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Steven A. Rosenberg
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Journal Articles

Impact of Cysteine Residues on MHC Binding Predictions and Recognition by Tumor-Reactive T Cells

Abraham Sachs, Eugene Moore, Zeynep Kosaloglu-Yalcin, Bjoern Peters, John Sidney, Steven A. Rosenberg, Paul F. Robbins, Alessandro Sette
Journal: The Journal of Immunology
J Immunol (2020) 205 (2): 539–549.
https://doi.org/10.4049/jimmunol.1901173
Published: 15 July 2020
View articletitled, Impact of Cysteine Residues on MHC Binding Predictions and Recognition by Tumor-Reactive T Cells
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Includes: Supplementary data
Journal Articles

High affinity oligoclonal TCRs define effective adoptive T-cell therapy targeting mutant KRAS-G12D

Malcolm John Wyness Sim, Jinghua Lu, Matthew Spencer, Francis Hopkins, Eric Tran, Steven A Rosenberg, Eric O Long, Peter Daopin Sun
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.11.
https://doi.org/10.4049/jimmunol.204.Supp.239.11
Published: 01 May 2020
View articletitled, High affinity oligoclonal TCRs define effective adoptive T-cell therapy targeting mutant KRAS-G12D
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Journal Articles

Identification of Neoantigen-Reactive Tumor-Infiltrating Lymphocytes in Primary Bladder Cancer

Vid Leko, Lucas A. McDuffie, Zhili Zheng, Jared J. Gartner, Todd D. Prickett, Andrea B. Apolo, Piyush K. Agarwal, Steven A. Rosenberg, Yong-Chen Lu
Journal: The Journal of Immunology
J Immunol (2019) 202 (12): 3458–3467.
https://doi.org/10.4049/jimmunol.1801022
Published: 15 June 2019
View articletitled, Identification of Neoantigen-Reactive Tumor-Infiltrating Lymphocytes in Primary Bladder Cancer
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Includes: Supplementary data
Journal Articles

Substitution of alpha aminobutyric acid for cysteine at class I MHC anchor positions can enhance recognition of cancer epitopes

Abraham E Sachs, Bjoern Peters, John Sidney, Alessandro Sette, Steven A Rosenberg, Paul F Robbins
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 134.11.
https://doi.org/10.4049/jimmunol.202.Supp.134.11
Published: 01 May 2019
View articletitled, Substitution of alpha aminobutyric acid for cysteine at class I MHC anchor positions can enhance recognition of cancer epitopes
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Journal Articles

A rapid single-cell RNA-seq approach to identify neoantigen-specific T-cell receptors targeting tumor-specific mutations for use in gene-engineered T-cell immunotherapy

Yong-Chen William Lu, Zhili Zheng, Paul F Robbins, Eric Tran, Todd D Prickett, Jared J Gartner, Yong F Li, Satyajit Ray, Valery Bliskovsky, Peter C Fitzgerald, Steven A Rosenberg
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 126.14.
https://doi.org/10.4049/jimmunol.198.Supp.126.14
Published: 01 May 2017
View articletitled, A rapid single-cell RNA-seq approach to identify neoantigen-specific T-cell receptors targeting tumor-specific mutations for use in gene-engineered T-cell immunotherapy
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Journal Articles

Specific Increase in Potency via Structure-Based Design of a TCR

Karolina Malecek, Arsen Grigoryan, Shi Zhong, Wei Jun Gu, Laura A. Johnson, Steven A. Rosenberg, Timothy Cardozo, Michelle Krogsgaard
Journal: The Journal of Immunology
J Immunol (2014) 193 (5): 2587–2599.
https://doi.org/10.4049/jimmunol.1302344
Published: 01 September 2014
View articletitled, Specific Increase in Potency via Structure-Based Design of a TCR
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Includes: Supplementary data
Journal Articles

IL-2: The First Effective Immunotherapy for Human Cancer

In Special Collection:
Translating Immunology
Steven A. Rosenberg
Journal: The Journal of Immunology
J Immunol (2014) 192 (12): 5451–5458.
https://doi.org/10.4049/jimmunol.1490019
Published: 15 June 2014
View articletitled, IL-2: The First Effective Immunotherapy for Human Cancer
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Journal Articles

Structure-Based Design of Altered MHC Class II–Restricted Peptide Ligands with Heterogeneous Immunogenicity

Shuming Chen, Yili Li, Florence R. Depontieu, Tracee L. McMiller, A. Michelle English, Jeffrey Shabanowitz, Ferdynand Kos, John Sidney, Alessandro Sette, Steven A. Rosenberg, Donald F. Hunt, Roy A. Mariuzza, Suzanne L. Topalian
Journal: The Journal of Immunology
J Immunol (2013) 191 (10): 5097–5106.
https://doi.org/10.4049/jimmunol.1300467
Published: 15 November 2013
View articletitled, Structure-Based Design of Altered MHC Class II–Restricted Peptide Ligands with Heterogeneous Immunogenicity
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Journal Articles

Phenotype and Function of T Cells Infiltrating Visceral Metastases from Gastrointestinal Cancers and Melanoma: Implications for Adoptive Cell Transfer Therapy

Simon Turcotte, Alena Gros, Katherine Hogan, Eric Tran, Christian S. Hinrichs, John R. Wunderlich, Mark E. Dudley, Steven A. Rosenberg
Journal: The Journal of Immunology
J Immunol (2013) 191 (5): 2217–2225.
https://doi.org/10.4049/jimmunol.1300538
Published: 01 September 2013
View articletitled, Phenotype and Function of T Cells Infiltrating Visceral Metastases from Gastrointestinal Cancers and Melanoma: Implications for Adoptive Cell Transfer Therapy
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Includes: Supplementary data
Journal Articles

Mutated PPP1R3B Is Recognized by T Cells Used To Treat a Melanoma Patient Who Experienced a Durable Complete Tumor Regression

Yong-Chen Lu, Xin Yao, Yong F. Li, Mona El-Gamil, Mark E. Dudley, James C. Yang, Jorge R. Almeida, Daniel C. Douek, Yardena Samuels, Steven A. Rosenberg, Paul F. Robbins
Journal: The Journal of Immunology
J Immunol (2013) 190 (12): 6034–6042.
https://doi.org/10.4049/jimmunol.1202830
Published: 15 June 2013
View articletitled, Mutated PPP1R3B Is Recognized by T Cells Used To Treat a Melanoma Patient Who Experienced a Durable Complete Tumor Regression
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Includes: Supplementary data
Journal Articles

A TCR Targeting the HLA-A*0201–Restricted Epitope of MAGE-A3 Recognizes Multiple Epitopes of the MAGE-A Antigen Superfamily in Several Types of Cancer

Nachimuthu Chinnasamy, Jennifer A. Wargo, Zhiya Yu, Mahadev Rao, Timothy L. Frankel, John P. Riley, Jenny J. Hong, Maria R. Parkhurst, Steven A. Feldman, David S. Schrump, Nicholas P. Restifo, Paul F. Robbins, Steven A. Rosenberg, Richard A. Morgan
Journal: The Journal of Immunology
J Immunol (2011) 186 (2): 685–696.
https://doi.org/10.4049/jimmunol.1001775
Published: 15 January 2011
View articletitled, A TCR Targeting the HLA-A*0201–Restricted Epitope of MAGE-A3 Recognizes Multiple Epitopes of the MAGE-A Antigen Superfamily in Several Types of Cancer
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Journal Articles

Both CD4 and CD8 T Cells Mediate Equally Effective In Vivo Tumor Treatment When Engineered with a Highly Avid TCR Targeting Tyrosinase

Timothy L. Frankel, William R. Burns, Peter D. Peng, Zhiya Yu, Dhanalakshmi Chinnasamy, Jennifer A. Wargo, Zhili Zheng, Nicholas P. Restifo, Steven A. Rosenberg, Richard A. Morgan
Journal: The Journal of Immunology
J Immunol (2010) 184 (11): 5988–5998.
https://doi.org/10.4049/jimmunol.1000189
Published: 01 June 2010
View articletitled, Both CD4 and CD8 T Cells Mediate Equally Effective In Vivo Tumor Treatment When Engineered with a Highly Avid TCR Targeting Tyrosinase
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Journal Articles

A Herceptin-Based Chimeric Antigen Receptor with Modified Signaling Domains Leads to Enhanced Survival of Transduced T Lymphocytes and Antitumor Activity

Yangbing Zhao, Qiong J. Wang, Shicheng Yang, James N. Kochenderfer, Zhili Zheng, Xiaosong Zhong, Michel Sadelain, Zelig Eshhar, Steven A. Rosenberg, Richard A. Morgan
Journal: The Journal of Immunology
J Immunol (2009) 183 (9): 5563–5574.
https://doi.org/10.4049/jimmunol.0900447
Published: 01 November 2009
View articletitled, A Herceptin-Based Chimeric Antigen Receptor with Modified Signaling Domains Leads to Enhanced Survival of Transduced T Lymphocytes and Antitumor Activity
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Includes: Supplementary data
Journal Articles

Single and Dual Amino Acid Substitutions in TCR CDRs Can Enhance Antigen-Specific T Cell Functions

Paul F. Robbins, Yong F. Li, Mona El-Gamil, Yangbing Zhao, Jennifer A. Wargo, Zhili Zheng, Hui Xu, Richard A. Morgan, Steven A. Feldman, Laura A. Johnson, Alan D. Bennett, Steven M. Dunn, Tara M. Mahon, Bent K. Jakobsen, Steven A. Rosenberg
Journal: The Journal of Immunology
J Immunol (2008) 180 (9): 6116–6131.
https://doi.org/10.4049/jimmunol.180.9.6116
Published: 01 May 2008
View articletitled, Single and Dual Amino Acid Substitutions in TCR CDRs Can Enhance Antigen-Specific T Cell Functions
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Journal Articles

High-Affinity TCRs Generated by Phage Display Provide CD4+ T Cells with the Ability to Recognize and Kill Tumor Cell Lines

Yangbing Zhao, Alan D. Bennett, Zhili Zheng, Qiong J. Wang, Paul F. Robbins, Lawrence Y. L. Yu, Yi Li, Peter E. Molloy, Steven M. Dunn, Bent K. Jakobsen, Steven A. Rosenberg, Richard A. Morgan
Journal: The Journal of Immunology
J Immunol (2007) 179 (9): 5845–5854.
https://doi.org/10.4049/jimmunol.179.9.5845
Published: 01 November 2007
View articletitled, High-Affinity TCRs Generated by Phage Display Provide CD4+ T Cells with the Ability to Recognize and Kill Tumor Cell Lines
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Journal Articles

Administration of a CD25-Directed Immunotoxin, LMB-2, to Patients with Metastatic Melanoma Induces a Selective Partial Reduction in Regulatory T Cells In Vivo

Daniel J. Powell, Jr., Aloisio Felipe-Silva, Maria J. Merino, Mojgan Ahmadzadeh, Tamika Allen, Catherine Levy, Donald E. White, Sharon Mavroukakis, Robert J. Kreitman, Steven A. Rosenberg, Ira Pastan
Journal: The Journal of Immunology
J Immunol (2007) 179 (7): 4919–4928.
https://doi.org/10.4049/jimmunol.179.7.4919
Published: 01 October 2007
View articletitled, Administration of a CD25-Directed Immunotoxin, LMB-2, to Patients with Metastatic Melanoma Induces a Selective Partial Reduction in Regulatory T Cells In Vivo
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Journal Articles

Memory T cells in the tumor-infiltrating lymphocytes for adoptive cell transfer therapy (B145)

Juhua Zhou, Prakash Nagarkatti, Paul F Robbins, Steven A Rosenberg, Mitzi Nagarkatti
Journal: The Journal of Immunology
J Immunol (2007) 178 (1_Supplement): LB30.
https://doi.org/10.4049/jimmunol.178.Supp.B145
Published: 01 April 2007
View articletitled, Memory T cells in the tumor-infiltrating lymphocytes for adoptive cell transfer therapy (B145)
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Journal Articles

Adoptive Transfer of Vaccine-Induced Peripheral Blood Mononuclear Cells to Patients with Metastatic Melanoma following Lymphodepletion

Daniel J. Powell, Jr., Mark E. Dudley, Katherine A. Hogan, John R. Wunderlich, Steven A. Rosenberg
Journal: The Journal of Immunology
J Immunol (2006) 177 (9): 6527–6539.
https://doi.org/10.4049/jimmunol.177.9.6527
Published: 01 November 2006
View articletitled, Adoptive Transfer of Vaccine-Induced Peripheral Blood Mononuclear Cells to Patients with Metastatic Melanoma following Lymphodepletion
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Journal Articles

Gene Transfer of Tumor-Reactive TCR Confers Both High Avidity and Tumor Reactivity to Nonreactive Peripheral Blood Mononuclear Cells and Tumor-Infiltrating Lymphocytes

Laura A. Johnson, Bianca Heemskerk, Daniel J. Powell, Jr., Cyrille J. Cohen, Richard A. Morgan, Mark E. Dudley, Paul F. Robbins, Steven A. Rosenberg
Journal: The Journal of Immunology
J Immunol (2006) 177 (9): 6548–6559.
https://doi.org/10.4049/jimmunol.177.9.6548
Published: 01 November 2006
View articletitled, Gene Transfer of Tumor-Reactive TCR Confers Both High Avidity and Tumor Reactivity to Nonreactive Peripheral Blood Mononuclear Cells and Tumor-Infiltrating Lymphocytes
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Journal Articles

Modulation by IL-2 of CD70 and CD27 Expression on CD8+ T Cells: Importance for the Therapeutic Effectiveness of Cell Transfer Immunotherapy

Jianping Huang, Keith W. Kerstann, Mojgan Ahmadzadeh, Yong F. Li, Mona El-Gamil, Steven A. Rosenberg, Paul F. Robbins
Journal: The Journal of Immunology
J Immunol (2006) 176 (12): 7726–7735.
https://doi.org/10.4049/jimmunol.176.12.7726
Published: 15 June 2006
View articletitled, Modulation by IL-2 of CD70 and CD27 Expression on CD8+ T Cells: Importance for the Therapeutic Effectiveness of Cell Transfer Immunotherapy
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