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Takachika Hiroi
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Journal Articles

Murine Th9 cell-mediated allergic inflammation shows different steroid responsiveness depending on target organs

Kento Miura, Teidai Koyama, Norimasa Yamasaki, Sawako Ogata, Mayumi Saeki, Takachika Hiroi, Akio Mori, Osamu Kaminuma
Journal: The Journal of Immunology
J Immunol (2021) 206 (1_Supplement): 23.03.
DOI: https://doi.org/10.4049/jimmunol.206.Supp.23.03
Published: 01 May 2021
View article titled, Murine Th9 cell-mediated allergic inflammation shows different steroid responsiveness depending on target organs
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Journal Articles

L-type amino acid transporter 1 is essential for Th2 cell-mediated allergic inflammation

Osamu Kaminuma, Kento Miura, Norimasa Yamasaki, Sawako Ogata, Mayumi Saeki, Takachika Hiroi, Yohei Iwata, Kazumitsu Sugiura, Akio Mori, Hitoshi Endou, Keitaro Hayashi
Journal: The Journal of Immunology
J Immunol (2021) 206 (1_Supplement): 23.01.
DOI: https://doi.org/10.4049/jimmunol.206.Supp.23.01
Published: 01 May 2021
View article titled, L-type amino acid transporter 1 is essential for Th2 cell-mediated allergic inflammation
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Downregulation of NFAT3 Due to Lack of T-Box Transcription Factor TBX5 Is Crucial for Cytokine Expression in T Cells

Osamu Kaminuma, Noriko Kitamura, Yasumasa Nishito, Soichi Nemoto, Hideki Tatsumi, Akio Mori, Takachika Hiroi
Journal: The Journal of Immunology
J Immunol (2018) 200 (1): 92–100.
DOI: https://doi.org/10.4049/jimmunol.1602113
Published: 01 January 2018
View article titled, Downregulation of NFAT3 Due to Lack of T-Box Transcription Factor TBX5 Is Crucial for Cytokine Expression in T Cells
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Includes: Supplementary data
Journal Articles

Identification of signaling molecules responsible for IL-2-mediated cytokine expression in human T cells (P6343)

Osamu Kaminuma, Noriko Kitamura, Akio Mori, Takachika Hiroi
Journal: The Journal of Immunology
J Immunol (2013) 190 (1_Supplement): 184.33.
DOI: https://doi.org/10.4049/jimmunol.190.Supp.184.33
Published: 01 May 2013
View article titled, Identification of signaling molecules responsible for IL-2-mediated cytokine expression in human T cells (P6343)
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Journal Articles

Differential Contribution of NFATc2 and NFATc1 to TNF-α Gene Expression in T Cells

Osamu Kaminuma, Fujiko Kitamura, Noriko Kitamura, Takachika Hiroi, Hiroyuki Miyoshi, Atsushi Miyawaki, Shoichiro Miyatake
Journal: The Journal of Immunology
J Immunol (2008) 180 (1): 319–326.
DOI: https://doi.org/10.4049/jimmunol.180.1.319
Published: 01 January 2008
View article titled, Differential Contribution of NFATc2 and NFATc1 to TNF-α Gene Expression in T Cells
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Development of needle-free vaccine: rice-based oral vaccine induced protective immunity against cholera toxin (41.4)

Tomonori Nochi, Yoshikazu Yuki, Hidenori Takagi, Lijun Yang, Takehiro Masumura, Mio Mejima, Ushio Nakanishi, Akiko Matsumura, Takachika Hiroi, Shigeto Morita, Kunisuke Tanaka, Fumio Takaiwa, Hiroshi Kiyono
Journal: The Journal of Immunology
J Immunol (2007) 178 (1_Supplement): S30.
DOI: https://doi.org/10.4049/jimmunol.178.Supp.41.4
Published: 01 April 2007
View article titled, Development of needle-free vaccine: rice-based oral vaccine induced protective immunity against cholera toxin (41.4)
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Journal Articles

CCR7 Is Critically Important for Migration of Dendritic Cells in Intestinal Lamina Propria to Mesenteric Lymph Nodes

Myoung Ho Jang, Nagako Sougawa, Toshiyuki Tanaka, Takako Hirata, Takachika Hiroi, Kazuo Tohya, Zijin Guo, Eiji Umemoto, Yukihiko Ebisuno, Bo-Gie Yang, Ju-Young Seoh, Martin Lipp, Hiroshi Kiyono, Masayuki Miyasaka
Journal: The Journal of Immunology
J Immunol (2006) 176 (2): 803–810.
DOI: https://doi.org/10.4049/jimmunol.176.2.803
Published: 15 January 2006
View article titled, CCR7 Is Critically Important for Migration of Dendritic Cells in Intestinal Lamina Propria to Mesenteric Lymph Nodes
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Includes: Supplementary data
Journal Articles

Prenatal Blockage of Lymphotoxin β Receptor and TNF Receptor p55 Signaling Cascade Resulted in the Acceleration of Tissue Genesis for Isolated Lymphoid Follicles in the Large Intestine

Mi-Na Kweon, Masafumi Yamamoto, Paul D. Rennert, Eun Jeong Park, Ah-Young Lee, Sun-Young Chang, Takachika Hiroi, Masanobu Nanno, Hiroshi Kiyono
Journal: The Journal of Immunology
J Immunol (2005) 174 (7): 4365–4372.
DOI: https://doi.org/10.4049/jimmunol.174.7.4365
Published: 01 April 2005
View article titled, Prenatal Blockage of Lymphotoxin β Receptor and TNF Receptor p55 Signaling Cascade Resulted in the Acceleration of Tissue Genesis for Isolated Lymphoid Follicles in the Large Intestine
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Journal Articles

Intracellularly Expressed TLR2s and TLR4s Contribution to an Immunosilent Environment at the Ocular Mucosal Epithelium

Mayumi Ueta, Tomonori Nochi, Myoung-Ho Jang, Eun Jeong Park, Osamu Igarashi, Ayako Hino, Satoshi Kawasaki, Takashi Shikina, Takachika Hiroi, Shigeru Kinoshita, Hiroshi Kiyono
Journal: The Journal of Immunology
J Immunol (2004) 173 (5): 3337–3347.
DOI: https://doi.org/10.4049/jimmunol.173.5.3337
Published: 01 September 2004
View article titled, Intracellularly Expressed TLR2s and TLR4s Contribution to an Immunosilent Environment at the Ocular Mucosal Epithelium
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Journal Articles

Role of Gut-Associated Lymphoreticular Tissues in Antigen-Specific Intestinal IgA Immunity

Masafumi Yamamoto, Mi-Na Kweon, Paul D. Rennert, Takachika Hiroi, Kohtaro Fujihashi, Jerry R. McGhee, Hiroshi Kiyono
Journal: The Journal of Immunology
J Immunol (2004) 173 (2): 762–769.
DOI: https://doi.org/10.4049/jimmunol.173.2.762
Published: 15 July 2004
View article titled, Role of Gut-Associated Lymphoreticular Tissues in Antigen-Specific Intestinal IgA Immunity
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Journal Articles

IgA Class Switch Occurs in the Organized Nasopharynx- and Gut-Associated Lymphoid Tissue, but Not in the Diffuse Lamina Propria of Airways and Gut

Takashi Shikina, Takachika Hiroi, Kohichi Iwatani, Myoung Ho Jang, Satoshi Fukuyama, Manabu Tamura, Takeshi Kubo, Hiromichi Ishikawa, Hiroshi Kiyono
Journal: The Journal of Immunology
J Immunol (2004) 172 (10): 6259–6264.
DOI: https://doi.org/10.4049/jimmunol.172.10.6259
Published: 15 May 2004
View article titled, IgA Class Switch Occurs in the Organized Nasopharynx- and Gut-Associated Lymphoid Tissue, but Not in the Diffuse Lamina Propria of Airways and Gut
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Journal Articles

HIV Mucosal Vaccine: Nasal Immunization with gp160-Encapsulated Hemagglutinating Virus of Japan-Liposome Induces Antigen-Specific CTLs and Neutralizing Antibody Responses

Gaku Sakaue, Takachika Hiroi, Yoko Nakagawa, Kenji Someya, Kohich Iwatani, Yoshiki Sawa, Hidemi Takahashi, Mitsuo Honda, Jun Kunisawa, Hiroshi Kiyono
Journal: The Journal of Immunology
J Immunol (2003) 170 (1): 495–502.
DOI: https://doi.org/10.4049/jimmunol.170.1.495
Published: 01 January 2003
View article titled, HIV Mucosal Vaccine: Nasal Immunization with gp160-Encapsulated Hemagglutinating Virus of Japan-Liposome Induces Antigen-Specific CTLs and Neutralizing Antibody Responses
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Journal Articles

Autocrine IL-15 Mediates Intestinal Epithelial Cell Death Via the Activation of Neighboring Intraepithelial NK Cells

Naotoshi Kinoshita, Takachika Hiroi, Noriyuki Ohta, Satoshi Fukuyama, Eun Jeong Park, Hiroshi Kiyono
Journal: The Journal of Immunology
J Immunol (2002) 169 (11): 6187–6192.
DOI: https://doi.org/10.4049/jimmunol.169.11.6187
Published: 01 December 2002
View article titled, Autocrine IL-15 Mediates Intestinal Epithelial Cell Death Via the Activation of Neighboring Intraepithelial NK Cells
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Journal Articles

IL-15-Dependent Activation-Induced Cell Death-Resistant Th1 Type CD8αβ+NK1.1+ T Cells for the Development of Small Intestinal Inflammation

Noriyuki Ohta, Takachika Hiroi, Mi-Na Kweon, Naotoshi Kinoshita, Myoung Ho Jang, Tadashi Mashimo, Jun-Ichi Miyazaki, Hiroshi Kiyono
Journal: The Journal of Immunology
J Immunol (2002) 169 (1): 460–468.
DOI: https://doi.org/10.4049/jimmunol.169.1.460
Published: 01 July 2002
View article titled, IL-15-Dependent Activation-Induced Cell Death-Resistant Th1 Type CD8αβ<sup>+</sup>NK1.1<sup>+</sup> T Cells for the Development of Small Intestinal Inflammation
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Journal Articles

Identification of Multiple Isolated Lymphoid Follicles on the Antimesenteric Wall of the Mouse Small Intestine

Hiromasa Hamada, Takachika Hiroi, Yasuhiro Nishiyama, Hidemi Takahashi, Yohei Masunaga, Satoshi Hachimura, Shuichi Kaminogawa, Hiromi Takahashi-Iwanaga, Toshihiko Iwanaga, Hiroshi Kiyono, Hiroshi Yamamoto, Hiromichi Ishikawa
Journal: The Journal of Immunology
J Immunol (2002) 168 (1): 57–64.
DOI: https://doi.org/10.4049/jimmunol.168.1.57
Published: 01 January 2002
View article titled, Identification of Multiple Isolated Lymphoid Follicles on the Antimesenteric Wall of the Mouse Small Intestine
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Journal Articles

HIV Mucosal Vaccine: Nasal Immunization with rBCG-V3J1 Induces a Long Term V3J1 Peptide-Specific Neutralizing Immunity in Th1- and Th2-Deficient Conditions

Takachika Hiroi, Hironobu Goto, Kenji Someya, Manabu Yanagita, Mitsuo Honda, Noboru Yamanaka, Hiroshi Kiyono
Journal: The Journal of Immunology
J Immunol (2001) 167 (10): 5862–5867.
DOI: https://doi.org/10.4049/jimmunol.167.10.5862
Published: 15 November 2001
View article titled, HIV Mucosal Vaccine: Nasal Immunization with rBCG-V3J1 Induces a Long Term V3J1 Peptide-Specific Neutralizing Immunity in Th1- and Th2-Deficient Conditions
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Journal Articles

IL-15 and IL-15 Receptor Selectively Regulate Differentiation of Common Mucosal Immune System-Independent B-1 Cells for IgA Responses

Takachika Hiroi, Manabu Yanagita, Noriyuki Ohta, Gaku Sakaue, Hiroshi Kiyono
Journal: The Journal of Immunology
J Immunol (2000) 165 (8): 4329–4337.
DOI: https://doi.org/10.4049/jimmunol.165.8.4329
Published: 15 October 2000
View article titled, IL-15 and IL-15 Receptor Selectively Regulate Differentiation of Common Mucosal Immune System-Independent B-1 Cells for IgA Responses
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Nasopharyngeal-Associated Lymphoreticular Tissue (NALT) Immunity: Fimbriae-Specific Th1 and Th2 Cell-Regulated IgA Responses for the Inhibition of Bacterial Attachment to Epithelial Cells and Subsequent Inflammatory Cytokine Production

Manabu Yanagita, Takachika Hiroi, Noriko Kitagaki, Shigeyuki Hamada, Hiro-o Ito, Hidetoshi Shimauchi, Shinya Murakami, Hiroshi Okada, Hiroshi Kiyono
Journal: The Journal of Immunology
J Immunol (1999) 162 (6): 3559–3565.
DOI: https://doi.org/10.4049/jimmunol.162.6.3559
Published: 15 March 1999
View article titled, Nasopharyngeal-Associated Lymphoreticular Tissue (NALT) Immunity: Fimbriae-Specific Th1 and Th2 Cell-Regulated IgA Responses for the Inhibition of Bacterial Attachment to Epithelial Cells and Subsequent Inflammatory Cytokine Production
Click here to open pdf in another window PDF for Nasopharyngeal-Associated Lymphoreticular Tissue (NALT) Immunity: Fimbriae-Specific Th1 and Th2 Cell-Regulated IgA Responses for the Inhibition of Bacterial Attachment to Epithelial Cells and Subsequent Inflammatory Cytokine Production
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Journal Articles

Deficiency of IL-5 Receptor α-Chain Selectively Influences the Development of the Common Mucosal Immune System Independent IgA-Producing B-1 Cell in Mucosa-Associated Tissues

Takachika Hiroi, Manabu Yanagita, Hideki Iijima, Kouichi Iwatani, Toshimi Yoshida, Kiyoshi Takatsu, Hiroshi Kiyono
Journal: The Journal of Immunology
J Immunol (1999) 162 (2): 821–828.
DOI: https://doi.org/10.4049/jimmunol.162.2.821
Published: 15 January 1999
View article titled, Deficiency of IL-5 Receptor α-Chain Selectively Influences the Development of the Common Mucosal Immune System Independent IgA-Producing B-1 Cell in Mucosa-Associated Tissues
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Deletion of Bone Marrow Stromal Cell Antigen-1 (CD157) Gene Impaired Systemic Thymus Independent-2 Antigen-Induced IgG3 and Mucosal TD Antigen-Elicited IgA Responses

Motoyuki Itoh, Katsuhiko Ishihara, Takachika Hiroi, Byung Ok Lee, Hisoka Maeda, Hideki Iijima, Manabu Yanagita, Hiroshi Kiyono, Toshio Hirano
Journal: The Journal of Immunology
J Immunol (1998) 161 (8): 3974–3983.
DOI: https://doi.org/10.4049/jimmunol.161.8.3974
Published: 15 October 1998
View article titled, Deletion of Bone Marrow Stromal Cell Antigen-1 (CD157) Gene Impaired Systemic Thymus Independent-2 Antigen-Induced IgG3 and Mucosal TD Antigen-Elicited IgA Responses
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