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Leonard D Shultz
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Journal Articles

Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model

Bei Jia, Chenchen Zhao, Kentaro Minagawa, Hiroko Shike, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Shin Mineishi, Ming Wang, Todd D. Schell, K. Sandeep Prabhu, Robert F. Paulson, Yi Zhang, Leonard D. Shultz, Hong Zheng
Journal: The Journal of Immunology
J Immunol (2023) 211 (9): 1426–1437.
https://doi.org/10.4049/jimmunol.2300111
Published: 15 September 2023
View article titled, Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model
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Includes: Supplementary data
Journal Articles

Enhanced development of functional human innate immune cells in a novel mouse FLT3null NSG mouse strain expressing human FLT3L

Shantashri Vaidya, Pamela St. Louis, Lisa Burzenski, Dale L Greiner, Michael A Brehm, Leonard D Shultz
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 223.24.
https://doi.org/10.4049/jimmunol.204.Supp.223.24
Published: 01 May 2020
View article titled, Enhanced development of functional human innate immune cells in a novel mouse FLT3<sup>null</sup> NSG mouse strain expressing human FLT3L
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Journal Articles

Characterization and use of human insulin transgenic mouse models for type 1 diabetes

Nitin Purushottam Amdare, Leonard D Shultz, Dale L Greiner, Teresa P DiLorenzo
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 142.14.
https://doi.org/10.4049/jimmunol.204.Supp.142.14
Published: 01 May 2020
View article titled, Characterization and use of human insulin transgenic mouse models for type 1 diabetes
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Journal Articles

Development of a humanized mouse model for functional testing of biomaterial fibrosis

Dale L Greiner, Joshua C Doloff, Atieh Sadraei, Shady Farah, Michael A Brehm, Leonard D Shultz, Robert Langer, daniel G Anderson
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 126.37.
https://doi.org/10.4049/jimmunol.202.Supp.126.37
Published: 01 May 2019
View article titled, Development of a humanized mouse model for functional testing of biomaterial fibrosis
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Journal Articles

Human Anti–HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1

Melissa A. Gawron, Mark Duval, Claudia Carbone, Smita Jaiswal, Aaron Wallace, Joseph C. Martin, III, Ann Dauphin, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, Jeremy Luban, Lisa A. Cavacini
Journal: The Journal of Immunology
J Immunol (2019) 202 (3): 799–804.
https://doi.org/10.4049/jimmunol.1801085
Published: 01 February 2019
View article titled, Human Anti–HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1
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Journal Articles

Transgenic expression of human IL15 in NOD-scid IL2rgnull (NSG) mice enhances the development and survival of functional human NK cells

Michael A. Brehm, Ken-Edwin Aryee, Lisa Bruzenksi, Dale L. Greiner, Leonard D. Shultz, James Keck
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 103.20.
https://doi.org/10.4049/jimmunol.200.Supp.103.20
Published: 01 May 2018
View article titled, Transgenic expression of human IL15 in NOD-<em>scid IL2rg</em><em><sup>null</sup></em> (NSG) mice enhances the development and survival of functional human NK cells
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Journal Articles

NOD-scid IL2rgnull (NSG) mice deficient in murine MHC Class I and Class II expression support engraftment of functional human T cells in the absence of acute xenogeneic GVHD following injection of PBMC

Michael A. Brehm, Michael Wiles, Laurie Lea Kenney, Lisa Burzenski, James Keck, Dale L. Greiner, Leonard D. Shultz
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 57.13.
https://doi.org/10.4049/jimmunol.200.Supp.57.13
Published: 01 May 2018
View article titled, NOD-<em>scid IL2rg</em><em><sup>null</sup></em> (NSG) mice deficient in murine MHC Class I and Class II expression support engraftment of functional human T cells in the absence of acute xenogeneic GVHD following injection of PBMC
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Journal Articles

Human natural killer cell education is dynamically controlled by environmental and cell-intrinsic HLA

Jeanette Boudreau, Xiao-Rong Liu, Zeguo Zhao, Aaron Zhang, Leonard D Shultz, Dale L Greiner, Bo Dupont, Katharine C Hsu
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 202.6.
https://doi.org/10.4049/jimmunol.196.Supp.202.6
Published: 01 May 2016
View article titled, Human natural killer cell education is dynamically controlled by environmental and cell-intrinsic HLA
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Journal Articles

Modeling immune system-tumor interactions using humanized mice

Ken-Edwin Aryee, Michael A Brehm, Leonard D Shultz, Agata Jurczyk
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 212.12.
https://doi.org/10.4049/jimmunol.196.Supp.212.12
Published: 01 May 2016
View article titled, Modeling immune system-tumor interactions using humanized mice
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Journal Articles

The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice

Maximiliano Presa, Yi-Guang Chen, Alexandra E. Grier, Edward H. Leiter, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, David V. Serreze
Journal: The Journal of Immunology
J Immunol (2015) 195 (7): 3011–3019.
https://doi.org/10.4049/jimmunol.1402446
Published: 01 October 2015
View article titled, The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-<em>scid</em> Mice
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Journal Articles

Development of Mature and Functional Human Myeloid Subsets in Hematopoietic Stem Cell-Engrafted NOD/SCID/IL2rγKO Mice

Satoshi Tanaka, Yoriko Saito, Jun Kunisawa, Yosuke Kurashima, Taichi Wake, Nahoko Suzuki, Leonard D. Shultz, Hiroshi Kiyono, Fumihiko Ishikawa
Journal: The Journal of Immunology
J Immunol (2012) 188 (12): 6145–6155.
https://doi.org/10.4049/jimmunol.1103660
Published: 15 June 2012
View article titled, Development of Mature and Functional Human Myeloid Subsets in Hematopoietic Stem Cell-Engrafted NOD/SCID/IL2rγKO Mice
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Includes: Supplementary data
Journal Articles

TLR Agonists Prevent the Establishment of Allogeneic Hematopoietic Chimerism in Mice Treated with Costimulation Blockade

David M. Miller, Thomas B. Thornley, Todd Pearson, Annie J. Kruger, Masahiro Yamazaki, Leonard D. Shultz, Raymond M. Welsh, Michael A. Brehm, Aldo A. Rossini, Dale L. Greiner
Journal: The Journal of Immunology
J Immunol (2009) 182 (9): 5547–5559.
https://doi.org/10.4049/jimmunol.0802077
Published: 01 May 2009
View article titled, TLR Agonists Prevent the Establishment of Allogeneic Hematopoietic Chimerism in Mice Treated with Costimulation Blockade
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Journal Articles

Long-Term Engraftment and Expansion of Tumor-Derived Memory T Cells Following the Implantation of Non-Disrupted Pieces of Human Lung Tumor into NOD-scid IL2Rγnull Mice

Michelle R. Simpson-Abelson, Gregory F. Sonnenberg, Hiroshi Takita, Sandra J. Yokota, Thomas F. Conway, Jr., Raymond J. Kelleher, Jr., Leonard D. Shultz, Maurice Barcos, Richard B. Bankert
Journal: The Journal of Immunology
J Immunol (2008) 180 (10): 7009–7018.
https://doi.org/10.4049/jimmunol.180.10.7009
Published: 15 May 2008
View article titled, Long-Term Engraftment and Expansion of Tumor-Derived Memory T Cells Following the Implantation of Non-Disrupted Pieces of Human Lung Tumor into NOD-scid IL2Rγ<sup>null</sup> Mice
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Journal Articles

Type 1 IFN Mediates Cross-Talk between Innate and Adaptive Immunity That Abrogates Transplantation Tolerance

Thomas B. Thornley, Nancy E. Phillips, Britte C. Beaudette-Zlatanova, Thomas G. Markees, Kapil Bahl, Michael A. Brehm, Leonard D. Shultz, Evelyn A. Kurt-Jones, John P. Mordes, Raymond M. Welsh, Aldo A. Rossini, Dale L. Greiner
Journal: The Journal of Immunology
J Immunol (2007) 179 (10): 6620–6629.
https://doi.org/10.4049/jimmunol.179.10.6620
Published: 15 November 2007
View article titled, Type 1 IFN Mediates Cross-Talk between Innate and Adaptive Immunity That Abrogates Transplantation Tolerance
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Journal Articles

The Leukotriene B4 Receptor (BLT1) Is Required for Effector CD8+ T Cell-Mediated, Mast Cell-Dependent Airway Hyperresponsiveness

Christian Taube, Nobuaki Miyahara, Vanessa Ott, Brad Swanson, Katsuyuki Takeda, Joan Loader, Leonard D. Shultz, Andrew M. Tager, Andrew D. Luster, Azzeddine Dakhama, Erwin W. Gelfand
Journal: The Journal of Immunology
J Immunol (2006) 176 (5): 3157–3164.
https://doi.org/10.4049/jimmunol.176.5.3157
Published: 01 March 2006
View article titled, The Leukotriene B4 Receptor (BLT1) Is Required for Effector CD8<sup>+</sup> T Cell-Mediated, Mast Cell-Dependent Airway Hyperresponsiveness
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Journal Articles

TLR Agonists Abrogate Costimulation Blockade-Induced Prolongation of Skin Allografts

Thomas B. Thornley, Michael A. Brehm, Thomas G. Markees, Leonard D. Shultz, John P. Mordes, Raymond M. Welsh, Aldo A. Rossini, Dale L. Greiner
Journal: The Journal of Immunology
J Immunol (2006) 176 (3): 1561–1570.
https://doi.org/10.4049/jimmunol.176.3.1561
Published: 01 February 2006
View article titled, TLR Agonists Abrogate Costimulation Blockade-Induced Prolongation of Skin Allografts
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Journal Articles

TGF-β1 Inhibits T-bet Induction by IFN-γ in Murine CD4+ T Cells through the Protein Tyrosine Phosphatase Src Homology Region 2 Domain-Containing Phosphatase-1

Il-Kyoo Park, Leonard D. Shultz, John J. Letterio, James D. Gorham
Journal: The Journal of Immunology
J Immunol (2005) 175 (9): 5666–5674.
https://doi.org/10.4049/jimmunol.175.9.5666
Published: 01 November 2005
View article titled, TGF-β1 Inhibits T-bet Induction by IFN-γ in Murine CD4<sup>+</sup> T Cells through the Protein Tyrosine Phosphatase Src Homology Region 2 Domain-Containing Phosphatase-1
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Journal Articles

Human Lymphoid and Myeloid Cell Development in NOD/LtSz-scid IL2Rγnull Mice Engrafted with Mobilized Human Hemopoietic Stem Cells

Leonard D. Shultz, Bonnie L. Lyons, Lisa M. Burzenski, Bruce Gott, Xiaohua Chen, Stanley Chaleff, Malak Kotb, Stephen D. Gillies, Marie King, Julie Mangada, Dale L. Greiner, Rupert Handgretinger
Journal: The Journal of Immunology
J Immunol (2005) 174 (10): 6477–6489.
https://doi.org/10.4049/jimmunol.174.10.6477
Published: 15 May 2005
View article titled, Human Lymphoid and Myeloid Cell Development in NOD/LtSz-<em>scid IL2R</em>γ<sup><em>null</em></sup> Mice Engrafted with Mobilized Human Hemopoietic Stem Cells
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Journal Articles

Distinct Osteoclast Precursors in the Bone Marrow and Extramedullary Organs Characterized by Responsiveness to Toll-Like Receptor Ligands and TNF-α

Shin-Ichi Hayashi, Takayuki Yamada, Motokazu Tsuneto, Toshiyuki Yamane, Masayuki Takahashi, Leonard D. Shultz, Hidetoshi Yamazaki
Journal: The Journal of Immunology
J Immunol (2003) 171 (10): 5130–5139.
https://doi.org/10.4049/jimmunol.171.10.5130
Published: 15 November 2003
View article titled, Distinct Osteoclast Precursors in the Bone Marrow and Extramedullary Organs Characterized by Responsiveness to Toll-Like Receptor Ligands and TNF-α
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Journal Articles

Genetic Disassociation of Autoimmunity and Resistance to Costimulation Blockade-Induced Transplantation Tolerance in Nonobese Diabetic Mice

Todd Pearson, Thomas G. Markees, David V. Serreze, Melissa A. Pierce, Michele P. Marron, Linda S. Wicker, Laurence B. Peterson, Leonard D. Shultz, John P. Mordes, Aldo A. Rossini, Dale L. Greiner
Journal: The Journal of Immunology
J Immunol (2003) 171 (1): 185–195.
https://doi.org/10.4049/jimmunol.171.1.185
Published: 01 July 2003
View article titled, Genetic Disassociation of Autoimmunity and Resistance to Costimulation Blockade-Induced Transplantation Tolerance in Nonobese Diabetic Mice
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