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M N Margolies
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Journal Articles

Contribution of heavy chain junctional amino acid diversity to antibody affinity among p-azophenylarsonate-specific antibodies.

B Parhami-Seren, M N Margolies
Journal: The Journal of Immunology
J Immunol (1996) 157 (5): 2066–2072.
https://doi.org/10.4049/jimmunol.157.5.2066
Published: 01 September 1996
View article titled, Contribution of heavy chain junctional amino acid diversity to antibody affinity among p-azophenylarsonate-specific antibodies.
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Journal Articles

Modulation of antibody affinity by an engineered amino acid substitution.

Y W Wong, P H Kussie, B Parhami-Seren, M N Margolies
Journal: The Journal of Immunology
J Immunol (1995) 154 (7): 3351–3358.
https://doi.org/10.4049/jimmunol.154.7.3351
Published: 01 April 1995
View article titled, Modulation of antibody affinity by an engineered amino acid substitution.
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Journal Articles

A single engineered amino acid substitution changes antibody fine specificity.

P H Kussie, B Parhami-Seren, L J Wysocki, M N Margolies
Journal: The Journal of Immunology
J Immunol (1994) 152 (1): 146–152.
https://doi.org/10.4049/jimmunol.152.1.146
Published: 01 January 1994
View article titled, A single engineered amino acid substitution changes antibody fine specificity.
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Journal Articles

Conservation of binding site geometry among p-azophenylarsonate-specific antibodies.

B Parhami-Seren, P H Kussie, R K Strong, M N Margolies
Journal: The Journal of Immunology
J Immunol (1993) 150 (5): 1829–1837.
https://doi.org/10.4049/jimmunol.150.5.1829
Published: 01 March 1993
View article titled, Conservation of binding site geometry among p-azophenylarsonate-specific antibodies.
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Journal Articles

A V kappa-J kappa junctional change in an antidigoxin recombinant antibody destroys digoxin-binding activity.

N W Hudson, R E Bruccoleri, L K Steinrauf, J A Hamilton, M Mudgett-Hunter, M N Margolies
Journal: The Journal of Immunology
J Immunol (1990) 145 (8): 2718–2724.
https://doi.org/10.4049/jimmunol.145.8.2718
Published: 15 October 1990
View article titled, A V kappa-J kappa junctional change in an antidigoxin recombinant antibody destroys digoxin-binding activity.
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Journal Articles

Clustered H chain somatic mutations shared by anti-p-azophenylarsonate antibodies confer enhanced affinity and ablate the cross-reactive idiotype.

B Parhami-Seren, L J Wysocki, M N Margolies, J Sharon
Journal: The Journal of Immunology
J Immunol (1990) 145 (7): 2340–2346.
https://doi.org/10.4049/jimmunol.145.7.2340
Published: 01 October 1990
View article titled, Clustered H chain somatic mutations shared by anti-p-azophenylarsonate antibodies confer enhanced affinity and ablate the cross-reactive idiotype.
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Journal Articles

Structural characterization of H chain-associated idiotopes of anti-p-azophenylarsonate monoclonal antibodies.

B Parhami-Seren, J Sharon, M N Margolies
Journal: The Journal of Immunology
J Immunol (1990) 144 (11): 4426–4433.
https://doi.org/10.4049/jimmunol.144.11.4426
Published: 01 June 1990
View article titled, Structural characterization of H chain-associated idiotopes of anti-p-azophenylarsonate monoclonal antibodies.
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Journal Articles

The amino acid residues at the VH-D-JH junctions affect the affinity of anti-p-azophenylarsonate antibodies.

B Parhami-Seren, L Wysocki, M N Margolies
Journal: The Journal of Immunology
J Immunol (1989) 143 (12): 4090–4097.
https://doi.org/10.4049/jimmunol.143.12.4090
Published: 15 December 1989
View article titled, The amino acid residues at the VH-D-JH junctions affect the affinity of anti-p-azophenylarsonate antibodies.
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Journal Articles

Recurrent somatic mutations in mouse antibodies to p-azophenylarsonate increase affinity for hapten.

J Sharon, M L Gefter, L J Wysocki, M N Margolies
Journal: The Journal of Immunology
J Immunol (1989) 142 (2): 596–601.
https://doi.org/10.4049/jimmunol.142.2.596
Published: 15 January 1989
View article titled, Recurrent somatic mutations in mouse antibodies to p-azophenylarsonate increase affinity for hapten.
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Journal Articles

J chain in Rana catesbeiana high molecular weight Ig.

C A Mikoryak, M N Margolies, L A Steiner
Journal: The Journal of Immunology
J Immunol (1988) 140 (12): 4279–4285.
https://doi.org/10.4049/jimmunol.140.12.4279
Published: 15 June 1988
View article titled, J chain in Rana catesbeiana high molecular weight Ig.
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Journal Articles

Immunoglobulin chain recombination among antidigoxin antibodies by hybridoma-hybridoma fusion.

N W Hudson, M Mudgett-Hunter, D J Panka, M N Margolies
Journal: The Journal of Immunology
J Immunol (1987) 139 (8): 2715–2723.
https://doi.org/10.4049/jimmunol.139.8.2715
Published: 15 October 1987
View article titled, Immunoglobulin chain recombination among antidigoxin antibodies by hybridoma-hybridoma fusion.
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Journal Articles

Complete variable region sequences of five homologous high affinity anti-digoxin antibodies.

D J Panka, M N Margolies
Journal: The Journal of Immunology
J Immunol (1987) 139 (7): 2385–2391.
https://doi.org/10.4049/jimmunol.139.7.2385
Published: 01 October 1987
View article titled, Complete variable region sequences of five homologous high affinity anti-digoxin antibodies.
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Journal Articles

Combinational diversity within variable regions bearing the predominant anti-p-azophenylarsonate idiotype of strain A mice.

L J Wysocki, M N Margolies, B Huang, D A Nemazee, D S Wechsler, V L Sato, J A Smith, M L Gefter
Journal: The Journal of Immunology
J Immunol (1985) 134 (4): 2740–2747.
https://doi.org/10.4049/jimmunol.134.4.2740
Published: 01 April 1985
View article titled, Combinational diversity within variable regions bearing the predominant anti-p-azophenylarsonate idiotype of strain A mice.
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Journal Articles

The association of various D elements with a single-immunoglobulin VH gene segment: influence on the expression of a major cross-reactive idiotype.

T Gridley, M N Margolies, M L Gefter
Journal: The Journal of Immunology
J Immunol (1985) 134 (2): 1236–1244.
https://doi.org/10.4049/jimmunol.134.2.1236
Published: 01 February 1985
View article titled, The association of various D elements with a single-immunoglobulin VH gene segment: influence on the expression of a major cross-reactive idiotype.
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Journal Articles

Complete heavy and light chain variable region sequence of anti-arsonate monoclonal antibodies from BALB/c and A/J mice sharing the 36-60 idiotype are highly homologous.

E Juszczak, R I Near, M L Gefter, M N Margolies
Journal: The Journal of Immunology
J Immunol (1984) 133 (5): 2603–2609.
https://doi.org/10.4049/jimmunol.133.5.2603
Published: 01 November 1984
View article titled, Complete heavy and light chain variable region sequence of anti-arsonate monoclonal antibodies from BALB/c and A/J mice sharing the 36-60 idiotype are highly homologous.
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Journal Articles

Immunoglobulin idiotype and anti-anti-idiotype utilize the same variable region genes irrespective of antigen specificity.

M N Margolies, L J Wysocki, V L Sato
Journal: The Journal of Immunology
J Immunol (1983) 130 (2): 515–517.
https://doi.org/10.4049/jimmunol.130.2.515
Published: 01 February 1983
View article titled, Immunoglobulin idiotype and anti-anti-idiotype utilize the same variable region genes irrespective of antigen specificity.
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Journal Articles

High-affinity monoclonal antibodies to the cardiac glycoside, digoxin.

M M Hunter, M N Margolies, A Ju, E Haber
Journal: The Journal of Immunology
J Immunol (1982) 129 (3): 1165–1172.
https://doi.org/10.4049/jimmunol.129.3.1165
Published: 01 September 1982
View article titled, High-affinity monoclonal antibodies to the cardiac glycoside, digoxin.
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Journal Articles

Studies with Anti-Pneumococcal Antibodies

E. Haber, J. C. Jaton, M. D. Waterfield, M. N. Margolies, K. J. Bloch, W. C. Cheng
Journal: The Journal of Immunology
J Immunol (1971) 107 (3): 932.
https://doi.org/10.4049/jimmunol.107.3.932.a
Published: 01 September 1971
View article titled, Studies with Anti-Pneumococcal Antibodies
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