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Steven A. Porcelli
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Journal Articles

Harnessing the Versatility of Invariant NKT Cells in a Stepwise Approach to Sepsis Immunotherapy

Joshua Choi, Tina S. Mele, Steven A. Porcelli, Paul B. Savage, S. M. Mansour Haeryfar
Journal: The Journal of Immunology
J Immunol (2021) 206 (2): 386–397.
https://doi.org/10.4049/jimmunol.2000220
Published: 15 January 2021
View article titled, Harnessing the Versatility of Invariant NKT Cells in a Stepwise Approach to Sepsis Immunotherapy
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Includes: Supplementary data
Journal Articles

Exploiting Pre-Existing CD4+ T Cell Help from Bacille Calmette–Guérin Vaccination to Improve Antiviral Antibody Responses

Tony W. Ng, Ariel S. Wirchnianski, Anna Z. Wec, J. Maximilian Fels, Christopher T. Johndrow, Kevin O. Saunders, Hua-Xin Liao, John Chan, William R. Jacobs, Jr., Kartik Chandran, Steven A. Porcelli
Journal: The Journal of Immunology
J Immunol (2020) 205 (2): 425–437.
https://doi.org/10.4049/jimmunol.2000191
Published: 15 July 2020
View article titled, Exploiting Pre-Existing CD4<sup>+</sup> T Cell Help from Bacille Calmette–Guérin Vaccination to Improve Antiviral Antibody Responses
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Includes: Supplementary data
Journal Articles

An Ebola virus vaccine that leverages helper T cells induced by prior BCG immunization

Tony W Ng, Ariel A Wirchnianski, John Chan, William R Jacobs, Jr., Kartik Chandran, Andrea Marzi, Steven A Porcelli
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 167.16.
https://doi.org/10.4049/jimmunol.204.Supp.167.16
Published: 01 May 2020
View article titled, An Ebola virus vaccine that leverages helper T cells induced by prior BCG immunization
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iNKT cell stimulation by glycolipid ligands modified from α-galactosylceramide results in differential interleukin-2 secretion profiles

Carolina E. Schafer, Álvaro Santibáñez, Matías Gutiérrez-González, Jessica Toro, Katherine Marcelain, Amy R. Howell, Steven A. Porcelli, Leandro J. Carreño
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 177.1.
https://doi.org/10.4049/jimmunol.202.Supp.177.1
Published: 01 May 2019
View article titled, iNKT cell stimulation by glycolipid ligands modified from α-galactosylceramide results in differential interleukin-2 secretion profiles
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Journal Articles

Suppression of Th1 Priming by TLR2 Agonists during Cutaneous Immunization Is Mediated by Recruited CCR2+ Monocytes

Christopher T. Johndrow, Michael F. Goldberg, Alison J. Johnson, Tony W. Ng, Shajo Kunnath-Velayudhan, Gregoire Lauvau, Daniel H. Kaplan, Graeme H. Gossel, Ulrich D. Kadolsky, Andrew J. Yates, John Chan, William R. Jacobs, Jr., Steven A. Porcelli
Journal: The Journal of Immunology
J Immunol (2018) 201 (12): 3604–3616.
https://doi.org/10.4049/jimmunol.1801185
Published: 15 December 2018
View article titled, Suppression of Th1 Priming by TLR2 Agonists during Cutaneous Immunization Is Mediated by Recruited CCR2<sup>+</sup> Monocytes
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Includes: Supplementary data
Journal Articles

Generation of IL-3 secreting T helper cells is associated with microbial challenge at barriers and IL-1 family of cytokines

Shajo Kunnath Velayudhan, Michael F. Goldberg, Neeraj Saini, Tony Ng, Christopher Johndrow, Alison Joy Johnson, Steven A. Porcelli
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 173.11.
https://doi.org/10.4049/jimmunol.200.Supp.173.11
Published: 01 May 2018
View article titled, Generation of IL-3 secreting T helper cells is associated with microbial challenge at barriers and IL-1 family of cytokines
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Journal Articles

Transcriptome Analysis of Mycobacteria-Specific CD4+ T Cells Identified by Activation-Induced Expression of CD154

Shajo Kunnath-Velayudhan, Michael F. Goldberg, Neeraj K. Saini, Christopher T. Johndrow, Tony W. Ng, Alison J. Johnson, Jiayong Xu, John Chan, William R. Jacobs, Jr., Steven A. Porcelli
Journal: The Journal of Immunology
J Immunol (2017) 199 (7): 2596–2606.
https://doi.org/10.4049/jimmunol.1700654
Published: 01 October 2017
View article titled, Transcriptome Analysis of Mycobacteria-Specific CD4<sup>+</sup> T Cells Identified by Activation-Induced Expression of CD154
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Includes: Supplementary data
Journal Articles

Cutaneous vaccination with TLR2 agonists results in the suppression of Th1 responses

Christopher T Johndrow, Michael F Goldberg, Alison J Johnson, Steven A Porcelli
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 75.3.
https://doi.org/10.4049/jimmunol.196.Supp.75.3
Published: 01 May 2016
View article titled, Cutaneous vaccination with TLR2 agonists results in the suppression of Th1 responses
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Journal Articles

Direct activation of iNKT cells by CD1d bound glycolipid antigens leads to a different kinetics of iNKT activation and expansion

Shalu Sharma Kharkwal, Himanshu Kharkwal, Christopher T Johndrow, Leandro J Carreno, Peter Jervis, Lianjun Zhang, Engyap Hui, Andras Fiser, Maurice Zauderer, Gurdyal S Besra, Alena Donda, Steven A Porcelli
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 75.21.
https://doi.org/10.4049/jimmunol.196.Supp.75.21
Published: 01 May 2016
View article titled, Direct activation of iNKT cells by CD1d bound glycolipid antigens leads to a different kinetics of iNKT activation and expansion
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Journal Articles

Identification of ribosomal targets for protective CD4+ T cell responses against mycobacteria

Alison Joy Johnson, Steven C Kennedy, Cecilia S Lindestam Arlehamn, Subray S. Hegde, John S. Blanchard, Alessandro Sette, John Chan, William R. Jacobs, Steven A. Porcelli
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 65.3.
https://doi.org/10.4049/jimmunol.196.Supp.65.3
Published: 01 May 2016
View article titled, Identification of ribosomal targets for protective CD4<sup>+</sup> T cell responses against mycobacteria
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Journal Articles

M. smegmatis vaccination reveals the mycobacterial ribosome as a potential CD4+ Tcell enhancing vaccine target

Steven C Kennedy, Alison J Johnson, Alessandro Sette, John Chan, William R Jacobs, Steven A Porcelli
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 65.10.
https://doi.org/10.4049/jimmunol.196.Supp.65.10
Published: 01 May 2016
View article titled, <em>M</em>. <em>smegmatis</em> vaccination reveals the mycobacterial ribosome as a potential CD4+ Tcell enhancing vaccine target
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Journal Articles

Colocalization of a CD1d-Binding Glycolipid with a Radiation-Attenuated Sporozoite Vaccine in Lymph Node–Resident Dendritic Cells for a Robust Adjuvant Effect

Xiangming Li, Akira Kawamura, Chasity D. Andrews, Jessica L. Miller, Douglass Wu, Tiffany Tsao, Min Zhang, Deena Oren, Neal N. Padte, Steven A. Porcelli, Chi-Huey Wong, Stefan H. I. Kappe, David D. Ho, Moriya Tsuji
Journal: The Journal of Immunology
J Immunol (2015) 195 (6): 2710–2721.
https://doi.org/10.4049/jimmunol.1403017
Published: 15 September 2015
View article titled, Colocalization of a CD1d-Binding Glycolipid with a Radiation-Attenuated Sporozoite Vaccine in Lymph Node–Resident Dendritic Cells for a Robust Adjuvant Effect
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Includes: Supplementary data
Journal Articles

A Subset of CD8αβ+ Invariant NKT Cells in a Humanized Mouse Model

Xiangshu Wen, Seil Kim, Ran Xiong, Michelle Li, Agnieszka Lawrenczyk, Xue Huang, Si-Yi Chen, Ping Rao, Gurdyal S. Besra, Paolo Dellabona, Giulia Casorati, Steven A. Porcelli, Omid Akbari, Mark A. Exley, Weiming Yuan
Journal: The Journal of Immunology
J Immunol (2015) 195 (4): 1459–1469.
https://doi.org/10.4049/jimmunol.1500574
Published: 15 August 2015
View article titled, A Subset of CD8αβ<sup>+</sup> Invariant NKT Cells in a Humanized Mouse Model
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Includes: Supplementary data
Journal Articles

A Novel Glycolipid Antigen for NKT Cells That Preferentially Induces IFN-γ Production

Alysia M. Birkholz, Enrico Girardi, Gerhard Wingender, Archana Khurana, Jing Wang, Meng Zhao, Sonja Zahner, Petr A. Illarionov, Xiangshu Wen, Michelle Li, Weiming Yuan, Steven A. Porcelli, Gurdyal S. Besra, Dirk M. Zajonc, Mitchell Kronenberg
Journal: The Journal of Immunology
J Immunol (2015) 195 (3): 924–933.
https://doi.org/10.4049/jimmunol.1500070
Published: 01 August 2015
View article titled, A Novel Glycolipid Antigen for NKT Cells That Preferentially Induces IFN-γ Production
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Includes: Supplementary data
Journal Articles

NKT TCR Recognition of CD1d-α-C-Galactosylceramide

Onisha Patel, Garth Cameron, Daniel G. Pellicci, Zheng Liu, Hoe-Sup Byun, Travis Beddoe, James McCluskey, Richard W. Franck, A. Raúl Castaño, Youssef Harrak, Amadeu Llebaria, Robert Bittman, Steven A. Porcelli, Dale I. Godfrey, Jamie Rossjohn
Journal: The Journal of Immunology
J Immunol (2011) 187 (9): 4705–4713.
https://doi.org/10.4049/jimmunol.1100794
Published: 01 November 2011
View article titled, NKT TCR Recognition of CD1d-α-<em>C</em>-Galactosylceramide
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Includes: Supplementary data
Journal Articles

A CD1d-Dependent Antagonist Inhibits the Activation of Invariant NKT Cells and Prevents Development of Allergen-Induced Airway Hyperreactivity

Vincent Lombardi, Philippe Stock, Abinav K. Singh, Jerome Kerzerho, Wen Yang, Barbara A. Sullivan, Xiangming Li, Takayuki Shiratsuchi, Nathan E. Hnatiuk, Amy R. Howell, Karl O. A. Yu, Steven A. Porcelli, Moriya Tsuji, Mitchell Kronenberg, S. Brian Wilson, Omid Akbari
Journal: The Journal of Immunology
J Immunol (2010) 184 (4): 2107–2115.
https://doi.org/10.4049/jimmunol.0901208
Published: 18 January 2010
View article titled, A CD1d-Dependent Antagonist Inhibits the Activation of Invariant NKT Cells and Prevents Development of Allergen-Induced Airway Hyperreactivity
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Journal Articles

Mechanisms for Glycolipid Antigen-Driven Cytokine Polarization by Vα14i NKT Cells

Barbara A. Sullivan, Niranjana A. Nagarajan, Gerhard Wingender, Jing Wang, Iain Scott, Moriya Tsuji, Richard W. Franck, Steven A. Porcelli, Dirk M. Zajonc, Mitchell Kronenberg
Journal: The Journal of Immunology
J Immunol (2010) 184 (1): 141–153.
https://doi.org/10.4049/jimmunol.0902880
Published: 14 December 2009
View article titled, Mechanisms for Glycolipid Antigen-Driven Cytokine Polarization by Vα14<em>i</em> NKT Cells
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Includes: Supplementary data
Journal Articles

Incorporation of NKT Cell-Activating Glycolipids Enhances Immunogenicity and Vaccine Efficacy of Mycobacterium bovis Bacillus Calmette-Guérin

Manjunatha M. Venkataswamy, Andres Baena, Michael F. Goldberg, Gabriel Bricard, Jin S. Im, John Chan, Faye Reddington, Gurdyal S. Besra, William R. Jacobs, Jr., Steven A. Porcelli
Journal: The Journal of Immunology
J Immunol (2009) 183 (3): 1644–1656.
https://doi.org/10.4049/jimmunol.0900858
Published: 01 August 2009
View article titled, Incorporation of NKT Cell-Activating Glycolipids Enhances Immunogenicity and Vaccine Efficacy of <em>Mycobacterium bovis</em> Bacillus Calmette-Guérin
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Includes: Supplementary data
Journal Articles

Enrichment of Human CD4+ Vα24/Vβ11 Invariant NKT Cells in Intrahepatic Malignant Tumors

Gabriel Bricard, Valerie Cesson, Estelle Devevre, Hanifa Bouzourene, Catherine Barbey, Nathalie Rufer, Jin S. Im, Pedro M. Alves, Olivier Martinet, Nermin Halkic, Jean-Charles Cerottini, Pedro Romero, Steven A. Porcelli, H. Robson MacDonald, Daniel E. Speiser
Journal: The Journal of Immunology
J Immunol (2009) 182 (8): 5140–5151.
https://doi.org/10.4049/jimmunol.0711086
Published: 15 April 2009
View article titled, Enrichment of Human CD4<sup>+</sup> Vα24/Vβ11 Invariant NKT Cells in Intrahepatic Malignant Tumors
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Journal Articles

Enhanced Early Expansion and Maturation of Semi-Invariant NK T Cells Inhibited Autoimmune Pathogenesis in Congenic Nonobese Diabetic Mice

Aito Ueno, Jianxiong Wang, Lu Cheng, Jin S. Im, Yan Shi, Steven A. Porcelli, Yang Yang
Journal: The Journal of Immunology
J Immunol (2008) 181 (10): 6789–6796.
https://doi.org/10.4049/jimmunol.181.10.6789
Published: 15 November 2008
View article titled, Enhanced Early Expansion and Maturation of Semi-Invariant NK T Cells Inhibited Autoimmune Pathogenesis in Congenic Nonobese Diabetic Mice
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