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CD9-mediated costimulation of TCR-triggered naive T cells leads to activation followed by apoptosis.

X G Tai, K Toyooka, Y Yashiro, R Abe, C S Park, T Hamaoka, M Kobayashi, S Neben, H Fujiwara

J Immunol (1997) 159 (8): 3799–3807.

DOI: https://doi.org/10.4049/jimmunol.159.8.3799

Published: 15 October 1997

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Administration of IL-12 induces a CD3+ CD4- CD8- B220+ lymphoid population capable of eliciting cytolysis against Fas-positive tumor cells.

T Tsutsui, J Mu, M Ogawa, W G Yu, T Suda, S Nagaga, F Saji, Y Murata, H Fujiwara, T Hamaoka

J Immunol (1997) 159 (6): 2599–2605.

DOI: https://doi.org/10.4049/jimmunol.159.6.2599

Published: 15 September 1997

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A mechanism underlying synergy between IL-12 and IFN-gamma-inducing factor in enhanced production of IFN-gamma.

H J Ahn, S Maruo, M Tomura, J Mu, T Hamaoka, K Nakanishi, S Clark, M Kurimoto, H Okamura, H Fujiwara

J Immunol (1997) 159 (5): 2125–2131.

DOI: https://doi.org/10.4049/jimmunol.159.5.2125

Published: 01 September 1997

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Expression of an inducible type of nitric oxide (NO) synthase in the thymus and involvement of NO in deletion of TCR-stimulated double-positive thymocytes.

X G Tai, K Toyo-oka, N Yamamoto, Y Yashiro, J Mu, T Hamaoka, H Fujiwara

J Immunol (1997) 158 (10): 4696–4703.

DOI: https://doi.org/10.4049/jimmunol.158.10.4696

Published: 15 May 1997

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B cells regulate CD40 ligand-induced IL-12 production in antigen-presenting cells (APC) during T cell/APC interactions.

S Maruo, M Oh-hora, H J Ahn, S Ono, M Wysocka, Y Kaneko, H Yagita, K Okumura, H Kikutani, T Kishimoto, M Kobayashi, T Hamaoka, G Trinchieri, H Fujiwara

J Immunol (1997) 158 (1): 120–126.

DOI: https://doi.org/10.4049/jimmunol.158.1.120

Published: 01 January 1997

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IL-12 produced by antigen-presenting cells induces IL-2-independent proliferation of T helper cell clones.

S Maruo, K Toyo-oka, M Oh-hora, X G Tai, H Iwata, H Takenaka, S Yamada, S Ono, T Hamaoka, M Kobayashi, M Wysocka, G Trinchieri, H Fujiwara

J Immunol (1996) 156 (5): 1748–1755.

DOI: https://doi.org/10.4049/jimmunol.156.5.1748

Published: 01 March 1996

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Modulation of TCR-mediated signaling pathway by thymic shared antigen-1 (TSA-1)/stem cell antigen-2 (Sca-2).

S Saitoh, A Kosugi, S Noda, N Yamamoto, M Ogata, Y Minami, K Miyake, T Hamaoka

J Immunol (1995) 155 (12): 5574–5581.

DOI: https://doi.org/10.4049/jimmunol.155.12.5574

Published: 15 December 1995

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Developmentally regulated expression of a murine receptor-type protein tyrosine phosphatase in the thymus.

M Ogata, M Sawada, A Kosugi, T Hamaoka

J Immunol (1994) 153 (10): 4478–4487.

DOI: https://doi.org/10.4049/jimmunol.153.10.4478

Published: 15 November 1994

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Identification and characterization of IL-2 hyper-responsive NZB/WF1 CD5- B cells.

S Hirose, K Nakanishi, T Yoshimoto, S Kashiwamura, K Hiroishi, H Matsumoto, T Hamaoka, S Shinka, K Higashino

J Immunol (1994) 153 (4): 1847–1857.

DOI: https://doi.org/10.4049/jimmunol.153.4.1847

Published: 15 August 1994

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Expression of VLA-4 on thymocytes. Maturation stage-associated transition and its correlation with their capacity to adhere to thymic stromal cells.

M Sawada, J Nagamine, K Takeda, K Utsumi, A Kosugi, Y Tatsumi, T Hamaoka, K Miyake, K Nakajima, T Watanabe

J Immunol (1992) 149 (11): 3517–3524.

DOI: https://doi.org/10.4049/jimmunol.149.11.3517

Published: 01 December 1992

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Type II collagen-induced murine arthritis: induction of arthritis depends on antigen-presenting cell function as well as susceptibility of host to an anticollagen immune response.

N Seki, Y Sudo, H Mizuhara, K Orito, A Imasaki, S Ono, T Hamaoka, H Senoh, H Fujiwara

J Immunol (1992) 148 (10): 3093–3099.

DOI: https://doi.org/10.4049/jimmunol.148.10.3093

Published: 15 May 1992

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Identification of IL-7-dependent bone marrow-derived Thy-1-B220- lymphoid cell clones that rearrange and express both Ig and T cell receptor genes.

Y Takai, T Sakata, S Iwagami, X G Tai, Y Kita, T Hamaoka, N Sakaguchi, H Yamagishi, Y Tsuruta, H Teraoka

J Immunol (1992) 148 (5): 1329–1337.

DOI: https://doi.org/10.4049/jimmunol.148.5.1329

Published: 01 March 1992

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Tumor-bearing mice exhibit a progressive increase in tumor antigen-presenting cell function and a reciprocal decrease in tumor antigen-responsive CD4+ T cell activity.

J P Zou, J Shimizu, K Ikegame, N Yamamoto, S Ono, H Fujiwara, T Hamaoka

J Immunol (1992) 148 (2): 648–655.

DOI: https://doi.org/10.4049/jimmunol.148.2.648

Published: 15 January 1992

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Role of a thymic stromal cell clone in inducing the stage-specific differentiation of various subpopulations of double negative thymocytes.

J Nagamine, K Takeda, Y Tatsumi, M Ogata, K Miyake, T Hamaoka, H Fujiwara

J Immunol (1991) 147 (4): 1147–1152.

DOI: https://doi.org/10.4049/jimmunol.147.4.1147

Published: 15 August 1991

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Heterogeneity of CD4+ T cells involved in anti-allo-class I H-2 immune responses. Functional discrimination between the major proliferating cells and helper cells assisting cytotoxic T cell responses.

S Kitagawa, S Sato, T Azuma, J Shimizu, T Hamaoka, H Fujiwara

J Immunol (1991) 146 (8): 2513–2521.

DOI: https://doi.org/10.4049/jimmunol.146.8.2513

Published: 15 April 1991

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Role of glycosaminoglycans in the regulation of T cell proliferation induced by thymic stroma-derived T cell growth factor.

K Kimura, H Matsubara, S Sogoh, Y Kita, T Sakata, Y Nishitani, S Watanabe, T Hamaoka, H Fujiwara

J Immunol (1991) 146 (8): 2618–2624.

DOI: https://doi.org/10.4049/jimmunol.146.8.2618

Published: 15 April 1991

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Evidence for the functional binding in vivo of tumor rejection antigens to antigen-presenting cells in tumor-bearing hosts.

J Shimizu, J P Zou, K Ikegame, T Katagiri, H Fujiwara, T Hamaoka

J Immunol (1991) 146 (5): 1708–1714.

DOI: https://doi.org/10.4049/jimmunol.146.5.1708

Published: 01 March 1991

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Transforming growth factor-beta-induced inhibition of T cell function. Susceptibility difference in T cells of various phenotypes and functions and its relevance to immunosuppression in the tumor-bearing state.

T Tada, S Ohzeki, K Utsumi, H Takiuchi, M Muramatsu, X F Li, J Shimizu, H Fujiwara, T Hamaoka

J Immunol (1991) 146 (3): 1077–1082.

DOI: https://doi.org/10.4049/jimmunol.146.3.1077

Published: 01 February 1991

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Lymphokine-regulated differential expression of mRNA for p75kDa-IL-2R and p55kDa-IL-2R in a cloned B lymphoma line (BLC1-CL-3 cells).

K Nakanishi, K Matsui, S Hirose, T Yoshimoto, K Hiroishi, T Kono, T Hada, T Hamaoka, K Higashino

J Immunol (1990) 145 (5): 1423–1429.

DOI: https://doi.org/10.4049/jimmunol.145.5.1423

Published: 01 September 1990

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Enhanced production of IL-6 in tumor-bearing mice and determination of cells responsible for its augmented production.

K Utsumi, Y Takai, T Tada, S Ohzeki, H Fujiwara, T Hamaoka

J Immunol (1990) 145 (1): 397–403.

DOI: https://doi.org/10.4049/jimmunol.145.1.397

Published: 01 July 1990

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2 3 4

NARROW

CD9-mediated costimulation of TCR-triggered naive T cells leads to activation followed by apoptosis.

Administration of IL-12 induces a CD3+ CD4- CD8- B220+ lymphoid population capable of eliciting cytolysis against Fas-positive tumor cells.

A mechanism underlying synergy between IL-12 and IFN-gamma-inducing factor in enhanced production of IFN-gamma.

Expression of an inducible type of nitric oxide (NO) synthase in the thymus and involvement of NO in deletion of TCR-stimulated double-positive thymocytes.

B cells regulate CD40 ligand-induced IL-12 production in antigen-presenting cells (APC) during T cell/APC interactions.

IL-12 produced by antigen-presenting cells induces IL-2-independent proliferation of T helper cell clones.

Modulation of TCR-mediated signaling pathway by thymic shared antigen-1 (TSA-1)/stem cell antigen-2 (Sca-2).

Developmentally regulated expression of a murine receptor-type protein tyrosine phosphatase in the thymus.

Identification and characterization of IL-2 hyper-responsive NZB/WF1 CD5- B cells.

Expression of VLA-4 on thymocytes. Maturation stage-associated transition and its correlation with their capacity to adhere to thymic stromal cells.

Type II collagen-induced murine arthritis: induction of arthritis depends on antigen-presenting cell function as well as susceptibility of host to an anticollagen immune response.

Identification of IL-7-dependent bone marrow-derived Thy-1-B220- lymphoid cell clones that rearrange and express both Ig and T cell receptor genes.

Tumor-bearing mice exhibit a progressive increase in tumor antigen-presenting cell function and a reciprocal decrease in tumor antigen-responsive CD4+ T cell activity.

Role of a thymic stromal cell clone in inducing the stage-specific differentiation of various subpopulations of double negative thymocytes.

Heterogeneity of CD4+ T cells involved in anti-allo-class I H-2 immune responses. Functional discrimination between the major proliferating cells and helper cells assisting cytotoxic T cell responses.

Role of glycosaminoglycans in the regulation of T cell proliferation induced by thymic stroma-derived T cell growth factor.

Evidence for the functional binding in vivo of tumor rejection antigens to antigen-presenting cells in tumor-bearing hosts.

Transforming growth factor-beta-induced inhibition of T cell function. Susceptibility difference in T cells of various phenotypes and functions and its relevance to immunosuppression in the tumor-bearing state.

Lymphokine-regulated differential expression of mRNA for p75kDa-IL-2R and p55kDa-IL-2R in a cloned B lymphoma line (BLC1-CL-3 cells).

Enhanced production of IL-6 in tumor-bearing mice and determination of cells responsible for its augmented production.

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