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Megan Sykes
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Journal Articles

Defects in Long-Term APC Repopulation Ability of Adult Human Bone Marrow Hematopoietic Stem Cells (HSCs) Compared with Fetal Liver HSCs

Grace Nauman, Nichole M. Danzl, Jaeyop Lee, Chiara Borsotti, Rachel Madley, Jianing Fu, Markus A. Hölzl, Alexander Dahmani, Akaitz Dorronsoro Gonzalez, Éstefania Chavez, Sean R. Campbell, Suxiao Yang, Prakash Satwani, Kang Liu, Megan Sykes
Journal: The Journal of Immunology
J Immunol (2022) 208 (7): 1652–1663.
https://doi.org/10.4049/jimmunol.2100966
Published: 01 April 2022
View article titled, Defects in Long-Term APC Repopulation Ability of Adult Human Bone Marrow Hematopoietic Stem Cells (HSCs) Compared with Fetal Liver HSCs
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Includes: Supplementary data
Journal Articles

Rapid Functional Decline of Activated and Memory Graft-versus-Host–Reactive T Cells Encountering Host Antigens in the Absence of Inflammation

Hao Wei Li, Giovanna Andreola, Alicia L. Carlson, Steven Shao, Charles P. Lin, Guiling Zhao, Megan Sykes
Journal: The Journal of Immunology
J Immunol (2015) 195 (3): 1282–1292.
https://doi.org/10.4049/jimmunol.1401511
Published: 01 August 2015
View article titled, Rapid Functional Decline of Activated and Memory Graft-versus-Host–Reactive T Cells Encountering Host Antigens in the Absence of Inflammation
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Includes: Supplementary data
Journal Articles

OX40- and CD27-Mediated Costimulation Synergizes with Anti–PD-L1 Blockade by Forcing Exhausted CD8+ T Cells To Exit Quiescence

Sarah L. Buchan, Teresa Manzo, Barry Flutter, Anne Rogel, Noha Edwards, Lei Zhang, Shivajanani Sivakumaran, Sara Ghorashian, Ben Carpenter, Clare L. Bennett, Gordon J. Freeman, Megan Sykes, Michael Croft, Aymen Al-Shamkhani, Ronjon Chakraverty
Journal: The Journal of Immunology
J Immunol (2015) 194 (1): 125–133.
https://doi.org/10.4049/jimmunol.1401644
Published: 01 January 2015
View article titled, OX40- and CD27-Mediated Costimulation Synergizes with Anti–PD-L1 Blockade by Forcing Exhausted CD8<sup>+</sup> T Cells To Exit Quiescence
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Includes: Supplementary data
Journal Articles

Xenograft Tolerance and Immune Function of Human T Cells Developing in Pig Thymus Xenografts

Hannes Kalscheuer, Takashi Onoe, Alexander Dahmani, Hao-Wei Li, Markus Hölzl, Kazuhiko Yamada, Megan Sykes
Journal: The Journal of Immunology
J Immunol (2014) 192 (7): 3442–3450.
https://doi.org/10.4049/jimmunol.1302886
Published: 01 April 2014
View article titled, Xenograft Tolerance and Immune Function of Human T Cells Developing in Pig Thymus Xenografts
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Includes: Supplementary data
Journal Articles

Nonalloreactive T Cells Prevent Donor Lymphocyte Infusion–Induced Graft-versus-Host Disease by Controlling Microbial Stimuli

Hao Wei Li, Jessica Sachs, Clarimel Pichardo, Roderick Bronson, Guiling Zhao, Megan Sykes
Journal: The Journal of Immunology
J Immunol (2012) 189 (12): 5572–5581.
https://doi.org/10.4049/jimmunol.1200045
Published: 15 December 2012
View article titled, Nonalloreactive T Cells Prevent Donor Lymphocyte Infusion–Induced Graft-versus-Host Disease by Controlling Microbial Stimuli
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Journal Articles

Human Natural Regulatory T Cell Development, Suppressive Function, and Postthymic Maturation in a Humanized Mouse Model

Takashi Onoe, Hannes Kalscheuer, Nichole Danzl, Meredith Chittenden, Guiling Zhao, Yong-Guang Yang, Megan Sykes
Journal: The Journal of Immunology
J Immunol (2011) 187 (7): 3895–3903.
https://doi.org/10.4049/jimmunol.1100394
Published: 01 October 2011
View article titled, Human Natural Regulatory T Cell Development, Suppressive Function, and Postthymic Maturation in a Humanized Mouse Model
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Includes: Supplementary data
Journal Articles

Invariant NKT Cells Are Required for Antitumor Responses Induced by Host-Versus-Graft Responses

Toshiki I. Saito, Hao Wei Li, Megan Sykes
Journal: The Journal of Immunology
J Immunol (2010) 185 (4): 2099–2105.
https://doi.org/10.4049/jimmunol.0901985
Published: 15 August 2010
View article titled, Invariant NKT Cells Are Required for Antitumor Responses Induced by Host-Versus-Graft Responses
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Includes: Supplementary data
Journal Articles

Homeostatic Expansion and Phenotypic Conversion of Human T Cells Depend on Peripheral Interactions with APCs

Takashi Onoe, Hannes Kalscheuer, Meredith Chittenden, Guiling Zhao, Yong-Guang Yang, Megan Sykes
Journal: The Journal of Immunology
J Immunol (2010) 184 (12): 6756–6765.
https://doi.org/10.4049/jimmunol.0901711
Published: 15 June 2010
View article titled, Homeostatic Expansion and Phenotypic Conversion of Human T Cells Depend on Peripheral Interactions with APCs
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Journal Articles

Alloreactive CD8 T cells require cell-intrinsic PD-1 and upregulate Nr4a and Egr family members during deletional tolerance in vivo (145.43)

Carrie Lucas, Megan Sykes
Journal: The Journal of Immunology
J Immunol (2010) 184 (1_Supplement): 145.43.
https://doi.org/10.4049/jimmunol.184.Supp.145.43
Published: 01 April 2010
View article titled, Alloreactive CD8 T cells require cell-intrinsic PD-1 and upregulate Nr4a and Egr family members during deletional tolerance in vivo (145.43)
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Journal Articles

CD40L-specific mAb mediates its tolerogenic effects through engagement of FcgRIIB, not via depletion of activated T cells (141.17)

Carrie L. Lucas, Thomas Fehr, Fabienne Haspot, Megan Sykes
Journal: The Journal of Immunology
J Immunol (2009) 182 (1_Supplement): 141.17.
https://doi.org/10.4049/jimmunol.182.Supp.141.17
Published: 01 April 2009
View article titled, CD40L-specific mAb mediates its tolerogenic effects through engagement of FcgRIIB, not via depletion of activated T cells (141.17)
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Journal Articles

Abnormal Regulatory and Effector T Cell Function Predispose to Autoimmunity following Xenogeneic Thymic Transplantation

Yasuhiro Fudaba, Takashi Onoe, Meredith Chittenden, Akira Shimizu, Juanita M. Shaffer, Roderick Bronson, Megan Sykes
Journal: The Journal of Immunology
J Immunol (2008) 181 (11): 7649–7659.
https://doi.org/10.4049/jimmunol.181.11.7649
Published: 01 December 2008
View article titled, Abnormal Regulatory and Effector T Cell Function Predispose to Autoimmunity following Xenogeneic Thymic Transplantation
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Includes: Supplementary data
Journal Articles

The Host Environment Regulates the Function of CD8+ Graft-versus-Host-Reactive Effector Cells

Ronjon Chakraverty, Barry Flutter, Farnaz Fallah-Arani, Hyeon-Seok Eom, Terry Means, Giovanna Andreola, Sebastian Schwarte, Jennifer Buchli, Pete Cotter, Guiling Zhao, Megan Sykes
Journal: The Journal of Immunology
J Immunol (2008) 181 (10): 6820–6828.
https://doi.org/10.4049/jimmunol.181.10.6820
Published: 15 November 2008
View article titled, The Host Environment Regulates the Function of CD8<sup>+</sup> Graft-versus-Host-Reactive Effector Cells
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Includes: Supplementary data
Journal Articles

Rapid Deletional Peripheral CD8 T Cell Tolerance Induced by Allogeneic Bone Marrow: Role of Donor Class II MHC and B Cells

Thomas Fehr, Sophia Wang, Fabienne Haspot, Josef Kurtz, Peter Blaha, Timothy Hogan, Meredith Chittenden, Thomas Wekerle, Megan Sykes
Journal: The Journal of Immunology
J Immunol (2008) 181 (6): 4371–4380.
https://doi.org/10.4049/jimmunol.181.6.4371
Published: 15 September 2008
View article titled, Rapid Deletional Peripheral CD8 T Cell Tolerance Induced by Allogeneic Bone Marrow: Role of Donor Class II MHC and B Cells
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Journal Articles

Alloreactive CD8 T Cell Tolerance Requires Recipient B Cells, Dendritic Cells, and MHC Class II

Thomas Fehr, Fabienne Haspot, Joshua Mollov, Meredith Chittenden, Timothy Hogan, Megan Sykes
Journal: The Journal of Immunology
J Immunol (2008) 181 (1): 165–173.
https://doi.org/10.4049/jimmunol.181.1.165
Published: 01 July 2008
View article titled, Alloreactive CD8 T Cell Tolerance Requires Recipient B Cells, Dendritic Cells, and MHC Class II
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Journal Articles

Mechanisms of the Antitumor Responses and Host-versus-Graft Reactions Induced by Recipient Leukocyte Infusions in Mixed Chimeras Prepared with Nonmyeloablative Conditioning: A Critical Role for Recipient CD4+ T Cells and Recipient Leukocyte Infusion-Derived IFN-γ-Producing CD8+ T Cells

Marie-Therese Rubio, Toshiki I. Saito, Kristin Kattleman, Guiling Zhao, Jennifer Buchli, Megan Sykes
Journal: The Journal of Immunology
J Immunol (2005) 175 (2): 665–676.
https://doi.org/10.4049/jimmunol.175.2.665
Published: 15 July 2005
View article titled, Mechanisms of the Antitumor Responses and Host-versus-Graft Reactions Induced by Recipient Leukocyte Infusions in Mixed Chimeras Prepared with Nonmyeloablative Conditioning: A Critical Role for Recipient CD4<sup>+</sup> T Cells and Recipient Leukocyte Infusion-Derived IFN-γ-Producing CD8<sup>+</sup> T Cells
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Journal Articles

Roles of Deletion and Regulation in Creating Mixed Chimerism and Allograft Tolerance Using a Nonlymphoablative Irradiation-Free Protocol

Christoph Domenig, Alberto Sanchez-Fueyo, Josef Kurtz, Sophoclis P. Alexopoulos, Christophe Mariat, Megan Sykes, Terry B. Strom, Xin Xiao Zheng
Journal: The Journal of Immunology
J Immunol (2005) 175 (1): 51–60.
https://doi.org/10.4049/jimmunol.175.1.51
Published: 01 July 2005
View article titled, Roles of Deletion and Regulation in Creating Mixed Chimerism and Allograft Tolerance Using a Nonlymphoablative Irradiation-Free Protocol
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Journal Articles

Peritoneal Cavity B Cells Are Precursors of Splenic IgM Natural Antibody-Producing Cells

Toshiyasu Kawahara, Hideki Ohdan, Guiling Zhao, Yong-Guang Yang, Megan Sykes
Journal: The Journal of Immunology
J Immunol (2003) 171 (10): 5406–5414.
https://doi.org/10.4049/jimmunol.171.10.5406
Published: 15 November 2003
View article titled, Peritoneal Cavity B Cells Are Precursors of Splenic IgM Natural Antibody-Producing Cells
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Journal Articles

NK Cell Tolerance in Mixed Allogeneic Chimeras

Yong Zhao, Hideki Ohdan, Jennifer O. Manilay, Megan Sykes
Journal: The Journal of Immunology
J Immunol (2003) 170 (11): 5398–5405.
https://doi.org/10.4049/jimmunol.170.11.5398
Published: 01 June 2003
View article titled, NK Cell Tolerance in Mixed Allogeneic Chimeras
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Journal Articles

Murine CD4 T Cells Selected in a Highly Disparate Xenogeneic Porcine Thymus Graft Do Not Show Rapid Decay in the Absence of Selecting MHC in the Periphery

Jose-Ignacio Rodriguez-Barbosa, Yong Zhao, Guiling Zhao, Angel Ezquerra, Megan Sykes
Journal: The Journal of Immunology
J Immunol (2002) 169 (12): 6697–6710.
https://doi.org/10.4049/jimmunol.169.12.6697
Published: 15 December 2002
View article titled, Murine CD4 T Cells Selected in a Highly Disparate Xenogeneic Porcine Thymus Graft Do Not Show Rapid Decay in the Absence of Selecting MHC in the Periphery
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Journal Articles

Elimination of Porcine Hemopoietic Cells by Macrophages in Mice

Masahiro Abe, Jane Cheng, Jin Qi, Roseann M. Glaser, Aron D. Thall, Megan Sykes, Yong-Guang Yang
Journal: The Journal of Immunology
J Immunol (2002) 168 (2): 621–628.
https://doi.org/10.4049/jimmunol.168.2.621
Published: 15 January 2002
View article titled, Elimination of Porcine Hemopoietic Cells by Macrophages in Mice
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