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Robert A. Kastelein
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Journal Articles

IL-27 Blocks RORc Expression to Inhibit Lineage Commitment of Th17 Cells

Caroline Diveu, Mandy J. McGeachy, Katia Boniface, Jason S. Stumhofer, Manjiri Sathe, Barbara Joyce-Shaikh, Yi Chen, Cristina M. Tato, Terrill K. McClanahan, René de Waal Malefyt, Christopher A. Hunter, Daniel J. Cua, Robert A. Kastelein
Journal: The Journal of Immunology
J Immunol (2009) 182 (9): 5748–5756.
https://doi.org/10.4049/jimmunol.0801162
Published: 01 May 2009
View article titled, IL-27 Blocks RORc Expression to Inhibit Lineage Commitment of Th17 Cells
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The Essential Role of Single Ig IL-1 Receptor-Related Molecule/Toll IL-1R8 in Regulation of Th2 Immune Response

Katarzyna Bulek, Shadi Swaidani, Jinzhong Qin, Yi Lu, Muhammet F. Gulen, Tomasz Herjan, Booki Min, Robert A. Kastelein, Mark Aronica, Magdalena Kosz-Vnenchak, Xiaoxia Li
Journal: The Journal of Immunology
J Immunol (2009) 182 (5): 2601–2609.
https://doi.org/10.4049/jimmunol.0802729
Published: 01 March 2009
View article titled, The Essential Role of Single Ig IL-1 Receptor-Related Molecule/Toll IL-1R8 in Regulation of Th2 Immune Response
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Journal Articles

Protective Immunity to Systemic Infection with Attenuated Salmonella enterica serovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-17

Silke M. Schulz, Gabriele Köhler, Nicole Schütze, Jens Knauer, Reinhard K. Straubinger, Alissa A. Chackerian, Ellen Witte, Kerstin Wolk, Robert Sabat, Yoichiro Iwakura, Christoph Holscher, Uwe Müller, Robert A. Kastelein, Gottfried Alber
Journal: The Journal of Immunology
J Immunol (2008) 181 (11): 7891–7901.
https://doi.org/10.4049/jimmunol.181.11.7891
Published: 01 December 2008
View article titled, Protective Immunity to Systemic Infection with Attenuated <em>Salmonella enterica</em> serovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-17
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Journal Articles

IL-1 Receptor Accessory Protein and ST2 Comprise the IL-33 Receptor Complex

Alissa A. Chackerian, Elizabeth R. Oldham, Erin E. Murphy, Jochen Schmitz, Stefan Pflanz, Robert A. Kastelein
Journal: The Journal of Immunology
J Immunol (2007) 179 (4): 2551–2555.
https://doi.org/10.4049/jimmunol.179.4.2551
Published: 15 August 2007
View article titled, IL-1 Receptor Accessory Protein and ST2 Comprise the IL-33 Receptor Complex
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Journal Articles

Differential Effects of IL-27 on Human B Cell Subsets

Frédérique Larousserie, Pascaline Charlot, Emilie Bardel, Josy Froger, Robert A. Kastelein, Odile Devergne
Journal: The Journal of Immunology
J Immunol (2006) 176 (10): 5890–5897.
https://doi.org/10.4049/jimmunol.176.10.5890
Published: 15 May 2006
View article titled, Differential Effects of IL-27 on Human B Cell Subsets
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Immunological and Antitumor Effects of IL-23 as a Cancer Vaccine Adjuvant

Willem W. Overwijk, Karin E. de Visser, Felicia H. Tirion, Laurina A. de Jong, Thijs W. H. Pols, Yme U. van der Velden, Jasper G. van den Boorn, Anna M. Keller, Wim A. Buurman, Marc R. Theoret, Bianca Blom, Nicholas P. Restifo, Ada M. Kruisbeek, Robert A. Kastelein, John B. A. G. Haanen
Journal: The Journal of Immunology
J Immunol (2006) 176 (9): 5213–5222.
https://doi.org/10.4049/jimmunol.176.9.5213
Published: 01 May 2006
View article titled, Immunological and Antitumor Effects of IL-23 as a Cancer Vaccine Adjuvant
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Journal Articles

IL-23 Enhances the Inflammatory Cell Response in Cryptococcus neoformans Infection and Induces a Cytokine Pattern Distinct from IL-12

Melanie A. Kleinschek, Uwe Muller, Scott J. Brodie, Werner Stenzel, Gabriele Kohler, Wendy M. Blumenschein, Reinhard K. Straubinger, Terrill McClanahan, Robert A. Kastelein, Gottfried Alber
Journal: The Journal of Immunology
J Immunol (2006) 176 (2): 1098–1106.
https://doi.org/10.4049/jimmunol.176.2.1098
Published: 15 January 2006
View article titled, IL-23 Enhances the Inflammatory Cell Response in <em>Cryptococcus neoformans</em> Infection and Induces a Cytokine Pattern Distinct from IL-12
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Journal Articles

IL-27 Limits IL-2 Production during Th1 Differentiation

Alejandro V. Villarino, Jason S. Stumhofer, Christiaan J. M. Saris, Robert A. Kastelein, Frederic J. de Sauvage, Christopher A. Hunter
Journal: The Journal of Immunology
J Immunol (2006) 176 (1): 237–247.
https://doi.org/10.4049/jimmunol.176.1.237
Published: 01 January 2006
View article titled, IL-27 Limits IL-2 Production during Th1 Differentiation
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Journal Articles

IL-23 Provides a Limited Mechanism of Resistance to Acute Toxoplasmosis in the Absence of IL-12

Linda A. Lieberman, Fabiola Cardillo, Alexander M. Owyang, Donna M. Rennick, Daniel J. Cua, Robert A. Kastelein, Christopher A. Hunter
Journal: The Journal of Immunology
J Immunol (2004) 173 (3): 1887–1893.
https://doi.org/10.4049/jimmunol.173.3.1887
Published: 01 August 2004
View article titled, IL-23 Provides a Limited Mechanism of Resistance to Acute Toxoplasmosis in the Absence of IL-12
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Journal Articles

WSX-1 and Glycoprotein 130 Constitute a Signal-Transducing Receptor for IL-27

Stefan Pflanz, Linda Hibbert, Jeanine Mattson, Rency Rosales, Elena Vaisberg, J. Fernando Bazan, Joseph H. Phillips, Terrill K. McClanahan, Rene de Waal Malefyt, Robert A. Kastelein
Journal: The Journal of Immunology
J Immunol (2004) 172 (4): 2225–2231.
https://doi.org/10.4049/jimmunol.172.4.2225
Published: 15 February 2004
View article titled, WSX-1 and Glycoprotein 130 Constitute a Signal-Transducing Receptor for IL-27
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Journal Articles

IL-23 Production by Cosecretion of Endogenous p19 and Transgenic p40 in Keratin 14/p40 Transgenic Mice: Evidence for Enhanced Cutaneous Immunity

Tamara Kopp, Petra Lenz, Concha Bello-Fernandez, Robert A. Kastelein, Thomas S. Kupper, Georg Stingl
Journal: The Journal of Immunology
J Immunol (2003) 170 (11): 5438–5444.
https://doi.org/10.4049/jimmunol.170.11.5438
Published: 01 June 2003
View article titled, IL-23 Production by Cosecretion of Endogenous p19 and Transgenic p40 in Keratin 14/p40 Transgenic Mice: Evidence for Enhanced Cutaneous Immunity
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Journal Articles

A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R

Christi Parham, Madaline Chirica, Jacqueline Timans, Elena Vaisberg, Marilyn Travis, Jeanne Cheung, Stefan Pflanz, Rebecca Zhang, Komal P. Singh, Felix Vega, Wayne To, Janet Wagner, Anne-Marie O’Farrell, Terrill McClanahan, Sandra Zurawski, Charles Hannum, Daniel Gorman, Donna M. Rennick, Robert A. Kastelein, Rene de Waal Malefyt, Kevin W. Moore
Journal: The Journal of Immunology
J Immunol (2002) 168 (11): 5699–5708.
https://doi.org/10.4049/jimmunol.168.11.5699
Published: 01 June 2002
View article titled, A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R
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Journal Articles

Two Novel IL-1 Family Members, IL-1δ and IL-1ε, Function as an Antagonist and Agonist of NF-κB Activation Through the Orphan IL-1 Receptor-Related Protein 2

Reno Debets, Jackie C. Timans, Bernhard Homey, Sandra Zurawski, Theodore R. Sana, Sylvia Lo, Janet Wagner, Gina Edwards, Teresa Clifford, Satish Menon, J. Fernando Bazan, Robert A. Kastelein
Journal: The Journal of Immunology
J Immunol (2001) 167 (3): 1440–1446.
https://doi.org/10.4049/jimmunol.167.3.1440
Published: 01 August 2001
View article titled, Two Novel IL-1 Family Members, IL-1δ and IL-1ε, Function as an Antagonist and Agonist of NF-κB Activation Through the Orphan IL-1 Receptor-Related Protein 2
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Journal Articles

Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells

Pedro A. Reche, Vassili Soumelis, Daniel M. Gorman, Teresa Clifford, Man-ru Liu, Marilyn Travis, Sandra M. Zurawski, Jim Johnston, Yong-Jun Liu, Hergen Spits, Rene de Waal Malefyt, Robert A. Kastelein, J. Fernando Bazan
Journal: The Journal of Immunology
J Immunol (2001) 167 (1): 336–343.
https://doi.org/10.4049/jimmunol.167.1.336
Published: 01 July 2001
View article titled, Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells
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Journal Articles

Ubiquitous Transgenic Expression of the IL-23 Subunit p19 Induces Multiorgan Inflammation, Runting, Infertility, and Premature Death

Maria T. Wiekowski, Michael W. Leach, Ellen W. Evans, Lee Sullivan, Shu-Cheng Chen, Galya Vassileva, J. Fernando Bazan, Daniel M. Gorman, Robert A. Kastelein, Satwant Narula, Sergio A. Lira
Journal: The Journal of Immunology
J Immunol (2001) 166 (12): 7563–7570.
https://doi.org/10.4049/jimmunol.166.12.7563
Published: 15 June 2001
View article titled, Ubiquitous Transgenic Expression of the IL-23 Subunit p19 Induces Multiorgan Inflammation, Runting, Infertility, and Premature Death
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Journal Articles

IL-18 Receptors, Their Role in Ligand Binding and Function: Anti-IL-1RAcPL Antibody, a Potent Antagonist of IL-18

Reno Debets, Jackie C. Timans, Tatyana Churakowa, Sandra Zurawski, Rene de Waal Malefyt, Kevin W. Moore, John S. Abrams, Anne O’Garra, J. Fernando Bazan, Robert A. Kastelein
Journal: The Journal of Immunology
J Immunol (2000) 165 (9): 4950–4956.
https://doi.org/10.4049/jimmunol.165.9.4950
Published: 01 November 2000
View article titled, IL-18 Receptors, Their Role in Ligand Binding and Function: Anti-IL-1RAcPL Antibody, a Potent Antagonist of IL-18
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Journal Articles

IL-18 and CD28 Use Distinct Molecular Mechanisms to Enhance NK Cell Production of IL-12-Induced IFN-γ

William Walker, Miguel Aste-Amezaga, Robert A. Kastelein, Giorgio Trinchieri, Christopher A. Hunter
Journal: The Journal of Immunology
J Immunol (1999) 162 (10): 5894–5901.
https://doi.org/10.4049/jimmunol.162.10.5894
Published: 15 May 1999
View article titled, IL-18 and CD28 Use Distinct Molecular Mechanisms to Enhance NK Cell Production of IL-12-Induced IFN-γ
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