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Journal Articles

DOCK8-expressing Tfh cells cause SLE: autoimmunity via repeated TCR stimulation by antigen to levels that surpass system’s self-organized criticality

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Shunichi Shiozawa, Ken Tsumiyama, Yumi Miyazaki, Kenichi Uto, Keiichi Sakurai, Toshie Nakashima, Hiroko Matsuyama, Ai Doi, Miho Tarui, Manabu Izumikawa, Mai Kimura, Chisato Satonaka, Yoko Fujita, Takahiko Horiuchi, Tsukasa Matsubara, Motohiro Oribe, Takashi Yamane, Hidetoshi Kagawa, Quan-Zhen Li, Keiko Mizuno, Yohei Mukai, Kazuhiro Murakami, Takuji Enya, Shota Tsukimoto, Yoshiyuki Hakata, Masaaki Miyazawa, Kazuko Shiozawa
Journal: The Journal of Immunology
J Immunol (2021) 206 (1_Supplement): 52.21.
https://doi.org/10.4049/jimmunol.206.Supp.52.21
Published: 01 May 2021
View articletitled, DOCK8-expressing Tfh cells cause SLE: autoimmunity via repeated TCR stimulation by antigen to levels that surpass system’s self-organized criticality
Add to Citation Manager for DOCK8-expressing Tfh cells cause SLE: autoimmunity via repeated TCR stimulation by antigen to levels that surpass system’s self-organized criticality
Journal Articles

Conditional Upregulation of IFN-α Alone Is Sufficient to Induce Systemic Lupus Erythematosus

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Chieri Akiyama, Ken Tsumiyama, Chiaki Uchimura, Eriko Honda, Yumi Miyazaki, Keiichi Sakurai, Yasushi Miura, Akira Hashiramoto, Dean W. Felsher, Shunichi Shiozawa
Journal: The Journal of Immunology
J Immunol (2019) 203 (4): 835–843.
https://doi.org/10.4049/jimmunol.1801617
Published: 15 August 2019
View articletitled, Conditional Upregulation of IFN-α Alone Is Sufficient to Induce Systemic Lupus Erythematosus
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Includes: Supplementary data
Journal Articles

Autoantibody-inducing CD4 T (aiCD4 T) cell that induces systemic lupus erythematosus (SLE) includes not only follicular helper T cell but also IL-21-producing CXCR5−ICOShiPD-1hi cell

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Ken Tsumiyama, Shunichi Shiozawa
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 163.3.
https://doi.org/10.4049/jimmunol.200.Supp.163.3
Published: 01 May 2018
View articletitled, Autoantibody-inducing CD4 T (aiCD4 T) cell that induces systemic lupus erythematosus (SLE) includes not only follicular helper T cell but also IL-21-producing CXCR5−ICOShiPD-1hi cell
Add to Citation Manager for Autoantibody-inducing CD4 T (aiCD4 T) cell that induces systemic lupus erythematosus (SLE) includes not only follicular helper T cell but also IL-21-producing CXCR5−ICOShiPD-1hi cell
Journal Articles

The contribution of autoantibody-inducing CD4+ T cell (aiCD4 T cell) help to the B cell maturation and possible autoantibody in Systemic Lupus Erythematosus

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Keiichi Sakurai, Ken Tsumiyama, Shunichi Shiozawa
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 163.17.
https://doi.org/10.4049/jimmunol.200.Supp.163.17
Published: 01 May 2018
View articletitled, The contribution of autoantibody-inducing CD4+ T cell (aiCD4 T cell) help to the B cell maturation and possible autoantibody in Systemic Lupus Erythematosus
Add to Citation Manager for The contribution of autoantibody-inducing CD4+ T cell (aiCD4 T cell) help to the B cell maturation and possible autoantibody in Systemic Lupus Erythematosus
Journal Articles

Dock8-Positive CD4 T cell as Autoantibody-Inducing CD4 T (aiCD4 T) Cell That Causes Systemic Lupus Erythematosus (SLE): Proof of Concept of Self-Organized Criticality Theory as the Cause of SLE

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Shunichi Shiozawa, Ken Tsumiyama, Yumi Miyazaki, Keiichi Sakurai, Masaaki Miyazawa
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 163.12.
https://doi.org/10.4049/jimmunol.200.Supp.163.12
Published: 01 May 2018
View articletitled, Dock8-Positive CD4 T cell as Autoantibody-Inducing CD4 T (aiCD4 T) Cell That Causes Systemic Lupus Erythematosus (SLE): Proof of Concept of Self-Organized Criticality Theory as the Cause of SLE
Add to Citation Manager for Dock8-Positive CD4 T cell as Autoantibody-Inducing CD4 T (aiCD4 T) Cell That Causes Systemic Lupus Erythematosus (SLE): Proof of Concept of Self-Organized Criticality Theory as the Cause of SLE
Journal Articles

SOCS1 Is a Key Molecule That Prevents Regulatory T Cell Plasticity under Inflammatory Conditions

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Reiko Takahashi, Hiroko Nakatsukasa, Shunichi Shiozawa, Akihiko Yoshimura
Journal: The Journal of Immunology
J Immunol (2017) 199 (1): 149–158.
https://doi.org/10.4049/jimmunol.1600441
Published: 01 July 2017
View articletitled, SOCS1 Is a Key Molecule That Prevents Regulatory T Cell Plasticity under Inflammatory Conditions
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Includes: Supplementary data
Journal Articles

Endosome-to-cytoplasm pathway via Sec61 and proteasomal degradation as an essential component of antigen cross-presentation and the lupus tissue injury in systemic lupus erythematosus (SLE): Extension of our self-organized criticality theory

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Ken Tsumiyama, Shunichi Shiozawa
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 49.11.
https://doi.org/10.4049/jimmunol.196.Supp.49.11
Published: 01 May 2016
View articletitled, Endosome-to-cytoplasm pathway via Sec61 and proteasomal degradation as an essential component of antigen cross-presentation and the lupus tissue injury in systemic lupus erythematosus (SLE): Extension of our self-organized criticality theory
Add to Citation Manager for Endosome-to-cytoplasm pathway via Sec61 and proteasomal degradation as an essential component of antigen cross-presentation and the lupus tissue injury in systemic lupus erythematosus (SLE): Extension of our self-organized criticality theory
Journal Articles

Increase of endosomal Sec61 enhances antigen cross-presentation and induces immune glomerular injury: a novel ‘self-organized criticality theory’ explaining the cause of systemic lupus erythematosus (BA4P.129)

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Ken Tsumiyama, Shunichi Shiozawa
Journal: The Journal of Immunology
J Immunol (2015) 194 (1_Supplement): 47.9.
https://doi.org/10.4049/jimmunol.194.Supp.47.9
Published: 01 May 2015
View articletitled, Increase of endosomal Sec61 enhances antigen cross-presentation and induces immune glomerular injury: a novel ‘self-organized criticality theory’ explaining the cause of systemic lupus erythematosus (BA4P.129)
Add to Citation Manager for Increase of endosomal Sec61 enhances antigen cross-presentation and induces immune glomerular injury: a novel ‘self-organized criticality theory’ explaining the cause of systemic lupus erythematosus (BA4P.129)
Journal Articles

Specifying the autoantibody-inducing CD4 T cell causing systemic lupus erythematosus out of PD-1+CD45RBlo122lo CD4 subpopulation using mass spectrometry (BA11P.135)

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Shunichi Shiozawa, Yumi Miyazaki, Ken Tsumiyama
Journal: The Journal of Immunology
J Immunol (2015) 194 (1_Supplement): 184.17.
https://doi.org/10.4049/jimmunol.194.Supp.184.17
Published: 01 May 2015
View articletitled, Specifying the autoantibody-inducing CD4 T cell causing systemic lupus erythematosus out of PD-1+CD45RBlo122lo CD4 subpopulation using mass spectrometry (BA11P.135)
Add to Citation Manager for Specifying the autoantibody-inducing CD4 T cell causing systemic lupus erythematosus out of PD-1+CD45RBlo122lo CD4 subpopulation using mass spectrometry (BA11P.135)
Journal Articles

Sec61 plays an essential role in facilitating antigen cross-presentation to induce immune glomerular injury: a novel ‘self-organized criticality theory’ explaining cause of SLE (BA8P.129)

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Ken Tsumiyama, Shunichi Shiozawa
Journal: The Journal of Immunology
J Immunol (2014) 192 (1_Supplement): 113.12.
https://doi.org/10.4049/jimmunol.192.Supp.113.12
Published: 01 May 2014
View articletitled, Sec61 plays an essential role in facilitating antigen cross-presentation to induce immune glomerular injury: a novel ‘self-organized criticality theory’ explaining cause of SLE (BA8P.129)
Add to Citation Manager for Sec61 plays an essential role in facilitating antigen cross-presentation to induce immune glomerular injury: a novel ‘self-organized criticality theory’ explaining cause of SLE (BA8P.129)
Journal Articles

The autoantibody-inducing CD4 T cell (aiCD4 T cell) causing to systemic lupus erythematosus (SLE) belongs to PD-1+CD45RBlo122lo CD4 subpopulation (BA13P.121)

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Yumi Miyazaki, Ken Tsumiyama, Shunichi Shiozawa
Journal: The Journal of Immunology
J Immunol (2014) 192 (1_Supplement): 177.7.
https://doi.org/10.4049/jimmunol.192.Supp.177.7
Published: 01 May 2014
View articletitled, The autoantibody-inducing CD4 T cell (aiCD4 T cell) causing to systemic lupus erythematosus (SLE) belongs to PD-1+CD45RBlo122lo CD4 subpopulation (BA13P.121)
Add to Citation Manager for The autoantibody-inducing CD4 T cell (aiCD4 T cell) causing to systemic lupus erythematosus (SLE) belongs to PD-1+CD45RBlo122lo CD4 subpopulation (BA13P.121)
Journal Articles

IFN-γ–Producing Effector CD8 T Lymphocytes Cause Immune Glomerular Injury by Recognizing Antigen Presented as Immune Complex on Target Tissue

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Ken Tsumiyama, Akira Hashiramoto, Mai Takimoto, Sachiyo Tsuji-Kawahara, Masaaki Miyazawa, Shunichi Shiozawa
Journal: The Journal of Immunology
J Immunol (2013) 191 (1): 91–96.
https://doi.org/10.4049/jimmunol.1203217
Published: 01 July 2013
View articletitled, IFN-γ–Producing Effector CD8 T Lymphocytes Cause Immune Glomerular Injury by Recognizing Antigen Presented as Immune Complex on Target Tissue
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Journal Articles

Antigen cross-presentation via Sec61 is indispensable for the development of lupus nephritis: a novel ‘self-organized criticality theory’ explaining the cause of SLE (P4014)

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Ken Tsumiyama, Shunichi Shiozawa
Journal: The Journal of Immunology
J Immunol (2013) 190 (1_Supplement): 42.8.
https://doi.org/10.4049/jimmunol.190.Supp.42.8
Published: 01 May 2013
View articletitled, Antigen cross-presentation via Sec61 is indispensable for the development of lupus nephritis: a novel ‘self-organized criticality theory’ explaining the cause of SLE (P4014)
Add to Citation Manager for Antigen cross-presentation via Sec61 is indispensable for the development of lupus nephritis: a novel ‘self-organized criticality theory’ explaining the cause of SLE (P4014)
Journal Articles

Pathogenesis of Systemic Lupus Erythematosus and aiCD4 T cell: new insight on autoimmunity (P4121)

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Shunichi Shiozawa, Yumi Miyazaki, Ken Tsumiyama
Journal: The Journal of Immunology
J Immunol (2013) 190 (1_Supplement): 133.14.
https://doi.org/10.4049/jimmunol.190.Supp.133.14
Published: 01 May 2013
View articletitled, Pathogenesis of Systemic Lupus Erythematosus and aiCD4 T cell: new insight on autoimmunity (P4121)
Add to Citation Manager for Pathogenesis of Systemic Lupus Erythematosus and aiCD4 T cell: new insight on autoimmunity (P4121)
Journal Articles

The autoantibody-inducing CD4 T cell causing systemic lupus erythematosus belongs to CCR4+CD45RBlo122lo CD4 subpopulation (P4125)

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Yumi Miyazaki, Ken Tsumiyama, Shunichi Shiozawa
Journal: The Journal of Immunology
J Immunol (2013) 190 (1_Supplement): 133.16.
https://doi.org/10.4049/jimmunol.190.Supp.133.16
Published: 01 May 2013
View articletitled, The autoantibody-inducing CD4 T cell causing systemic lupus erythematosus belongs to CCR4+CD45RBlo122lo CD4 subpopulation (P4125)
Add to Citation Manager for The autoantibody-inducing CD4 T cell causing systemic lupus erythematosus belongs to CCR4+CD45RBlo122lo CD4 subpopulation (P4125)
Journal Articles

Weak TCR signaling due to repeated immunization with antigen is the key for peripheral TCR revision generating aiCD4 T cell: a novel self-organized criticality theory (P4537)

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Shunichi Shiozawa, Kenichi Uto, Ken Tsumiyama
Journal: The Journal of Immunology
J Immunol (2013) 190 (1_Supplement): 197.3.
https://doi.org/10.4049/jimmunol.190.Supp.197.3
Published: 01 May 2013
View articletitled, Weak TCR signaling due to repeated immunization with antigen is the key for peripheral TCR revision generating aiCD4 T cell: a novel self-organized criticality theory (P4537)
Add to Citation Manager for Weak TCR signaling due to repeated immunization with antigen is the key for peripheral TCR revision generating aiCD4 T cell: a novel self-organized criticality theory (P4537)
Journal Articles

Anti-U1C autoantibody interferes with the U1C-mediated splicing of both Ang1 and Tie2 genes in human pulmonary artery smooth muscle cells (159.10)

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Koichiro Komai, Tatsuki Okuyama, Yohei Sasaki, Akira Hashiramoto, Kazuko Shiozawa, Shunichi Shiozawa
Journal: The Journal of Immunology
J Immunol (2012) 188 (1_Supplement): 159.10.
https://doi.org/10.4049/jimmunol.188.Supp.159.10
Published: 01 May 2012
View articletitled, Anti-U1C autoantibody interferes with the U1C-mediated splicing of both Ang1 and Tie2 genes in human pulmonary artery smooth muscle cells (159.10)
Add to Citation Manager for Anti-U1C autoantibody interferes with the U1C-mediated splicing of both Ang1 and Tie2 genes in human pulmonary artery smooth muscle cells (159.10)
Journal Articles

CD45RBlo 122lo autoantibody-inducing CD4 T cell (aiCD4 T cell) causes systemic lupus erytematosus (SLE) (159.7)

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Yumi Miyazaki, Ken Tsumiyama, Shunichi Shiozawa
Journal: The Journal of Immunology
J Immunol (2012) 188 (1_Supplement): 159.7.
https://doi.org/10.4049/jimmunol.188.Supp.159.7
Published: 01 May 2012
View articletitled, CD45RBlo 122lo autoantibody-inducing CD4 T cell (aiCD4 T cell) causes systemic lupus erytematosus (SLE) (159.7)
Add to Citation Manager for CD45RBlo 122lo autoantibody-inducing CD4 T cell (aiCD4 T cell) causes systemic lupus erytematosus (SLE) (159.7)
Journal Articles

Sec61 is essential for antigen cross-presentation and the development of lupus nephritis (171.4)

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Ken Tsumiyama, Shunichi Shiozawa
Journal: The Journal of Immunology
J Immunol (2012) 188 (1_Supplement): 171.4.
https://doi.org/10.4049/jimmunol.188.Supp.171.4
Published: 01 May 2012
View articletitled, Sec61 is essential for antigen cross-presentation and the development of lupus nephritis (171.4)
Add to Citation Manager for Sec61 is essential for antigen cross-presentation and the development of lupus nephritis (171.4)
Journal Articles

The de novo revision of TCRα but not TCRβ is responsible for generating autoantibody-inducing CD4+ (aiCD4+) T cell that causes systemic autoimmunity, i.e., SLE (47.26)

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Kenichi Uto, Ken Tsumiyama, Mai Takimoto, Shunichi Shiozawa
Journal: The Journal of Immunology
J Immunol (2011) 186 (1_Supplement): 47.26.
https://doi.org/10.4049/jimmunol.186.Supp.47.26
Published: 01 April 2011
View articletitled, The de novo revision of TCRα but not TCRβ is responsible for generating autoantibody-inducing CD4+ (aiCD4+) T cell that causes systemic autoimmunity, i.e., SLE (47.26)
Add to Citation Manager for The de novo revision of TCRα but not TCRβ is responsible for generating autoantibody-inducing CD4+ (aiCD4+) T cell that causes systemic autoimmunity, i.e., SLE (47.26)