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Robert B. Sim
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Journal Articles

Analogous Interactions in Initiating Complexes of the Classical and Lectin Pathways of Complement

Anna E. Phillips, Julia Toth, Alister W. Dodds, Umakhanth Venkatraman Girija, Christopher M. Furze, Eleni Pala, Robert B. Sim, Kenneth B. M. Reid, Wilhelm J. Schwaeble, Ralf Schmid, Anthony H. Keeble, Russell Wallis
Journal: The Journal of Immunology
J Immunol (2009) 182 (12): 7708–7717.
https://doi.org/10.4049/jimmunol.0900666
Published: 15 June 2009
View article titled, Analogous Interactions in Initiating Complexes of the Classical and Lectin Pathways of Complement
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Includes: Supplementary data
Journal Articles

Scrapie Pathogenesis: The Role of Complement C1q in Scrapie Agent Uptake by Conventional Dendritic Cells

Adriana Flores-Langarica, Yasmine Sebti, Daniel A. Mitchell, Robert B. Sim, Gordon G. MacPherson
Journal: The Journal of Immunology
J Immunol (2009) 182 (3): 1305–1313.
https://doi.org/10.4049/jimmunol.182.3.1305
Published: 01 February 2009
View article titled, Scrapie Pathogenesis: The Role of Complement C1q in Scrapie Agent Uptake by Conventional Dendritic Cells
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Journal Articles

Functional Significance of Factor H Binding to Neisseria meningitidis

Muriel C. Schneider, Rachel M. Exley, Hannah Chan, Ian Feavers, Yu-Hoi Kang, Robert B. Sim, Christoph M. Tang
Journal: The Journal of Immunology
J Immunol (2006) 176 (12): 7566–7575.
https://doi.org/10.4049/jimmunol.176.12.7566
Published: 15 June 2006
View article titled, Functional Significance of Factor H Binding to <em>Neisseria meningitidis</em>
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Journal Articles

The Glycosylation of Human Serum IgD and IgE and the Accessibility of Identified Oligomannose Structures for Interaction with Mannan-Binding Lectin

James N. Arnold, Catherine M. Radcliffe, Mark R. Wormald, Louise Royle, David J. Harvey, Max Crispin, Raymond A. Dwek, Robert B. Sim, Pauline M. Rudd
Journal: The Journal of Immunology
J Immunol (2004) 173 (11): 6831–6840.
https://doi.org/10.4049/jimmunol.173.11.6831
Published: 01 December 2004
View article titled, The Glycosylation of Human Serum IgD and IgE and the Accessibility of Identified Oligomannose Structures for Interaction with Mannan-Binding Lectin
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Journal Articles

Human Complement Factor I Does Not Require Cofactors for Cleavage of Synthetic Substrates

Stefanos A. Tsiftsoglou, Robert B. Sim
Journal: The Journal of Immunology
J Immunol (2004) 173 (1): 367–375.
https://doi.org/10.4049/jimmunol.173.1.367
Published: 01 July 2004
View article titled, Human Complement Factor I Does Not Require Cofactors for Cleavage of Synthetic Substrates
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Journal Articles

Mutational Analyses of the Recombinant Globular Regions of Human C1q A, B, and C Chains Suggest an Essential Role for Arginine and Histidine Residues in the C1q-IgG Interaction

Mihaela S. Kojouharova, Mihaela G. Gadjeva, Ivanka G. Tsacheva, Aleksandra Zlatarova, Liubka T. Roumenina, Magdalena I. Tchorbadjieva, Boris P. Atanasov, Patrick Waters, Britta C. Urban, Robert B. Sim, Kenneth B. M. Reid, Uday Kishore
Journal: The Journal of Immunology
J Immunol (2004) 172 (7): 4351–4358.
https://doi.org/10.4049/jimmunol.172.7.4351
Published: 01 April 2004
View article titled, Mutational Analyses of the Recombinant Globular Regions of Human C1q A, B, and C Chains Suggest an Essential Role for Arginine and Histidine Residues in the C1q-IgG Interaction
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Journal Articles

Natural Substrates and Inhibitors of Mannan-Binding Lectin-Associated Serine Protease-1 and -2: A Study on Recombinant Catalytic Fragments

Géza Ambrus, Péter Gál, Mayumi Kojima, Katalin Szilágyi, Júlia Balczer, József Antal, László Gráf, Andreas Laich, Beryl E. Moffatt, Wilhelm Schwaeble, Robert B. Sim, Péter Závodszky
Journal: The Journal of Immunology
J Immunol (2003) 170 (3): 1374–1382.
https://doi.org/10.4049/jimmunol.170.3.1374
Published: 01 February 2003
View article titled, Natural Substrates and Inhibitors of Mannan-Binding Lectin-Associated Serine Protease-1 and -2: A Study on Recombinant Catalytic Fragments
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Journal Articles

Distinct Pathways of Mannan-Binding Lectin (MBL)- and C1-Complex Autoactivation Revealed by Reconstitution of MBL with Recombinant MBL-Associated Serine Protease-2

Thomas Vorup-Jensen, Steen V. Petersen, Annette G. Hansen, Knud Poulsen, Wilhelm Schwaeble, Robert B. Sim, Kenneth B. M. Reid, Simon J. Davis, Steffen Thiel, Jens C. Jensenius
Journal: The Journal of Immunology
J Immunol (2000) 165 (4): 2093–2100.
https://doi.org/10.4049/jimmunol.165.4.2093
Published: 15 August 2000
View article titled, Distinct Pathways of Mannan-Binding Lectin (MBL)- and C1-Complex Autoactivation Revealed by Reconstitution of MBL with Recombinant MBL-Associated Serine Protease-2
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Journal Articles

Complement C1q Is Dramatically Up-Regulated in Brain Microglia in Response to Transient Global Cerebral Ischemia

Martin K.-H. Schäfer, Wilhelm J. Schwaeble, Claes Post, Patricia Salvati, Marcello Calabresi, Robert B. Sim, Franz Petry, Michael Loos, Eberhard Weihe
Journal: The Journal of Immunology
J Immunol (2000) 164 (10): 5446–5452.
https://doi.org/10.4049/jimmunol.164.10.5446
Published: 15 May 2000
View article titled, Complement C1q Is Dramatically Up-Regulated in Brain Microglia in Response to Transient Global Cerebral Ischemia
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Journal Articles

In Vitro Analysis of Complement-Dependent HIV-1 Cell Infection Using a Model System

Pascale Tacnet-Delorme, Véronique Boyer, Nicole M. Thielens, Jean-François Hernandez, Isabelle Bally, Robert B. Sim, Claude Desgranges, Gérard J. Arlaud
Journal: The Journal of Immunology
J Immunol (1999) 162 (7): 4088–4093.
https://doi.org/10.4049/jimmunol.162.7.4088
Published: 01 April 1999
View article titled, In Vitro Analysis of Complement-Dependent HIV-1 Cell Infection Using a Model System
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Journal Articles

The First Subcomponent of Complement, C1q, Triggers the Production of IL-8, IL-6, and Monocyte Chemoattractant Peptide-1 by Human Umbilical Vein Endothelial Cells

Rocco H. van den Berg, Maria C. Faber-Krol, Robert B. Sim, Mohamed R. Daha
Journal: The Journal of Immunology
J Immunol (1998) 161 (12): 6924–6930.
https://doi.org/10.4049/jimmunol.161.12.6924
Published: 15 December 1998
View article titled, The First Subcomponent of Complement, C1q, Triggers the Production of IL-8, IL-6, and Monocyte Chemoattractant Peptide-1 by Human Umbilical Vein Endothelial Cells
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