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Scott R. Burrows
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Journal Articles

Autoreactive CD8+ T-cells are highly dependent on CD8 for activation and as such targeting CD8 is an effective way of blocking autoreactive CD8+ T-cell activation

Linda Wooldridge, David Morgan, James Alexander Pearson, Stephanie Gras, Hugo van den Berg, Anya Lissina, Sian Llewellyn-Lacey, Mark Willis, Tamsin Dockree, James E McLaren, Julia Ekeruche-Makinde, Emma Gostick, Neil Robertson, Jamie Rossjohn, Scott R Burrows, David Price, Susan Wong, Mark Peakman, Ania Skowera, Matthew Clement
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 127.26.
https://doi.org/10.4049/jimmunol.198.Supp.127.26
Published: 01 May 2017
View article titled, Autoreactive CD8<sup>+</sup> T-cells are highly dependent on CD8 for activation and as such targeting CD8 is an effective way of blocking autoreactive CD8<sup>+</sup> T-cell activation
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Journal Articles

Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells

Bruno Laugel, Angharad Lloyd, Erin W. Meermeier, Michael D. Crowther, Thomas R. Connor, Garry Dolton, John J. Miles, Scott R. Burrows, Marielle C. Gold, David M. Lewinsohn, Andrew K. Sewell
Journal: The Journal of Immunology
J Immunol (2016) 197 (3): 971–982.
https://doi.org/10.4049/jimmunol.1501402
Published: 01 August 2016
View article titled, Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells
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Includes: Supplementary data
Journal Articles

T Cell Cross-Reactivity between a Highly Immunogenic EBV Epitope and a Self-Peptide Naturally Presented by HLA-B*18:01+ Cells

Melissa J. Rist, Kelly M. Hibbert, Nathan P. Croft, Corey Smith, Michelle A. Neller, Jacqueline M. Burrows, John J. Miles, Anthony W. Purcell, Jamie Rossjohn, Stephanie Gras, Scott R. Burrows
Journal: The Journal of Immunology
J Immunol (2015) 194 (10): 4668–4675.
https://doi.org/10.4049/jimmunol.1500233
Published: 15 May 2015
View article titled, T Cell Cross-Reactivity between a Highly Immunogenic EBV Epitope and a Self-Peptide Naturally Presented by HLA-B*18:01<sup>+</sup> Cells
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Journal Articles

HLA Peptide Length Preferences Control CD8+ T Cell Responses

Melissa J. Rist, Alex Theodossis, Nathan P. Croft, Michelle A. Neller, Andrew Welland, Zhenjun Chen, Lucy C. Sullivan, Jacqueline M. Burrows, John J. Miles, Rebekah M. Brennan, Stephanie Gras, Rajiv Khanna, Andrew G. Brooks, James McCluskey, Anthony W. Purcell, Jamie Rossjohn, Scott R. Burrows
Journal: The Journal of Immunology
J Immunol (2013) 191 (2): 561–571.
https://doi.org/10.4049/jimmunol.1300292
Published: 15 July 2013
View article titled, HLA Peptide Length Preferences Control CD8<sup>+</sup> T Cell Responses
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Includes: Supplementary data
Journal Articles

The Impact of a Large and Frequent Deletion in the Human TCR β Locus on Antiviral Immunity

Rebekah M. Brennan, Jan Petersen, Michelle A. Neller, John J. Miles, Jacqueline M. Burrows, Corey Smith, James McCluskey, Rajiv Khanna, Jamie Rossjohn, Scott R. Burrows
Journal: The Journal of Immunology
J Immunol (2012) 188 (6): 2742–2748.
https://doi.org/10.4049/jimmunol.1102675
Published: 15 March 2012
View article titled, The Impact of a Large and Frequent Deletion in the Human TCR β Locus on Antiviral Immunity
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Includes: Supplementary data
Journal Articles

A Structural Basis for Varied αβ TCR Usage against an Immunodominant EBV Antigen Restricted to a HLA-B8 Molecule

Stephanie Gras, Pascal G. Wilmann, Zhenjun Chen, Hanim Halim, Yu Chih Liu, Lars Kjer-Nielsen, Anthony W. Purcell, Scott R. Burrows, James McCluskey, Jamie Rossjohn
Journal: The Journal of Immunology
J Immunol (2012) 188 (1): 311–321.
https://doi.org/10.4049/jimmunol.1102686
Published: 01 January 2012
View article titled, A Structural Basis for Varied αβ TCR Usage against an Immunodominant EBV Antigen Restricted to a HLA-B8 Molecule
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Includes: Supplementary data
Journal Articles

Anti-CD8 Antibodies Can Trigger CD8+ T Cell Effector Function in the Absence of TCR Engagement and Improve Peptide–MHCI Tetramer Staining

Mathew Clement, Kristin Ladell, Julia Ekeruche-Makinde, John J. Miles, Emily S. J. Edwards, Garry Dolton, Tamsin Williams, Andrea J. A. Schauenburg, David K. Cole, Sarah N. Lauder, Awen M. Gallimore, Andrew J. Godkin, Scott R. Burrows, David A. Price, Andrew K. Sewell, Linda Wooldridge
Journal: The Journal of Immunology
J Immunol (2011) 187 (2): 654–663.
https://doi.org/10.4049/jimmunol.1003941
Published: 15 July 2011
View article titled, Anti-CD8 Antibodies Can Trigger CD8<sup>+</sup> T Cell Effector Function in the Absence of TCR Engagement and Improve Peptide–MHCI Tetramer Staining
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Includes: Supplementary data
Journal Articles

Antigen-Driven Patterns of TCR Bias Are Shared across Diverse Outcomes of Human Hepatitis C Virus Infection

John J. Miles, Duangtawan Thammanichanond, Sarah Moneer, Usha K. Nivarthi, Lars Kjer-Nielsen, Samantha L. Tracy, Campbell K. Aitken, Rebekah M. Brennan, Weiguang Zeng, Louise Marquart, David Jackson, Scott R. Burrows, David S. Bowden, Joseph Torresi, Margaret Hellard, Jamie Rossjohn, James McCluskey, Mandvi Bharadwaj
Journal: The Journal of Immunology
J Immunol (2011) 186 (2): 901–912.
https://doi.org/10.4049/jimmunol.1003167
Published: 15 January 2011
View article titled, Antigen-Driven Patterns of TCR Bias Are Shared across Diverse Outcomes of Human Hepatitis C Virus Infection
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Includes: Supplementary data
Journal Articles

MHC Class I Molecules with Superenhanced CD8 Binding Properties Bypass the Requirement for Cognate TCR Recognition and Nonspecifically Activate CTLs

Linda Wooldridge, Mathew Clement, Anna Lissina, Emily S. J. Edwards, Kristin Ladell, Julia Ekeruche, Rachel E. Hewitt, Bruno Laugel, Emma Gostick, David K. Cole, Reno Debets, Cor Berrevoets, John J. Miles, Scott R. Burrows, David A. Price, Andrew K. Sewell
Journal: The Journal of Immunology
J Immunol (2010) 184 (7): 3357–3366.
https://doi.org/10.4049/jimmunol.0902398
Published: 01 April 2010
View article titled, MHC Class I Molecules with Superenhanced CD8 Binding Properties Bypass the Requirement for Cognate TCR Recognition and Nonspecifically Activate CTLs
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Journal Articles

TCRα Genes Direct MHC Restriction in the Potent Human T Cell Response to a Class I-Bound Viral Epitope

John J. Miles, Natalie A. Borg, Rebekah M. Brennan, Fleur E. Tynan, Lars Kjer-Nielsen, Sharon L. Silins, Melissa J. Bell, Jacqueline M. Burrows, James McCluskey, Jamie Rossjohn, Scott R. Burrows
Journal: The Journal of Immunology
J Immunol (2006) 177 (10): 6804–6814.
https://doi.org/10.4049/jimmunol.177.10.6804
Published: 15 November 2006
View article titled, TCRα Genes Direct MHC Restriction in the Potent Human T Cell Response to a Class I-Bound Viral Epitope
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Journal Articles

CTL Recognition of a Bulged Viral Peptide Involves Biased TCR Selection

John J. Miles, Diah Elhassen, Natalie A. Borg, Sharon L. Silins, Fleur E. Tynan, Jacqueline M. Burrows, Anthony W. Purcell, Lars Kjer-Nielsen, Jamie Rossjohn, Scott R. Burrows, James McCluskey
Journal: The Journal of Immunology
J Immunol (2005) 175 (6): 3826–3834.
https://doi.org/10.4049/jimmunol.175.6.3826
Published: 15 September 2005
View article titled, CTL Recognition of a Bulged Viral Peptide Involves Biased TCR Selection
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Journal Articles

Antagonism of Antiviral and Allogeneic Activity of a Human Public CTL Clonotype by a Single Altered Peptide Ligand: Implications for Allograft Rejection

Lauren K. Ely, Katherine J. Green, Travis Beddoe, Craig S. Clements, John J. Miles, Stephen P. Bottomley, Danielle Zernich, Lars Kjer-Nielsen, Anthony W. Purcell, James McCluskey, Jamie Rossjohn, Scott R. Burrows
Journal: The Journal of Immunology
J Immunol (2005) 174 (9): 5593–5601.
https://doi.org/10.4049/jimmunol.174.9.5593
Published: 01 May 2005
View article titled, Antagonism of Antiviral and Allogeneic Activity of a Human Public CTL Clonotype by a Single Altered Peptide Ligand: Implications for Allograft Rejection
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Journal Articles

Promiscuous CTL Recognition of Viral Epitopes on Multiple Human Leukocyte Antigens: Biological Validation of the Proposed HLA A24 Supertype

Scott R. Burrows, Rebecca A. Elkington, John J. Miles, Katherine J. Green, Susan Walker, Sofia M. Haryana, Denis J. Moss, Heather Dunckley, Jacqueline M. Burrows, Rajiv Khanna
Journal: The Journal of Immunology
J Immunol (2003) 171 (3): 1407–1412.
https://doi.org/10.4049/jimmunol.171.3.1407
Published: 01 August 2003
View article titled, Promiscuous CTL Recognition of Viral Epitopes on Multiple Human Leukocyte Antigens: Biological Validation of the Proposed HLA A24 Supertype
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Journal Articles

Quantitative and Qualitative Influences of Tapasin on the Class I Peptide Repertoire

Anthony W. Purcell, Jeffrey J. Gorman, Marína Garcia-Peydró, Alberto Paradela, Scott R. Burrows, Gert H. Talbo, Nihay Laham, Chen Au Peh, Eric C. Reynolds, José A. López de Castro, James McCluskey
Journal: The Journal of Immunology
J Immunol (2001) 166 (2): 1016–1027.
https://doi.org/10.4049/jimmunol.166.2.1016
Published: 15 January 2001
View article titled, Quantitative and Qualitative Influences of Tapasin on the Class I Peptide Repertoire
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Journal Articles

Peptide-MHC Class I Tetrameric Complexes Display Exquisite Ligand Specificity

Scott R. Burrows, Norbert Kienzle, Adam Winterhalter, Mandvi Bharadwaj, John D. Altman, Andrew Brooks
Journal: The Journal of Immunology
J Immunol (2000) 165 (11): 6229–6234.
https://doi.org/10.4049/jimmunol.165.11.6229
Published: 01 December 2000
View article titled, Peptide-MHC Class I Tetrameric Complexes Display Exquisite Ligand Specificity
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Journal Articles

Differential Splicing of Antigen-Encoding RNA Reduces Endogenous Epitope Presentation That Regulates the Expansion and Cytotoxicity of T Cells

Norbert Kienzle, Marion Buck, Sharon L. Silins, Scott R. Burrows, Denis J. Moss, Adam Winterhalter, Andrew Brooks, Rajiv Khanna
Journal: The Journal of Immunology
J Immunol (2000) 165 (4): 1840–1846.
https://doi.org/10.4049/jimmunol.165.4.1840
Published: 15 August 2000
View article titled, Differential Splicing of Antigen-Encoding RNA Reduces Endogenous Epitope Presentation That Regulates the Expansion and Cytotoxicity of T Cells
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Journal Articles

Distinct Functions of Tapasin Revealed by Polymorphism in MHC Class I Peptide Loading

Chen Au Peh, Nihay Laham, Scott R. Burrows, Yong Zhu, James McCluskey
Journal: The Journal of Immunology
J Immunol (2000) 164 (1): 292–299.
https://doi.org/10.4049/jimmunol.164.1.292
Published: 01 January 2000
View article titled, Distinct Functions of Tapasin Revealed by Polymorphism in MHC Class I Peptide Loading
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Journal Articles

EBV Structural Antigens, gp350 and gp85, as Targets for Ex Vivo Virus-Specific CTL During Acute Infectious Mononucleosis: Potential Use of gp350/gp85 CTL Epitopes for Vaccine Design

Rajiv Khanna, Martina Sherritt, Scott R. Burrows
Journal: The Journal of Immunology
J Immunol (1999) 162 (5): 3063–3069.
https://doi.org/10.4049/jimmunol.162.5.3063
Published: 01 March 1999
View article titled, EBV Structural Antigens, gp350 and gp85, as Targets for Ex Vivo Virus-Specific CTL During Acute Infectious Mononucleosis: Potential Use of gp350/gp85 CTL Epitopes for Vaccine Design
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