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Journal Articles

Transcriptional regulation of the junB gene in B lymphocytes: role of protein kinase A and a membrane Ig-regulated protein phosphatase.

S F Amato, K Nakajima, T Hirano, T C Chiles
Journal: The Journal of Immunology
J Immunol (1997) 159 (10): 4676–4685.
https://doi.org/10.4049/jimmunol.159.10.4676
Published: 15 November 1997
View articletitled, Transcriptional regulation of the junB gene in B lymphocytes: role of protein kinase A and a membrane Ig-regulated protein phosphatase.
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Journal Articles

Transcriptional regulation of the junB promoter in mature B lymphocytes. Activation through a cyclic adenosine 3',5'-monophosphate-like binding site.

S F Amato, K Nakajima, T Hirano, T C Chiles
Journal: The Journal of Immunology
J Immunol (1996) 157 (1): 146–155.
https://doi.org/10.4049/jimmunol.157.1.146
Published: 01 July 1996
View articletitled, Transcriptional regulation of the junB promoter in mature B lymphocytes. Activation through a cyclic adenosine 3',5'-monophosphate-like binding site.
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Journal Articles

Activation of B lymphocyte maturation by a human follicular dendritic cell line, FDC-1.

E A Clark, K H Grabstein, A M Gown, M Skelly, T Kaisho, T Hirano, G L Shu
Journal: The Journal of Immunology
J Immunol (1995) 155 (2): 545–555.
https://doi.org/10.4049/jimmunol.155.2.545
Published: 15 July 1995
View articletitled, Activation of B lymphocyte maturation by a human follicular dendritic cell line, FDC-1.
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Journal Articles

Anti-IL-4 antibody prevents graft-versus-host disease in mice after bone marrow transplantation. The IgE allotype is an important marker of graft-versus-host disease.

C Ushiyama, T Hirano, H Miyajima, K Okumura, Z Ovary, H Hashimoto
Journal: The Journal of Immunology
J Immunol (1995) 154 (6): 2687–2696.
https://doi.org/10.4049/jimmunol.154.6.2687
Published: 15 March 1995
View articletitled, Anti-IL-4 antibody prevents graft-versus-host disease in mice after bone marrow transplantation. The IgE allotype is an important marker of graft-versus-host disease.
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Journal Articles

E1A repression of IL-6-induced gene activation by blocking the assembly of IL-6 response element binding complexes.

T Takeda, K Nakajima, H Kojima, T Hirano
Journal: The Journal of Immunology
J Immunol (1994) 153 (10): 4573–4582.
https://doi.org/10.4049/jimmunol.153.10.4573
Published: 15 November 1994
View articletitled, E1A repression of IL-6-induced gene activation by blocking the assembly of IL-6 response element binding complexes.
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Journal Articles

Human bone marrow stromal cell lines from myeloma and rheumatoid arthritis that can support murine pre-B cell growth.

T Kaisho, K Oritani, J Ishikawa, M Tanabe, O Muraoka, T Ochi, T Hirano
Journal: The Journal of Immunology
J Immunol (1992) 149 (12): 4088–4095.
https://doi.org/10.4049/jimmunol.149.12.4088
Published: 15 December 1992
View articletitled, Human bone marrow stromal cell lines from myeloma and rheumatoid arthritis that can support murine pre-B cell growth.
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Journal Articles

Retinoic acid-induced growth inhibition of a human myeloma cell line via down-regulation of IL-6 receptors.

N Sidell, T Taga, T Hirano, T Kishimoto, A Saxon
Journal: The Journal of Immunology
J Immunol (1991) 146 (11): 3809–3814.
https://doi.org/10.4049/jimmunol.146.11.3809
Published: 01 June 1991
View articletitled, Retinoic acid-induced growth inhibition of a human myeloma cell line via down-regulation of IL-6 receptors.
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Journal Articles

Cytokine regulation of localized inflammation. Induction of activated B cells and IL-6-mediated polyclonal IgG and IgA synthesis in inflamed human gingiva.

Y Kono, K W Beagley, K Fujihashi, J R McGhee, T Taga, T Hirano, T Kishimoto, H Kiyono
Journal: The Journal of Immunology
J Immunol (1991) 146 (6): 1812–1821.
https://doi.org/10.4049/jimmunol.146.6.1812
Published: 15 March 1991
View articletitled, Cytokine regulation of localized inflammation. Induction of activated B cells and IL-6-mediated polyclonal IgG and IgA synthesis in inflamed human gingiva.
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Journal Articles

Suppression by IL-2 of IgE production by B cells stimulated by IL-4.

H Miyajima, T Hirano, S Hirose, H Karasuyama, K Okumura, Z Ovary
Journal: The Journal of Immunology
J Immunol (1991) 146 (2): 457–462.
https://doi.org/10.4049/jimmunol.146.2.457
Published: 15 January 1991
View articletitled, Suppression by IL-2 of IgE production by B cells stimulated by IL-4.
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Journal Articles

Quantitative analysis of serum IL-6 and its correlation with increased levels of serum IL-2R in HIV-induced diseases.

M Honda, K Kitamura, Y Mizutani, M Oishi, M Arai, T Okura, K Igarahi, K Yasukawa, T Hirano, T Kishimoto
Journal: The Journal of Immunology
J Immunol (1990) 145 (12): 4059–4064.
https://doi.org/10.4049/jimmunol.145.12.4059
Published: 15 December 1990
View articletitled, Quantitative analysis of serum IL-6 and its correlation with increased levels of serum IL-2R in HIV-induced diseases.
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Journal Articles

IL-6 is produced by osteoblasts and induces bone resorption.

Y Ishimi, C Miyaura, C H Jin, T Akatsu, E Abe, Y Nakamura, A Yamaguchi, S Yoshiki, T Matsuda, T Hirano
Journal: The Journal of Immunology
J Immunol (1990) 145 (10): 3297–3303.
https://doi.org/10.4049/jimmunol.145.10.3297
Published: 15 November 1990
View articletitled, IL-6 is produced by osteoblasts and induces bone resorption.
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Journal Articles

Infection with HIV is associated with elevated IL-6 levels and production.

E C Breen, A R Rezai, K Nakajima, G N Beall, R T Mitsuyasu, T Hirano, T Kishimoto, O Martinez-Maza
Journal: The Journal of Immunology
J Immunol (1990) 144 (2): 480–484.
https://doi.org/10.4049/jimmunol.144.2.480
Published: 15 January 1990
View articletitled, Infection with HIV is associated with elevated IL-6 levels and production.
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Journal Articles

Characterization of IL-6 receptor expression by monoclonal and polyclonal antibodies.

Y Hirata, T Taga, M Hibi, N Nakano, T Hirano, T Kishimoto
Journal: The Journal of Immunology
J Immunol (1989) 143 (9): 2900–2906.
https://doi.org/10.4049/jimmunol.143.9.2900
Published: 01 November 1989
View articletitled, Characterization of IL-6 receptor expression by monoclonal and polyclonal antibodies.
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Journal Articles

Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV.

K Nakajima, O Martínez-Maza, T Hirano, E C Breen, P G Nishanian, J F Salazar-Gonzalez, J L Fahey, T Kishimoto
Journal: The Journal of Immunology
J Immunol (1989) 142 (2): 531–536.
https://doi.org/10.4049/jimmunol.142.2.531
Published: 15 January 1989
View articletitled, Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV.
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Journal Articles

Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells.

F R Jirik, T J Podor, T Hirano, T Kishimoto, D J Loskutoff, D A Carson, M Lotz
Journal: The Journal of Immunology
J Immunol (1989) 142 (1): 144–147.
https://doi.org/10.4049/jimmunol.142.1.144
Published: 01 January 1989
View articletitled, Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells.
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Journal Articles

Identification of alpha 2-macroglobulin as a carrier protein for IL-6.

T Matsuda, T Hirano, S Nagasawa, T Kishimoto
Journal: The Journal of Immunology
J Immunol (1989) 142 (1): 148–152.
https://doi.org/10.4049/jimmunol.142.1.148
Published: 01 January 1989
View articletitled, Identification of alpha 2-macroglobulin as a carrier protein for IL-6.
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Journal Articles

Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human.

O Tanabe, S Akira, T Kamiya, G G Wong, T Hirano, T Kishimoto
Journal: The Journal of Immunology
J Immunol (1988) 141 (11): 3875–3881.
https://doi.org/10.4049/jimmunol.141.11.3875
Published: 01 December 1988
View articletitled, Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human.
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Journal Articles

Human recombinant IL-6/B cell stimulatory factor 2 augments murine antigen-specific antibody responses in vitro and in vivo.

F Takatsuki, A Okano, C Suzuki, R Chieda, Y Takahara, T Hirano, T Kishimoto, J Hamuro, Y Akiyama
Journal: The Journal of Immunology
J Immunol (1988) 141 (9): 3072–3077.
https://doi.org/10.4049/jimmunol.141.9.3072
Published: 01 November 1988
View articletitled, Human recombinant IL-6/B cell stimulatory factor 2 augments murine antigen-specific antibody responses in vitro and in vivo.
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Journal Articles

IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells.

M Okada, M Kitahara, S Kishimoto, T Matsuda, T Hirano, T Kishimoto
Journal: The Journal of Immunology
J Immunol (1988) 141 (5): 1543–1549.
https://doi.org/10.4049/jimmunol.141.5.1543
Published: 01 September 1988
View articletitled, IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells.
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Journal Articles

Regulation of BSF-2/IL-6 production by human mononuclear cells. Macrophage-dependent synthesis of BSF-2/IL-6 by T cells.

Y Horii, A Muraguchi, S Suematsu, T Matsuda, K Yoshizaki, T Hirano, T Kishimoto
Journal: The Journal of Immunology
J Immunol (1988) 141 (5): 1529–1535.
https://doi.org/10.4049/jimmunol.141.5.1529
Published: 01 September 1988
View articletitled, Regulation of BSF-2/IL-6 production by human mononuclear cells. Macrophage-dependent synthesis of BSF-2/IL-6 by T cells.
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