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P S Linsley
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Journal Articles

Prevention of immunotoxin-induced immunogenicity by coadministration with CTLA4Ig enhances antitumor efficacy.

C B Siegall, H G Haggerty, G L Warner, D Chace, B Mixan, P S Linsley, T Davidson
Journal: The Journal of Immunology
J Immunol (1997) 159 (10): 5168–5173.
DOI: https://doi.org/10.4049/jimmunol.159.10.5168
Published: 15 November 1997
View article titled, Prevention of immunotoxin-induced immunogenicity by coadministration with CTLA4Ig enhances antitumor efficacy.
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Journal Articles

Differential effects of B7-1 blockade in the rat experimental autoimmune encephalomyelitis model.

L Gallon, A Chandraker, S Issazadeh, R Peach, P S Linsley, L A Turka, M H Sayegh, S J Khoury
Journal: The Journal of Immunology
J Immunol (1997) 159 (9): 4212–4216.
DOI: https://doi.org/10.4049/jimmunol.159.9.4212
Published: 01 November 1997
View article titled, Differential effects of B7-1 blockade in the rat experimental autoimmune encephalomyelitis model.
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Journal Articles

Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways.

D I Daikh, B K Finck, P S Linsley, D Hollenbaugh, D Wofsy
Journal: The Journal of Immunology
J Immunol (1997) 159 (7): 3104–3108.
DOI: https://doi.org/10.4049/jimmunol.159.7.3104
Published: 01 October 1997
View article titled, Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways.
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Journal Articles

CD28-B7 T cell costimulatory blockade by CTLA4Ig in sensitized rat recipients: induction of transplantation tolerance in association with depressed cell-mediated and humoral immune responses.

K Onodera, A Chandraker, M Schaub, T H Stadlbauer, S Korom, R Peach, P S Linsley, M H Sayegh, J W Kupiec-Weglinski
Journal: The Journal of Immunology
J Immunol (1997) 159 (4): 1711–1717.
DOI: https://doi.org/10.4049/jimmunol.159.4.1711
Published: 15 August 1997
View article titled, CD28-B7 T cell costimulatory blockade by CTLA4Ig in sensitized rat recipients: induction of transplantation tolerance in association with depressed cell-mediated and humoral immune responses.
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Journal Articles

The role of donor and recipient B7-1 (CD80) in allograft rejection.

X X Zheng, M H Sayegh, X G Zheng, Y Li, P S Linsley, R Peach, F Borriello, T B Strom, A H Sharpe, L A Turka
Journal: The Journal of Immunology
J Immunol (1997) 159 (3): 1169–1173.
DOI: https://doi.org/10.4049/jimmunol.159.3.1169
Published: 01 August 1997
View article titled, The role of donor and recipient B7-1 (CD80) in allograft rejection.
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Journal Articles

CD28 engagement and proinflammatory cytokines contribute to T cell expansion and long-term survival in vivo.

A T Vella, T Mitchell, B Groth, P S Linsley, J M Green, C B Thompson, J W Kappler, P Marrack
Journal: The Journal of Immunology
J Immunol (1997) 158 (10): 4714–4720.
DOI: https://doi.org/10.4049/jimmunol.158.10.4714
Published: 15 May 1997
View article titled, CD28 engagement and proinflammatory cytokines contribute to T cell expansion and long-term survival in vivo.
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Journal Articles

Effects of blocking B7-1 and B7-2 interactions during a type 2 in vivo immune response.

R J Greenwald, P Lu, M J Halvorson, X Zhou, S Chen, K B Madden, P J Perrin, S C Morris, F D Finkelman, R Peach, P S Linsley, J F Urban, Jr, W C Gause
Journal: The Journal of Immunology
J Immunol (1997) 158 (9): 4088–4096.
DOI: https://doi.org/10.4049/jimmunol.158.9.4088
Published: 01 May 1997
View article titled, Effects of blocking B7-1 and B7-2 interactions during a type 2 in vivo immune response.
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Journal Articles

The role of the CD28/B7 interaction in the regulation of NK cell responses during infection with Toxoplasma gondii.

C A Hunter, L Ellis-Neyer, K E Gabriel, M K Kennedy, K H Grabstein, P S Linsley, J S Remington
Journal: The Journal of Immunology
J Immunol (1997) 158 (5): 2285–2293.
DOI: https://doi.org/10.4049/jimmunol.158.5.2285
Published: 01 March 1997
View article titled, The role of the CD28/B7 interaction in the regulation of NK cell responses during infection with Toxoplasma gondii.
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Journal Articles

B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens.

A Keane-Myers, W C Gause, P S Linsley, S J Chen, M Wills-Karp
Journal: The Journal of Immunology
J Immunol (1997) 158 (5): 2042–2049.
DOI: https://doi.org/10.4049/jimmunol.158.5.2042
Published: 01 March 1997
View article titled, B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens.
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Journal Articles

Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4.

F G Lakkis, B T Konieczny, S Saleem, F K Baddoura, P S Linsley, D Z Alexander, R P Lowry, T C Pearson, C P Larsen
Journal: The Journal of Immunology
J Immunol (1997) 158 (5): 2443–2448.
DOI: https://doi.org/10.4049/jimmunol.158.5.2443
Published: 01 March 1997
View article titled, Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4.
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Journal Articles

Intracellular CD22 rapidly moves to the cell surface in a tyrosine kinase-dependent manner following antigen receptor stimulation.

N V Sherbina, P S Linsley, S Myrdal, L S Grosmaire, J A Ledbetter, G L Schieven
Journal: The Journal of Immunology
J Immunol (1996) 157 (10): 4390–4398.
DOI: https://doi.org/10.4049/jimmunol.157.10.4390
Published: 15 November 1996
View article titled, Intracellular CD22 rapidly moves to the cell surface in a tyrosine kinase-dependent manner following antigen receptor stimulation.
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Journal Articles

Ex vivo treatment of antigen-presenting cells with CTLA4Ig and encephalitogenic peptide prevents experimental autoimmune encephalomyelitis in the Lewis rat.

S J Khoury, L Gallon, R R Verburg, A Chandraker, R Peach, P S Linsley, L A Turka, W W Hancock, M H Sayegh
Journal: The Journal of Immunology
J Immunol (1996) 157 (8): 3700–3705.
DOI: https://doi.org/10.4049/jimmunol.157.8.3700
Published: 15 October 1996
View article titled, Ex vivo treatment of antigen-presenting cells with CTLA4Ig and encephalitogenic peptide prevents experimental autoimmune encephalomyelitis in the Lewis rat.
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Journal Articles

Costimulatory effects of T cell proliferation during infection with human T lymphotropic virus types I and II are mediated through CD80 and CD86 ligands.

R B Lal, D L Rudolph, C S Dezzutti, P S Linsley, H E Prince
Journal: The Journal of Immunology
J Immunol (1996) 157 (3): 1288–1296.
DOI: https://doi.org/10.4049/jimmunol.157.3.1288
Published: 01 August 1996
View article titled, Costimulatory effects of T cell proliferation during infection with human T lymphotropic virus types I and II are mediated through CD80 and CD86 ligands.
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Journal Articles

The role of the B7-1a molecule, an alternatively spliced form of murine B7-1 (CD80), on T cell activation.

M Inobe, N Aoki, P S Linsley, J A Ledbetter, R Abe, M Murakami, T Uede
Journal: The Journal of Immunology
J Immunol (1996) 157 (2): 582–588.
DOI: https://doi.org/10.4049/jimmunol.157.2.582
Published: 15 July 1996
View article titled, The role of the B7-1a molecule, an alternatively spliced form of murine B7-1 (CD80), on T cell activation.
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Journal Articles

Intervention of CD4+ cell subset shifts and autoimmunity in the BXSB mouse by murine CTLA4Ig.

E B Chu, M V Hobbs, C B Wilson, C G Romball, P S Linsley, W O Weigle
Journal: The Journal of Immunology
J Immunol (1996) 156 (3): 1262–1268.
DOI: https://doi.org/10.4049/jimmunol.156.3.1262
Published: 01 February 1996
View article titled, Intervention of CD4+ cell subset shifts and autoimmunity in the BXSB mouse by murine CTLA4Ig.
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Journal Articles

CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system.

S J Khoury, E Akalin, A Chandraker, L A Turka, P S Linsley, M H Sayegh, W W Hancock
Journal: The Journal of Immunology
J Immunol (1995) 155 (10): 4521–4524.
DOI: https://doi.org/10.4049/jimmunol.155.10.4521
Published: 15 November 1995
View article titled, CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system.
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Journal Articles

Activated T cells can induce high levels of CTLA-4 expression on B cells.

H M Kuiper, M Brouwer, P S Linsley, R A van Lier
Journal: The Journal of Immunology
J Immunol (1995) 155 (4): 1776–1783.
DOI: https://doi.org/10.4049/jimmunol.155.4.1776
Published: 15 August 1995
View article titled, Activated T cells can induce high levels of CTLA-4 expression on B cells.
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Journal Articles

Induction and reversal of long-lived specific unresponsiveness to a T-dependent antigen following CTLA4Ig treatment.

P M Wallace, J N Rodgers, G M Leytze, J S Johnson, P S Linsley
Journal: The Journal of Immunology
J Immunol (1995) 154 (11): 5885–5895.
DOI: https://doi.org/10.4049/jimmunol.154.11.5885
Published: 01 June 1995
View article titled, Induction and reversal of long-lived specific unresponsiveness to a T-dependent antigen following CTLA4Ig treatment.
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Journal Articles

CD28 cross-linking augments TCR-mediated signals and costimulates superantigen responses.

H Ohnishi, J A Ledbetter, S B Kanner, P S Linsley, T Tanaka, A M Geller, M Kotb
Journal: The Journal of Immunology
J Immunol (1995) 154 (7): 3180–3193.
DOI: https://doi.org/10.4049/jimmunol.154.7.3180
Published: 01 April 1995
View article titled, CD28 cross-linking augments TCR-mediated signals and costimulates superantigen responses.
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Journal Articles

CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.

L L Lanier, S O'Fallon, C Somoza, J H Phillips, P S Linsley, K Okumura, D Ito, M Azuma
Journal: The Journal of Immunology
J Immunol (1995) 154 (1): 97–105.
DOI: https://doi.org/10.4049/jimmunol.154.1.97
Published: 01 January 1995
View article titled, CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.
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