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Steffen Thiel
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Journal Articles

Trypanosoma brucei Invariant Surface Glycoprotein 75 Is an Immunoglobulin Fc Receptor Inhibiting Complement Activation and Antibody-Mediated Cellular Phagocytosis

Jakob Hauge Mikkelsen, Kristian Stødkilde, Maria Pauladòttir Jensen, Annette Gudmann Hansen, Qi Wu, Josefine Lorentzen, Jonas Heilskov Graversen, Gregers Rom Andersen, Robert Andrew Fenton, Anders Etzerodt, Steffen Thiel, Christian Brix Folsted Andersen
Journal: The Journal of Immunology
J Immunol (2024) 212 (8): 1334–1344.
https://doi.org/10.4049/jimmunol.2300862
Published: 23 February 2024
View article titled, <em>Trypanosoma brucei</em> Invariant Surface Glycoprotein 75 Is an Immunoglobulin Fc Receptor Inhibiting Complement Activation and Antibody-Mediated Cellular Phagocytosis
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Includes: Supplementary data
Journal Articles

Trypanosoma brucei Invariant Surface gp65 Inhibits the Alternative Pathway of Complement by Accelerating C3b Degradation

Josefine Lorentzen, Heidi G. Olesen, Annette G. Hansen, Steffen Thiel, Svend Birkelund, Christian B. F. Andersen, Gregers R. Andersen
Journal: The Journal of Immunology
J Immunol (2023) 211 (5): 862–873.
https://doi.org/10.4049/jimmunol.2300128
Published: 19 July 2023
View article titled, <em>Trypanosoma brucei</em> Invariant Surface gp65 Inhibits the Alternative Pathway of Complement by Accelerating C3b Degradation
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Includes: Supplementary data
Journal Articles

Bispecific Complement Engagers for Targeted Complement Activation

Dennis V. Pedersen, Heidi Gytz, Mikael B. L. Winkler, Alessandra Zarantonello, Niklas Baumann, Annette G. Hansen, Steffen Thiel, Gregers R. Andersen, Thomas Valerius, Nick S. Laursen
Journal: The Journal of Immunology
J Immunol (2023) 211 (3): 403–413.
https://doi.org/10.4049/jimmunol.2200952
Published: 23 June 2023
View article titled, Bispecific Complement Engagers for Targeted Complement Activation
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Includes: Supplementary data
Journal Articles

A Complement C3–Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity

Henrik Pedersen, Rasmus K. Jensen, Jens Magnus B. Jensen, Rachel Fox, Dennis V. Pedersen, Heidi G. Olesen, Annette G. Hansen, Dorte Christiansen, Sofia M. M. Mazarakis, Neal Lojek, Pernille Hansen, Trine A. F. Gadeberg, Alessandra Zarantonello, Nick S. Laursen, Tom Eirik Mollnes, Matthew B. Johnson, Beth Stevens, Steffen Thiel, Gregers R. Andersen
Journal: The Journal of Immunology
J Immunol (2020) 205 (8): 2287–2300.
https://doi.org/10.4049/jimmunol.2000752
Published: 15 October 2020
View article titled, A Complement C3–Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity
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Includes: Supplementary data
Journal Articles

An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase

Alessandra Zarantonello, Jessy Presumey, Léa Simoni, Esra Yalcin, Rachel Fox, Annette Hansen, Heidi Gytz Olesen, Steffen Thiel, Matthew B. Johnson, Beth Stevens, Nick Stub Laursen, Michael C. Carroll, Gregers R. Andersen
Journal: The Journal of Immunology
J Immunol (2020) 205 (6): 1678–1694.
https://doi.org/10.4049/jimmunol.2000528
Published: 15 September 2020
View article titled, An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase
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Includes: Supplementary data
Journal Articles

Molecular requirements for B cell receptor engagement and activation

Alexey Ferapontov, Marjan Omer, Jesper Nielsen, Steffen Thiel, Jørgen Kjems, Søren Egedal Degn
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 217.20.
https://doi.org/10.4049/jimmunol.204.Supp.217.20
Published: 01 May 2020
View article titled, Molecular requirements for B cell receptor engagement and activation
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Journal Articles

Analysis of Factor D Isoforms in Malpuech–Michels–Mingarelli–Carnevale Patients Highlights the Role of MASP-3 as a Maturase in the Alternative Pathway of Complement

Rasmus Pihl, Lisbeth Jensen, Annette G. Hansen, Ida B. Thøgersen, Stephanie Andres, Frederik Dagnæs-Hansen, Konrad Oexle, Jan J. Enghild, Steffen Thiel
Journal: The Journal of Immunology
J Immunol (2017) 199 (6): 2158–2170.
https://doi.org/10.4049/jimmunol.1700518
Published: 15 September 2017
View article titled, Analysis of Factor D Isoforms in Malpuech–Michels–Mingarelli–Carnevale Patients Highlights the Role of MASP-3 as a Maturase in the Alternative Pathway of Complement
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Includes: Supplementary data
Journal Articles

Endogenous Natural Complement Inhibitor Regulates Cardiac Development

Simon A. Mortensen, Louise L. Skov, Kasper Kjaer-Sorensen, Annette G. Hansen, Søren Hansen, Frederik Dagnæs-Hansen, Jens C. Jensenius, Claus Oxvig, Steffen Thiel, Søren E. Degn
Journal: The Journal of Immunology
J Immunol (2017) 198 (8): 3118–3126.
https://doi.org/10.4049/jimmunol.1601958
Published: 15 April 2017
View article titled, Endogenous Natural Complement Inhibitor Regulates Cardiac Development
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Includes: Multimedia, Supplementary data
Journal Articles

Mannan-Binding Lectin–Associated Serine Protease 1/3 Cleavage of Pro–Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference–Mediated Gene Silencing

Nirmal K. Banda, Sumitra Acharya, Robert I. Scheinman, Gaurav Mehta, Marilyne Coulombe, Minoru Takahashi, Hideharu Sekine, Steffen Thiel, Teizo Fujita, V. Michael Holers
Journal: The Journal of Immunology
J Immunol (2016) 197 (9): 3680–3694.
https://doi.org/10.4049/jimmunol.1600719
Published: 01 November 2016
View article titled, Mannan-Binding Lectin–Associated Serine Protease 1/3 Cleavage of Pro–Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference–Mediated Gene Silencing
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Includes: Supplementary data
Journal Articles

Complement mannan-binding lectin associated serine proteases 1 and 3 generated by allo-liver transplantation cleave in vivo pro-Factor D generated by the adipose tissue into active Factor D

Nirmal K Banda, Sumitra Acharya, Robert I. Scheinman, Gaurav Mehta, Minoru Takahashi, Steffen Thiel, Hideharu Sekine, Teizo Fujita, V Michael Holers
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 124.30.
https://doi.org/10.4049/jimmunol.196.Supp.124.30
Published: 01 May 2016
View article titled, Complement mannan-binding lectin associated serine proteases 1 and 3 generated by allo-liver transplantation cleave in vivo pro-Factor D generated by the adipose tissue into active Factor D
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Journal Articles

Essential Role for the Lectin Pathway in Collagen Antibody–Induced Arthritis Revealed through Use of Adenovirus Programming Complement Inhibitor MAp44 Expression

Nirmal K. Banda, Gaurav Mehta, Troels R. Kjaer, Minoru Takahashi, Jerome Schaack, Thomas E. Morrison, Steffen Thiel, William P. Arend, V. Michael Holers
Journal: The Journal of Immunology
J Immunol (2014) 193 (5): 2455–2468.
https://doi.org/10.4049/jimmunol.1400752
Published: 01 September 2014
View article titled, Essential Role for the Lectin Pathway in Collagen Antibody–Induced Arthritis Revealed through Use of Adenovirus Programming Complement Inhibitor MAp44 Expression
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Includes: Supplementary data
Journal Articles

The Pro-Factor D Cleaving Activity of MASP-1/-3 Is Not Required for Alternative Pathway Function

Søren E. Degn, Jens C. Jensenius, Steffen Thiel
Journal: The Journal of Immunology
J Immunol (2014) 192 (12): 5447–5448.
https://doi.org/10.4049/jimmunol.1400777
Published: 15 June 2014
View article titled, The Pro-Factor D Cleaving Activity of MASP-1/-3 Is Not Required for Alternative Pathway Function
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Journal Articles

Co-Complexes of MASP-1 and MASP-2 Associated with the Soluble Pattern-Recognition Molecules Drive Lectin Pathway Activation in a Manner Inhibitable by MAp44

Søren E. Degn, Lisbeth Jensen, Tomasz Olszowski, Jens C. Jensenius, Steffen Thiel
Journal: The Journal of Immunology
J Immunol (2013) 191 (3): 1334–1345.
https://doi.org/10.4049/jimmunol.1300780
Published: 01 August 2013
View article titled, Co-Complexes of MASP-1 and MASP-2 Associated with the Soluble Pattern-Recognition Molecules Drive Lectin Pathway Activation in a Manner Inhibitable by MAp44
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Includes: Supplementary data
Journal Articles

Response to Comment on “Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function”

Søren E. Degn, Jens C. Jensenius, Steffen Thiel
Journal: The Journal of Immunology
J Immunol (2013) 190 (6): 2477–2478.
https://doi.org/10.4049/jimmunol.1390003
Published: 15 March 2013
View article titled, Response to Comment on “Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function”
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Journal Articles

Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function

Søren E. Degn, Lisbeth Jensen, Annette G. Hansen, Duygu Duman, Mustafa Tekin, Jens C. Jensenius, Steffen Thiel
Journal: The Journal of Immunology
J Immunol (2012) 189 (8): 3957–3969.
https://doi.org/10.4049/jimmunol.1201736
Published: 15 October 2012
View article titled, Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function
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Includes: Supplementary data
Journal Articles

Human H-Ficolin Inhibits Replication of Seasonal and Pandemic Influenza A Viruses

Anamika Verma, Mitchell White, Vinod Vathipadiekal, Shweta Tripathi, Julvet Mbianda, Micheal Ieong, Li Qi, Jeffery K. Taubenberger, Kazue Takahashi, Jens C. Jensenius, Steffen Thiel, Kevan L. Hartshorn
Journal: The Journal of Immunology
J Immunol (2012) 189 (5): 2478–2487.
https://doi.org/10.4049/jimmunol.1103786
Published: 01 September 2012
View article titled, Human H-Ficolin Inhibits Replication of Seasonal and Pandemic Influenza A Viruses
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Journal Articles

The Role of Nanometer-Scaled Ligand Patterns in Polyvalent Binding by Large Mannan-Binding Lectin Oligomers

Louise C. Gjelstrup, Jørn D. Kaspersen, Manja A. Behrens, Jan S. Pedersen, Steffen Thiel, Peter Kingshott, Cristiano L. P. Oliveira, Nicole M. Thielens, Thomas Vorup-Jensen
Journal: The Journal of Immunology
J Immunol (2012) 188 (3): 1292–1306.
https://doi.org/10.4049/jimmunol.1103012
Published: 01 February 2012
View article titled, The Role of Nanometer-Scaled Ligand Patterns in Polyvalent Binding by Large Mannan-Binding Lectin Oligomers
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Journal Articles

Shedding of Large Functionally Active CD11/CD18 Integrin Complexes from Leukocyte Membranes during Synovial Inflammation Distinguishes Three Types of Arthritis through Differential Epitope Exposure

Louise Carstensen Gjelstrup, Thomas Boesen, Tue Wenzel Kragstrup, Annette Jørgensen, Nigel J. Klein, Steffen Thiel, Bent Winding Deleuran, Thomas Vorup-Jensen
Journal: The Journal of Immunology
J Immunol (2010) 185 (7): 4154–4168.
https://doi.org/10.4049/jimmunol.1000952
Published: 01 October 2010
View article titled, Shedding of Large Functionally Active CD11/CD18 Integrin Complexes from Leukocyte Membranes during Synovial Inflammation Distinguishes Three Types of Arthritis through Differential Epitope Exposure
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Journal Articles

Mannose-binding lectin deficiency increases susceptibility to influenza A virus infection. (37.20)

Kazue Takahashi, Wei-Chuan Chang, Mitchell White, Patience Moyo, Sheree McClear, Steffen Thiel, Kevan Hartshorn
Journal: The Journal of Immunology
J Immunol (2010) 184 (1_Supplement): 37.20.
https://doi.org/10.4049/jimmunol.184.Supp.37.20
Published: 01 April 2010
View article titled, Mannose-binding lectin deficiency increases susceptibility to influenza A virus infection. (37.20)
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Journal Articles

MAp44, a Human Protein Associated with Pattern Recognition Molecules of the Complement System and Regulating the Lectin Pathway of Complement Activation

Søren E. Degn, Annette G. Hansen, Rudi Steffensen, Christian Jacobsen, Jens C. Jensenius, Steffen Thiel
Journal: The Journal of Immunology
J Immunol (2009) 183 (11): 7371–7378.
https://doi.org/10.4049/jimmunol.0902388
Published: 01 December 2009
View article titled, MAp44, a Human Protein Associated with Pattern Recognition Molecules of the Complement System and Regulating the Lectin Pathway of Complement Activation
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Includes: Supplementary data