny of Olfr2 Expressing Vascular Macrophages in Atherosclerotic Plaques
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Journal Articles

An Alternative Immune Cell Labeling System Based on the New Two-Dimensional Nanomaterials MXenes

Linda Giro, Laura Fusco, Arianna Gazzi, Chacon Benjamin, Christopher Shuck, Klaus Ley, Marco Orecchioni, Yury Gogotsi, Lucia Delogu
Journal: The Journal of Immunology
J Immunol (2024) 212 (1_Supplement): 0268_5819.
https://doi.org/10.4049/jimmunol.212.supp.0268.5819
Published: 01 May 2024
View article titled, An Alternative Immune Cell Labeling System Based on the New Two-Dimensional Nanomaterials MXenes
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Journal Articles

Sex-specific and immune-cell-specific contributions of CD18 in myocardial ischemia-reperfusion injury

Zhichao Fan, Wei Liu, Chunxia G Cronin, Lai Wen, Klaus Ley, Bruce T Liang
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 70.07.
https://doi.org/10.4049/jimmunol.210.Supp.70.07
Published: 01 May 2023
View article titled, Sex-specific and immune-cell-specific contributions of CD18 in myocardial ischemia-reperfusion injury
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Journal Articles

Thresholding CITE-Seq-based Antibody Expression Data to Improve Cell Type Identification in scRNA-Seq

Amir Khan, Mohammad Oliaeimotlagh, Sujit Silas Armstrong Suthahar, Shahad Iqneibi, Felix Nettersheim, Klaus Ley
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 249.09.
https://doi.org/10.4049/jimmunol.210.Supp.249.09
Published: 01 May 2023
View article titled, Thresholding CITE-Seq-based Antibody Expression Data to Improve Cell Type Identification in scRNA-Seq
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Journal Articles

Single cell transcriptomic changes of CD8T cells in male and female patients with coronary artery disease and diabetes

Shahad Iqneibi, Ryosuke Saigusa, Sujit Silas Armstrong Suthahar, Amir Khan, Mohammad Oliaeimotlagh, Rishab Gulati, Vasantika Suryawanshi, Ahmad Alimadadi, William Pandori, Jeff Makings, Christopher Durant, Yanal Ghosheh, Fabrizio Durant, Coleen McNamara, Avishai Shemesh, Lewis L Lanier, Catherine Hedrick, Klaus Ley
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 176.03.
https://doi.org/10.4049/jimmunol.210.Supp.176.03
Published: 01 May 2023
View article titled, Single cell transcriptomic changes of CD8T cells in male and female patients with coronary artery disease and diabetes
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Journal Articles

Distinct roles of kindlin-3 and talin-1 in neutrophil beta2 integrin clustering

Yuanyuan Wu, Lai Wen, Klaus Ley, Zhichao Fan
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 79.01.
https://doi.org/10.4049/jimmunol.210.Supp.79.01
Published: 01 May 2023
View article titled, Distinct roles of kindlin-3 and talin-1 in neutrophil beta2 integrin clustering
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Journal Articles

Myeloid cell interleukin-10 is essential for atherosclerosis protection in Apoe−/− mice.

Marco Orecchioni, Dennis Wolf, Vasantika Suryawanshi, Holger Winkels, Koji Kobiyama, Jeffrey Makings, William B. Kiosses, Klaus Ley
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 54.22.
https://doi.org/10.4049/jimmunol.208.Supp.54.22
Published: 01 May 2022
View article titled, Myeloid cell interleukin-10 is essential for atherosclerosis protection in Apoe<sup>−/−</sup> mice.
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Journal Articles

A new β2 integrin activation reporter mouse reveals localized intra- and extra-vascular neutrophil integrin activation in vivo

Lai Wen, Alex Marki, Zhihao Wang, Marco Orecchioni, Jeffrey Makings, Kenneth Kim, William B. Kiosses, Zbigniew Mikulski, Klaus Ley
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 105.07.
https://doi.org/10.4049/jimmunol.208.Supp.105.07
Published: 01 May 2022
View article titled, A new β<sub>2</sub> integrin activation reporter mouse reveals localized intra- and extra-vascular neutrophil integrin activation in vivo
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Journal Articles

Bone Marrow Transplantation Rescues Monocyte Recruitment Defect and Improves Cystic Fibrosis in Mice

Zhichao Fan, Elise Pitmon, Lai Wen, Jacqueline Miller, Erik Ehinger, Rana Herro, Wei Liu, Ju Chen, Zbigniew Mikulski, Douglas J. Conrad, Alex Marki, Marco Orecchioni, Puja Kumari, Yanfang Peipei Zhu, Paola M. Marcovecchio, Catherine C. Hedrick, Craig A. Hodges, Vijay A. Rathinam, Kepeng Wang, Klaus Ley
Journal: The Journal of Immunology
J Immunol (2022) 208 (3): 745–752.
https://doi.org/10.4049/jimmunol.1901171
Published: 01 February 2022
View article titled, Bone Marrow Transplantation Rescues Monocyte Recruitment Defect and Improves Cystic Fibrosis in Mice
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Includes: Multimedia, Supplementary data
Journal Articles

Thymus-Derived CD4+CD8+ Cells Reside in Mediastinal Adipose Tissue and the Aortic Arch

Holger Winkels, Yanal Ghosheh, Kouji Kobiyama, William B. Kiosses, Marco Orecchioni, Erik Ehinger, Vasantika Suryawanshi, Sara Herrera-De La Mata, Paola Marchovecchio, Thomas Riffelmacher, Nicolas Thiault, Mitchell Kronenberg, Dennis Wolf, Gregory Seumois, Pandurangan Vijayanand, Klaus Ley
Journal: The Journal of Immunology
J Immunol (2021) 207 (11): 2720–2732.
https://doi.org/10.4049/jimmunol.2100208
Published: 01 December 2021
View article titled, Thymus-Derived CD4<sup>+</sup>CD8<sup>+</sup> Cells Reside in Mediastinal Adipose Tissue and the Aortic Arch
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Includes: Supplementary data
Journal Articles

Single cell profiling identifies IgMMDA-LDL-producing human B cells and a novel role for CD24

Tanyaporn Pattarabanjird, Anh Tram Nguyen, Chantel McSkimming, Huy Dinh, Melissa A Marshall, Yanal Ghosheh, Rishab Gulati, Chistopher Durant, Jenifer Vallejo, Ryosuke Saigusa, Fabrizio Drago, Angela M Taylor, Sotirios Tsimikas, Yury Miller, Klaus Ley, Catherine C. Hedrick, Coleen A McNamara
Journal: The Journal of Immunology
J Immunol (2021) 206 (1_Supplement): 52.23.
https://doi.org/10.4049/jimmunol.206.Supp.52.23
Published: 01 May 2021
View article titled, Single cell profiling identifies IgM<sup>MDA-LDL</sup>-producing human B cells and a novel role for CD24
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Journal Articles

CD4 and CD8 double positive T cell progenitors in mediastinal adipose tissue and the aortic arch differentiate to CD4 T cells

Holger Winkels, Yanal Ghosheh, Kouji Kobiyama, William B Kiosses, Paola Marcovecchio, Marco Orecchioni, Dennis Wolf, Nicolas Thiault, Gregory Seumois, Pandurangan Vijayanand, Klaus Ley
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 61.4.
https://doi.org/10.4049/jimmunol.204.Supp.61.4
Published: 01 May 2020
View article titled, CD4 and CD8 double positive T cell progenitors in mediastinal adipose tissue and the aortic arch differentiate to CD4 T cells
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Kindlin-3 organizes a ring of clustered high affinity β2 integrins during human neutrophil spreading under flow

Zhichao Fan, Lai Wen, Yi-Ting Yeh, William B Kiosses, Edgar Gutierrez, Alex Groisman, Joshua Francois, Juan C Lasheras, Juan C del Alamo, Shu Chien, Mark H Ginsberg, Brian G Petrich, Klaus Ley
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 220.1.
https://doi.org/10.4049/jimmunol.204.Supp.220.1
Published: 01 May 2020
View article titled, Kindlin-3 organizes a ring of clustered high affinity β<sub>2</sub> integrins during human neutrophil spreading under flow
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Journal Articles

Recruitment of kindlin-3 to plasma membrane through its PH domain precedes high affinity β2 integrin activation and neutrophil arrest

Lai Wen, Alex Marki, Payel Roy, Sara McArdle, Hao Sun, Zhichao Fan, Alexandre R. Gingras, Mark H Ginsberg, Klaus Ley
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 220.7.
https://doi.org/10.4049/jimmunol.204.Supp.220.7
Published: 01 May 2020
View article titled, Recruitment of kindlin-3 to plasma membrane through its PH domain precedes high affinity β<sub>2</sub> integrin activation and neutrophil arrest
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