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Robert H. Wiltrout
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Journal Articles

Regulatory T Cells and Myeloid-Derived Suppressor Cells in the Tumor Microenvironment Undergo Fas-Dependent Cell Death during IL-2/αCD40 Therapy

Jonathan M. Weiss, Jeff J. Subleski, Tim Back, Xin Chen, Stephanie K. Watkins, Hideo Yagita, Thomas J. Sayers, William J. Murphy, Robert H. Wiltrout
Journal: The Journal of Immunology
J Immunol (2014) 192 (12): 5821–5829.
https://doi.org/10.4049/jimmunol.1400404
Published: 15 June 2014
View article titled, Regulatory T Cells and Myeloid-Derived Suppressor Cells in the Tumor Microenvironment Undergo Fas-Dependent Cell Death during IL-2/αCD40 Therapy
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Includes: Supplementary data
Journal Articles

TCR-Dependent and -Independent Activation Underlie Liver-Specific Regulation of NKT Cells

Jeff J. Subleski, Veronica L. Hall, Thomas B. Wolfe, Anthony J. Scarzello, Jonathan M. Weiss, Tim Chan, Deborah L. Hodge, Timothy C. Back, John R. Ortaldo, Robert H. Wiltrout
Journal: The Journal of Immunology
J Immunol (2011) 186 (2): 838–847.
https://doi.org/10.4049/jimmunol.1001735
Published: 15 January 2011
View article titled, TCR-Dependent and -Independent Activation Underlie Liver-Specific Regulation of NKT Cells
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Journal Articles

Acute inflammation with IL-18/IL-12 or α-GalCer treatment induces liver iNKT cell apoptosis and repopulation from peripheral tissues, whereas chronic inflammation ablates systemic iNKT cells with thymic-dependent repopulation (134.24)

Jeff J Subleski, Veronica L Hall, Anthony J Scarzello, Thomas B Wolfe, John R Ortaldo, Deborah L Hodge, Jon M Weiss, Tim Chan, Robert H Wiltrout
Journal: The Journal of Immunology
J Immunol (2009) 182 (1_Supplement): 134.24.
https://doi.org/10.4049/jimmunol.182.Supp.134.24
Published: 01 April 2009
View article titled, Acute inflammation with IL-18/IL-12 or α-GalCer treatment induces liver iNKT cell apoptosis and repopulation from peripheral tissues, whereas chronic inflammation ablates systemic iNKT cells with thymic-dependent repopulation (134.24)
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Journal Articles

Regulatory and Conventional CD4+ T Cells Show Differential Effects Correlating with PD-1 and B7-H1 Expression after Immunotherapy

Kory L. Alderson, Qing Zhou, Vanessa Berner, Danice E. C. Wilkins, Jonathan M. Weiss, Bruce R. Blazar, Lisbeth A. Welniak, Robert H. Wiltrout, Doug Redelman, William J. Murphy
Journal: The Journal of Immunology
J Immunol (2008) 180 (5): 2981–2988.
https://doi.org/10.4049/jimmunol.180.5.2981
Published: 01 March 2008
View article titled, Regulatory and Conventional CD4<sup>+</sup> T Cells Show Differential Effects Correlating with PD-1 and B7-H1 Expression after Immunotherapy
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Journal Articles

Friend or Foe? IFNγ Mediates Pro-Metastatic Gene Expression in the Tumor Microenvironment (48.34)

Veronica L Hall, Jeff Subleski, Tim C Back, M. Eilene Gruys, Lynnette Shorts-Cary, Jonathan M. Weiss, Robert H Wiltrout
Journal: The Journal of Immunology
J Immunol (2007) 178 (1_Supplement): S81.
https://doi.org/10.4049/jimmunol.178.Supp.48.34
Published: 01 April 2007
View article titled, Friend or Foe? IFNγ Mediates Pro-Metastatic Gene Expression in the Tumor Microenvironment (48.34)
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Journal Articles

Differential modulation of NK and NKT cells in the liver and spleen following IL-18 + IL-12 treatment of mice (98.9)

Jeff John Subleski, Veronica L Hall, Jonathan M Weiss, John R Ortaldo, Robert H Wiltrout
Journal: The Journal of Immunology
J Immunol (2007) 178 (1_Supplement): S193.
https://doi.org/10.4049/jimmunol.178.Supp.98.9
Published: 01 April 2007
View article titled, Differential modulation of NK and NKT cells in the liver and spleen following IL-18 + IL-12 treatment of mice (98.9)
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Journal Articles

Stimulation through CD40 on Mouse and Human Renal Cell Carcinomas Triggers Cytokine Production, Leukocyte Recruitment, and Antitumor Responses that Can Be Independent of Host CD40 Expression

Lynnette Shorts, Jonathan M. Weiss, Jong-Keuk Lee, Lisbeth A. Welniak, Jeffrey Subleski, Timothy Back, William J. Murphy, Robert H. Wiltrout
Journal: The Journal of Immunology
J Immunol (2006) 176 (11): 6543–6552.
https://doi.org/10.4049/jimmunol.176.11.6543
Published: 01 June 2006
View article titled, Stimulation through CD40 on Mouse and Human Renal Cell Carcinomas Triggers Cytokine Production, Leukocyte Recruitment, and Antitumor Responses that Can Be Independent of Host CD40 Expression
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Journal Articles

In Vivo Hydrodynamic Delivery of cDNA Encoding IL-2: Rapid, Sustained Redistribution, Activation of Mouse NK Cells, and Therapeutic Potential in the Absence of NKT Cells

John R. Ortaldo, Robin T. Winkler-Pickett, Earl W. Bere, Jr, Morihiro Watanabe, William J. Murphy, Robert H. Wiltrout
Journal: The Journal of Immunology
J Immunol (2005) 175 (2): 693–699.
https://doi.org/10.4049/jimmunol.175.2.693
Published: 15 July 2005
View article titled, In Vivo Hydrodynamic Delivery of cDNA Encoding IL-2: Rapid, Sustained Redistribution, Activation of Mouse NK Cells, and Therapeutic Potential in the Absence of NKT Cells
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Journal Articles

Dissociation of NKT Stimulation, Cytokine Induction, and NK Activation In Vivo by the Use of Distinct TCR-Binding Ceramides

John R. Ortaldo, Howard A. Young, Robin T. Winkler-Pickett, Earl W. Bere, Jr., William J. Murphy, Robert H. Wiltrout
Journal: The Journal of Immunology
J Immunol (2004) 172 (2): 943–953.
https://doi.org/10.4049/jimmunol.172.2.943
Published: 15 January 2004
View article titled, Dissociation of NKT Stimulation, Cytokine Induction, and NK Activation In Vivo by the Use of Distinct TCR-Binding Ceramides
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Journal Articles

Activation of Cutaneous Protein Kinase Cα Induces Keratinocyte Apoptosis and Intraepidermal Inflammation by Independent Signaling Pathways

Christophe Cataisson, Elizabeth Joseloff, Rodolfo Murillas, Alice Wang, Coralyn Atwell, Sara Torgerson, Michael Gerdes, Jeffrey Subleski, Ji-Liang Gao, Philip M. Murphy, Robert H. Wiltrout, Charles Vinson, Stuart H. Yuspa
Journal: The Journal of Immunology
J Immunol (2003) 171 (5): 2703–2713.
https://doi.org/10.4049/jimmunol.171.5.2703
Published: 01 September 2003
View article titled, Activation of Cutaneous Protein Kinase Cα Induces Keratinocyte Apoptosis and Intraepidermal Inflammation by Independent Signaling Pathways
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Journal Articles

Synergistic Anti-Tumor Responses After Administration of Agonistic Antibodies to CD40 and IL-2: Coordination of Dendritic and CD8+ Cell Responses

William J. Murphy, Lisbeth Welniak, Timothy Back, Julie Hixon, Jeff Subleski, Naoko Seki, Jon M. Wigginton, Susan E. Wilson, Bruce R. Blazar, Anatoli M. Malyguine, Thomas J. Sayers, Robert H. Wiltrout
Journal: The Journal of Immunology
J Immunol (2003) 170 (5): 2727–2733.
https://doi.org/10.4049/jimmunol.170.5.2727
Published: 01 March 2003
View article titled, Synergistic Anti-Tumor Responses After Administration of Agonistic Antibodies to CD40 and IL-2: Coordination of Dendritic and CD8<sup>+</sup> Cell Responses
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Journal Articles

Synergistic Engagement of an Ineffective Endogenous Anti-Tumor Immune Response and Induction of IFN-γ and Fas-Ligand-Dependent Tumor Eradication by Combined Administration of IL-18 and IL-2

Jon M. Wigginton, Jong-Keuk Lee, Theresa A. Wiltrout, W. Gregory Alvord, Julie A. Hixon, Jeffrey Subleski, Timothy C. Back, Robert H. Wiltrout
Journal: The Journal of Immunology
J Immunol (2002) 169 (8): 4467–4474.
https://doi.org/10.4049/jimmunol.169.8.4467
Published: 15 October 2002
View article titled, Synergistic Engagement of an Ineffective Endogenous Anti-Tumor Immune Response and Induction of IFN-γ and Fas-Ligand-Dependent Tumor Eradication by Combined Administration of IL-18 and IL-2
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Journal Articles

Tumor-Specific CTL Kill Murine Renal Cancer Cells Using Both Perforin and Fas Ligand-Mediated Lysis In Vitro, But Cause Tumor Regression In Vivo in the Absence of Perforin

Naoko Seki, Alan D. Brooks, Clive R. D. Carter, Timothy C. Back, Erin M. Parsoneault, Mark J. Smyth, Robert H. Wiltrout, Thomas J. Sayers
Journal: The Journal of Immunology
J Immunol (2002) 168 (7): 3484–3492.
https://doi.org/10.4049/jimmunol.168.7.3484
Published: 01 April 2002
View article titled, Tumor-Specific CTL Kill Murine Renal Cancer Cells Using Both Perforin and Fas Ligand-Mediated Lysis In Vitro, But Cause Tumor Regression In Vivo in the Absence of Perforin
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Journal Articles

Primary Hepatocytes from Mice Treated with IL-2/IL-12 Produce T Cell Chemoattractant Activity that Is Dependent on Monokine Induced by IFN-γ (Mig) and Chemokine Responsive to γ-2 (Crg-2)

Jong-Wook Park, M. Eilene Gruys, Kathy McCormick, Jong-Keuk Lee, Jeffrey Subleski, Jon M. Wigginton, Robert G. Fenton, Ji-Ming Wang, Robert H. Wiltrout
Journal: The Journal of Immunology
J Immunol (2001) 166 (6): 3763–3770.
https://doi.org/10.4049/jimmunol.166.6.3763
Published: 15 March 2001
View article titled, Primary Hepatocytes from Mice Treated with IL-2/IL-12 Produce T Cell Chemoattractant Activity that Is Dependent on Monokine Induced by IFN-γ (Mig) and Chemokine Responsive to γ-2 (Crg-2)
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Journal Articles

Gastrointestinal Cells of IL-7 Receptor Null Mice Exhibit Increased Sensitivity to Irradiation

Lisbeth A. Welniak, Annette R. Khaled, Miriam R. Anver, Kristin L. Komschlies, Robert H. Wiltrout, Scott Durum, Francis R. Ruscetti, Bruce R. Blazar, William J. Murphy
Journal: The Journal of Immunology
J Immunol (2001) 166 (5): 2923–2928.
https://doi.org/10.4049/jimmunol.166.5.2923
Published: 01 March 2001
View article titled, Gastrointestinal Cells of IL-7 Receptor Null Mice Exhibit Increased Sensitivity to Irradiation
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Journal Articles

Complete Regression of Established Spontaneous Mammary Carcinoma and the Therapeutic Prevention of Genetically Programmed Neoplastic Transition by IL-12/Pulse IL-2: Induction of Local T Cell Infiltration, Fas/Fas Ligand Gene Expression, and Mammary Epithelial Apoptosis

Jon M. Wigginton, Jong-Wook Park, M. Eilene Gruys, Howard A. Young, Cheryl L. Jorcyk, Timothy C. Back, Michael J. Brunda, Robert M. Strieter, Jerrold Ward, Jeffrey E. Green, Robert H. Wiltrout
Journal: The Journal of Immunology
J Immunol (2001) 166 (2): 1156–1168.
https://doi.org/10.4049/jimmunol.166.2.1156
Published: 15 January 2001
View article titled, Complete Regression of Established Spontaneous Mammary Carcinoma and the Therapeutic Prevention of Genetically Programmed Neoplastic Transition by IL-12/Pulse IL-2: Induction of Local T Cell Infiltration, Fas/Fas Ligand Gene Expression, and Mammary Epithelial Apoptosis
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Journal Articles

IFN-γ-Dependent Delay of In Vivo Tumor Progression by Fas Overexpression on Murine Renal Cancer Cells

Jong-Keuk Lee, Thomas J. Sayers, Alan D. Brooks, Timothy C. Back, Howard A. Young, Kristin L. Komschlies, Jon M. Wigginton, Robert H. Wiltrout
Journal: The Journal of Immunology
J Immunol (2000) 164 (1): 231–239.
https://doi.org/10.4049/jimmunol.164.1.231
Published: 01 January 2000
View article titled, IFN-γ-Dependent Delay of In Vivo Tumor Progression by Fas Overexpression on Murine Renal Cancer Cells
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Journal Articles

Mice with a Targeted Mutation in Lymphotoxin-α Exhibit Enhanced Tumor Growth and Metastasis: Impaired NK Cell Development and Recruitment

Daisuke Ito, Timothy C. Back, Alexander N. Shakhov, Robert H. Wiltrout, Sergei A. Nedospasov
Journal: The Journal of Immunology
J Immunol (1999) 163 (5): 2809–2815.
https://doi.org/10.4049/jimmunol.163.5.2809
Published: 01 September 1999
View article titled, Mice with a Targeted Mutation in Lymphotoxin-α Exhibit Enhanced Tumor Growth and Metastasis: Impaired NK Cell Development and Recruitment
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Journal Articles

Intradermal Delivery of IL-12 Naked DNA Induces Systemic NK Cell Activation and Th1 Response In Vivo That Is Independent of Endogenous IL-12 Production

Morihiro Watanabe, Robert G. Fenton, Jon M. Wigginton, Kathryn L. McCormick, Kirk M. Volker, William E. Fogler, Philip G. Roessler, Robert H. Wiltrout
Journal: The Journal of Immunology
J Immunol (1999) 163 (4): 1943–1950.
https://doi.org/10.4049/jimmunol.163.4.1943
Published: 15 August 1999
View article titled, Intradermal Delivery of IL-12 Naked DNA Induces Systemic NK Cell Activation and Th1 Response In Vivo That Is Independent of Endogenous IL-12 Production
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Journal Articles

IL-18 Is a Potent Coinducer of IL-13 in NK and T Cells: A New Potential Role for IL-18 in Modulating the Immune Response

Tomoaki Hoshino, Robert H. Wiltrout, Howard A. Young
Journal: The Journal of Immunology
J Immunol (1999) 162 (9): 5070–5077.
https://doi.org/10.4049/jimmunol.162.9.5070
Published: 01 May 1999
View article titled, IL-18 Is a Potent Coinducer of IL-13 in NK and T Cells: A New Potential Role for IL-18 in Modulating the Immune Response
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