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Journal Articles

Role of Rab7 in activating NF-kB in B cells to mediate class-switching and plasma cell survival in antibody and autoantibody responses and to promote B cell lymphomagenesis

Hui Yan, Rui Wang, Tonika Lam, Dennis Kulp, Carlos Eduardo Rivera, Julia R. Taylor, Zhonghua Wang, Hong Zan, Guangming Zhong, Dmitri Ivanov, Paolo Casali, Zhenming Xu
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 195.10.
https://doi.org/10.4049/jimmunol.198.Supp.195.10
Published: 01 May 2017
View article titled, Role of Rab7 in activating NF-kB in B cells to mediate class-switching and plasma cell survival in antibody and autoantibody responses and to promote B cell lymphomagenesis
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Journal Articles

Small Molecule Inhibition of Rab7 Impairs B Cell Class Switching and Plasma Cell Survival To Dampen the Autoantibody Response in Murine Lupus

Tonika Lam, Dennis V. Kulp, Rui Wang, Zheng Lou, Julia Taylor, Carlos E. Rivera, Hui Yan, Qi Zhang, Zhonghua Wang, Hong Zan, Dmitri N. Ivanov, Guangming Zhong, Paolo Casali, Zhenming Xu
Journal: The Journal of Immunology
J Immunol (2016) 197 (10): 3792–3805.
https://doi.org/10.4049/jimmunol.1601427
Published: 15 November 2016
View article titled, Small Molecule Inhibition of Rab7 Impairs B Cell Class Switching and Plasma Cell Survival To Dampen the Autoantibody Response in Murine Lupus
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Includes: Supplementary data
Journal Articles

Targeting of B cell class-switching and plasma cell survival pathways by a Rab7 inhibitor suppresses autoantibody responses in murine lupus

Zheng Lou, Tonika Lam, Dennis Kulp, Rui Wang, Julia Taylor, Paolo Casali, Zhenming Xu
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 47.1.
https://doi.org/10.4049/jimmunol.196.Supp.47.1
Published: 01 May 2016
View article titled, Targeting of B cell class-switching and plasma cell survival pathways by a Rab7 inhibitor suppresses autoantibody responses in murine lupus
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Journal Articles

B cell Rab7 mediates induction of AID expression and class-switching in T-dependent and T-independent antibody responses (IRM10P.605)

Zheng Lou, Egest Pone, Tonika Lam, Rui Wang, Yuhui Chen, Dongfang Liu, Aimee Edinger, Zhenming Xu, Paolo Casali
Journal: The Journal of Immunology
J Immunol (2015) 194 (1_Supplement): 131.3.
https://doi.org/10.4049/jimmunol.194.Supp.131.3
Published: 01 May 2015
View article titled, B cell Rab7 mediates induction of AID expression and class-switching in T-dependent and T-independent antibody responses (IRM10P.605)
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Journal Articles

Histone deacetylase inhibitors dampen antibody and autoantibody responses by upregulating selected B cell microRNAs that silence AID and Blimp-1 expression (IRM10P.603)

Hong Zan, Clayton White, Egest Pone, Tonika Lam, Connie Tat, Guideng Li, Paolo Casali
Journal: The Journal of Immunology
J Immunol (2015) 194 (1_Supplement): 131.1.
https://doi.org/10.4049/jimmunol.194.Supp.131.1
Published: 01 May 2015
View article titled, Histone deacetylase inhibitors dampen antibody and autoantibody responses by upregulating selected B cell microRNAs that silence AID and Blimp-1 expression (IRM10P.603)
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Journal Articles

B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: modulation by BCR and CD40, and relevance to T-independent antibody responses (IRM10P.608)

Tonika Lam, Egest Pone, Zheng Lou, Rui Wang, Milton Greenberg, Zhenming Xu, Paolo Casali
Journal: The Journal of Immunology
J Immunol (2015) 194 (1_Supplement): 131.6.
https://doi.org/10.4049/jimmunol.194.Supp.131.6
Published: 01 May 2015
View article titled, B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: modulation by BCR and CD40, and relevance to T-independent antibody responses (IRM10P.608)
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Journal Articles

B Cell Rab7 Mediates Induction of Activation-Induced Cytidine Deaminase Expression and Class-Switching in T-Dependent and T-Independent Antibody Responses

Egest J. Pone, Tonika Lam, Zheng Lou, Rui Wang, Yuhui Chen, Dongfang Liu, Aimee L. Edinger, Zhenming Xu, Paolo Casali
Journal: The Journal of Immunology
J Immunol (2015) 194 (7): 3065–3078.
https://doi.org/10.4049/jimmunol.1401896
Published: 01 April 2015
View article titled, B Cell Rab7 Mediates Induction of Activation-Induced Cytidine Deaminase Expression and Class-Switching in T-Dependent and T-Independent Antibody Responses
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Includes: Supplementary data
Journal Articles

Histone Deacetylase Inhibitors Upregulate B Cell microRNAs That Silence AID and Blimp-1 Expression for Epigenetic Modulation of Antibody and Autoantibody Responses

Clayton A. White, Egest J. Pone, Tonika Lam, Connie Tat, Ken L. Hayama, Guideng Li, Hong Zan, Paolo Casali
Journal: The Journal of Immunology
J Immunol (2014) 193 (12): 5933–5950.
https://doi.org/10.4049/jimmunol.1401702
Published: 15 December 2014
View article titled, Histone Deacetylase Inhibitors Upregulate B Cell microRNAs That Silence AID and Blimp-1 Expression for Epigenetic Modulation of Antibody and Autoantibody Responses
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Includes: Supplementary data
Journal Articles

Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination (IRC3P.472)

Tonika Lam, Lisa Thomas, Clayton White, Guideng Li, Egest Pone, Zhenming Xu, Paolo Casali
Journal: The Journal of Immunology
J Immunol (2014) 192 (1_Supplement): 59.15.
https://doi.org/10.4049/jimmunol.192.Supp.59.15
Published: 01 May 2014
View article titled, Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination (IRC3P.472)
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Journal Articles

Rab7 plays a B cell-intrinsic and critical role in T-dependent and T-independent antibody responses by mediating AID expression and class switch DNA recombination (IRM8P.706)

Zhenming Xu, Egest Pone, Tonika Lam, Aimee Edinger, Paolo Casali
Journal: The Journal of Immunology
J Immunol (2014) 192 (1_Supplement): 127.7.
https://doi.org/10.4049/jimmunol.192.Supp.127.7
Published: 01 May 2014
View article titled, Rab7 plays a B cell-intrinsic and critical role in T-dependent and T-independent antibody responses by mediating AID expression and class switch DNA recombination (IRM8P.706)
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