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Journal Articles

Correction: Engineered Pigs Carrying a Gain-of-Function NLRP3 Homozygous Mutation Can Survive to Adulthood and Accurately Recapitulate Human Systemic Spontaneous Inflammatory Responses

Wenjing Li, Lei Shi, Zhenpeng Zhuang, Han Wu, Meng Lian, Yihui Chen, Lei Li, Weikai Ge, Qin Jin, Quanjun Zhang, Yu Zhao, Zhaoming Liu, Zhen Ouyang, Yinghua Ye, Yingying Li, Hai Wang, Yuan Liao, Longquan Quan, Lei Xiao, Liangxue Lai, Guangxun Meng, Kepin Wang
Journal: The Journal of Immunology
J Immunol (2021) 207 (9): 2385–2386.
https://doi.org/10.4049/jimmunol.2100753
Published: 01 November 2021
View articletitled, Correction: Engineered Pigs Carrying a Gain-of-Function NLRP3 Homozygous Mutation Can Survive to Adulthood and Accurately Recapitulate Human Systemic Spontaneous Inflammatory Responses
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Journal Articles

Non-Lyn Src Family Kinases Activate SIRPα–SHP-1 to Inhibit PI3K–Akt2 and Dampen Proinflammatory Macrophage Polarization

Lei Shi, Zhen Bian, Koby Kidder, Hongwei Liang, Yuan Liu
Journal: The Journal of Immunology
J Immunol (2021) 207 (5): 1419–1427.
https://doi.org/10.4049/jimmunol.2100266
Published: 01 September 2021
View articletitled, Non-Lyn Src Family Kinases Activate SIRPα–SHP-1 to Inhibit PI3K–Akt2 and Dampen Proinflammatory Macrophage Polarization
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Includes: Supplementary data
Journal Articles

Retargeting IL-2 Signaling to NKG2D-Expressing Tumor-Infiltrating Leukocytes Improves Adoptive Transfer Immunotherapy

Anirban Banerjee, Dongge Li, Yizhan Guo, Bayan Mahgoub, Lea Paragas, Jacqueline Slobin, Zhongcheng Mei, Amir Manafi, Atsushi Hata, Kang Li, Lei Shi, John Westwick, Craig Slingluff, Eric Lazear, Alexander Sasha Krupnick
Journal: The Journal of Immunology
J Immunol (2021) 207 (1): 333–343.
https://doi.org/10.4049/jimmunol.2000926
Published: 01 July 2021
View articletitled, Retargeting IL-2 Signaling to NKG2D-Expressing Tumor-Infiltrating Leukocytes Improves Adoptive Transfer Immunotherapy
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Includes: Supplementary data
Journal Articles

Inflammation Unrestrained by SIRPα Induces Secondary Hemophagocytic Lymphohistiocytosis Independent of IFN-γ

Koby Kidder, Zhen Bian, Lei Shi, Yuan Liu
Journal: The Journal of Immunology
J Immunol (2020) 205 (10): 2821–2833.
https://doi.org/10.4049/jimmunol.2000652
Published: 15 November 2020
View articletitled, Inflammation Unrestrained by SIRPα Induces Secondary Hemophagocytic Lymphohistiocytosis Independent of IFN-γ
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Includes: Supplementary data
Journal Articles

Engineered Pigs Carrying a Gain-of-Function NLRP3 Homozygous Mutation Can Survive to Adulthood and Accurately Recapitulate Human Systemic Spontaneous Inflammatory Responses

Wenjing Li, Lei Shi, Zhenpeng Zhuang, Han Wu, Meng Lian, Yihui Chen, Lei Li, Weikai Ge, Qin Jin, Quanjun Zhang, Yu Zhao, Zhaoming Liu, Zhen Ouyang, Yinghua Ye, Yingying Li, Hai Wang, Yuan Liao, Longquan Quan, Lei Xiao, Liangxue Lai, Guangxun Meng, Kepin Wang
Journal: The Journal of Immunology
J Immunol (2020) 205 (9): 2532–2544.
https://doi.org/10.4049/jimmunol.1901468
Published: 01 November 2020
View articletitled, Engineered Pigs Carrying a Gain-of-Function NLRP3 Homozygous Mutation Can Survive to Adulthood and Accurately Recapitulate Human Systemic Spontaneous Inflammatory Responses
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Includes: Supplementary data
Journal Articles

Absence of SIRPα signaling drives TLR9-induced hemophagocytic lymphohistiocytosis-like disease independent of IFN-γ in mice

Koby Kidder, Zhen Bian, Lei Shi, Yuan Liu
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 145.5.
https://doi.org/10.4049/jimmunol.204.Supp.145.5
Published: 01 May 2020
View articletitled, Absence of SIRPα signaling drives TLR9-induced hemophagocytic lymphohistiocytosis-like disease independent of IFN-γ in mice
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Journal Articles

TSC1-mTOR-controlled metabolic-epigenetic crosstalk underlies DC control of CD8+ T cell homeostasis

Hui Xiao, Lei Shi, Xia Chen, Aiping Zang, Tiantian Li, Jianbo Yang
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 56.4.
https://doi.org/10.4049/jimmunol.202.Supp.56.4
Published: 01 May 2019
View articletitled, TSC1-mTOR-controlled metabolic-epigenetic crosstalk underlies DC control of CD8+ T cell homeostasis
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Journal Articles

Arginase-1 is neither constitutively expressed in nor require for myeloid-derived suppressor cell (MDSC)-mediated inhibition of T cell proliferation

Koby S. Kidder, Zhen Bian, Lei Shi, Yuan Liu
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 177.7.
https://doi.org/10.4049/jimmunol.200.Supp.177.7
Published: 01 May 2018
View articletitled, Arginase-1 is neither constitutively expressed in nor require for myeloid-derived suppressor cell (MDSC)-mediated inhibition of T cell proliferation
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Journal Articles

Dual role of SIRPα in macrophage activation: inhibiting M1 while promoting M2 polarization via selectively activating SHP-1 and SHP-2 signal

Lei Shi, Zhen Bian, Yuan Liu
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 67.12.
https://doi.org/10.4049/jimmunol.198.Supp.67.12
Published: 01 May 2017
View articletitled, Dual role of SIRPα in macrophage activation: inhibiting M1 while promoting M2 polarization via selectively activating SHP-1 and SHP-2 signal
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Journal Articles

Phagocytic plasticity of macrophage towards healthy self cells: inflammatory activation elicit self-attacking phenotype in macrophages lacking SIRPα-CD47 restraint

Zhen Bian, Lei Shi, Yuan Liu
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 154.7.
https://doi.org/10.4049/jimmunol.198.Supp.154.7
Published: 01 May 2017
View articletitled, Phagocytic plasticity of macrophage towards healthy self cells: inflammatory activation elicit self-attacking phenotype in macrophages lacking SIRPα-CD47 restraint
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Journal Articles

Pyruvate kinase type M2 promotes tumor cell exocytosis via phosphorylating synaptosome-associated protein-23

Yuan Liu, Yao Wei, Chaoyun Pan, Dihan Zhu, Lei Shi, Zhen Bian, Ke Zen
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 72.14.
https://doi.org/10.4049/jimmunol.196.Supp.72.14
Published: 01 May 2016
View articletitled, Pyruvate kinase type M2 promotes tumor cell exocytosis via phosphorylating synaptosome-associated protein-23
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Journal Articles

Controlling macrophage phagocytosis towards healthy self cells: Two layers of activating and inhibitory mechanisms

Zhen Bian, Lei Shi, Zhiyuan Lv, Alexandra V Tremblay, Shuo Niu, Ke Zen, Yongliang Zhang, Yuan Liu
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 126.26.
https://doi.org/10.4049/jimmunol.196.Supp.126.26
Published: 01 May 2016
View articletitled, Controlling macrophage phagocytosis towards healthy self cells: Two layers of activating and inhibitory mechanisms
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Journal Articles

Signal regulatory protein α suppresses macrophage inflammatory responses via reducing PKM2 tyrosine phosphorylation

Dihan Zhu, Chaoyun Pan, Lei Shi, Zhen Bian, Yuan Liu, Zen Ke
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 59.14.
https://doi.org/10.4049/jimmunol.196.Supp.59.14
Published: 01 May 2016
View articletitled, Signal regulatory protein α suppresses macrophage inflammatory responses via reducing PKM2 tyrosine phosphorylation
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Journal Articles

Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8+ T Cell Hyporesponsiveness to Alloantigen

Emmy L. D. de Mare-Bredemeijer, Xiao-lei Shi, Shanta Mancham, Rogier van Gent, Marieke van der Heide-Mulder, Renate de Boer, Mirjam H. M. Heemskerk, Jeroen de Jonge, Luc J. W. van der Laan, Herold J. Metselaar, Jaap Kwekkeboom
Journal: The Journal of Immunology
J Immunol (2015) 195 (4): 1838–1848.
https://doi.org/10.4049/jimmunol.1500440
Published: 15 August 2015
View articletitled, Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8+ T Cell Hyporesponsiveness to Alloantigen
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Includes: Supplementary data
Journal Articles

Loss of Cell Surface CD47 Clustering Formation and Binding Avidity to SIRPα Facilitate Apoptotic Cell Clearance by Macrophages

Zhiyuan Lv, Zhen Bian, Lei Shi, Shuo Niu, Binh Ha, Alexandra Tremblay, Liangwei Li, Xiugen Zhang, John Paluszynski, Ming Liu, Ke Zen, Yuan Liu
Journal: The Journal of Immunology
J Immunol (2015) 195 (2): 661–671.
https://doi.org/10.4049/jimmunol.1401719
Published: 15 July 2015
View articletitled, Loss of Cell Surface CD47 Clustering Formation and Binding Avidity to SIRPα Facilitate Apoptotic Cell Clearance by Macrophages
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Journal Articles

CD47 deficiency ameliorates autoimmune nephritis in Faslpr mice via suppressing IgG autoantibody production (THER5P.912)

Lei Shi, Zhen Bian, Zhiyuan Lv, Yuan Liu
Journal: The Journal of Immunology
J Immunol (2015) 194 (1_Supplement): 139.14.
https://doi.org/10.4049/jimmunol.194.Supp.139.14
Published: 01 May 2015
View articletitled, CD47 deficiency ameliorates autoimmune nephritis in Faslpr mice via suppressing IgG autoantibody production (THER5P.912)
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Journal Articles

Identification of CXCR2 as an important regulator of granulocytic myeloid-derived suppressor cell mobilization during tumor progression (TUM4P.912)

Zhen Bian, Lei Shi, Yuan Liu
Journal: The Journal of Immunology
J Immunol (2014) 192 (1_Supplement): 138.13.
https://doi.org/10.4049/jimmunol.192.Supp.138.13
Published: 01 May 2014
View articletitled, Identification of CXCR2 as an important regulator of granulocytic myeloid-derived suppressor cell mobilization during tumor progression (TUM4P.912)
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Journal Articles

KLRG1 Impairs CD4+ T Cell Responses via p16ink4a and p27kip1 Pathways: Role in Hepatitis B Vaccine Failure in Individuals with Hepatitis C Virus Infection

Lei Shi, Jia M. Wang, Jun P. Ren, Yong Q. Cheng, Ruo S. Ying, Xiao Y. Wu, Shu M. Lin, Jeddidiah W. D. Griffin, Guang Y. Li, Jonathan P. Moorman, Zhi Q. Yao
Journal: The Journal of Immunology
J Immunol (2014) 192 (2): 649–657.
https://doi.org/10.4049/jimmunol.1302069
Published: 15 January 2014
View articletitled, KLRG1 Impairs CD4+ T Cell Responses via p16ink4a and p27kip1 Pathways: Role in Hepatitis B Vaccine Failure in Individuals with Hepatitis C Virus Infection
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Journal Articles

MicroRNA-146a Feedback Suppresses T Cell Immune Function by Targeting Stat1 in Patients with Chronic Hepatitis B

Saifeng Wang, Xiaojun Zhang, Ying Ju, Bao Zhao, Xiaoli Yan, Jun Hu, Lei Shi, Lebing Yang, Zhibo Ma, Lizhao Chen, Yali Liu, Zhongping Duan, Xinyue Chen, Songdong Meng
Journal: The Journal of Immunology
J Immunol (2013) 191 (1): 293–301.
https://doi.org/10.4049/jimmunol.1202100
Published: 01 July 2013
View articletitled, MicroRNA-146a Feedback Suppresses T Cell Immune Function by Targeting Stat1 in Patients with Chronic Hepatitis B
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Journal Articles

Valosin-Containing Protein Cleavage by Granzyme K Accelerates an Endoplasmic Reticulum Stress Leading to Caspase-Independent Cytotoxicity of Target Tumor Cells

Yuming Guo, Jun Chen, Lei Shi, Zusen Fan
Journal: The Journal of Immunology
J Immunol (2010) 185 (9): 5348–5359.
https://doi.org/10.4049/jimmunol.0903792
Published: 01 November 2010
View articletitled, Valosin-Containing Protein Cleavage by Granzyme K Accelerates an Endoplasmic Reticulum Stress Leading to Caspase-Independent Cytotoxicity of Target Tumor Cells
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Includes: Supplementary data