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Theo Rispens
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Journal Articles

Cross-Reactivity of Antibodies to Rituximab with Other Therapeutic Anti-CD20 Antibodies

Theo Rispens, Taco W. Kuijpers, Joep Killestein, Zoé L. E. van Kempen, Karien Bloem
Journal: The Journal of Immunology
J Immunol (2024) 212 (4): 529–533.
https://doi.org/10.4049/jimmunol.2300647
Published: 27 December 2023
View article titled, Cross-Reactivity of Antibodies to Rituximab with Other Therapeutic Anti-CD20 Antibodies
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Includes: Supplementary data
Journal Articles

The Influence of Human IgG Subclass and Allotype on Complement Activation

Timon Damelang, Steven W. de Taeye, Rosa Rentenaar, Kasra Roya-Kouchaki, Esther de Boer, Ninotska I. L. Derksen, Kok van Kessel, Suzanne Lissenberg-Thunnissen, Suzan H. M. Rooijakkers, Ilse Jongerius, Mirjam M. Mebius, Janine Schuurman, Aran F. Labrijn, Gestur Vidarsson, Theo Rispens
Journal: The Journal of Immunology
J Immunol (2023) 211 (11): 1725–1735.
https://doi.org/10.4049/jimmunol.2300307
Published: 16 October 2023
View article titled, The Influence of Human IgG Subclass and Allotype on Complement Activation
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Includes: Supplementary data
Journal Articles

At Critically Low Antigen Densities, IgM Hexamers Outcompete Both IgM Pentamers and IgG1 for Human Complement Deposition and Complement-Dependent Cytotoxicity

Nienke Oskam, Pleuni Ooijevaar-de Heer, Ninotska I. L. Derksen, Simone Kruithof, Steven W. de Taeye, Gestur Vidarsson, Sanne Reijm, Theresa Kissel, René E. M. Toes, Theo Rispens
Journal: The Journal of Immunology
J Immunol (2022) 209 (1): 16–25.
https://doi.org/10.4049/jimmunol.2101196
Published: 01 July 2022
View article titled, At Critically Low Antigen Densities, IgM Hexamers Outcompete Both IgM Pentamers and IgG1 for Human Complement Deposition and Complement-Dependent Cytotoxicity
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Includes: Supplementary data
Journal Articles

Fc Galactosylation Promotes Hexamerization of Human IgG1, Leading to Enhanced Classical Complement Activation

Thijs L. J. van Osch, Jan Nouta, Ninotska I. L. Derksen, Gerard van Mierlo, C. Ellen van der Schoot, Manfred Wuhrer, Theo Rispens, Gestur Vidarsson
Journal: The Journal of Immunology
J Immunol (2021) 207 (6): 1545–1554.
https://doi.org/10.4049/jimmunol.2100399
Published: 15 September 2021
View article titled, Fc Galactosylation Promotes Hexamerization of Human IgG1, Leading to Enhanced Classical Complement Activation
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Includes: Supplementary data
Journal Articles

Development of a SARS-CoV-2 Total Antibody Assay and the Dynamics of Antibody Response over Time in Hospitalized and Nonhospitalized Patients with COVID-19

In Special Collection:
COVID-19, SARS, and MERS Articles
Erik H. Vogelzang, Floris C. Loeff, Ninotska I. L. Derksen, Simone Kruithof, Pleuni Ooijevaar-de Heer, Gerard van Mierlo, Federica Linty, Juk Yee Mok, Wim van Esch, Sanne de Bruin, Alexander P. J. Vlaar, Amsterdam University Medical Center COVID-19 Biobank Study Group, Robert Hemke, Diederik van de Beek, Martijn Beudel, Matthijs C. Brouwer, Bart Geerts, Markus Hollmann, Bennedikt Preckel, Denise Veelo, A. H. (Koos) Zwinderman, Theo Geijtenbeek, Florianne Hafkamp, Diane Bax, Alex Cloherty, Michiel van Agtmael, Marije Bomers, Suzanne Geerlings, Martin P. Grobusch, Vanessa Harris, Sabine M. Hermans, Joppe W. Hovius, Jeaninne Nellen, Edgar Peters, Tom van der Poll, Jan M. Prins, Kim Sigaloff, Cornelis S. Stijnis, Marc van der Valk, Michèle van Vugt, W. Joost Wiersinga, Godelieve Bree, Alexander P. J. Vlaar, Sanne de Bruin, Anne Geke Algera, Frank van Baarle, Lieuwe Bos, Michela Botta, Esther Bulle, Paul Elbers, Lucas Fleuren, Armand Girbes, Laura Hagens, Leo Heunks, Janneke Horn, Mourik van Mourik, Frederique Paulus, Jorinde Raasveld, Marcus Schultz, Marry Smit, Willemke Stilma, Patrick Thoral, Anissa Tsonas, Heder de Vries, Alex Schuurmans, Menno de Jong, Marianna Bugiani, Harm Jan Bogaard, Charlotte Teunissen, Jorg Hamann, Bart Seppen, Maureen Leeuw, Anne J. G. van Oudheusden, Anton G. M. Buiting, Kin Ki Jim, Hans Vrielink, Francis Swaneveld, Gestur Vidarsson, C. Ellen van der Schoot, Peter C. Wever, Wentao Li, Frank van Kuppeveld, Jean-Luc Murk, Berend Jan Bosch, Gerrit-Jan Wolbink, Theo Rispens
Journal: The Journal of Immunology
J Immunol (2020) 205 (12): 3491–3499.
https://doi.org/10.4049/jimmunol.2000767
Published: 15 December 2020
View article titled, Development of a SARS-CoV-2 Total Antibody Assay and the Dynamics of Antibody Response over Time in Hospitalized and Nonhospitalized Patients with COVID-19
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Includes: Supplementary data
Journal Articles

Glycine 236 in the Lower Hinge Region of Human IgG1 Differentiates FcγR from Complement Effector Function

Maximilian Brinkhaus, Ruben G. J. Douwes, Arthur E. H. Bentlage, A. Robin Temming, Steven W. de Taeye, Matthias Tammes Buirs, Jacoline Gerritsen, Juk Yee Mok, Giso Brasser, Peter C. Ligthart, Wim J. E. van Esch, Peter Verheesen, Hans de Haard, Theo Rispens, Gestur Vidarsson
Journal: The Journal of Immunology
J Immunol (2020) 205 (12): 3456–3467.
https://doi.org/10.4049/jimmunol.2000961
Published: 15 December 2020
View article titled, Glycine 236 in the Lower Hinge Region of Human IgG1 Differentiates FcγR from Complement Effector Function
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Includes: Supplementary data
Journal Articles

Unraveling the Effect of a Potentiating Anti–Factor H Antibody on Atypical Hemolytic Uremic Syndrome–Associated Factor H Variants

Gillian Dekkers, Mieke C. Brouwer, Jorn Jeremiasse, Angela Kamp, Robyn M. Biggs, Gerard van Mierlo, Scott Lauder, Suresh Katti, Taco W. Kuijpers, Theo Rispens, Ilse Jongerius
Journal: The Journal of Immunology
J Immunol (2020) 205 (7): 1778–1786.
https://doi.org/10.4049/jimmunol.2000368
Published: 01 October 2020
View article titled, Unraveling the Effect of a Potentiating Anti–Factor H Antibody on Atypical Hemolytic Uremic Syndrome–Associated Factor H Variants
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Includes: Supplementary data
Journal Articles

Functional Attributes of Antibodies, Effector Cells, and Target Cells Affecting NK Cell–Mediated Antibody-Dependent Cellular Cytotoxicity

A. Robin Temming, Steven W. de Taeye, Erik L. de Graaf, Louise A. de Neef, Gillian Dekkers, Christine W. Bruggeman, Jana Koers, Peter Ligthart, Sietse Q. Nagelkerke, James C. Zimring, Taco W. Kuijpers, Manfred Wuhrer, Theo Rispens, Gestur Vidarsson
Journal: The Journal of Immunology
J Immunol (2019) 203 (12): 3126–3135.
https://doi.org/10.4049/jimmunol.1900985
Published: 15 December 2019
View article titled, Functional Attributes of Antibodies, Effector Cells, and Target Cells Affecting NK Cell–Mediated Antibody-Dependent Cellular Cytotoxicity
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Includes: Supplementary data
Journal Articles

Biased N-Glycosylation Site Distribution and Acquisition across the Antibody V Region during B Cell Maturation

Jana Koers, Ninotska I. L. Derksen, Pleuni Ooijevaar-de Heer, Benjamin Nota, Fleur S. van de Bovenkamp, Gestur Vidarsson, Theo Rispens
Journal: The Journal of Immunology
J Immunol (2019) 202 (8): 2220–2228.
https://doi.org/10.4049/jimmunol.1801622
Published: 15 April 2019
View article titled, Biased <em>N</em>-Glycosylation Site Distribution and Acquisition across the Antibody V Region during B Cell Maturation
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Includes: Supplementary data
Journal Articles

Enhanced Effector Functions Due to Antibody Defucosylation Depend on the Effector Cell Fcγ Receptor Profile

Christine W. Bruggeman, Gillian Dekkers, Arthur E. H. Bentlage, Louise W. Treffers, Sietse Q. Nagelkerke, Suzanne Lissenberg-Thunnissen, Carolien A. M. Koeleman, Manfred Wuhrer, Timo K. van den Berg, Theo Rispens, Gestur Vidarsson, Taco W. Kuijpers
Journal: The Journal of Immunology
J Immunol (2017) 199 (1): 204–211.
https://doi.org/10.4049/jimmunol.1700116
Published: 01 July 2017
View article titled, Enhanced Effector Functions Due to Antibody Defucosylation Depend on the Effector Cell Fcγ Receptor Profile
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Journal Articles

Anti-Hinge Antibodies Recognize IgG Subclass– and Protease-Restricted Neoepitopes

Willem J. J. Falkenburg, Dirkjan van Schaardenburg, Pleuni Ooijevaar-de Heer, Michel W. P. Tsang-A-Sjoe, Irene E. M. Bultink, Alexandre E. Voskuyl, Arthur E. H. Bentlage, Gestur Vidarsson, Gertjan Wolbink, Theo Rispens
Journal: The Journal of Immunology
J Immunol (2017) 198 (1): 82–93.
https://doi.org/10.4049/jimmunol.1601096
Published: 01 January 2017
View article titled, Anti-Hinge Antibodies Recognize IgG Subclass– and Protease-Restricted Neoepitopes
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Includes: Supplementary data
Journal Articles

The Emerging Importance of IgG Fab Glycosylation in Immunity

In Special Collection:
Brief Reviews
Fleur S. van de Bovenkamp, Lise Hafkenscheid, Theo Rispens, Yoann Rombouts
Journal: The Journal of Immunology
J Immunol (2016) 196 (4): 1435–1441.
https://doi.org/10.4049/jimmunol.1502136
Published: 15 February 2016
View article titled, The Emerging Importance of IgG Fab Glycosylation in Immunity
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Journal Articles

Haplotypes of FcγRIIa and FcγRIIIb Polymorphic Variants Influence IgG-Mediated Responses in Neutrophils

Joris van der Heijden, Sietse Nagelkerke, Xiwen Zhao, Judy Geissler, Theo Rispens, Timo K. van den Berg, Taco W. Kuijpers
Journal: The Journal of Immunology
J Immunol (2014) 192 (6): 2715–2721.
https://doi.org/10.4049/jimmunol.1203570
Published: 15 March 2014
View article titled, Haplotypes of FcγRIIa and FcγRIIIb Polymorphic Variants Influence IgG-Mediated Responses in Neutrophils
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Includes: Supplementary data
Journal Articles

Species-Specific Determinants in the IgG CH3 Domain Enable Fab-Arm Exchange by Affecting the Noncovalent CH3–CH3 Interaction Strength

Aran F. Labrijn, Theo Rispens, Joyce Meesters, Rebecca J. Rose, Tamara H. den Bleker, Stefan Loverix, Ewald T. J. van den Bremer, Joost Neijssen, Tom Vink, Ignace Lasters, Rob C. Aalberse, Albert J. R. Heck, Jan G. J. van de Winkel, Janine Schuurman, Paul W. H. I. Parren
Journal: The Journal of Immunology
J Immunol (2011) 187 (6): 3238–3246.
https://doi.org/10.4049/jimmunol.1003336
Published: 15 September 2011
View article titled, Species-Specific Determinants in the IgG CH3 Domain Enable Fab-Arm Exchange by Affecting the Noncovalent CH3–CH3 Interaction Strength
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Includes: Supplementary data
Journal Articles

Human IgG4 Binds to IgG4 and Conformationally Altered IgG1 via Fc-Fc Interactions

Theo Rispens, Pleuni Ooievaar-De Heer, Ellen Vermeulen, Janine Schuurman, Marijn van der Neut Kolfschoten, Rob C. Aalberse
Journal: The Journal of Immunology
J Immunol (2009) 182 (7): 4275–4281.
https://doi.org/10.4049/jimmunol.0804338
Published: 01 April 2009
View article titled, Human IgG4 Binds to IgG4 and Conformationally Altered IgG1 via Fc-Fc Interactions
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Includes: Supplementary data