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N H Ruddle
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Journal Articles

Transgenic expression of lymphotoxin restores lymph nodes to lymphotoxin-alpha-deficient mice.

R Sacca, S Turley, L Soong, I Mellman, N H Ruddle
Journal: The Journal of Immunology
J Immunol (1997) 159 (9): 4252–4260.
DOI: https://doi.org/10.4049/jimmunol.159.9.4252
Published: 01 November 1997
View article titled, Transgenic expression of lymphotoxin restores lymph nodes to lymphotoxin-alpha-deficient mice.
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Presentation via the class I pathway by Leishmania amazonensis-infected macrophages of an endogenous leishmanial antigen to CD8+ T cells.

P E Kima, N H Ruddle, D McMahon-Pratt
Journal: The Journal of Immunology
J Immunol (1997) 159 (4): 1828–1834.
DOI: https://doi.org/10.4049/jimmunol.159.4.1828
Published: 15 August 1997
View article titled, Presentation via the class I pathway by Leishmania amazonensis-infected macrophages of an endogenous leishmanial antigen to CD8+ T cells.
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Journal Articles

Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection.

L Soong, C H Chang, J Sun, B J Longley, Jr, N H Ruddle, R A Flavell, D McMahon-Pratt
Journal: The Journal of Immunology
J Immunol (1997) 158 (11): 5374–5383.
DOI: https://doi.org/10.4049/jimmunol.158.11.5374
Published: 01 June 1997
View article titled, Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection.
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Journal Articles

Presence of T cells with activated and memory phenotypes in inflammatory spinal cord lesions.

D M Barten, R B Clark, N H Ruddle
Journal: The Journal of Immunology
J Immunol (1995) 155 (11): 5409–5418.
DOI: https://doi.org/10.4049/jimmunol.155.11.5409
Published: 01 December 1995
View article titled, Presence of T cells with activated and memory phenotypes in inflammatory spinal cord lesions.
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Journal Articles

Differential regulation of lymphotoxin (LT), lymphotoxin-beta (LT-beta), and TNF-alpha in murine T cell clones activated through the TCR.

I Millet, N H Ruddle
Journal: The Journal of Immunology
J Immunol (1994) 152 (9): 4336–4346.
DOI: https://doi.org/10.4049/jimmunol.152.9.4336
Published: 01 May 1994
View article titled, Differential regulation of lymphotoxin (LT), lymphotoxin-beta (LT-beta), and TNF-alpha in murine T cell clones activated through the TCR.
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Studies on the mechanisms by which transforming growth factor-beta (TGF-beta) protects against allergic encephalomyelitis. Antagonism between TGF-beta and tumor necrosis factor.

L Santambrogio, G M Hochwald, B Saxena, C H Leu, J E Martz, J A Carlino, N H Ruddle, M A Palladino, L I Gold, G J Thorbecke
Journal: The Journal of Immunology
J Immunol (1993) 151 (2): 1116–1127.
DOI: https://doi.org/10.4049/jimmunol.151.2.1116
Published: 15 July 1993
View article titled, Studies on the mechanisms by which transforming growth factor-beta (TGF-beta) protects against allergic encephalomyelitis. Antagonism between TGF-beta and tumor necrosis factor.
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Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice.

D E Picarella, A Kratz, C B Li, N H Ruddle, R A Flavell
Journal: The Journal of Immunology
J Immunol (1993) 150 (9): 4136–4150.
DOI: https://doi.org/10.4049/jimmunol.150.9.4136
Published: 01 May 1993
View article titled, Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice.
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Journal Articles

The murine lymphotoxin gene promoter. Characterization and negative regulation.

S J Fashena, W L Tang, T Sarr, N H Ruddle
Journal: The Journal of Immunology
J Immunol (1990) 145 (1): 177–183.
DOI: https://doi.org/10.4049/jimmunol.145.1.177
Published: 01 July 1990
View article titled, The murine lymphotoxin gene promoter. Characterization and negative regulation.
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Journal Articles

Production of tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) by murine pre-B and B cell lymphomas.

R Laskov, G Lancz, N H Ruddle, K M McGrath, S Specter, T Klein, J Y Djeu, H Friedman
Journal: The Journal of Immunology
J Immunol (1990) 144 (9): 3424–3430.
DOI: https://doi.org/10.4049/jimmunol.144.9.3424
Published: 01 May 1990
View article titled, Production of tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) by murine pre-B and B cell lymphomas.
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Journal Articles

Expression of two distinct cytolytic mechanisms among murine CD4 subsets.

S T Ju, N H Ruddle, P Strack, M E Dorf, R H DeKruyff
Journal: The Journal of Immunology
J Immunol (1990) 144 (1): 23–31.
DOI: https://doi.org/10.4049/jimmunol.144.1.23
Published: 01 January 1990
View article titled, Expression of two distinct cytolytic mechanisms among murine CD4 subsets.
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Journal Articles

Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors.

K C Sheehan, N H Ruddle, R D Schreiber
Journal: The Journal of Immunology
J Immunol (1989) 142 (11): 3884–3893.
DOI: https://doi.org/10.4049/jimmunol.142.11.3884
Published: 01 June 1989
View article titled, Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors.
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Journal Articles

Subtypes of helper cells. Non-inflammatory type 1 helper T cells.

R L Wong, N H Ruddle, S J Padula, E G Lingenheld, C M Bergman, R V Rugen, D I Epstein, R B Clark
Journal: The Journal of Immunology
J Immunol (1988) 141 (10): 3329–3334.
DOI: https://doi.org/10.4049/jimmunol.141.10.3329
Published: 15 November 1988
View article titled, Subtypes of helper cells. Non-inflammatory type 1 helper T cells.
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Journal Articles

Cloning and expression of murine lymphotoxin cDNA.

C B Li, P W Gray, P F Lin, K M McGrath, F H Ruddle, N H Ruddle
Journal: The Journal of Immunology
J Immunol (1987) 138 (12): 4496–4501.
DOI: https://doi.org/10.4049/jimmunol.138.12.4496
Published: 15 June 1987
View article titled, Cloning and expression of murine lymphotoxin cDNA.
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Journal Articles

Anti-tumor activity of class II MHC antigen-restricted cloned autoreactive T cells. II. Novel immunotherapy of B16 melanomas by local and systemic adoptive transfer.

T Shiohara, G Moellmann, K Jacobson, E Kuklinska, N H Ruddle, A B Lerner
Journal: The Journal of Immunology
J Immunol (1987) 138 (6): 1979–1986.
DOI: https://doi.org/10.4049/jimmunol.138.6.1979
Published: 15 March 1987
View article titled, Anti-tumor activity of class II MHC antigen-restricted cloned autoreactive T cells. II. Novel immunotherapy of B16 melanomas by local and systemic adoptive transfer.
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Journal Articles

Anti-tumor activity of class II MHC antigen-restricted cloned autoreactive T cells. I. Destruction of B16 melanoma cells mediated by bystander cytolysis in vitro.

T Shiohara, N H Ruddle, M Horowitz, G E Moellmann, A B Lerner
Journal: The Journal of Immunology
J Immunol (1987) 138 (6): 1971–1978.
DOI: https://doi.org/10.4049/jimmunol.138.6.1971
Published: 15 March 1987
View article titled, Anti-tumor activity of class II MHC antigen-restricted cloned autoreactive T cells. I. Destruction of B16 melanoma cells mediated by bystander cytolysis in vitro.
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Journal Articles

Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.

N H Ruddle
Journal: The Journal of Immunology
J Immunol (1986) 136 (6): 2335–2336.
DOI: https://doi.org/10.4049/jimmunol.136.6.2335.a
Published: 15 March 1986
View article titled, Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.
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Journal Articles

A new name for lymphotoxin.

N H Ruddle
Journal: The Journal of Immunology
J Immunol (1986) 136 (6): 2335–2336.
DOI: https://doi.org/10.4049/jimmunol.136.6.2335
Published: 15 March 1986
View article titled, A new name for lymphotoxin.
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Protein-antigen specific Ia-restricted cytolytic T cells: analysis of frequency, target cell susceptibility, and mechanism of cytolysis.

J P Tite, M B Powell, N H Ruddle
Journal: The Journal of Immunology
J Immunol (1985) 135 (1): 25–33.
DOI: https://doi.org/10.4049/jimmunol.135.1.25
Published: 01 July 1985
View article titled, Protein-antigen specific Ia-restricted cytolytic T cells: analysis of frequency, target cell susceptibility, and mechanism of cytolysis.
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Journal Articles

Activation of Lyt-1+ and Lyt-2+ T cell cloned lines: stimulation of proliferation, lymphokine production, and self-destruction.

B S Conta, M B Powell, N H Ruddle
Journal: The Journal of Immunology
J Immunol (1985) 134 (4): 2185–2190.
DOI: https://doi.org/10.4049/jimmunol.134.4.2185
Published: 01 April 1985
View article titled, Activation of Lyt-1+ and Lyt-2+ T cell cloned lines: stimulation of proliferation, lymphokine production, and self-destruction.
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The delayed-type hypersensitivity response to (4-hydroxy-3-nitrophenyl) acetyl- (NP) coupled proteins is carrier-specific: in vivo and in vitro demonstrations.

W C Barry, N H Ruddle
Journal: The Journal of Immunology
J Immunol (1983) 131 (1): 70–76.
DOI: https://doi.org/10.4049/jimmunol.131.1.70
Published: 01 July 1983
View article titled, The delayed-type hypersensitivity response to (4-hydroxy-3-nitrophenyl) acetyl- (NP) coupled proteins is carrier-specific: in vivo and in vitro demonstrations.
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