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Identification of a macrophage activation threshold associated with malignant transformation and the sensing of candidate “danger signals”

Camille Jacqueline, Rachel Gottschalk, Jonathan Minden, Olivera J Finn

J Immunol (2021) 206 (1_Supplement): 101.09.

https://doi.org/10.4049/jimmunol.206.Supp.101.09

Published: 01 May 2021

View article titled, Identification of a macrophage activation threshold associated with malignant transformation and the sensing of candidate “danger signals”

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Inflammation-induced tumor antigen expression on epithelial cells reveals the mechanism of their generation and provides a system for identification of new tumor targets

Camille Jacqueline, Amanda Lee, Nolan Frey, Jonathan S Minden, Olivera J Finn

J Immunol (2020) 204 (1_Supplement): 242.15.

https://doi.org/10.4049/jimmunol.204.Supp.242.15

Published: 01 May 2020

View article titled, Inflammation-induced tumor antigen expression on epithelial cells reveals the mechanism of their generation and provides a system for identification of new tumor targets

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The cross-talk between infiltrating macrophages and inflamed or malignant colonic epithelium promotes overexpression of ST6GALNAC1 and epithelial MUC1 tumor form MUC1-sTn

Sandra Cascio, Michael Kvorjak, Yamine Ahmed, Michelle Miller, Jana Al Hashash, Douglas Hartman, Natasa Miskov-Zivanov, Cheryl Telmer, Olivera J Finn

J Immunol (2019) 202 (1_Supplement): 135.5.

https://doi.org/10.4049/jimmunol.202.Supp.135.5

Published: 01 May 2019

View article titled, The cross-talk between infiltrating macrophages and inflamed or malignant colonic epithelium promotes overexpression of ST6GALNAC1 and epithelial MUC1 tumor form MUC1-sTn

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Patient-derived, vaccine-elicited MUC1 antibodies mediate immune effector functions against cancer cells

Michelle L Miller, Jason Lohmueller, Eric Ricci, William Lu, Olivera J Finn

J Immunol (2019) 202 (1_Supplement): 136.17.

https://doi.org/10.4049/jimmunol.202.Supp.136.17

Published: 01 May 2019

View article titled, Patient-derived, vaccine-elicited MUC1 antibodies mediate immune effector functions against cancer cells

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Covalent adaptor synNotch and chimeric antigen receptors (CARs) for programmable antigen targeting

Jason Jakob Lomueller, Adam Butchy, Yaniv Tivon, Michael Kvorjak, Natasa Miskov-Zivanov, Alexander Deiters, Olivera J Finn

J Immunol (2019) 202 (1_Supplement): 71.18.

https://doi.org/10.4049/jimmunol.202.Supp.71.18

Published: 01 May 2019

View article titled, Covalent adaptor synNotch and chimeric antigen receptors (CARs) for programmable antigen targeting

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Tumor-resident macrophages modulate intestinal barrier function through sialylation of Mucin 1 in IBD and colitis-associated cancer.

Sandra Cascio, Michael Kvorjak, Jana Al Hashash, Raahul Sriram, Douglas Hartman, David Binion, Olivera J. Finn

J Immunol (2018) 200 (1_Supplement): 178.12.

https://doi.org/10.4049/jimmunol.200.Supp.178.12

Published: 01 May 2018

View article titled, Tumor-resident macrophages modulate intestinal barrier function through sialylation of Mucin 1 in IBD and colitis-associated cancer.

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Myeloid derived suppressor cells (MDSC) and anti-MUC1 immunosurveillance in pre-malignancy and cancer

Peiwen Ma, Pamela Beatty, John McKolanis, Robert Schoen, Randal Brand, Olivera J. Finn

J Immunol (2018) 200 (1_Supplement): 122.17.

https://doi.org/10.4049/jimmunol.200.Supp.122.17

Published: 01 May 2018

View article titled, Myeloid derived suppressor cells (MDSC) and anti-MUC1 immunosurveillance in pre-malignancy and cancer

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A Believer’s Overview of Cancer Immunosurveillance and Immunotherapy

In Special Collection:

Brief Reviews , The Cancer Immunotherapy Revolution: Mechanistic Insights

Olivera J. Finn

J Immunol (2018) 200 (2): 385–391.

https://doi.org/10.4049/jimmunol.1701302

Published: 15 January 2018

View article titled, A Believer’s Overview of Cancer Immunosurveillance and Immunotherapy

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MUC1 promotes an inflammatory microenvironment aggravating colitis-associated tumorigenesis in mice through up-regulation of pro-inflammatory cytokines.

Sandra Cascio, Jacque Faylo, Joshua Sciurba, Jia Xue, Olivera J Finn

J Immunol (2016) 196 (1_Supplement): 73.7.

https://doi.org/10.4049/jimmunol.196.Supp.73.7

Published: 01 May 2016

View article titled, MUC1 promotes an inflammatory microenvironment aggravating colitis-associated tumorigenesis in mice through up-regulation of pro-inflammatory cytokines.

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Human anti-MUC1 antibodies elicited by a prophylactic cancer vaccine for CAR T cell immunotherapy.

Jason Jakob Lomueller, Shuji Sato, Lana Popova, Isabel M Chu, Meghan A Tucker, Roberto Barberena, Gregory M Innocenti, Mare Cudic, James D Ham, Wan Cheung Cheung, Roberto D Polakiewicz, Olivera J Finn

J Immunol (2016) 196 (1_Supplement): 214.6.

https://doi.org/10.4049/jimmunol.196.Supp.214.6

Published: 01 May 2016

View article titled, Human anti-MUC1 antibodies elicited by a prophylactic cancer vaccine for CAR T cell immunotherapy.

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Novel Mechanisms Underlying the Immediate and Transient Global Tolerization of Splenic Dendritic Cells after Vaccination with a Self-Antigen

Adam M. Farkas, Olivera J. Finn

J Immunol (2014) 192 (2): 658–665.

https://doi.org/10.4049/jimmunol.1301904

Published: 15 January 2014

View article titled, Novel Mechanisms Underlying the Immediate and Transient Global Tolerization of Splenic Dendritic Cells after Vaccination with a Self-Antigen

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Includes: Supplementary data

Journal Articles

Antigen Choice Determines Vaccine-Induced Generation of Immunogenic versus Tolerogenic Dendritic Cells That Are Marked by Differential Expression of Pancreatic Enzymes

Adam M. Farkas, Douglas M. Marvel, Olivera J. Finn

J Immunol (2013) 190 (7): 3319–3327.

https://doi.org/10.4049/jimmunol.1203321

Published: 01 April 2013

View article titled, Antigen Choice Determines Vaccine-Induced Generation of Immunogenic versus Tolerogenic Dendritic Cells That Are Marked by Differential Expression of Pancreatic Enzymes

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Includes: Supplementary data

Journal Articles

IL-33 promotes type 1 cell-mediated immunity and has a potent antitumor function (46.25)

Gang Li, Qianting Yang, Yibei Zhu, Xin Gao, Xueguang Zhang, Olivera J. Finn, Binfeng Lu

J Immunol (2012) 188 (1_Supplement): 46.25.

https://doi.org/10.4049/jimmunol.188.Supp.46.25

Published: 01 May 2012

View article titled, IL-33 promotes type 1 cell-mediated immunity and has a potent antitumor function (46.25)

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Journal Articles

Tumor-associated antigen MUC1 contains self epitopes subject to self-tolerance and tumor-associated “foreign” epitopes that elicit effective immunity: important distinction for cancer vaccines (41.60)

Sean O. Ryan, Michael S. Turner, Leigh Revers, Jean Gariepy, Olivera J. Finn

J Immunol (2009) 182 (1_Supplement): 41.60.

https://doi.org/10.4049/jimmunol.182.Supp.41.60

Published: 01 April 2009

View article titled, Tumor-associated antigen MUC1 contains self epitopes subject to self-tolerance and tumor-associated “foreign” epitopes that elicit effective immunity: important distinction for cancer vaccines (41.60)

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Journal Articles

Antigen dose over-rides DC phenotype in the control of CD4+ regulatory T cell induction through reduced Akt/mTOR signaling (89.30)

Michael S Turner, Olivera J Finn, Penelope A Morel

J Immunol (2009) 182 (1_Supplement): 89.30.

https://doi.org/10.4049/jimmunol.182.Supp.89.30

Published: 01 April 2009

View article titled, Antigen dose over-rides DC phenotype in the control of CD4+ regulatory T cell induction through reduced Akt/mTOR signaling (89.30)

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Journal Articles

Immunological Weapons Acquired Early in Life Win Battles with Cancer Late in Life

Olivera J. Finn

J Immunol (2008) 181 (3): 1589–1592.

https://doi.org/10.4049/jimmunol.181.3.1589

Published: 01 August 2008

View article titled, Immunological Weapons Acquired Early in Life Win Battles with Cancer Late in Life

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Journal Articles

Cutting Edge: Transgenic Expression of Human MUC1 in IL-10^−/− Mice Accelerates Inflammatory Bowel Disease and Progression to Colon Cancer

Pamela L. Beatty, Scott E. Plevy, Antonia R. Sepulveda, Olivera J. Finn

J Immunol (2007) 179 (2): 735–739.

https://doi.org/10.4049/jimmunol.179.2.735

Published: 15 July 2007

View article titled, Cutting Edge: Transgenic Expression of Human MUC1 in IL-10<sup>−/−</sup> Mice Accelerates Inflammatory Bowel Disease and Progression to Colon Cancer

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Journal Articles

MUC1 Mucin Expressed no Activated T Cells has a Regulatory Function (87.17)

Ee W Su, Lawrence P Kane, Olivera J Finn

J Immunol (2007) 178 (1_Supplement): S131.

https://doi.org/10.4049/jimmunol.178.Supp.87.17

Published: 01 April 2007

View article titled, MUC1 Mucin Expressed no Activated T Cells has a Regulatory Function (87.17)

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Journal Articles

Human Tumor Immunology at the Molecular Divide

In Special Collection:

Pillars of Immunology

Olivera J. Finn

J Immunol (2007) 178 (5): 2615–2616.

https://doi.org/10.4049/jimmunol.178.5.2615

Published: 01 March 2007

View article titled, Human Tumor Immunology at the Molecular Divide

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Journal Articles

Lack of Effective MUC1 Tumor Antigen-Specific Immunity in MUC1-Transgenic Mice Results from a Th/T Regulatory Cell Imbalance That Can Be Corrected by Adoptive Transfer of Wild-Type Th Cells

Michael S. Turner, Patrice A. Cohen, Olivera J. Finn

J Immunol (2007) 178 (5): 2787–2793.

https://doi.org/10.4049/jimmunol.178.5.2787

Published: 01 March 2007

View article titled, Lack of Effective MUC1 Tumor Antigen-Specific Immunity in MUC1-Transgenic Mice Results from a Th/T Regulatory Cell Imbalance That Can Be Corrected by Adoptive Transfer of Wild-Type Th Cells

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NARROW

Identification of a macrophage activation threshold associated with malignant transformation and the sensing of candidate “danger signals”

Inflammation-induced tumor antigen expression on epithelial cells reveals the mechanism of their generation and provides a system for identification of new tumor targets

The cross-talk between infiltrating macrophages and inflamed or malignant colonic epithelium promotes overexpression of ST6GALNAC1 and epithelial MUC1 tumor form MUC1-sTn

Patient-derived, vaccine-elicited MUC1 antibodies mediate immune effector functions against cancer cells

Covalent adaptor synNotch and chimeric antigen receptors (CARs) for programmable antigen targeting

Tumor-resident macrophages modulate intestinal barrier function through sialylation of Mucin 1 in IBD and colitis-associated cancer.

Myeloid derived suppressor cells (MDSC) and anti-MUC1 immunosurveillance in pre-malignancy and cancer

A Believer’s Overview of Cancer Immunosurveillance and Immunotherapy

MUC1 promotes an inflammatory microenvironment aggravating colitis-associated tumorigenesis in mice through up-regulation of pro-inflammatory cytokines.

Human anti-MUC1 antibodies elicited by a prophylactic cancer vaccine for CAR T cell immunotherapy.

Novel Mechanisms Underlying the Immediate and Transient Global Tolerization of Splenic Dendritic Cells after Vaccination with a Self-Antigen

Antigen Choice Determines Vaccine-Induced Generation of Immunogenic versus Tolerogenic Dendritic Cells That Are Marked by Differential Expression of Pancreatic Enzymes

IL-33 promotes type 1 cell-mediated immunity and has a potent antitumor function (46.25)

Tumor-associated antigen MUC1 contains self epitopes subject to self-tolerance and tumor-associated “foreign” epitopes that elicit effective immunity: important distinction for cancer vaccines (41.60)

Antigen dose over-rides DC phenotype in the control of CD4+ regulatory T cell induction through reduced Akt/mTOR signaling (89.30)

Immunological Weapons Acquired Early in Life Win Battles with Cancer Late in Life

Cutting Edge: Transgenic Expression of Human MUC1 in IL-10^−/− Mice Accelerates Inflammatory Bowel Disease and Progression to Colon Cancer

MUC1 Mucin Expressed no Activated T Cells has a Regulatory Function (87.17)

Human Tumor Immunology at the Molecular Divide

Lack of Effective MUC1 Tumor Antigen-Specific Immunity in MUC1-Transgenic Mice Results from a Th/T Regulatory Cell Imbalance That Can Be Corrected by Adoptive Transfer of Wild-Type Th Cells

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