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Stefan Rose-John
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Journal Articles

Constitutive Activation of gp130 in T Cells Results in Senescence and Premature Aging

Puyan Rafii, Friedrich Reusswig, Julia Werner, Haifeng Xu, Philpp A. Lang, Stefan Rose-John, Simone Gorressen, Christina Alter, Jürgen Schrader, Diran Herebian, Doreen M. Floss, Margitta Elvers, Roland P. Piekorz, Jürgen Scheller, Kristina Behnke
Journal: The Journal of Immunology
J Immunol (2023) 210 (11): 1641–1652.
https://doi.org/10.4049/jimmunol.2200788
Published: 14 April 2023
View article titled, Constitutive Activation of gp130 in T Cells Results in Senescence and Premature Aging
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Includes: Supplementary data
Journal Articles

Cell-Autonomous Constitutive gp130 Signaling in T Cells Amplifies TH17 Cell Responses and Causes Severe Lung Inflammation

Lisa Charlotte Heinig, Emily Valentina Madelaine Huth, Karsten Yan, Neele Schumacher, Mikolaj Nawrocki, Niels Christian Lory, Peter Bradtke, Tabea Bertram, Guido Rattay, Joanna Schmid, Samuel Huber, Thorsten Wiech, Dirk Schmidt-Arras, Stefan Rose-John, Hans-Willi Mittrücker
Journal: The Journal of Immunology
J Immunol (2023) 210 (11): 1717–1727.
https://doi.org/10.4049/jimmunol.2200461
Published: 14 April 2023
View article titled, Cell-Autonomous Constitutive gp130 Signaling in T Cells Amplifies T<sub>H</sub>17 Cell Responses and Causes Severe Lung Inflammation
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Includes: Supplementary data
Journal Articles

Diverse IL-6 signalling modalities drive pathogenic T cell differentiation and graft-versus-host-disease after allotransplantation

Kate H Gartlan, Andrew Wilkinson, Karshing Chang, Rachel D Kuns, Andrea Henden, Simone A Minnie, Kathleen S Ensbey, Andrew Clouston, Ping Zhang, Motoko Koyama, Juan Hidalgo, Stefan Rose-John, Antiopi Varelias, Slavica Vuckovic, Geoffrey R Hill
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 87.33.
https://doi.org/10.4049/jimmunol.204.Supp.87.33
Published: 01 May 2020
View article titled, Diverse IL-6 signalling modalities drive pathogenic T cell differentiation and graft-versus-host-disease after allotransplantation
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Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells

Anne-Sophie Cabron, Karim El azzouzi, Melanie Boss, Philipp Arnold, Jeanette Schwarz, Marcela Rosas, Jan Philipp Dobert, Egor Pavlenko, Neele Schumacher, Thomas Renné, Philip R. Taylor, Stefan Linder, Stefan Rose-John, Friederike Zunke
Journal: The Journal of Immunology
J Immunol (2018) 201 (10): 3106–3118.
https://doi.org/10.4049/jimmunol.1701556
Published: 15 November 2018
View article titled, Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells
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Includes: Supplementary data
Journal Articles

DISTINCT IL-6 SIGNALING PATHWAYS DRIVE ALTERNATE PATHOGENIC T CELL DIFFERENTIATION AND GVHD AFTER TRANSPLANT IN VIVO

Andrew N. Wilkinson, Rachel D. Kuns, Antiopi Varelias, Slavica Vuckovic, Stefan Rose-John, Kate H. Gartlan, Geoffrey R. Hill
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 55.2.
https://doi.org/10.4049/jimmunol.200.Supp.55.2
Published: 01 May 2018
View article titled, DISTINCT IL-6 SIGNALING PATHWAYS DRIVE ALTERNATE PATHOGENIC T CELL DIFFERENTIATION AND GVHD AFTER TRANSPLANT IN VIVO
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Journal Articles

Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation

Neele Schumacher, Stefanie Schmidt, Jeanette Schwarz, Dana Dohr, Juliane Lokau, Jürgen Scheller, Christoph Garbers, Athena Chalaris, Stefan Rose-John, Björn Rabe
Journal: The Journal of Immunology
J Immunol (2016) 197 (9): 3705–3715.
https://doi.org/10.4049/jimmunol.1600909
Published: 01 November 2016
View article titled, Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation
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Includes: Supplementary data
Journal Articles

A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130

Soon-Sun Hong, Jung Ho Choi, Sung Yoon Lee, Yeon-Hwa Park, Kyung-Yeon Park, Joo Young Lee, Juyoung Kim, Veeraswamy Gajulapati, Ja-Il Goo, Sarbjit Singh, Kyeong Lee, Young-Kook Kim, So Hee Im, Sung-Hoon Ahn, Stefan Rose-John, Tae-Hwe Heo, Yongseok Choi
Journal: The Journal of Immunology
J Immunol (2015) 195 (1): 237–245.
https://doi.org/10.4049/jimmunol.1402908
Published: 01 July 2015
View article titled, A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130
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Includes: Supplementary data
Journal Articles

The Role of Metalloproteinase ADAM17 in Regulating ICOS Ligand–Mediated Humoral Immune Responses

Joanna Marczynska, Aleksandra Ozga, Agnieszka Wlodarczyk, Monika Majchrzak-Gorecka, Paulina Kulig, Magdalena Banas, Dominika Michalczyk-Wetula, Pawel Majewski, Andreas Hutloff, Jeanette Schwarz, Athena Chalaris, Jürgen Scheller, Stefan Rose-John, Joanna Cichy
Journal: The Journal of Immunology
J Immunol (2014) 193 (6): 2753–2763.
https://doi.org/10.4049/jimmunol.1302893
Published: 15 September 2014
View article titled, The Role of Metalloproteinase ADAM17 in Regulating ICOS Ligand–Mediated Humoral Immune Responses
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Includes: Supplementary data
Journal Articles

“Activated” STAT Proteins: A Paradoxical Consequence of Inhibited JAK-STAT Signaling in Cytomegalovirus-Infected Cells

Mirko Trilling, Vu Thuy Khanh Le, Jassin Rashidi-Alavijeh, Benjamin Katschinski, Jürgen Scheller, Stefan Rose-John, Gabriela Elena Androsiac, Stipan Jonjić, Valeria Poli, Klaus Pfeffer, Hartmut Hengel
Journal: The Journal of Immunology
J Immunol (2014) 192 (1): 447–458.
https://doi.org/10.4049/jimmunol.1203516
Published: 01 January 2014
View article titled, “Activated” STAT Proteins: A Paradoxical Consequence of Inhibited JAK-STAT Signaling in Cytomegalovirus-Infected Cells
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Journal Articles

Hepatocytes Contribute to Immune Regulation in the Liver by Activation of the Notch Signaling Pathway in T Cells

Sven Burghardt, Annette Erhardt, Benjamin Claass, Samuel Huber, Guido Adler, Thomas Jacobs, Athena Chalaris, Dirk Schmidt-Arras, Stefan Rose-John, Khalil Karimi, Gisa Tiegs
Journal: The Journal of Immunology
J Immunol (2013) 191 (11): 5574–5582.
https://doi.org/10.4049/jimmunol.1300826
Published: 01 December 2013
View article titled, Hepatocytes Contribute to Immune Regulation in the Liver by Activation of the Notch Signaling Pathway in T Cells
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Includes: Supplementary data
Journal Articles

Trp53 Deficiency Protects against Acute Intestinal Inflammation

Martina E. Spehlmann, Carolin F. Manthey, Sara M. Dann, Elaine Hanson, Sukhman S. Sandhu, Linus Y. Liu, Farid K. Abdelmalak, Michaela A. Diamanti, Kristin Retzlaff, Jürgen Scheller, Stefan Rose-John, Florian R. Greten, Jean Y. J. Wang, Lars Eckmann
Journal: The Journal of Immunology
J Immunol (2013) 191 (2): 837–847.
https://doi.org/10.4049/jimmunol.1201716
Published: 15 July 2013
View article titled, <em>Trp53</em> Deficiency Protects against Acute Intestinal Inflammation
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Includes: Supplementary data
Journal Articles

IL-6 Controls the Innate Immune Response against Listeria monocytogenes via Classical IL-6 Signaling

Judith Hoge, Isabell Yan, Nathalie Jänner, Valéa Schumacher, Athena Chalaris, Oliver M. Steinmetz, Daniel R. Engel, Jürgen Scheller, Stefan Rose-John, Hans-Willi Mittrücker
Journal: The Journal of Immunology
J Immunol (2013) 190 (2): 703–711.
https://doi.org/10.4049/jimmunol.1201044
Published: 15 January 2013
View article titled, IL-6 Controls the Innate Immune Response against <em>Listeria monocytogenes</em> via Classical IL-6 Signaling
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Includes: Supplementary data
Journal Articles

High endothelial venules at the nexus of an IL-6/gp130/STAT3 axis controlling immune surveillance during fever (173.22)

Trupti Vardam, Michelle Appenheimer, Lei Zhou, Qing Chen, Wan-Chao Wang, Matthias Ernst, Stefan Rose-John, Heinz Baumann, Sharon Evans
Journal: The Journal of Immunology
J Immunol (2012) 188 (1_Supplement): 173.22.
https://doi.org/10.4049/jimmunol.188.Supp.173.22
Published: 01 May 2012
View article titled, High endothelial venules at the nexus of an IL-6/gp130/STAT3 axis controlling immune surveillance during fever (173.22)
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Journal Articles

Trans-signaling mediates some key actions of interleukin-6 in the central nervous system (117.6)

Iain Campbell, Sue Lim, Ricardo Frausto, Stefan Rose-John, Jürgen Scheller
Journal: The Journal of Immunology
J Immunol (2011) 186 (1_Supplement): 117.6.
https://doi.org/10.4049/jimmunol.186.Supp.117.6
Published: 01 April 2011
View article titled, Trans-signaling mediates some key actions of interleukin-6 in the central nervous system (117.6)
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Journal Articles

IL-6 Trans-Signaling Modulates TLR4-Dependent Inflammatory Responses via STAT3

Claire J. Greenhill, Stefan Rose-John, Rami Lissilaa, Walter Ferlin, Matthias Ernst, Paul J. Hertzog, Ashley Mansell, Brendan J. Jenkins
Journal: The Journal of Immunology
J Immunol (2011) 186 (2): 1199–1208.
https://doi.org/10.4049/jimmunol.1002971
Published: 15 January 2011
View article titled, IL-6 <em>Trans</em>-Signaling Modulates TLR4-Dependent Inflammatory Responses via STAT3
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Journal Articles

Loss of CD4+ T Cell IL-6R Expression during Inflammation Underlines a Role for IL-6 Trans Signaling in the Local Maintenance of Th17 Cells

Gareth W. Jones, Rachel M. McLoughlin, Victoria J. Hammond, Clare R. Parker, John D. Williams, Raj Malhotra, Jürgen Scheller, Anwen S. Williams, Stefan Rose-John, Nicholas Topley, Simon A. Jones
Journal: The Journal of Immunology
J Immunol (2010) 184 (4): 2130–2139.
https://doi.org/10.4049/jimmunol.0901528
Published: 18 January 2010
View article titled, Loss of CD4<sup>+</sup> T Cell IL-6R Expression during Inflammation Underlines a Role for IL-6 <em>Trans</em> Signaling in the Local Maintenance of Th17 Cells
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Essential Roles of IL-6 Trans-Signaling in Colonic Epithelial Cells, Induced by the IL-6/Soluble–IL-6 Receptor Derived from Lamina Propria Macrophages, on the Development of Colitis-Associated Premalignant Cancer in a Murine Model

Satoshi Matsumoto, Taeko Hara, Keiichi Mitsuyama, Mayuko Yamamoto, Osamu Tsuruta, Michio Sata, Jürgen Scheller, Stefan Rose-John, Sho-ichi Kado, Toshihiko Takada
Journal: The Journal of Immunology
J Immunol (2010) 184 (3): 1543–1551.
https://doi.org/10.4049/jimmunol.0801217
Published: 30 December 2009
View article titled, Essential Roles of IL-6 <em>Trans</em>-Signaling in Colonic Epithelial Cells, Induced by the IL-6/Soluble–IL-6 Receptor Derived from Lamina Propria Macrophages, on the Development of Colitis-Associated Premalignant Cancer in a Murine Model
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G Protein-Coupled Receptor 43 Is Essential for Neutrophil Recruitment during Intestinal Inflammation

Christian Sina, Olga Gavrilova, Matti Förster, Andreas Till, Stefanie Derer, Friederike Hildebrand, Björn Raabe, Athena Chalaris, Jürgen Scheller, Ateequr Rehmann, Andre Franke, Stephan Ott, Robert Häsler, Susanna Nikolaus, Ulrich R. Fölsch, Stefan Rose-John, Hui-Ping Jiang, Jun Li, Stefan Schreiber, Philip Rosenstiel
Journal: The Journal of Immunology
J Immunol (2009) 183 (11): 7514–7522.
https://doi.org/10.4049/jimmunol.0900063
Published: 01 December 2009
View article titled, G Protein-Coupled Receptor 43 Is Essential for Neutrophil Recruitment during Intestinal Inflammation
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Includes: Supplementary data
Journal Articles

The impact of defective gp130/SOCS3 signaling on the astrocyte response to hyper-IL6 (38.17)

Ricardo F Frausto, Gareth Denyer, Jurgen Scheller, Stefan Rose-John, Brendan J Jenkins, Matthias Ernst, Iain L Campbell
Journal: The Journal of Immunology
J Immunol (2009) 182 (1_Supplement): 38.17.
https://doi.org/10.4049/jimmunol.182.Supp.38.17
Published: 01 April 2009
View article titled, The impact of defective gp130/SOCS3 signaling on the astrocyte response to hyper-IL6 (38.17)
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The role of IL-6 and IL-23 in colitis associated cancer (88.30)

Sergei Grivennikov, Daniel Mucida, Janos Terzic, Stefan Rose-John, Lars Eckmann, Hilde Cheroutre, Michael Karin
Journal: The Journal of Immunology
J Immunol (2009) 182 (1_Supplement): 88.30.
https://doi.org/10.4049/jimmunol.182.Supp.88.30
Published: 01 April 2009
View article titled, The role of IL-6 and IL-23 in colitis associated cancer (88.30)
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