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Noel G. McElvaney
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Journal Articles

Neutrophil-Derived Peptidyl Arginine Deiminase Activity Contributes to Pulmonary Emphysema by Enhancing Elastin Degradation

Mark P. Murphy, David Hunt, Malcolm Herron, Jake McDonnell, Rashed Alshuhoumi, Lorcan P. McGarvey, Aurelie Fabré, Helen O’Brien, Cormac McCarthy, S. Lorraine Martin, Noel G. McElvaney, Emer P. Reeves
Journal: The Journal of Immunology
J Immunol (2024) 213 (1): 75–85.
https://doi.org/10.4049/jimmunol.2300658
Published: 17 May 2024
View article titled, Neutrophil-Derived Peptidyl Arginine Deiminase Activity Contributes to Pulmonary Emphysema by Enhancing Elastin Degradation
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Journal Articles

Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity

Emer P. Reeves, Danielle M. Dunlea, Karen McQuillan, Ciara A. O’Dwyer, Tomás P. Carroll, Radka Saldova, Prithvi Reddy Akepati, Mark R. Wormald, Oliver J. McElvaney, Vipatsorn Shutchaidat, Michael Henry, Paula Meleady, Joanne Keenan, Derek C. Liberti, Darrell N. Kotton, Pauline M. Rudd, Andrew A. Wilson, Noel G. McElvaney
Journal: The Journal of Immunology
J Immunol (2019) 202 (8): 2240–2253.
https://doi.org/10.4049/jimmunol.1801045
Published: 15 April 2019
View article titled, Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity
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Includes: Supplementary data
Journal Articles

The BLT1 Inhibitory Function of α-1 Antitrypsin Augmentation Therapy Disrupts Leukotriene B4 Neutrophil Signaling

Ciara A. O’Dwyer, M. Emmet O’Brien, Mark R. Wormald, Michelle M. White, Nessa Banville, Killian Hurley, Cormac McCarthy, Noel G. McElvaney, Emer P. Reeves
Journal: The Journal of Immunology
J Immunol (2015) 195 (8): 3628–3641.
https://doi.org/10.4049/jimmunol.1500038
Published: 15 October 2015
View article titled, The BLT1 Inhibitory Function of α-1 Antitrypsin Augmentation Therapy Disrupts Leukotriene B<sub>4</sub> Neutrophil Signaling
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Includes: Supplementary data
Journal Articles

Alpha-1 Antitrypsin Augmentation Therapy Corrects Accelerated Neutrophil Apoptosis in Deficient Individuals

Killian Hurley, Noreen Lacey, Ciara A. O’Dwyer, David A. Bergin, Oliver J. McElvaney, M. Emmet O’Brien, Oisín F. McElvaney, Emer P. Reeves, Noel G. McElvaney
Journal: The Journal of Immunology
J Immunol (2014) 193 (8): 3978–3991.
https://doi.org/10.4049/jimmunol.1400132
Published: 15 October 2014
View article titled, Alpha-1 Antitrypsin Augmentation Therapy Corrects Accelerated Neutrophil Apoptosis in Deficient Individuals
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Includes: Supplementary data
Journal Articles

Galectin-9 Signaling through TIM-3 Is Involved in Neutrophil-Mediated Gram-Negative Bacterial Killing: An Effect Abrogated within the Cystic Fibrosis Lung

Isabel Vega-Carrascal, David A. Bergin, Oliver J. McElvaney, Cormac McCarthy, Nessa Banville, Kerstin Pohl, Mitsuomi Hirashima, Vijay K. Kuchroo, Emer P. Reeves, Noel G. McElvaney
Journal: The Journal of Immunology
J Immunol (2014) 192 (5): 2418–2431.
https://doi.org/10.4049/jimmunol.1300711
Published: 01 March 2014
View article titled, Galectin-9 Signaling through TIM-3 Is Involved in Neutrophil-Mediated Gram-Negative Bacterial Killing: An Effect Abrogated within the Cystic Fibrosis Lung
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Journal Articles

Regulation of Cystic Fibrosis Transmembrane Conductance Regulator by MicroRNA-145, -223, and -494 Is Altered in ΔF508 Cystic Fibrosis Airway Epithelium

Irene K. Oglesby, Sanjay H. Chotirmall, Noel G. McElvaney, Catherine M. Greene
Journal: The Journal of Immunology
J Immunol (2013) 190 (7): 3354–3362.
https://doi.org/10.4049/jimmunol.1202960
Published: 01 April 2013
View article titled, Regulation of Cystic Fibrosis Transmembrane Conductance Regulator by MicroRNA-145, -223, and -494 Is Altered in ΔF508 Cystic Fibrosis Airway Epithelium
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Includes: Supplementary data
Journal Articles

Dysregulation of TIM-3–Galectin-9 Pathway in the Cystic Fibrosis Airways

Isabel Vega-Carrascal, Emer P. Reeves, Toshiro Niki, Tomohiro Arikawa, Paul McNally, Shane J. O’Neill, Mitsuomi Hirashima, Noel G. McElvaney
Journal: The Journal of Immunology
J Immunol (2011) 186 (5): 2897–2909.
https://doi.org/10.4049/jimmunol.1003187
Published: 01 March 2011
View article titled, Dysregulation of TIM-3–Galectin-9 Pathway in the Cystic Fibrosis Airways
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Journal Articles

Evidence for Unfolded Protein Response Activation in Monocytes from Individuals with α-1 Antitrypsin Deficiency

Tomás P. Carroll, Catherine M. Greene, Catherine A. O’Connor, Áine M. Nolan, Shane J. O’Neill, Noel G. McElvaney
Journal: The Journal of Immunology
J Immunol (2010) 184 (8): 4538–4546.
https://doi.org/10.4049/jimmunol.0802864
Published: 15 April 2010
View article titled, Evidence for Unfolded Protein Response Activation in Monocytes from Individuals with α-1 Antitrypsin Deficiency
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Journal Articles

miR-126 Is Downregulated in Cystic Fibrosis Airway Epithelial Cells and Regulates TOM1 Expression

Irene K. Oglesby, Isabella M. Bray, Sanjay H. Chotirmall, Raymond L. Stallings, Shane J. O’Neill, Noel G. McElvaney, Catherine M. Greene
Journal: The Journal of Immunology
J Immunol (2010) 184 (4): 1702–1709.
https://doi.org/10.4049/jimmunol.0902669
Published: 18 January 2010
View article titled, miR-126 Is Downregulated in Cystic Fibrosis Airway Epithelial Cells and Regulates TOM1 Expression
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Includes: Supplementary data
Journal Articles

IL-8 Dictates Glycosaminoglycan Binding and Stability of IL-18 in Cystic Fibrosis

Emer P. Reeves, Michael Williamson, Barry Byrne, David A. Bergin, Stephen G. J. Smith, Peter Greally, Richard O’Kennedy, Shane J. O’Neill, Noel G. McElvaney
Journal: The Journal of Immunology
J Immunol (2010) 184 (3): 1642–1652.
https://doi.org/10.4049/jimmunol.0902605
Published: 21 December 2009
View article titled, IL-8 Dictates Glycosaminoglycan Binding and Stability of IL-18 in Cystic Fibrosis
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Journal Articles

Decreased Levels of Secretory Leucoprotease Inhibitor in the Pseudomonas-Infected Cystic Fibrosis Lung Are Due to Neutrophil Elastase Degradation

Sinéad Weldon, Paul McNally, Noel G. McElvaney, J. Stuart Elborn, Danny F. McAuley, Julien Wartelle, Abderrazzaq Belaaouaj, Rodney L. Levine, Clifford C. Taggart
Journal: The Journal of Immunology
J Immunol (2009) 183 (12): 8148–8156.
https://doi.org/10.4049/jimmunol.0901716
Published: 15 December 2009
View article titled, Decreased Levels of Secretory Leucoprotease Inhibitor in the <em>Pseudomonas</em>-Infected Cystic Fibrosis Lung Are Due to Neutrophil Elastase Degradation
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Journal Articles

LL-37 Complexation with Glycosaminoglycans in Cystic Fibrosis Lungs Inhibits Antimicrobial Activity, Which Can Be Restored by Hypertonic Saline

Gudmundur Bergsson, Emer P. Reeves, Paul McNally, Sanjay H. Chotirmall, Catherine M. Greene, Peter Greally, Philip Murphy, Shane J. O'Neill, Noel G. McElvaney
Journal: The Journal of Immunology
J Immunol (2009) 183 (1): 543–551.
https://doi.org/10.4049/jimmunol.0803959
Published: 01 July 2009
View article titled, LL-37 Complexation with Glycosaminoglycans in Cystic Fibrosis Lungs Inhibits Antimicrobial Activity, Which Can Be Restored by Hypertonic Saline
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Journal Articles

Neutrophil Elastase Up-Regulates Cathepsin B and Matrix Metalloprotease-2 Expression

Patrick Geraghty, Mark P. Rogan, Catherine M. Greene, Rachel M. M. Boxio, Tiphaine Poiriert, Michael O’Mahony, Abderazzaq Belaaouaj, Shane J. O’Neill, Clifford C. Taggart, Noel G. McElvaney
Journal: The Journal of Immunology
J Immunol (2007) 178 (9): 5871–5878.
https://doi.org/10.4049/jimmunol.178.9.5871
Published: 01 May 2007
View article titled, Neutrophil Elastase Up-Regulates Cathepsin B and Matrix Metalloprotease-2 Expression
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Journal Articles

Viral Inhibition of IL-1- and Neutrophil Elastase-Induced Inflammatory Responses in Bronchial Epithelial Cells

Tomás P. Carroll, Catherine M. Greene, Clifford C. Taggart, Andrew G. Bowie, Shane J. O’Neill, Noel G. McElvaney
Journal: The Journal of Immunology
J Immunol (2005) 175 (11): 7594–7601.
https://doi.org/10.4049/jimmunol.175.11.7594
Published: 01 December 2005
View article titled, Viral Inhibition of IL-1- and Neutrophil Elastase-Induced Inflammatory Responses in Bronchial Epithelial Cells
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Journal Articles

TLR-Induced Inflammation in Cystic Fibrosis and Non-Cystic Fibrosis Airway Epithelial Cells

Catherine M. Greene, Tomás P. Carroll, Stephen G. J. Smith, Clifford C. Taggart, James Devaney, Siobhan Griffin, Shane J. O’Neill, Noel G. McElvaney
Journal: The Journal of Immunology
J Immunol (2005) 174 (3): 1638–1646.
https://doi.org/10.4049/jimmunol.174.3.1638
Published: 01 February 2005
View article titled, TLR-Induced Inflammation in Cystic Fibrosis and Non-Cystic Fibrosis Airway Epithelial Cells
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Journal Articles

Activation of Endoplasmic Reticulum-Specific Stress Responses Associated with the Conformational Disease Z α1-Antitrypsin Deficiency

Matthew W. Lawless, Catherine M. Greene, Alan Mulgrew, Clifford C. Taggart, Shane J. O’Neill, Noel G. McElvaney
Journal: The Journal of Immunology
J Immunol (2004) 172 (9): 5722–5726.
https://doi.org/10.4049/jimmunol.172.9.5722
Published: 01 May 2004
View article titled, Activation of Endoplasmic Reticulum-Specific Stress Responses Associated with the Conformational Disease Z α1-Antitrypsin Deficiency
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Journal Articles

Inactivation of Human β-Defensins 2 and 3 by Elastolytic Cathepsins

Clifford C. Taggart, Catherine M. Greene, Stephen G. Smith, Rodney L. Levine, Paul B. McCray, Jr., Shane O’Neill, Noel G. McElvaney
Journal: The Journal of Immunology
J Immunol (2003) 171 (2): 931–937.
https://doi.org/10.4049/jimmunol.171.2.931
Published: 15 July 2003
View article titled, Inactivation of Human β-Defensins 2 and 3 by Elastolytic Cathepsins
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Journal Articles

Role of IL-18 in CD4+ T Lymphocyte Activation in Sarcoidosis

Catherine M. Greene, Gerard Meachery, Clifford C. Taggart, Cyril P. Rooney, Raymond Coakley, Shane J. O’Neill, Noel G. McElvaney
Journal: The Journal of Immunology
J Immunol (2000) 165 (8): 4718–4724.
https://doi.org/10.4049/jimmunol.165.8.4718
Published: 15 October 2000
View article titled, Role of IL-18 in CD4<sup>+</sup> T Lymphocyte Activation in Sarcoidosis
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