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SUV39H1 disruption imparts functional persistence to CD28-costimulated human CAR T cells

Nayan Jain, Zeguo Zhao, Richard Koche, Yosi Gozlan, David Brocks, Tali Raveh-Sadka, Danny Wells, Anton Dobrin, Yuzhe Shi, Michael Lopez, Gertrude Gunset, Michel Sadelain

J Immunol (2022) 208 (1_Supplement): 122.05.

https://doi.org/10.4049/jimmunol.208.Supp.122.05

Published: 01 May 2022

View article titled, SUV39H1 disruption imparts functional persistence to CD28-costimulated human CAR T cells

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BATF3/MYC axis drives hyper-proliferation of TET2 deficient CAR T cells

Nayan Jain, Zeguo Zhao, Archana Iyer, Michael Lopez, Judith Feucht, Richard Koche, Julie Yang, Yingqian Zhan, Michel Sadelain

J Immunol (2021) 206 (1_Supplement): 58.02.

https://doi.org/10.4049/jimmunol.206.Supp.58.02

Published: 01 May 2021

View article titled, BATF3/MYC axis drives hyper-proliferation of TET2 deficient CAR T cells

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Development of citrullinated-vimentin-specific CAR for targeting Tregs to treat autoimmune rheumatoid arthritis

Caroline Raffin, Yu Zhou, Luca Piccoli, Antonio Lanzavecchia, Michel Sadelain, Semih U. Tareen, Jason D. Fontenot, Jeffrey A. Bluestone

J Immunol (2018) 200 (1_Supplement): 176.17.

https://doi.org/10.4049/jimmunol.200.Supp.176.17

Published: 01 May 2018

View article titled, Development of citrullinated-vimentin-specific CAR for targeting Tregs to treat autoimmune rheumatoid arthritis

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Development of citrullinated-vimentin-specific CAR for targeting Tregs to treat autoimmune rheumatoid arthritis.

Caroline Raffin, Yu Zhou, Luca Piccoli, Antonio Lanzavecchia, Michel Sadelain, Jeffrey A Bluestone

J Immunol (2016) 196 (1_Supplement): 210.19.

https://doi.org/10.4049/jimmunol.196.Supp.210.19

Published: 01 May 2016

View article titled, Development of citrullinated-vimentin-specific CAR for targeting Tregs to treat autoimmune rheumatoid arthritis.

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Chimeric-antigen receptor engineered human T lymphocytes from induced pluripotent stem cells for cancer therapy. (VAC11P.1003)

Maria Themeli, Michel Sadelain

J Immunol (2014) 192 (1_Supplement): 205.4.

https://doi.org/10.4049/jimmunol.192.Supp.205.4

Published: 01 May 2014

View article titled, Chimeric-antigen receptor engineered human T lymphocytes from induced pluripotent stem cells for cancer therapy. (VAC11P.1003)

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Journal Articles

Donor CD19-targeted T cells exert potent graft versus lymphoma activity without GVHD (P2134)

Arnab Ghosh, Marco Davila, Lauren Young, Robert Jenq, Michel Sadelain, Marcel van den Brink

J Immunol (2013) 190 (1_Supplement): 69.5.

https://doi.org/10.4049/jimmunol.190.Supp.69.5

Published: 01 May 2013

View article titled, Donor CD19-targeted T cells exert potent graft versus lymphoma activity without GVHD (P2134)

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4-1BBL costimulation enables CD4 T cells expressing a CD28/zeta chimeric antigen receptor to eliminate aggressive leukemia. (P4338)

Maud Condomines, Zeguo Zhao, Xiuyan Wang, Christopher Kloss, Marco Davila, Michel Sadelain

J Immunol (2013) 190 (1_Supplement): 177.2.

https://doi.org/10.4049/jimmunol.190.Supp.177.2

Published: 01 May 2013

View article titled, 4-1BBL costimulation enables CD4 T cells expressing a CD28/zeta chimeric antigen receptor to eliminate aggressive leukemia. (P4338)

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Retrovirally expressed 4-1BBL dramatically increases proliferation and in vivo persistence of adoptively transferred CD19-targeted T cells, promoting complete tumor elimination. (131.16)

Maud Condomines, Jason Plotkin, John Markley, Gertrude Gunset, Michel Sadelain

J Immunol (2010) 184 (1_Supplement): 131.16.

https://doi.org/10.4049/jimmunol.184.Supp.131.16

Published: 01 April 2010

View article titled, Retrovirally expressed 4-1BBL dramatically increases proliferation and in vivo persistence of adoptively transferred CD19-targeted T cells, promoting complete tumor elimination. (131.16)

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A Herceptin-Based Chimeric Antigen Receptor with Modified Signaling Domains Leads to Enhanced Survival of Transduced T Lymphocytes and Antitumor Activity

Yangbing Zhao, Qiong J. Wang, Shicheng Yang, James N. Kochenderfer, Zhili Zheng, Xiaosong Zhong, Michel Sadelain, Zelig Eshhar, Steven A. Rosenberg, Richard A. Morgan

J Immunol (2009) 183 (9): 5563–5574.

https://doi.org/10.4049/jimmunol.0900447

Published: 01 November 2009

View article titled, A Herceptin-Based Chimeric Antigen Receptor with Modified Signaling Domains Leads to Enhanced Survival of Transduced T Lymphocytes and Antitumor Activity

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Includes: Supplementary data

Journal Articles

A Panel of Artificial APCs Expressing Prevalent HLA Alleles Permits Generation of Cytotoxic T Cells Specific for Both Dominant and Subdominant Viral Epitopes for Adoptive Therapy

Aisha N. Hasan, Wouter J. Kollen, Deepa Trivedi, Annamalai Selvakumar, Bo Dupont, Michel Sadelain, Richard J. O'Reilly

J Immunol (2009) 183 (4): 2837–2850.

https://doi.org/10.4049/jimmunol.0804178

Published: 15 August 2009

View article titled, A Panel of Artificial APCs Expressing Prevalent HLA Alleles Permits Generation of Cytotoxic T Cells Specific for Both Dominant and Subdominant Viral Epitopes for Adoptive Therapy

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Includes: Supplementary data

Journal Articles

Cutting Edge: CD28 Controls Dominant Regulatory T Cell Activity during Active Immunization

Clay Lyddane, Beata U. Gajewska, Elmer Santos, Philip D. King, Glaucia C. Furtado, Michel Sadelain

J Immunol (2006) 176 (6): 3306–3310.

https://doi.org/10.4049/jimmunol.176.6.3306

Published: 15 March 2006

View article titled, Cutting Edge: CD28 Controls Dominant Regulatory T Cell Activity during Active Immunization

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Journal Articles

Langerhans-Type Dendritic Cells Genetically Modified to Express Full-Length Antigen Optimally Stimulate CTLs in a CD4-Dependent Manner

Jianda Yuan, Jean-Baptiste Latouche, Joanna Hodges, Alan N. Houghton, Glenn Heller, Michel Sadelain, Isabelle Riviere, James W. Young

J Immunol (2006) 176 (4): 2357–2365.

https://doi.org/10.4049/jimmunol.176.4.2357

Published: 15 February 2006

View article titled, Langerhans-Type Dendritic Cells Genetically Modified to Express Full-Length Antigen Optimally Stimulate CTLs in a CD4-Dependent Manner

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Journal Articles

Langerhans Cells Derived from Genetically Modified Human CD34⁺ Hemopoietic Progenitors Are More Potent Than Peptide-Pulsed Langerhans Cells for Inducing Antigen-Specific CD8⁺ Cytolytic T Lymphocyte Responses

Jianda Yuan, Jean-Baptiste Latouche, John L. Reagan, Glenn Heller, Isabelle Riviere, Michel Sadelain, James W. Young

J Immunol (2005) 174 (2): 758–766.

https://doi.org/10.4049/jimmunol.174.2.758

Published: 15 January 2005

View article titled, Langerhans Cells Derived from Genetically Modified Human CD34+ Hemopoietic Progenitors Are More Potent Than Peptide-Pulsed Langerhans Cells for Inducing Antigen-Specific CD8+ Cytolytic T Lymphocyte Responses

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Journal Articles

Ligand Binding to Inhibitory Killer Cell Ig-Like Receptors Induce Colocalization with Src Homology Domain 2-Containing Protein Tyrosine Phosphatase 1 and Interruption of Ongoing Activation Signals

Yatin M. Vyas, Hina Maniar, Clay E. Lyddane, Michel Sadelain, Bo Dupont

J Immunol (2004) 173 (3): 1571–1578.

https://doi.org/10.4049/jimmunol.173.3.1571

Published: 01 August 2004

View article titled, Ligand Binding to Inhibitory Killer Cell Ig-Like Receptors Induce Colocalization with Src Homology Domain 2-Containing Protein Tyrosine Phosphatase 1 and Interruption of Ongoing Activation Signals

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Journal Articles

Negative-Feedback Regulation of CD28 Costimulation by a Novel Mitogen-Activated Protein Kinase Phosphatase, MKP6

Francesc Marti, Anja Krause, Nicholas H. Post, Clay Lyddane, Bo Dupont, Michel Sadelain, Philip D. King

J Immunol (2001) 166 (1): 197–206.

https://doi.org/10.4049/jimmunol.166.1.197

Published: 01 January 2001

View article titled, Negative-Feedback Regulation of CD28 Costimulation by a Novel Mitogen-Activated Protein Kinase Phosphatase, MKP6

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Journal Articles

Retrovirally Transduced Mouse Dendritic Cells Require CD4⁺ T Cell Help to Elicit Antitumor Immunity: Implications for the Clinical Use of Dendritic Cells

Stefan Schnell, James W. Young, Alan N. Houghton, Michel Sadelain

J Immunol (2000) 164 (3): 1243–1250.

https://doi.org/10.4049/jimmunol.164.3.1243

Published: 01 February 2000

View article titled, Retrovirally Transduced Mouse Dendritic Cells Require CD4+ T Cell Help to Elicit Antitumor Immunity: Implications for the Clinical Use of Dendritic Cells

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NARROW

SUV39H1 disruption imparts functional persistence to CD28-costimulated human CAR T cells

BATF3/MYC axis drives hyper-proliferation of TET2 deficient CAR T cells

Development of citrullinated-vimentin-specific CAR for targeting Tregs to treat autoimmune rheumatoid arthritis

Development of citrullinated-vimentin-specific CAR for targeting Tregs to treat autoimmune rheumatoid arthritis.

Chimeric-antigen receptor engineered human T lymphocytes from induced pluripotent stem cells for cancer therapy. (VAC11P.1003)

Donor CD19-targeted T cells exert potent graft versus lymphoma activity without GVHD (P2134)

4-1BBL costimulation enables CD4 T cells expressing a CD28/zeta chimeric antigen receptor to eliminate aggressive leukemia. (P4338)

Retrovirally expressed 4-1BBL dramatically increases proliferation and in vivo persistence of adoptively transferred CD19-targeted T cells, promoting complete tumor elimination. (131.16)

A Herceptin-Based Chimeric Antigen Receptor with Modified Signaling Domains Leads to Enhanced Survival of Transduced T Lymphocytes and Antitumor Activity

A Panel of Artificial APCs Expressing Prevalent HLA Alleles Permits Generation of Cytotoxic T Cells Specific for Both Dominant and Subdominant Viral Epitopes for Adoptive Therapy

Cutting Edge: CD28 Controls Dominant Regulatory T Cell Activity during Active Immunization

Langerhans-Type Dendritic Cells Genetically Modified to Express Full-Length Antigen Optimally Stimulate CTLs in a CD4-Dependent Manner

Langerhans Cells Derived from Genetically Modified Human CD34⁺ Hemopoietic Progenitors Are More Potent Than Peptide-Pulsed Langerhans Cells for Inducing Antigen-Specific CD8⁺ Cytolytic T Lymphocyte Responses

Ligand Binding to Inhibitory Killer Cell Ig-Like Receptors Induce Colocalization with Src Homology Domain 2-Containing Protein Tyrosine Phosphatase 1 and Interruption of Ongoing Activation Signals

Negative-Feedback Regulation of CD28 Costimulation by a Novel Mitogen-Activated Protein Kinase Phosphatase, MKP6

Retrovirally Transduced Mouse Dendritic Cells Require CD4⁺ T Cell Help to Elicit Antitumor Immunity: Implications for the Clinical Use of Dendritic Cells

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