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Tom E. Mollnes
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Journal Articles

Synthetic Oligodeoxynucleotide CpG Motifs Activate Human Complement through Their Backbone Structure and Induce Complement-Dependent Cytokine Release

Eline de Boer, Marina Sokolova, Huy Q. Quach, Karin E. McAdam, Maximilian P. Götz, Viktoriia Chaban, Jarle Vaage, Beatrice Fageräng, Trent M. Woodruff, Peter Garred, Per H. Nilsson, Tom E. Mollnes, Søren E. Pischke
Journal: The Journal of Immunology
J Immunol (2022) 209 (9): 1760–1767.
https://doi.org/10.4049/jimmunol.2101191
Published: 01 November 2022
View article titled, Synthetic Oligodeoxynucleotide CpG Motifs Activate Human Complement through Their Backbone Structure and Induce Complement-Dependent Cytokine Release
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Includes: Supplementary data
Journal Articles

Cholesterol Crystals Induce Coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor

Caroline S. Gravastrand, Bjørg Steinkjer, Bente Halvorsen, Anne Landsem, Mona Skjelland, Eva Astrid Jacobsen, Trent M. Woodruff, John D. Lambris, Tom E. Mollnes, Ole-Lars Brekke, Terje Espevik, Anne Mari A. Rokstad
Journal: The Journal of Immunology
J Immunol (2019) 203 (4): 853–863.
https://doi.org/10.4049/jimmunol.1900503
Published: 15 August 2019
View article titled, Cholesterol Crystals Induce Coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor
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Includes: Supplementary data
Journal Articles

Cyclodextrin Reduces Cholesterol Crystal–Induced Inflammation by Modulating Complement Activation

Siril S. Bakke, Marie H. Aune, Nathalie Niyonzima, Katrine Pilely, Liv Ryan, Mona Skjelland, Peter Garred, Pål Aukrust, Bente Halvorsen, Eicke Latz, Jan K. Damås, Tom E. Mollnes, Terje Espevik
Journal: The Journal of Immunology
J Immunol (2017) 199 (8): 2910–2920.
https://doi.org/10.4049/jimmunol.1700302
Published: 15 October 2017
View article titled, Cyclodextrin Reduces Cholesterol Crystal–Induced Inflammation by Modulating Complement Activation
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Includes: Supplementary data
Journal Articles

TLR8 Senses Staphylococcus aureus RNA in Human Primary Monocytes and Macrophages and Induces IFN-β Production via a TAK1–IKKβ–IRF5 Signaling Pathway

Bjarte Bergstrøm, Marie H. Aune, Jane A. Awuh, June F. Kojen, Kjetil J. Blix, Liv Ryan, Trude H. Flo, Tom E. Mollnes, Terje Espevik, Jørgen Stenvik
Journal: The Journal of Immunology
J Immunol (2015) 195 (3): 1100–1111.
https://doi.org/10.4049/jimmunol.1403176
Published: 01 August 2015
View article titled, TLR8 Senses <em>Staphylococcus aureus</em> RNA in Human Primary Monocytes and Macrophages and Induces IFN-β Production via a TAK1–IKKβ–IRF5 Signaling Pathway
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Includes: Supplementary data
Journal Articles

Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal–Induced Inflammatory Responses by Reducing Complement Activation

Nathalie Niyonzima, Eivind O. Samstad, Marie H. Aune, Liv Ryan, Siril S. Bakke, Anne Mari Rokstad, Samuel D. Wright, Jan K. Damås, Tom E. Mollnes, Eicke Latz, Terje Espevik
Journal: The Journal of Immunology
J Immunol (2015) 195 (1): 257–264.
https://doi.org/10.4049/jimmunol.1403044
Published: 01 July 2015
View article titled, Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal–Induced Inflammatory Responses by Reducing Complement Activation
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Journal Articles

Double Blockade of CD14 and Complement C5 Abolishes the Cytokine Storm and Improves Morbidity and Survival in Polymicrobial Sepsis in Mice

Markus Huber-Lang, Andreas Barratt-Due, Søren E. Pischke, Øystein Sandanger, Per H. Nilsson, Miles A. Nunn, Stephanie Denk, Wilhelm Gaus, Terje Espevik, Tom E. Mollnes
Journal: The Journal of Immunology
J Immunol (2014) 192 (11): 5324–5331.
https://doi.org/10.4049/jimmunol.1400341
Published: 01 June 2014
View article titled, Double Blockade of CD14 and Complement C5 Abolishes the Cytokine Storm and Improves Morbidity and Survival in Polymicrobial Sepsis in Mice
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Includes: Supplementary data
Journal Articles

Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release

Eivind O. Samstad, Nathalie Niyonzima, Stig Nymo, Marie H. Aune, Liv Ryan, Siril S. Bakke, Knut T. Lappegård, Ole-Lars Brekke, John D. Lambris, Jan K. Damås, Eicke Latz, Tom E. Mollnes, Terje Espevik
Journal: The Journal of Immunology
J Immunol (2014) 192 (6): 2837–2845.
https://doi.org/10.4049/jimmunol.1302484
Published: 15 March 2014
View article titled, Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release
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Includes: Supplementary data
Journal Articles

Combined Inhibition of Complement and CD14 Efficiently Attenuated the Inflammatory Response Induced by Staphylococcus aureus in a Human Whole Blood Model

Espen W. Skjeflo, Dorte Christiansen, Terje Espevik, Erik W. Nielsen, Tom E. Mollnes
Journal: The Journal of Immunology
J Immunol (2014) 192 (6): 2857–2864.
https://doi.org/10.4049/jimmunol.1300755
Published: 15 March 2014
View article titled, Combined Inhibition of Complement and CD14 Efficiently Attenuated the Inflammatory Response Induced by <em>Staphylococcus aureus</em> in a Human Whole Blood Model
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Journal Articles

Combined Inhibition of Complement (C5) and CD14 Markedly Attenuates Inflammation, Thrombogenicity, and Hemodynamic Changes in Porcine Sepsis

Andreas Barratt-Due, Ebbe B. Thorgersen, Kjetil Egge, Søren Pischke, Andrey Sokolov, Bernt C. Hellerud, Julie K. Lindstad, Anne Pharo, Anjan K. Bongoni, Robert Rieben, Miles Nunn, Helge Scott, Tom E. Mollnes
Journal: The Journal of Immunology
J Immunol (2013) 191 (2): 819–827.
https://doi.org/10.4049/jimmunol.1201909
Published: 15 July 2013
View article titled, Combined Inhibition of Complement (C5) and CD14 Markedly Attenuates Inflammation, Thrombogenicity, and Hemodynamic Changes in Porcine Sepsis
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Includes: Supplementary data
Journal Articles

The Role of Properdin in Zymosan- and Escherichia coli-Induced Complement Activation

Morten Harboe, Peter Garred, Julie K. Lindstad, Anne Pharo, Fredrik Müller, Gregory L. Stahl, John D. Lambris, Tom E. Mollnes
Journal: The Journal of Immunology
J Immunol (2012) 189 (5): 2606–2613.
https://doi.org/10.4049/jimmunol.1200269
Published: 01 September 2012
View article titled, The Role of Properdin in Zymosan- and <em>Escherichia coli</em>-Induced Complement Activation
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Includes: Supplementary data
Journal Articles

Cytokine Secretion Depends on Galα(1,3)Gal Expression in a Pig-to-Human Whole Blood Model

Marit Sæthre, Mårten K. J. Schneider, John D. Lambris, Paola Magotti, Guttorm Haraldsen, Jörg D. Seebach, Tom E. Mollnes
Journal: The Journal of Immunology
J Immunol (2008) 180 (9): 6346–6353.
https://doi.org/10.4049/jimmunol.180.9.6346
Published: 01 May 2008
View article titled, Cytokine Secretion Depends on Galα(1,3)Gal Expression in a Pig-to-Human Whole Blood Model
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