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Journal Articles

Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production in Th2 Cells

Aki Ejima, Shinya Abe, Akihiro Shimba, Susumu Sato, Takuya Uehata, Shizue Tani-ichi, Satoru Munakata, Guangwei Cui, Osamu Takeuchi, Toyohiro Hirai, Shigeaki Kato, Koichi Ikuta
Journal: The Journal of Immunology
J Immunol (2022) 209 (6): 1083–1094.
https://doi.org/10.4049/jimmunol.2200294
Published: 15 September 2022
View article titled, Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production in Th2 Cells
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Includes: Supplementary data
Journal Articles

Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis

Xiaotong Cui, Takashi Mino, Masanori Yoshinaga, Yoshinari Nakatsuka, Fabian Hia, Daichi Yamasoba, Tohru Tsujimura, Keizo Tomonaga, Yutaka Suzuki, Takuya Uehata, Osamu Takeuchi
Journal: The Journal of Immunology
J Immunol (2017) 199 (12): 4066–4077.
https://doi.org/10.4049/jimmunol.1701211
Published: 15 December 2017
View article titled, Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis
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Includes: Supplementary data
Journal Articles

Pillars Article: Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product. J. Immunol. 1999. 162: 3749–3752

Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai, Hideki Sanjo, Tomohiko Ogawa, Yoshifumi Takeda, Kiyoshi Takeda, Shizuo Akira
Journal: The Journal of Immunology
J Immunol (2016) 197 (7): 2563–2566.
Published: 01 October 2016
View article titled, Pillars Article: Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <em>Lps</em> Gene Product. <em>J. Immunol.</em> 1999. 162: 3749–3752
Open the PDF for Pillars Article: Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <em>Lps</em> Gene Product. <em>J. Immunol.</em> 1999. 162: 3749–3752 in another window
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Journal Articles

Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses

Sarang Tartey, Kazufumi Matsushita, Tomoko Imamura, Atsuko Wakabayashi, Daisuke Ori, Takashi Mino, Osamu Takeuchi
Journal: The Journal of Immunology
J Immunol (2015) 195 (2): 519–527.
https://doi.org/10.4049/jimmunol.1500373
Published: 15 July 2015
View article titled, Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses
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Includes: Supplementary data
Journal Articles

Critical Role of AZI2 in GM-CSF–Induced Dendritic Cell Differentiation

Masahiro Fukasaka, Daisuke Ori, Tatsukata Kawagoe, Satoshi Uematsu, Kenta Maruyama, Toshihiko Okazaki, Tatsuya Kozaki, Tomoko Imamura, Sarang Tartey, Takashi Mino, Takashi Satoh, Shizuo Akira, Osamu Takeuchi
Journal: The Journal of Immunology
J Immunol (2013) 190 (11): 5702–5711.
https://doi.org/10.4049/jimmunol.1203155
Published: 01 June 2013
View article titled, Critical Role of AZI2 in GM-CSF–Induced Dendritic Cell Differentiation
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Journal Articles

Regulation of 4-1BBL-mediated inflammation at the late phase of TLR response (P1228)

Young Kang, Jianhui Ma, Eun-Jin Shim, Jiawei Lu, So-Young Eun, Mick Croft, Peter Tobias, Osamu Takeuchi, Shizuo Akira, Jiahuai Han, Michael Karin
Journal: The Journal of Immunology
J Immunol (2013) 190 (1_Supplement): 138.12.
https://doi.org/10.4049/jimmunol.190.Supp.138.12
Published: 01 May 2013
View article titled, Regulation of 4-1BBL-mediated inflammation at the late phase of TLR response (P1228)
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Journal Articles

Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs

Daisuke Ori, Hiroki Kato, Hideki Sanjo, Sarang Tartey, Takashi Mino, Shizuo Akira, Osamu Takeuchi
Journal: The Journal of Immunology
J Immunol (2013) 190 (8): 4037–4045.
https://doi.org/10.4049/jimmunol.1300173
Published: 15 April 2013
View article titled, Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs
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Journal Articles

B lineage-specific deletion of Bim leads to lymphoproliferative and autoimmune disease (159.23)

Jacqueline Wright, Emily Clark, Osamu Takeuchi, Sandra Zinkel, Anne Satterthwaite, Wasif Khan
Journal: The Journal of Immunology
J Immunol (2012) 188 (1_Supplement): 159.23.
https://doi.org/10.4049/jimmunol.188.Supp.159.23
Published: 01 May 2012
View article titled, B lineage-specific deletion of Bim leads to lymphoproliferative and autoimmune disease (159.23)
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Journal Articles

NO Is a Macrophage Autonomous Modifier of the Cytokine Response to Streptococcal Single-Stranded RNA

Sachin D. Deshmukh, Sabrina Müller, Katrin Hese, Katharina S. Rauch, Julia Wennekamp, Osamu Takeuchi, Shizuo Akira, Douglas T. Golenbock, Philipp Henneke
Journal: The Journal of Immunology
J Immunol (2012) 188 (2): 774–780.
https://doi.org/10.4049/jimmunol.1101383
Published: 15 January 2012
View article titled, NO Is a Macrophage Autonomous Modifier of the Cytokine Response to Streptococcal Single-Stranded RNA
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Includes: Multimedia, Supplementary data
Journal Articles

IL-1α Modulates Neutrophil Recruitment in Chronic Inflammation Induced by Hydrocarbon Oil

Pui Y. Lee, Yutaro Kumagai, Yuan Xu, Yi Li, Tolga Barker, Chao Liu, Eric S. Sobel, Osamu Takeuchi, Shizuo Akira, Minoru Satoh, Westley H. Reeves
Journal: The Journal of Immunology
J Immunol (2011) 186 (3): 1747–1754.
https://doi.org/10.4049/jimmunol.1001328
Published: 01 February 2011
View article titled, IL-1α Modulates Neutrophil Recruitment in Chronic Inflammation Induced by Hydrocarbon Oil
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Includes: Supplementary data
Journal Articles

Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1

Sun Myung Joung, Zee-Yong Park, Shilpa Rani, Osamu Takeuchi, Shizuo Akira, Joo Young Lee
Journal: The Journal of Immunology
J Immunol (2011) 186 (1): 499–507.
https://doi.org/10.4049/jimmunol.0903534
Published: 01 January 2011
View article titled, Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1
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Includes: Supplementary data
Journal Articles

Poly I:C-Induced Activation of NK Cells by CD8α+ Dendritic Cells via the IPS-1 and TRIF-Dependent Pathways

Tohru Miyake, Yutaro Kumagai, Hiroki Kato, Zijin Guo, Kazufumi Matsushita, Takashi Satoh, Tatsukata Kawagoe, Himanshu Kumar, Myoung Ho Jang, Taro Kawai, Tohru Tani, Osamu Takeuchi, Shizuo Akira
Journal: The Journal of Immunology
J Immunol (2009) 183 (4): 2522–2528.
https://doi.org/10.4049/jimmunol.0901500
Published: 15 August 2009
View article titled, Poly I:C-Induced Activation of NK Cells by CD8α<sup>+</sup> Dendritic Cells via the IPS-1 and TRIF-Dependent Pathways
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Journal Articles

Cutting Edge: TLR-Dependent Viral Recognition Along with Type I IFN Positive Feedback Signaling Masks the Requirement of Viral Replication for IFN-α Production in Plasmacytoid Dendritic Cells

Yutaro Kumagai, Himanshu Kumar, Shohei Koyama, Taro Kawai, Osamu Takeuchi, Shizuo Akira
Journal: The Journal of Immunology
J Immunol (2009) 182 (7): 3960–3964.
https://doi.org/10.4049/jimmunol.0804315
Published: 01 April 2009
View article titled, Cutting Edge: TLR-Dependent Viral Recognition Along with Type I IFN Positive Feedback Signaling Masks the Requirement of Viral Replication for IFN-α Production in Plasmacytoid Dendritic Cells
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Journal Articles

Cutting Edge: Pivotal Function of Ubc13 in Thymocyte TCR Signaling

Masahiro Yamamoto, Shintaro Sato, Tatsuya Saitoh, Hiroaki Sakurai, Satoshi Uematsu, Taro Kawai, Ken J. Ishii, Osamu Takeuchi, Shizuo Akira
Journal: The Journal of Immunology
J Immunol (2006) 177 (11): 7520–7524.
https://doi.org/10.4049/jimmunol.177.11.7520
Published: 01 December 2006
View article titled, Cutting Edge: Pivotal Function of Ubc13 in Thymocyte TCR Signaling
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Journal Articles

Cutting Edge: Role of TANK-Binding Kinase 1 and Inducible IκB Kinase in IFN Responses against Viruses in Innate Immune Cells

Kosuke Matsui, Yutaro Kumagai, Hiroki Kato, Shintaro Sato, Tatsukata Kawagoe, Satoshi Uematsu, Osamu Takeuchi, Shizuo Akira
Journal: The Journal of Immunology
J Immunol (2006) 177 (9): 5785–5789.
https://doi.org/10.4049/jimmunol.177.9.5785
Published: 01 November 2006
View article titled, Cutting Edge: Role of TANK-Binding Kinase 1 and Inducible IκB Kinase in IFN Responses against Viruses in Innate Immune Cells
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Includes: Supplementary data
Journal Articles

Role of Lipoteichoic Acid in the Phagocyte Response to Group B Streptococcus

Philipp Henneke, Siegfried Morath, Satoshi Uematsu, Stefan Weichert, Markus Pfitzenmaier, Osamu Takeuchi, Andrea Müller, Claire Poyart, Shizuo Akira, Reinhard Berner, Giuseppe Teti, Armin Geyer, Thomas Hartung, Patrick Trieu-Cuot, Dennis L. Kasper, Douglas T. Golenbock
Journal: The Journal of Immunology
J Immunol (2005) 174 (10): 6449–6455.
https://doi.org/10.4049/jimmunol.174.10.6449
Published: 15 May 2005
View article titled, Role of Lipoteichoic Acid in the Phagocyte Response to Group B <em>Streptococcus</em>
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Journal Articles

Lipopolysaccharide from Coxiella burnetii Is Involved in Bacterial Phagocytosis, Filamentous Actin Reorganization, and Inflammatory Responses through Toll-Like Receptor 4

Amélie Honstettre, Eric Ghigo, Alix Moynault, Christian Capo, Rudolf Toman, Shizuo Akira, Osamu Takeuchi, Hubert Lepidi, Didier Raoult, Jean-Louis Mege
Journal: The Journal of Immunology
J Immunol (2004) 172 (6): 3695–3703.
https://doi.org/10.4049/jimmunol.172.6.3695
Published: 15 March 2004
View article titled, Lipopolysaccharide from <em>Coxiella burnetii</em> Is Involved in Bacterial Phagocytosis, Filamentous Actin Reorganization, and Inflammatory Responses through Toll-Like Receptor 4
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Journal Articles

Toll-Like Receptor 2 Plays a Role in the Early Inflammatory Response to Murine Pneumococcal Pneumonia but Does Not Contribute to Antibacterial Defense

Sylvia Knapp, Catharina W. Wieland, Cornelis van ’t Veer, Osamu Takeuchi, Shizuo Akira, Sandrine Florquin, Tom van der Poll
Journal: The Journal of Immunology
J Immunol (2004) 172 (5): 3132–3138.
https://doi.org/10.4049/jimmunol.172.5.3132
Published: 01 March 2004
View article titled, Toll-Like Receptor 2 Plays a Role in the Early Inflammatory Response to Murine Pneumococcal Pneumonia but Does Not Contribute to Antibacterial Defense
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Journal Articles

Inhibitory Effect of Toll-Like Receptor 4 on Fusion between Phagosomes and Endosomes/Lysosomes in Macrophages

Akiko Shiratsuchi, Ikuko Watanabe, Osamu Takeuchi, Shizuo Akira, Yoshinobu Nakanishi
Journal: The Journal of Immunology
J Immunol (2004) 172 (4): 2039–2047.
https://doi.org/10.4049/jimmunol.172.4.2039
Published: 15 February 2004
View article titled, Inhibitory Effect of Toll-Like Receptor 4 on Fusion between Phagosomes and Endosomes/Lysosomes in Macrophages
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Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

Masahiro Yamamoto, Shintaro Sato, Kiyotoshi Mori, Katsuaki Hoshino, Osamu Takeuchi, Kiyoshi Takeda, Shizuo Akira
Journal: The Journal of Immunology
J Immunol (2002) 169 (12): 6668–6672.
https://doi.org/10.4049/jimmunol.169.12.6668
Published: 15 December 2002
View article titled, Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling
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