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Paul V. Beum
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Journal Articles

Exhaustion of Cytotoxic Effector Systems May Limit Monoclonal Antibody-Based Immunotherapy in Cancer Patients

Frank J. Beurskens, Margaret A. Lindorfer, Mohammed Farooqui, Paul V. Beum, Patrick Engelberts, Wendy J. M. Mackus, Paul W. H. I. Parren, Adrian Wiestner, Ronald P. Taylor
Journal: The Journal of Immunology
J Immunol (2012) 188 (7): 3532–3541.
https://doi.org/10.4049/jimmunol.1103693
Published: 01 April 2012
View article titled, Exhaustion of Cytotoxic Effector Systems May Limit Monoclonal Antibody-Based Immunotherapy in Cancer Patients
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Includes: Supplementary data
Journal Articles

Loss of CD20 and Bound CD20 Antibody from Opsonized B Cells Occurs More Rapidly Because of Trogocytosis Mediated by Fc Receptor-Expressing Effector Cells Than Direct Internalization by the B Cells

Paul V. Beum, Elizabeth M. Peek, Margaret A. Lindorfer, Frank J. Beurskens, Patrick J. Engelberts, Paul W. H. I. Parren, Jan G. J. van de Winkel, Ronald P. Taylor
Journal: The Journal of Immunology
J Immunol (2011) 187 (6): 3438–3447.
https://doi.org/10.4049/jimmunol.1101189
Published: 15 September 2011
View article titled, Loss of CD20 and Bound CD20 Antibody from Opsonized B Cells Occurs More Rapidly Because of Trogocytosis Mediated by Fc Receptor-Expressing Effector Cells Than Direct Internalization by the B Cells
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Includes: Supplementary data
Journal Articles

Binding of Submaximal C1q Promotes Complement-Dependent Cytotoxicity (CDC) of B Cells Opsonized with Anti-CD20 mAbs Ofatumumab (OFA) or Rituximab (RTX): Considerably Higher Levels of CDC Are Induced by OFA than by RTX

Andrew W. Pawluczkowycz, Frank J. Beurskens, Paul V. Beum, Margaret A. Lindorfer, Jan G. J. van de Winkel, Paul W. H. I. Parren, Ronald P. Taylor
Journal: The Journal of Immunology
J Immunol (2009) 183 (1): 749–758.
https://doi.org/10.4049/jimmunol.0900632
Published: 01 July 2009
View article titled, Binding of Submaximal C1q Promotes Complement-Dependent Cytotoxicity (CDC) of B Cells Opsonized with Anti-CD20 mAbs Ofatumumab (OFA) or Rituximab (RTX): Considerably Higher Levels of CDC Are Induced by OFA than by RTX
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Journal Articles

Binding of Rituximab, Trastuzumab, Cetuximab, or mAb T101 to Cancer Cells Promotes Trogocytosis Mediated by THP-1 Cells and Monocytes

Paul V. Beum, David A. Mack, Andrew W. Pawluczkowycz, Margaret A. Lindorfer, Ronald P. Taylor
Journal: The Journal of Immunology
J Immunol (2008) 181 (11): 8120–8132.
https://doi.org/10.4049/jimmunol.181.11.8120
Published: 01 December 2008
View article titled, Binding of Rituximab, Trastuzumab, Cetuximab, or mAb T101 to Cancer Cells Promotes Trogocytosis Mediated by THP-1 Cells and Monocytes
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Journal Articles

Within Peripheral Blood Mononuclear Cells, Antibody-Dependent Cellular Cytotoxicity of Rituximab-Opsonized Daudi cells Is Promoted by NK Cells and Inhibited by Monocytes due to Shaving

Paul V. Beum, Margaret A. Lindorfer, Ronald P. Taylor
Journal: The Journal of Immunology
J Immunol (2008) 181 (4): 2916–2924.
https://doi.org/10.4049/jimmunol.181.4.2916
Published: 15 August 2008
View article titled, Within Peripheral Blood Mononuclear Cells, Antibody-Dependent Cellular Cytotoxicity of Rituximab-Opsonized Daudi cells Is Promoted by NK Cells and Inhibited by Monocytes due to Shaving
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Journal Articles

Complement Activation on B Lymphocytes Opsonized with Rituximab or Ofatumumab Produces Substantial Changes in Membrane Structure Preceding Cell Lysis

Paul V. Beum, Margaret A. Lindorfer, Frank Beurskens, P. Todd Stukenberg, Henk M. Lokhorst, Andrew W. Pawluczkowycz, Paul W. H. I. Parren, Jan G. J. van de Winkel, Ronald P. Taylor
Journal: The Journal of Immunology
J Immunol (2008) 181 (1): 822–832.
https://doi.org/10.4049/jimmunol.181.1.822
Published: 01 July 2008
View article titled, Complement Activation on B Lymphocytes Opsonized with Rituximab or Ofatumumab Produces Substantial Changes in Membrane Structure Preceding Cell Lysis
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Includes: Multimedia, Supplementary data
Journal Articles

Thrice-Weekly Low-Dose Rituximab Decreases CD20 Loss via Shaving and Promotes Enhanced Targeting in Chronic Lymphocytic Leukemia

Michael E. Williams, John J. Densmore, Andrew W. Pawluczkowycz, Paul V. Beum, Adam D. Kennedy, Margaret A. Lindorfer, Susan H. Hamil, Jane C. Eggleton, Ronald P. Taylor
Journal: The Journal of Immunology
J Immunol (2006) 177 (10): 7435–7443.
https://doi.org/10.4049/jimmunol.177.10.7435
Published: 15 November 2006
View article titled, Thrice-Weekly Low-Dose Rituximab Decreases CD20 Loss via Shaving and Promotes Enhanced Targeting in Chronic Lymphocytic Leukemia
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Journal Articles

The Shaving Reaction: Rituximab/CD20 Complexes Are Removed from Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia Cells by THP-1 Monocytes

Paul V. Beum, Adam D. Kennedy, Michael E. Williams, Margaret A. Lindorfer, Ronald P. Taylor
Journal: The Journal of Immunology
J Immunol (2006) 176 (4): 2600–2609.
https://doi.org/10.4049/jimmunol.176.4.2600
Published: 15 February 2006
View article titled, The Shaving Reaction: Rituximab/CD20 Complexes Are Removed from Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia Cells by THP-1 Monocytes
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Journal Articles

Rituximab Infusion Promotes Rapid Complement Depletion and Acute CD20 Loss in Chronic Lymphocytic Leukemia

Adam D. Kennedy, Paul V. Beum, Michael D. Solga, David J. DiLillo, Margaret A. Lindorfer, Charles E. Hess, John J. Densmore, Michael E. Williams, Ronald P. Taylor
Journal: The Journal of Immunology
J Immunol (2004) 172 (5): 3280–3288.
https://doi.org/10.4049/jimmunol.172.5.3280
Published: 01 March 2004
View article titled, Rituximab Infusion Promotes Rapid Complement Depletion and Acute CD20 Loss in Chronic Lymphocytic Leukemia
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