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Santhakumar Manicassamy
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Journal Articles

The Transcription Factor RXRα in CD11c+ APCs Regulates Intestinal Immune Homeostasis and Inflammation

Indumathi Manoharan, Arulkumaran Shanmugam, Malarvizhi Ramalingam, Nikhil Patel, Muthusamy Thangaraju, Satyanarayana Ande, Rafal Pacholczyk, Puttur D. Prasad, Santhakumar Manicassamy
Journal: The Journal of Immunology
J Immunol (2023) 211 (5): 853–861.
https://doi.org/10.4049/jimmunol.2200909
Published: 21 July 2023
View article titled, The Transcription Factor RXRα in CD11c<sup>+</sup> APCs Regulates Intestinal Immune Homeostasis and Inflammation
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Includes: Supplementary data
Journal Articles

Genetic Deletion of LRP5 and LRP6 in Macrophages Exacerbates Colitis-Associated Systemic Inflammation and Kidney Injury in Response to Intestinal Commensal Microbiota

Indumathi Manoharan, Daniel Swafford, Arulkumaran Shanmugam, Nikhil Patel, Puttur D. Prasad, Riyaz Mohamed, Qingqing Wei, Zheng Dong, Muthusamy Thangaraju, Santhakumar Manicassamy
Journal: The Journal of Immunology
J Immunol (2022) 209 (2): 368–378.
https://doi.org/10.4049/jimmunol.2101172
Published: 15 July 2022
View article titled, Genetic Deletion of LRP5 and LRP6 in Macrophages Exacerbates Colitis-Associated Systemic Inflammation and Kidney Injury in Response to Intestinal Commensal Microbiota
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Includes: Supplementary data
Journal Articles

Activation of Transcription Factor 4 in Dendritic Cells Controls Th1/Th17 Responses and Autoimmune Neuroinflammation

Indumathi Manoharan, Daniel Swafford, Arulkumaran Shanmugam, Nikhil Patel, Puttur D. Prasad, Muthusamy Thangaraju, Santhakumar Manicassamy
Journal: The Journal of Immunology
J Immunol (2021) 207 (5): 1428–1436.
https://doi.org/10.4049/jimmunol.2100010
Published: 01 September 2021
View article titled, Activation of Transcription Factor 4 in Dendritic Cells Controls Th1/Th17 Responses and Autoimmune Neuroinflammation
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Includes: Supplementary data
Journal Articles

The Wnt–β-Catenin–IL-10 Signaling Axis in Intestinal APCs Protects Mice from Colitis-Associated Colon Cancer in Response to Gut Microbiota

Daniel Swafford, Arulkumaran Shanmugam, Punithavathi Ranganathan, Indumathi Manoharan, Mohamed S. Hussein, Nikhil Patel, Humberto Sifuentes, Pandelakis A. Koni, Puttur D. Prasad, Muthusamy Thangaraju, Santhakumar Manicassamy
Journal: The Journal of Immunology
J Immunol (2020) 205 (8): 2265–2275.
https://doi.org/10.4049/jimmunol.1901376
Published: 15 October 2020
View article titled, The Wnt–β-Catenin–IL-10 Signaling Axis in Intestinal APCs Protects Mice from Colitis-Associated Colon Cancer in Response to Gut Microbiota
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Includes: Supplementary data
Journal Articles

The Wnt-β-catenin-IL-10 signaling axis in intestinal antigen-presenting cells protects mice from colitis-associated colon cancer in response to gut microbiota

Mohamed Ahmed Shawky Hussein, Daniel Swafford, Arulkumaran Shanmugam, Punithavathi Ranganathan, Santhakumar Manicassamy
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 233.14.
https://doi.org/10.4049/jimmunol.204.Supp.233.14
Published: 01 May 2020
View article titled, The Wnt-β-catenin-IL-10 signaling axis in intestinal antigen-presenting cells protects mice from colitis-associated colon cancer in response to gut microbiota
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Journal Articles

Canonical Wnt Signaling in CD11c+ APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon

Daniel Swafford, Arulkumaran Shanmugam, Punithavathi Ranganathan, Mohamed S. Hussein, Pandelakis A. Koni, Puttur D. Prasad, Muthusamy Thangaraju, Santhakumar Manicassamy
Journal: The Journal of Immunology
J Immunol (2018) 200 (9): 3259–3268.
https://doi.org/10.4049/jimmunol.1701086
Published: 01 May 2018
View article titled, Canonical Wnt Signaling in CD11c<sup>+</sup> APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon
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Includes: Supplementary data
Journal Articles

GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis

Punithavathi Ranganathan, Arulkumaran Shanmugam, Daniel Swafford, Amol Suryawanshi, Pushpak Bhattacharjee, Mohamed S. Hussein, Pandelakis A. Koni, Puttur D. Prasad, Zoya B. Kurago, Muthusamy Thangaraju, Vadivel Ganapathy, Santhakumar Manicassamy
Journal: The Journal of Immunology
J Immunol (2018) 200 (5): 1781–1789.
https://doi.org/10.4049/jimmunol.1700604
Published: 01 March 2018
View article titled, GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis
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Includes: Supplementary data
Journal Articles

Canonical Wnt Signaling in CD11c+ antigen presenting cells controls inflammation-associated colon carcinogenesis and commensal homeostasis

Daniel J Swafford, Arulkumaran Shanmugam, Punithavathi Ranganathan, Santhakumar Manicassamy
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 65.8.
https://doi.org/10.4049/jimmunol.198.Supp.65.8
Published: 01 May 2017
View article titled, Canonical Wnt Signaling in CD11c<sup>+</sup> antigen presenting cells controls inflammation-associated colon carcinogenesis and commensal homeostasis
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Journal Articles

Homeostatic PPARα Signaling Limits Inflammatory Responses to Commensal Microbiota in the Intestine

Indumathi Manoharan, Amol Suryawanshi, Yuan Hong, Punithavathi Ranganathan, Arulkumaran Shanmugam, Shamim Ahmad, Daniel Swafford, Balaji Manicassamy, Ganesan Ramesh, Pandelakis A. Koni, Muthusamy Thangaraju, Santhakumar Manicassamy
Journal: The Journal of Immunology
J Immunol (2016) 196 (11): 4739–4749.
https://doi.org/10.4049/jimmunol.1501489
Published: 01 June 2016
View article titled, Homeostatic PPARα Signaling Limits Inflammatory Responses to Commensal Microbiota in the Intestine
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Includes: Supplementary data
Journal Articles

Canonical Wnt Signaling in Dendritic Cells Regulates Th1/Th17 Responses and Suppresses Autoimmune Neuroinflammation

Amol Suryawanshi, Indumathi Manoharan, Yuan Hong, Daniel Swafford, Tanmay Majumdar, M. Mark Taketo, Balaji Manicassamy, Pandelakis A. Koni, Muthusamy Thangaraju, Zuoming Sun, Andrew L. Mellor, David H. Munn, Santhakumar Manicassamy
Journal: The Journal of Immunology
J Immunol (2015) 194 (7): 3295–3304.
https://doi.org/10.4049/jimmunol.1402691
Published: 01 April 2015
View article titled, Canonical Wnt Signaling in Dendritic Cells Regulates Th1/Th17 Responses and Suppresses Autoimmune Neuroinflammation
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Includes: Supplementary data
Journal Articles

TLR2-Dependent Activation of β-Catenin Pathway in Dendritic Cells Induces Regulatory Responses and Attenuates Autoimmune Inflammation

Indumathi Manoharan, Yuan Hong, Amol Suryawanshi, Melinda L. Angus-Hill, Zuoming Sun, Andrew L. Mellor, David H. Munn, Santhakumar Manicassamy
Journal: The Journal of Immunology
J Immunol (2014) 193 (8): 4203–4213.
https://doi.org/10.4049/jimmunol.1400614
Published: 15 October 2014
View article titled, TLR2-Dependent Activation of β-Catenin Pathway in Dendritic Cells Induces Regulatory Responses and Attenuates Autoimmune Inflammation
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Includes: Supplementary data
Journal Articles

Functional Specializations of Intestinal Dendritic Cell and Macrophage Subsets That Control Th17 and Regulatory T Cell Responses Are Dependent on the T Cell/APC Ratio, Source of Mouse Strain, and Regional Localization

Timothy L. Denning, Brian A. Norris, Oscar Medina-Contreras, Santhakumar Manicassamy, Duke Geem, Rajat Madan, Christopher L. Karp, Bali Pulendran
Journal: The Journal of Immunology
J Immunol (2011) 187 (2): 733–747.
https://doi.org/10.4049/jimmunol.1002701
Published: 15 July 2011
View article titled, Functional Specializations of Intestinal Dendritic Cell and Macrophage Subsets That Control Th17 and Regulatory T Cell Responses Are Dependent on the T Cell/APC Ratio, Source of Mouse Strain, and Regional Localization
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Journal Articles

A Critical Role for Protein Kinase C-θ-Mediated T Cell Survival in Cardiac Allograft Rejection

Santhakumar Manicassamy, Dengping Yin, Zheng Zhang, Luciana L. Molinero, Marisa-Luisa Alegre, Zuoming Sun
Journal: The Journal of Immunology
J Immunol (2008) 181 (1): 513–520.
https://doi.org/10.4049/jimmunol.181.1.513
Published: 01 July 2008
View article titled, A Critical Role for Protein Kinase C-θ-Mediated T Cell Survival in Cardiac Allograft Rejection
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Journal Articles

Stabilized β-Catenin Potentiates Fas-Mediated T Cell Apoptosis

Zhaofeng Huang, Ruiqing Wang, Huimin Xie, Weirong Shang, Santhakumar Manicassamy, Zuoming Sun
Journal: The Journal of Immunology
J Immunol (2008) 180 (10): 6586–6592.
https://doi.org/10.4049/jimmunol.180.10.6586
Published: 15 May 2008
View article titled, Stabilized β-Catenin Potentiates Fas-Mediated T Cell Apoptosis
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Journal Articles

Requirement of Calcineurin Aβ for the Survival of Naive T Cells

Santhakumar Manicassamy, Sonal Gupta, Zhaofeng Huang, Jeffery D. Molkentin, Weirong Shang, Zuoming Sun
Journal: The Journal of Immunology
J Immunol (2008) 180 (1): 106–112.
https://doi.org/10.4049/jimmunol.180.1.106
Published: 01 January 2008
View article titled, Requirement of Calcineurin Aβ for the Survival of Naive T Cells
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Journal Articles

The Critical Role of Protein Kinase C-θ in Fas/Fas Ligand-Mediated Apoptosis

Santhakumar Manicassamy, Zuoming Sun
Journal: The Journal of Immunology
J Immunol (2007) 178 (1): 312–319.
https://doi.org/10.4049/jimmunol.178.1.312
Published: 01 January 2007
View article titled, The Critical Role of Protein Kinase C-θ in Fas/Fas Ligand-Mediated Apoptosis
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Journal Articles

Protein Kinase C-θ-Mediated Signals Enhance CD4+ T Cell Survival by Up-Regulating Bcl-xL

Santhakumar Manicassamy, Sonal Gupta, Zhaofeng Huang, Zuoming Sun
Journal: The Journal of Immunology
J Immunol (2006) 176 (11): 6709–6716.
https://doi.org/10.4049/jimmunol.176.11.6709
Published: 01 June 2006
View article titled, Protein Kinase C-θ-Mediated Signals Enhance CD4<sup>+</sup> T Cell Survival by Up-Regulating Bcl-x<sub>L</sub>
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