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Thymus-Derived CD4⁺CD8⁺ Cells Reside in Mediastinal Adipose Tissue and the Aortic Arch

Holger Winkels, Yanal Ghosheh, Kouji Kobiyama, William B. Kiosses, Marco Orecchioni, Erik Ehinger, Vasantika Suryawanshi, Sara Herrera-De La Mata, Paola Marchovecchio, Thomas Riffelmacher, Nicolas Thiault, Mitchell Kronenberg, Dennis Wolf, Gregory Seumois, Pandurangan Vijayanand, Klaus Ley

J Immunol (2021) 207 (11): 2720–2732.

DOI: https://doi.org/10.4049/jimmunol.2100208

Published: 01 December 2021

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Includes: Supplementary data

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CD4 and CD8 double positive T cell progenitors in mediastinal adipose tissue and the aortic arch differentiate to CD4 T cells

Holger Winkels, Yanal Ghosheh, Kouji Kobiyama, William B Kiosses, Paola Marcovecchio, Marco Orecchioni, Dennis Wolf, Nicolas Thiault, Gregory Seumois, Pandurangan Vijayanand, Klaus Ley

J Immunol (2020) 204 (1_Supplement): 61.4.

DOI: https://doi.org/10.4049/jimmunol.204.Supp.61.4

Published: 01 May 2020

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Olfactory receptor 2 (Olfr2) and its human ortholog OR6A2 expressed in macrophages drive NLRP3 inflammasome activation and exacerbate atherosclerosis in mice

Marco Orecchioni, Kouji Kobiyama, Holger Winkels, Yanal Ghosheh, Sara McArdle, Zbigniew Mikulski, Zhichao Fan, Lai Wen, Yunmin Jung, Payel Roy, Yukiko Myamoto, Hiroaki Matsunami, Lars Eckmann, Eicke Latz, Zeneng Wang, Stanley L Hazen, Klaus Ley

J Immunol (2020) 204 (1_Supplement): 68.22.

DOI: https://doi.org/10.4049/jimmunol.204.Supp.68.22

Published: 01 May 2020

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Comprehensive assessment of immune cells in mouse and human atherosclerosis by single cell RNA sequencing and mass cytometry

J Immunol (2018) 200 (1_Supplement): 120.3.

DOI: https://doi.org/10.4049/jimmunol.200.Supp.120.3

Published: 01 May 2018

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Oncolytic Reovirus Inhibits Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in a TLR3-Dependent Manner

Yuki Katayama, Masashi Tachibana, Nozomi Kurisu, Yukako Oya, Yuichi Terasawa, Hiroshi Goda, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi, Fuminori Sakurai

J Immunol (2018) 200 (8): 2987–2999.

DOI: https://doi.org/10.4049/jimmunol.1700435

Published: 15 April 2018

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An Antigen-Free, Plasmacytoid Dendritic Cell–Targeting Immunotherapy To Bolster Memory CD8⁺ T Cells in Nonhuman Primates

Yuji Masuta, Takuya Yamamoto, Yayoi Natsume-Kitatani, Tomohiro Kanuma, Eiko Moriishi, Kouji Kobiyama, Kenji Mizuguchi, Yasuhiro Yasutomi, Ken J. Ishii

J Immunol (2018) 200 (6): 2067–2075.

DOI: https://doi.org/10.4049/jimmunol.1701183

Published: 15 March 2018

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Essential Role of CARD14 in Murine Experimental Psoriasis

Mayuri Tanaka, Kouji Kobiyama, Tetsuya Honda, Kozue Uchio-Yamada, Yayoi Natsume-Kitatani, Kenji Mizuguchi, Kenji Kabashima, Ken J. Ishii

J Immunol (2018) 200 (1): 71–81.

DOI: https://doi.org/10.4049/jimmunol.1700995

Published: 01 January 2018

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CD63-Mediated Antigen Delivery into Extracellular Vesicles via DNA Vaccination Results in Robust CD8⁺ T Cell Responses

Tomohiro Kanuma, Takuya Yamamoto, Kouji Kobiyama, Eiko Moriishi, Yuji Masuta, Takato Kusakabe, Koji Ozasa, Etsushi Kuroda, Nao Jounai, Ken J. Ishii

J Immunol (2017) 198 (12): 4707–4715.

DOI: https://doi.org/10.4049/jimmunol.1600731

Published: 15 June 2017

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DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity

Yuichi Kitai, Takumi Kawasaki, Takuya Sueyoshi, Kouji Kobiyama, Ken J. Ishii, Jian Zou, Shizuo Akira, Tadashi Matsuda, Taro Kawai

J Immunol (2017) 198 (4): 1649–1659.

DOI: https://doi.org/10.4049/jimmunol.1601694

Published: 15 February 2017

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Hydroxypropyl-β-Cyclodextrin Spikes Local Inflammation That Induces Th2 Cell and T Follicular Helper Cell Responses to the Coadministered Antigen

J Immunol (2015) 194 (6): 2673–2682.

DOI: https://doi.org/10.4049/jimmunol.1402027

Published: 15 March 2015

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Includes: Multimedia, Supplementary data

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NLRP4 Negatively Regulates Autophagic Processes through an Association with Beclin1

Nao Jounai, Kouji Kobiyama, Masaaki Shiina, Kazuhiro Ogata, Ken J. Ishii, Fumihiko Takeshita

J Immunol (2011) 186 (3): 1646–1655.

DOI: https://doi.org/10.4049/jimmunol.1001654

Published: 01 February 2011

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A Signaling Polypeptide Derived from an Innate Immune Adaptor Molecule Can Be Harnessed as a New Class of Vaccine Adjuvant

Kouji Kobiyama, Fumihiko Takeshita, Ken J. Ishii, Shohei Koyama, Taiki Aoshi, Shizuo Akira, Asako Sakaue-Sawano, Atsushi Miyawaki, Yuko Yamanaka, Hisashi Hirano, Koichi Suzuki, Kenji Okuda

J Immunol (2009) 182 (3): 1593–1601.

DOI: https://doi.org/10.4049/jimmunol.182.3.1593

Published: 01 February 2009

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Blocking of the TLR5 Activation Domain Hampers Protective Potential of Flagellin DNA Vaccine

Sukumar Saha, Fumihiko Takeshita, Tomoko Matsuda, Nao Jounai, Kouji Kobiyama, Tetsuya Matsumoto, Shin Sasaki, Atsushi Yoshida, Ke-Qin Xin, Dennis M. Klinman, Satoshi Uematsu, Ken J. Ishii, Shizuo Akira, Kenji Okuda

J Immunol (2007) 179 (2): 1147–1154.

DOI: https://doi.org/10.4049/jimmunol.179.2.1147

Published: 15 July 2007

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NARROW

Thymus-Derived CD4⁺CD8⁺ Cells Reside in Mediastinal Adipose Tissue and the Aortic Arch

CD4 and CD8 double positive T cell progenitors in mediastinal adipose tissue and the aortic arch differentiate to CD4 T cells

Olfactory receptor 2 (Olfr2) and its human ortholog OR6A2 expressed in macrophages drive NLRP3 inflammasome activation and exacerbate atherosclerosis in mice

Comprehensive assessment of immune cells in mouse and human atherosclerosis by single cell RNA sequencing and mass cytometry

Oncolytic Reovirus Inhibits Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in a TLR3-Dependent Manner

An Antigen-Free, Plasmacytoid Dendritic Cell–Targeting Immunotherapy To Bolster Memory CD8⁺ T Cells in Nonhuman Primates

Essential Role of CARD14 in Murine Experimental Psoriasis

CD63-Mediated Antigen Delivery into Extracellular Vesicles via DNA Vaccination Results in Robust CD8⁺ T Cell Responses

DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity

Hydroxypropyl-β-Cyclodextrin Spikes Local Inflammation That Induces Th2 Cell and T Follicular Helper Cell Responses to the Coadministered Antigen

NLRP4 Negatively Regulates Autophagic Processes through an Association with Beclin1

A Signaling Polypeptide Derived from an Innate Immune Adaptor Molecule Can Be Harnessed as a New Class of Vaccine Adjuvant

Blocking of the TLR5 Activation Domain Hampers Protective Potential of Flagellin DNA Vaccine

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