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Journal Articles

Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo.

T A Wynn, R Morawetz, T Scharton-Kersten, S Hieny, H C Morse, 3rd, R Kühn, W Müller, A W Cheever, A Sher
Journal: The Journal of Immunology
J Immunol (1997) 159 (10): 5014–5023.
DOI: https://doi.org/10.4049/jimmunol.159.10.5014
Published: 15 November 1997
View article titled, Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo.
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In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.

T M Scharton-Kersten, T A Wynn, E Y Denkers, S Bala, E Grunvald, S Hieny, R T Gazzinelli, A Sher
Journal: The Journal of Immunology
J Immunol (1996) 157 (9): 4045–4054.
DOI: https://doi.org/10.4049/jimmunol.157.9.4045
Published: 01 November 1996
View article titled, In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.
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Journal Articles

IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite.

T A Wynn, A Reynolds, S James, A W Cheever, P Caspar, S Hieny, D Jankovic, M Strand, A Sher
Journal: The Journal of Immunology
J Immunol (1996) 157 (9): 4068–4078.
DOI: https://doi.org/10.4049/jimmunol.157.9.4068
Published: 01 November 1996
View article titled, IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite.
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Journal Articles

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

R T Gazzinelli, M Wysocka, S Hieny, T Scharton-Kersten, A Cheever, R Kühn, W Müller, G Trinchieri, A Sher
Journal: The Journal of Immunology
J Immunol (1996) 157 (2): 798–805.
DOI: https://doi.org/10.4049/jimmunol.157.2.798
Published: 15 July 1996
View article titled, In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.
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Journal Articles

Toxoplasma gondii infection induces specific nonresponsiveness in lymphocytes bearing the V beta 5 chain of the mouse T cell receptor.

E Y Denkers, P Caspar, S Hieny, A Sher
Journal: The Journal of Immunology
J Immunol (1996) 156 (3): 1089–1094.
DOI: https://doi.org/10.4049/jimmunol.156.3.1089
Published: 01 February 1996
View article titled, Toxoplasma gondii infection induces specific nonresponsiveness in lymphocytes bearing the V beta 5 chain of the mouse T cell receptor.
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Journal Articles

IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia.

T A Wynn, D Jankovic, S Hieny, A W Cheever, A Sher
Journal: The Journal of Immunology
J Immunol (1995) 154 (9): 4701–4709.
DOI: https://doi.org/10.4049/jimmunol.154.9.4701
Published: 01 May 1995
View article titled, IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia.
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Journal Articles

IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-gamma.

T A Wynn, D Jankovic, S Hieny, K Zioncheck, P Jardieu, A W Cheever, A Sher
Journal: The Journal of Immunology
J Immunol (1995) 154 (8): 3999–4009.
DOI: https://doi.org/10.4049/jimmunol.154.8.3999
Published: 15 April 1995
View article titled, IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-gamma.
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Journal Articles

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

R T Gazzinelli, M Wysocka, S Hayashi, E Y Denkers, S Hieny, P Caspar, G Trinchieri, A Sher
Journal: The Journal of Immunology
J Immunol (1994) 153 (6): 2533–2543.
DOI: https://doi.org/10.4049/jimmunol.153.6.2533
Published: 15 September 1994
View article titled, Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.
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Journal Articles

Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis.

A W Cheever, M E Williams, T A Wynn, F D Finkelman, R A Seder, T M Cox, S Hieny, P Caspar, A Sher
Journal: The Journal of Immunology
J Immunol (1994) 153 (2): 753–759.
DOI: https://doi.org/10.4049/jimmunol.153.2.753
Published: 15 July 1994
View article titled, Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis.
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Journal Articles

Toxoplasma gondii induces a T-independent IFN-gamma response in natural killer cells that requires both adherent accessory cells and tumor necrosis factor-alpha.

A Sher, I P Oswald, S Hieny, R T Gazzinelli
Journal: The Journal of Immunology
J Immunol (1993) 150 (9): 3982–3989.
DOI: https://doi.org/10.4049/jimmunol.150.9.3982
Published: 01 May 1993
View article titled, Toxoplasma gondii induces a T-independent IFN-gamma response in natural killer cells that requires both adherent accessory cells and tumor necrosis factor-alpha.
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Journal Articles

Bone marrow macrophages process exogenous Toxoplasma gondii polypeptides for recognition by parasite-specific cytolytic T lymphocytes.

E Y Denkers, R T Gazzinelli, S Hieny, P Caspar, A Sher
Journal: The Journal of Immunology
J Immunol (1993) 150 (2): 517–526.
DOI: https://doi.org/10.4049/jimmunol.150.2.517
Published: 15 January 1993
View article titled, Bone marrow macrophages process exogenous Toxoplasma gondii polypeptides for recognition by parasite-specific cytolytic T lymphocytes.
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Journal Articles

Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii.

R Gazzinelli, Y Xu, S Hieny, A Cheever, A Sher
Journal: The Journal of Immunology
J Immunol (1992) 149 (1): 175–180.
DOI: https://doi.org/10.4049/jimmunol.149.1.175
Published: 01 July 1992
View article titled, Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii.
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Journal Articles

CD8+ T cells from mice vaccinated against Toxoplasma gondii are cytotoxic for parasite-infected or antigen-pulsed host cells.

F T Hakim, R T Gazzinelli, E Denkers, S Hieny, G M Shearer, A Sher
Journal: The Journal of Immunology
J Immunol (1991) 147 (7): 2310–2316.
DOI: https://doi.org/10.4049/jimmunol.147.7.2310
Published: 01 October 1991
View article titled, CD8+ T cells from mice vaccinated against Toxoplasma gondii are cytotoxic for parasite-infected or antigen-pulsed host cells.
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Journal Articles

Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine.

R T Gazzinelli, F T Hakim, S Hieny, G M Shearer, A Sher
Journal: The Journal of Immunology
J Immunol (1991) 146 (1): 286–292.
DOI: https://doi.org/10.4049/jimmunol.146.1.286
Published: 01 January 1991
View article titled, Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine.
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Journal Articles

Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse.

A Sher, R L Coffman, S Hieny, A W Cheever
Journal: The Journal of Immunology
J Immunol (1990) 145 (11): 3911–3916.
DOI: https://doi.org/10.4049/jimmunol.145.11.3911
Published: 01 December 1990
View article titled, Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse.
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Journal Articles

Evasion of the alternative complement pathway by metacyclic trypomastigotes of Trypanosoma cruzi: dependence on the developmentally regulated synthesis of surface protein and N-linked carbohydrate.

A Sher, S Hieny, K Joiner
Journal: The Journal of Immunology
J Immunol (1986) 137 (9): 2961–2967.
DOI: https://doi.org/10.4049/jimmunol.137.9.2961
Published: 01 November 1986
View article titled, Evasion of the alternative complement pathway by metacyclic trypomastigotes of Trypanosoma cruzi: dependence on the developmentally regulated synthesis of surface protein and N-linked carbohydrate.
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Journal Articles

Induction of protective immunity against Schistosoma mansoni by a nonliving vaccine. IV. Fractionation and antigenic properties of a soluble adult worm immunoprophylactic activity.

A Sher, E Pearce, S Hieny, S James
Journal: The Journal of Immunology
J Immunol (1986) 136 (10): 3878–3883.
DOI: https://doi.org/10.4049/jimmunol.136.10.3878
Published: 15 May 1986
View article titled, Induction of protective immunity against Schistosoma mansoni by a nonliving vaccine. IV. Fractionation and antigenic properties of a soluble adult worm immunoprophylactic activity.
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Journal Articles

Molecular mimicry of a carbohydrate epitope on a major surface glycoprotein of Trypanosoma cruzi by using anti-idiotypic antibodies.

D L Sacks, L V Kirchhoff, S Hieny, A Sher
Journal: The Journal of Immunology
J Immunol (1985) 135 (6): 4155–4159.
DOI: https://doi.org/10.4049/jimmunol.135.6.4155
Published: 01 December 1985
View article titled, Molecular mimicry of a carbohydrate epitope on a major surface glycoprotein of Trypanosoma cruzi by using anti-idiotypic antibodies.
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Journal Articles

Identification of cell surface carbohydrate and antigenic changes between noninfective and infective developmental stages of Leishmania major promastigotes.

D L Sacks, S Hieny, A Sher
Journal: The Journal of Immunology
J Immunol (1985) 135 (1): 564–569.
DOI: https://doi.org/10.4049/jimmunol.135.1.564
Published: 01 July 1985
View article titled, Identification of cell surface carbohydrate and antigenic changes between noninfective and infective developmental stages of Leishmania major promastigotes.
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Journal Articles

Cryptic epitope explains the failure of a monoclonal antibody to bind to certain isolates of Trypanosoma cruzi.

L V Kirchhoff, S Hieny, G M Shiver, D Snary, A Sher
Journal: The Journal of Immunology
J Immunol (1984) 133 (5): 2731–2735.
DOI: https://doi.org/10.4049/jimmunol.133.5.2731
Published: 01 November 1984
View article titled, Cryptic epitope explains the failure of a monoclonal antibody to bind to certain isolates of Trypanosoma cruzi.
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