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Nikolaos Sgourakis
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Journal Articles

Exploring engineered HLA-I chaperones for enhancing the immunogenicity of cold tumors.

Daniel Hwang, Shirley Sun, Nikolaos Sgourakis
Journal: The Journal of Immunology
J Immunol (2024) 212 (1_Supplement): 0550_4889.
https://doi.org/10.4049/jimmunol.212.supp.0550.4889
Published: 01 May 2024
View article titled, Exploring engineered HLA-I chaperones for enhancing the immunogenicity of cold tumors.
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Journal Articles

Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion

Nikolaos Sgourakis, Yi Sun, Tyler Florio, Sagar Gupta, Quinlen Marshall, Samuel Garfinkle, Michael Young, Georgia Papadaki, Hau Truong, Peiyao Li, Emily Mycek, Alvin Farrel, Mark Yarmarkovich, Leena Mallik, John Maris
Journal: The Journal of Immunology
J Immunol (2024) 212 (1_Supplement): 1402_5734.
https://doi.org/10.4049/jimmunol.212.supp.1402.5734
Published: 01 May 2024
View article titled, Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion
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Xeno-interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes

Yi Sun, Georgia Papadaki, Christine Devlin, Julia Danon, Michael Young, Trenton Winters, George Burslem, Erik Procko, Nikolaos Sgourakis
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 222.04.
https://doi.org/10.4049/jimmunol.210.Supp.222.04
Published: 01 May 2023
View article titled, Xeno-interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes
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Journal Articles

Mechanistic aspects of tapasin-mediated antigen presentation revealed by structure of a tapasin/MHC-I complex

Kannan Natarajan, Jiansheng Jiang, Daniel Kyle Taylor, Ellen J Kim, Lisa F. Boyd, Javeed Ahmad Dhobi, Michael G Mage, Hau Truong, Claire Woodward, Nikolaos Sgourakis, Peter Cresswell, David H Margulies
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 221.28.
https://doi.org/10.4049/jimmunol.210.Supp.221.28
Published: 01 May 2023
View article titled, Mechanistic aspects of tapasin-mediated antigen presentation revealed by structure of a tapasin/MHC-I complex
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Journal Articles

Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules

Georgia Papadaki, Omar Ani, Tyler Florio, Michael Young, Julia Danon, Yi Sun, Devin Dersh, Nikolaos Sgourakis
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 251.06.
https://doi.org/10.4049/jimmunol.210.Supp.251.06
Published: 01 May 2023
View article titled, Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules
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Journal Articles

Illuminating the Mechanism of MHC-I Folding and Antigen Repertoire Selection Using Deep Mutational Scanning and Biophysical Studies

Nikolaos Sgourakis, Andrew C McShan, Christine A Devlin, Giora Morozov, Erik Procko
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 140.21.
https://doi.org/10.4049/jimmunol.204.Supp.140.21
Published: 01 May 2020
View article titled, Illuminating the Mechanism of MHC-I Folding and Antigen Repertoire Selection Using Deep Mutational Scanning and Biophysical Studies
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Journal Articles

Getting in the groove: Editing of MHC-I antigen repertoires by molecular chaperones is governed by a network of protein dynamics

Nikolaos Sgourakis, Andrew McShan, Kannan Natarajan, Jiansheng Jiang, Jihye Park, Sarah Overall, Jugmohit S Toor, Vlad Kumirov, David Flores-Solis, Mareike Badstubner, Evgenii L Kovrigin, Clive R Bagshaw, Jesper Pallesen, Erik Procko, David H Margulies
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 177.31.
https://doi.org/10.4049/jimmunol.202.Supp.177.31
Published: 01 May 2019
View article titled, <em>Getting in the groove:</em> Editing of MHC-I antigen repertoires by molecular chaperones is governed by a network of protein dynamics
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Journal Articles

Chaperone-assisted peptide exchange on MHC-I is driven by a negative allostery release cycle: Implications for a role of peptide-editing Molecular Chaperones in scrutinizing the peptide repertoire

Nikolaos Sgourakis, Andrew C. McShan, Kannan Natarajan, Vlad K. Kumirov, David Flores-Solis, Jiansheng Jiang, Mareike Badstuebner, Evgenii L. Kovrigin, David H. Margulies
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 99.23.
https://doi.org/10.4049/jimmunol.200.Supp.99.23
Published: 01 May 2018
View article titled, Chaperone-assisted peptide exchange on MHC-I is driven by a negative allostery release cycle: Implications for a role of peptide-editing Molecular Chaperones in scrutinizing the peptide repertoire
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Journal Articles

An allosteric site in the T cell receptor β-chain constant domain plays a critical role in T cell signaling

Nikolaos Sgourakis, Kannan Natarajan, Andrew McShan, Jiansheng Jiang, Huaying Zhao, Peter Schuck, Lisa F Boyd, Mulualem E Tilahun, Jinfa Ying, Ad Bax, David H Margulies
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 146.9.
https://doi.org/10.4049/jimmunol.198.Supp.146.9
Published: 01 May 2017
View article titled, An allosteric site in the T cell receptor β-chain constant domain plays a critical role in T cell signaling
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Journal Articles

Mapping the interaction footprint of Viral Immunoevasins on a “platform” MHC-I molecule using solution NMR spectroscopy (APP2P.102)

Nikolaos Sgourakis
Journal: The Journal of Immunology
J Immunol (2015) 194 (1_Supplement): 45.3.
https://doi.org/10.4049/jimmunol.194.Supp.45.3
Published: 01 May 2015
View article titled, Mapping the interaction footprint of Viral Immunoevasins on a “platform” MHC-I molecule using solution NMR spectroscopy (APP2P.102)
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Journal Articles

A structural approach to the study of viral immune evasion mechanisms (TECH1P.850)

Nikolaos Sgourakis, Kannan Natarajan, David Margulies, Ad Bax
Journal: The Journal of Immunology
J Immunol (2014) 192 (1_Supplement): 69.18.
https://doi.org/10.4049/jimmunol.192.Supp.69.18
Published: 01 May 2014
View article titled, A structural approach to the study of viral immune evasion mechanisms (TECH1P.850)
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