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Lyle L. Moldawer
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Journal Articles

A Whole Blood Enzyme-Linked Immunospot Assay for Functional Immune Endotyping of Septic Patients

Monty B. Mazer, Charles C. Caldwell, Jodi Hanson, Daniel Mannion, Isaiah R. Turnbull, Anne Drewry, Dale Osborne, Andrew Walton, Tessa Blood, Lyle L. Moldawer, Scott Brakenridge, Kenneth E. Remy, Richard S. Hotchkiss
Journal: The Journal of Immunology
J Immunol (2021) 206 (1): 23–36.
https://doi.org/10.4049/jimmunol.2001088
Published: 01 January 2021
View article titled, A Whole Blood Enzyme-Linked Immunospot Assay for Functional Immune Endotyping of Septic Patients
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Includes: Supplementary data
Journal Articles

A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged

Dina C. Nacionales, Benjamin Szpila, Ricardo Ungaro, M. Cecilia Lopez, Jianyi Zhang, Lori F. Gentile, Angela L. Cuenca, Erin Vanzant, Brittany Mathias, Jeevan Jyot, Donevan Westerveld, Azra Bihorac, Anna Joseph, Alicia Mohr, Lizette V. Duckworth, Frederick A. Moore, Henry V. Baker, Christiaan Leeuwenburgh, Lyle L. Moldawer, Scott Brakenridge, Philip A. Efron
Journal: The Journal of Immunology
J Immunol (2015) 195 (5): 2396–2407.
https://doi.org/10.4049/jimmunol.1500984
Published: 01 September 2015
View article titled, A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged
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Includes: Supplementary data
Journal Articles

TRIF-Dependent Innate Immune Activation Is Critical for Survival to Neonatal Gram-Negative Sepsis

Alex G. Cuenca, Dallas N. Joiner, Lori F. Gentile, Angela L. Cuenca, James L. Wynn, Kindra M. Kelly-Scumpia, Philip O. Scumpia, Kevin E. Behrns, Philip A. Efron, Dina Nacionales, Chao Lui, Shannon M. Wallet, Westley H. Reeves, Clayton E. Mathews, Lyle L. Moldawer
Journal: The Journal of Immunology
J Immunol (2015) 194 (3): 1169–1177.
https://doi.org/10.4049/jimmunol.1302676
Published: 01 February 2015
View article titled, TRIF-Dependent Innate Immune Activation Is Critical for Survival to Neonatal Gram-Negative Sepsis
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Includes: Supplementary data
Journal Articles

Novel Role for Tumor-Induced Expansion of Myeloid-Derived Cells in Cancer Cachexia

Alex G. Cuenca, Angela L. Cuenca, Robert D. Winfield, Dallas N. Joiner, Lori Gentile, Matthew J. Delano, Kindra M. Kelly-Scumpia, Philip O. Scumpia, Michael K. Matheny, Philip J. Scarpace, Lizette Vila, Philip A. Efron, Drake M. LaFace, Lyle L. Moldawer
Journal: The Journal of Immunology
J Immunol (2014) 192 (12): 6111–6119.
https://doi.org/10.4049/jimmunol.1302895
Published: 15 June 2014
View article titled, Novel Role for Tumor-Induced Expansion of Myeloid-Derived Cells in Cancer Cachexia
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Includes: Supplementary data
Journal Articles

Protective Immunity and Defects in the Neonatal and Elderly Immune Response to Sepsis

Lori F. Gentile, Dina C. Nacionales, M. Cecilia Lopez, Erin Vanzant, Angela Cuenca, Alex G. Cuenca, Ricardo Ungaro, Ben E. Szpila, Shawn Larson, Anna Joseph, Frederick A. Moore, Christiaan Leeuwenburgh, Henry V. Baker, Lyle L. Moldawer, Philip A. Efron
Journal: The Journal of Immunology
J Immunol (2014) 192 (7): 3156–3165.
https://doi.org/10.4049/jimmunol.1301726
Published: 01 April 2014
View article titled, Protective Immunity and Defects in the Neonatal and Elderly Immune Response to Sepsis
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Includes: Supplementary data
Journal Articles

Aged Mice Are Unable To Mount an Effective Myeloid Response to Sepsis

Dina C. Nacionales, Lori F. Gentile, Erin Vanzant, M. Cecilia Lopez, Angela Cuenca, Alex G. Cuenca, Ricardo Ungaro, Yi Li, Tezcan Ozrazgat Baslanti, Azra Bihorac, Frederick A. Moore, Henry V. Baker, Christiaan Leeuwenburgh, Lyle L. Moldawer, Philip A. Efron
Journal: The Journal of Immunology
J Immunol (2014) 192 (2): 612–622.
https://doi.org/10.4049/jimmunol.1302109
Published: 15 January 2014
View article titled, Aged Mice Are Unable To Mount an Effective Myeloid Response to Sepsis
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Journal Articles

Maintenance of Anti-Sm/RNP Autoantibody Production by Plasma Cells Residing in Ectopic Lymphoid Tissue and Bone Marrow Memory B Cells

Jason S. Weinstein, Matthew J. Delano, Yuan Xu, Kindra M. Kelly-Scumpia, Dina C. Nacionales, Yi Li, Pui Y. Lee, Philip O. Scumpia, Lijun Yang, Eric Sobel, Lyle L. Moldawer, Westley H. Reeves
Journal: The Journal of Immunology
J Immunol (2013) 190 (8): 3916–3927.
https://doi.org/10.4049/jimmunol.1201880
Published: 15 April 2013
View article titled, Maintenance of Anti-Sm/RNP Autoantibody Production by Plasma Cells Residing in Ectopic Lymphoid Tissue and Bone Marrow Memory B Cells
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Includes: Supplementary data
Journal Articles

Pleiotropic IFN-Dependent and -Independent Effects of IRF5 on the Pathogenesis of Experimental Lupus

Yuan Xu, Pui Y. Lee, Yi Li, Chao Liu, Haoyang Zhuang, Shuhong Han, Dina C. Nacionales, Jason Weinstein, Clayton E. Mathews, Lyle L. Moldawer, Shi-Wu Li, Minoru Satoh, Li-Jun Yang, Westley H. Reeves
Journal: The Journal of Immunology
J Immunol (2012) 188 (8): 4113–4121.
https://doi.org/10.4049/jimmunol.1103113
Published: 15 April 2012
View article titled, Pleiotropic IFN-Dependent and -Independent Effects of IRF5 on the Pathogenesis of Experimental Lupus
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Includes: Supplementary data
Journal Articles

Neutrophil Mobilization from the Bone Marrow during Polymicrobial Sepsis Is Dependent on CXCL12 Signaling

Matthew J. Delano, Kindra M. Kelly-Scumpia, Terri C. Thayer, Robert D. Winfield, Philip O. Scumpia, Alex G. Cuenca, Phillips B. Harrington, Kerri A. O’Malley, Elizabeth Warner, Sonia Gabrilovich, Clayton E. Mathews, Drake Laface, Paul G. Heyworth, Reuben Ramphal, Robert M. Strieter, Lyle L. Moldawer, Philip A. Efron
Journal: The Journal of Immunology
J Immunol (2011) 187 (2): 911–918.
https://doi.org/10.4049/jimmunol.1100588
Published: 15 July 2011
View article titled, Neutrophil Mobilization from the Bone Marrow during Polymicrobial Sepsis Is Dependent on CXCL12 Signaling
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Journal Articles

Sepsis Induces Early Alterations in Innate Immunity That Impact Mortality to Secondary Infection

Matthew J. Delano, Terri Thayer, Sonia Gabrilovich, Kindra M. Kelly-Scumpia, Robert D. Winfield, Philip O. Scumpia, Alex G. Cuenca, Elizabeth Warner, Shannon M. Wallet, Mark A. Wallet, Kerri A. O’Malley, Reuben Ramphal, Michael Clare-Salzer, Philip A. Efron, Clayton E. Mathews, Lyle L. Moldawer
Journal: The Journal of Immunology
J Immunol (2011) 186 (1): 195–202.
https://doi.org/10.4049/jimmunol.1002104
Published: 01 January 2011
View article titled, Sepsis Induces Early Alterations in Innate Immunity That Impact Mortality to Secondary Infection
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Includes: Supplementary data
Journal Articles

Cutting Edge: Bacterial Infection Induces Hematopoietic Stem and Progenitor Cell Expansion in the Absence of TLR Signaling

Philip O. Scumpia, Kindra M. Kelly-Scumpia, Matthew J. Delano, Jason S. Weinstein, Alex G. Cuenca, Samer Al-Quran, Ian Bovio, Shizuo Akira, Yutaro Kumagai, Lyle L. Moldawer
Journal: The Journal of Immunology
J Immunol (2010) 184 (5): 2247–2251.
https://doi.org/10.4049/jimmunol.0903652
Published: 01 March 2010
View article titled, Cutting Edge: Bacterial Infection Induces Hematopoietic Stem and Progenitor Cell Expansion in the Absence of TLR Signaling
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Includes: Supplementary data
Journal Articles

Variable Requirement of Dendritic Cells for Recruitment of NK and T Cells to Different TLR Agonists

Takefumi Uchida, Philip O. Scumpia, Donna M. Murasko, Shuhji Seki, Susan Woulfe, Michael J. Clare-Salzler, Lyle L. Moldawer
Journal: The Journal of Immunology
J Immunol (2007) 178 (6): 3886–3892.
https://doi.org/10.4049/jimmunol.178.6.3886
Published: 15 March 2007
View article titled, Variable Requirement of Dendritic Cells for Recruitment of NK and T Cells to Different TLR Agonists
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Journal Articles

Increased Natural CD4+CD25+ Regulatory T Cells and Their Suppressor Activity Do Not Contribute to Mortality in Murine Polymicrobial Sepsis

Philip O. Scumpia, Matthew J. Delano, Kindra M. Kelly, Kerri A. O’Malley, Philip A. Efron, Priscilla F. McAuliffe, Todd Brusko, Ricardo Ungaro, Tolga Barker, James L. Wynn, Mark A. Atkinson, Westley H. Reeves, Michael J. Clare Salzler, Lyle L. Moldawer
Journal: The Journal of Immunology
J Immunol (2006) 177 (11): 7943–7949.
https://doi.org/10.4049/jimmunol.177.11.7943
Published: 01 December 2006
View article titled, Increased Natural CD4<sup>+</sup>CD25<sup>+</sup> Regulatory T Cells and Their Suppressor Activity Do Not Contribute to Mortality in Murine Polymicrobial Sepsis
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Journal Articles

Selective Activation of Peripheral Blood T Cell Subsets by Endotoxin Infusion in Healthy Human Subjects Corresponds to Differential Chemokine Activation

Asit K. De, Carol L. Miller-Graziano, Steve E. Calvano, Krzysztof Laudanski, Stephen F. Lowry, Lyle L. Moldawer, Daniel G. Remick, Jr, Natasa Rajicic, David Schoenfeld, Ronald G. Tompkins
Journal: The Journal of Immunology
J Immunol (2005) 175 (9): 6155–6162.
https://doi.org/10.4049/jimmunol.175.9.6155
Published: 01 November 2005
View article titled, Selective Activation of Peripheral Blood T Cell Subsets by Endotoxin Infusion in Healthy Human Subjects Corresponds to Differential Chemokine Activation
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Journal Articles

CD11c+ Dendritic Cells Are Required for Survival in Murine Polymicrobial Sepsis

Philip O. Scumpia, Priscilla F. McAuliffe, Kerri A. O’Malley, Ricardo Ungaro, Takefumi Uchida, Tadashi Matsumoto, Daniel G. Remick, Michael J. Clare-Salzler, Lyle L. Moldawer, Philip A. Efron
Journal: The Journal of Immunology
J Immunol (2005) 175 (5): 3282–3286.
https://doi.org/10.4049/jimmunol.175.5.3282
Published: 01 September 2005
View article titled, CD11c<sup>+</sup> Dendritic Cells Are Required for Survival in Murine Polymicrobial Sepsis
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Journal Articles

Characterization of the Systemic Loss of Dendritic Cells in Murine Lymph Nodes During Polymicrobial Sepsis

Philip A. Efron, Antonio Martins, Douglas Minnich, Kevin Tinsley, Ricardo Ungaro, Frances R. Bahjat, Richard Hotchkiss, Michael Clare-Salzler, Lyle L. Moldawer
Journal: The Journal of Immunology
J Immunol (2004) 173 (5): 3035–3043.
https://doi.org/10.4049/jimmunol.173.5.3035
Published: 01 September 2004
View article titled, Characterization of the Systemic Loss of Dendritic Cells in Murine Lymph Nodes During Polymicrobial Sepsis
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Journal Articles

Genomic and Proteomic Determinants of Outcome in Patients Undergoing Thoracoabdominal Aortic Aneurysm Repair

Robert J. Feezor, Henry V. Baker, Wenzhong Xiao, W. Anthony Lee, Thomas S. Huber, Michael Mindrinos, Raymond A. Kim, Laurence Ruiz-Taylor, Lyle L. Moldawer, Ronald W. Davis, James M. Seeger
Journal: The Journal of Immunology
J Immunol (2004) 172 (11): 7103–7109.
https://doi.org/10.4049/jimmunol.172.11.7103
Published: 01 June 2004
View article titled, Genomic and Proteomic Determinants of Outcome in Patients Undergoing Thoracoabdominal Aortic Aneurysm Repair
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Includes: Supplementary data
Journal Articles

Increased Survival in Sepsis by In Vivo Adenovirus-Induced Expression of IL-10 in Dendritic Cells

Andreas Oberholzer, Caroline Oberholzer, Keith S. Bahjat, Ricardo Ungaro, Cynthia L. Tannahill, Michelle Murday, Frances R. Bahjat, Zaher Abouhamze, Van Tsai, Drake LaFace, Beth Hutchins, Lyle L. Moldawer, Michael J. Clare-Salzler
Journal: The Journal of Immunology
J Immunol (2002) 168 (7): 3412–3418.
https://doi.org/10.4049/jimmunol.168.7.3412
Published: 01 April 2002
View article titled, Increased Survival in Sepsis by In Vivo Adenovirus-Induced Expression of IL-10 in Dendritic Cells
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Journal Articles

Adenoviral Delivery of Human and Viral IL-10 in Murine Sepsis

Rebecca M. Minter, Maria A. Ferry, Michelle E. Murday, Cynthia L. Tannahill, Frances R. Bahjat, Caroline Oberholzer, Andreas Oberholzer, Drake LaFace, Beth Hutchins, Shufen Wen, Jeremy Shinoda, Edward M. Copeland, III, Lyle L. Moldawer
Journal: The Journal of Immunology
J Immunol (2001) 167 (2): 1053–1059.
https://doi.org/10.4049/jimmunol.167.2.1053
Published: 15 July 2001
View article titled, Adenoviral Delivery of Human and Viral IL-10 in Murine Sepsis
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Journal Articles

Reduced Susceptibility of Nonobese Diabetic Mice to TNF-α and d-Galactosamine-Mediated Hepatocellular Apoptosis and Lethality1

Frances R. Bahjat, Vikas R. Dharnidharka, Kunitaro Fukuzuka, Laurence Morel, James M. Crawford, Michael J. Clare-Salzler, Lyle L. Moldawer
Journal: The Journal of Immunology
J Immunol (2000) 165 (11): 6559–6567.
https://doi.org/10.4049/jimmunol.165.11.6559
Published: 01 December 2000
View article titled, Reduced Susceptibility of Nonobese Diabetic Mice to TNF-α and <sc>d</sc>-Galactosamine-Mediated Hepatocellular Apoptosis and Lethality<sup>1</sup>
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