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Thomas R. Malek
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Journal Articles

Targeting the high-affinity IL-2R with high-dose mIL-2/CD25 induces effective antitumor responses

KATHRYN M LAPORTE, Rosmely Hernandez, Thomas R Malek
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 117.12.
DOI: https://doi.org/10.4049/jimmunol.208.Supp.117.12
Published: 01 May 2022
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CEACAM1 is an IL-2R-dependent biomarker in patients with multiple autoimmune-diseases undergoing low-dose IL-2 therapy

Aixin Yu, Alejandro Moro, Michelle Rosenzwajg, Nicolas Tchitchet, David Klatzmann, Thomas R Malek
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 160.14.
DOI: https://doi.org/10.4049/jimmunol.208.Supp.160.14
Published: 01 May 2022
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Interleukin-2 signaling engages de novo cholesterol biosynthesis in regulatory T cells

Acacia Crouch, Thomas R Malek
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 46.15.
DOI: https://doi.org/10.4049/jimmunol.208.Supp.46.15
Published: 01 May 2022
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Regulation of IL-2- and IL-6-dependent signaling in human Tregs by CISH and SOCS3

Milos Vujanac, Ying Ding, Thomas R Malek
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 45.05.
DOI: https://doi.org/10.4049/jimmunol.208.Supp.45.05
Published: 01 May 2022
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Transcriptome and chromatin changes as regulatory T cells expand and contract to IL-2R signaling in vivo

Alejandro Moro, Zhen Gao, Lily Wang, Aixin Yu, Sunny Hsiung, Yuguang Ban, Aimin Yan, Corneliu M Sologon, Steven Chen, Thomas R Malek
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 56.02.
DOI: https://doi.org/10.4049/jimmunol.208.Supp.56.02
Published: 01 May 2022
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Blimp1 regulates the growth and function of human regulatory T cells

Ying Ding, Milos Vujanac, Luis Nivelo, Alejandro Villarino, Thomas R Malek
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 56.04.
DOI: https://doi.org/10.4049/jimmunol.208.Supp.56.04
Published: 01 May 2022
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Mouse IL-2/CD25 Fusion Protein Induces Regulatory T Cell Expansion and Immune Suppression in Preclinical Models of Systemic Lupus Erythematosus

Jenny H. Xie, Yifan Zhang, Martine Loubeau, Paul Mangan, Elizabeth Heimrich, Christian Tovar, Xiadi Zhou, Priyanka Madia, Michael Doyle, Shailesh Dudhgaonkar, Anjuman Rudra, Siva Subramani, James Young, Luisa Salter-Cid, Thomas R. Malek, Mary Struthers
Journal: The Journal of Immunology
J Immunol (2021) 207 (1): 34–43.
DOI: https://doi.org/10.4049/jimmunol.2100078
Published: 01 July 2021
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Includes: Supplementary data
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Amplification of neoantigen-specific antitumor responses using a long-lasting IL-2 fusion protein

Rosmely Hernandez, Kevin H Toomer, Janika Põder, Kathryn M LaPorte, Thomas R Malek
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.9.
DOI: https://doi.org/10.4049/jimmunol.204.Supp.239.9
Published: 01 May 2020
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Endogenous IL-33 contributes to Treg expansion induced by IL-2/CD25, a novel IL-2 biologic developed for low-dose IL-2 therapy

Jen Bon P Lui, Thomas R Malek
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 237.13.
DOI: https://doi.org/10.4049/jimmunol.204.Supp.237.13
Published: 01 May 2020
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Inflammation impairs IL-2R signaling in regulatory T cells

Sunnie Hsiung, Thomas R Malek
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 221.13.
DOI: https://doi.org/10.4049/jimmunol.204.Supp.221.13
Published: 01 May 2020
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Limited application of IL-2/CD25 leads to persistent IL-2R signaling that promotes gene expression for Treg expansion

Alejandro Moro, Yuguang Ban, Gao Zhen, Lily Wang, Aixin Yu, Xi Chen, Thomas R Malek
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 221.11.
DOI: https://doi.org/10.4049/jimmunol.204.Supp.221.11
Published: 01 May 2020
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Blimp1 suppresses proliferation in human regulatory T cells as a potential homeostasis regulator

Ying Ding, Thomas R Malek
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 78.17.
DOI: https://doi.org/10.4049/jimmunol.204.Supp.78.17
Published: 01 May 2020
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CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells

Ying Ding, Aixin Yu, George C. Tsokos, Thomas R. Malek
Journal: The Journal of Immunology
J Immunol (2019) 203 (1): 93–104.
DOI: https://doi.org/10.4049/jimmunol.1801570
Published: 01 July 2019
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IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells

Natasha C. Ward, Aixin Yu, Alejandro Moro, Yuguang Ban, Xi Chen, Sunnie Hsiung, James Keegan, Jaren M. Arbanas, Martine Loubeau, Anil Thankappan, Aaron P. Yamniuk, Jonathan H. Davis, Mary Struthers, Thomas R. Malek
Journal: The Journal of Immunology
J Immunol (2018) 201 (9): 2579–2592.
DOI: https://doi.org/10.4049/jimmunol.1800907
Published: 01 November 2018
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Conditional deletion of CD25 in Tregs abrogates their suppressive function independently of Foxp3

Kevin Henry Toomer, Thomas R. Malek
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 101.6.
DOI: https://doi.org/10.4049/jimmunol.200.Supp.101.6
Published: 01 May 2018
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Protein phosphatase 2A promotes IL-2R signaling in human regulatory T cells

Ying Ding, Aixin Yu, Thomas R. Malek
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 176.10.
DOI: https://doi.org/10.4049/jimmunol.200.Supp.176.10
Published: 01 May 2018
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The Lower Limit of Regulatory CD4+ Foxp3+ TCRβ Repertoire Diversity Required To Control Autoimmunity

Aixin Yu, Michael J. Dee, Dennis Adeegbe, Connor J. Dwyer, Norman H. Altman, Thomas R. Malek
Journal: The Journal of Immunology
J Immunol (2017) 198 (8): 3127–3135.
DOI: https://doi.org/10.4049/jimmunol.1601966
Published: 15 April 2017
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Developmental Progression and Interrelationship of Central and Effector Regulatory T Cell Subsets

Kevin H. Toomer, Xiaomei Yuan, Jing Yang, Michael J. Dee, Aixin Yu, Thomas R. Malek
Journal: The Journal of Immunology
J Immunol (2016) 196 (9): 3665–3676.
DOI: https://doi.org/10.4049/jimmunol.1500595
Published: 01 May 2016
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IL-2Rβ–Dependent Signaling and CD103 Functionally Cooperate To Maintain Tolerance in the Gut Mucosa

Xiaomei Yuan, Michael J. Dee, Norman H. Altman, Thomas R. Malek
Journal: The Journal of Immunology
J Immunol (2015) 194 (3): 1334–1346.
DOI: https://doi.org/10.4049/jimmunol.1400955
Published: 01 February 2015
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IL7Rα Contributes to Experimental Autoimmune Encephalomyelitis through Altered T Cell Responses and Nonhematopoietic Cell Lineages

Jessica J. Ashbaugh, Roberta Brambilla, Shaffiat A. Karmally, Cecilia Cabello, Thomas R. Malek, John R. Bethea
Journal: The Journal of Immunology
J Immunol (2013) 190 (9): 4525–4534.
DOI: https://doi.org/10.4049/jimmunol.1203214
Published: 01 May 2013
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Includes: Supplementary data