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Toshiyuki Hamaoka
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Journal Articles

Pillars Article: Identification of a T Cell-Derived B Cell Growth Factor Distinct from Interleukin 2. J. Exp. Med. 1982. 155: 914–923

Maureen Howard, John Farrar, Mary Hilfiker, Barbara Johnson, Kiyoshi Takatsu, Toshiyuki Hamaoka, William E. Paul
Journal: The Journal of Immunology
J Immunol (2013) 190 (3): 864–873.
Published: 01 February 2013
View article titled, Pillars Article: Identification of a T Cell-Derived B Cell Growth Factor Distinct from Interleukin 2. <em>J. Exp. Med</em>. 1982. 155: 914–923
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Cutting Edge: Fyn Is Essential for Tyrosine Phosphorylation of Csk-Binding Protein/Phosphoprotein Associated with Glycolipid-Enriched Microdomains in Lipid Rafts in Resting T Cells

Koubun Yasuda, Masakazu Nagafuku, Takaki Shima, Masato Okada, Takeshi Yagi, Takenao Yamada, Yasuko Minaki, Akiko Kato, Shizue Tani-ichi, Toshiyuki Hamaoka, Atsushi Kosugi
Journal: The Journal of Immunology
J Immunol (2002) 169 (6): 2813–2817.
https://doi.org/10.4049/jimmunol.169.6.2813
Published: 15 September 2002
View article titled, Cutting Edge: Fyn Is Essential for Tyrosine Phosphorylation of Csk-Binding Protein/Phosphoprotein Associated with Glycolipid-Enriched Microdomains in Lipid Rafts in Resting T Cells
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Molecular Mechanisms Underlying Differential Contribution of CD28 Versus Non-CD28 Costimulatory Molecules to IL-2 Promoter Activation

Xu-Yu Zhou, Yumi Yashiro-Ohtani, Masakiyo Nakahira, Woong Ryeon Park, Ryo Abe, Toshiyuki Hamaoka, Mayumi Naramura, Hua Gu, Hiromi Fujiwara
Journal: The Journal of Immunology
J Immunol (2002) 168 (8): 3847–3854.
https://doi.org/10.4049/jimmunol.168.8.3847
Published: 15 April 2002
View article titled, Molecular Mechanisms Underlying Differential Contribution of CD28 Versus Non-CD28 Costimulatory Molecules to IL-2 Promoter Activation
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Journal Articles

Synergy of IL-12 and IL-18 for IFN-γ Gene Expression: IL-12-Induced STAT4 Contributes to IFN-γ Promoter Activation by Up-Regulating the Binding Activity of IL-18-Induced Activator Protein 1

Masakiyo Nakahira, Hyun-Jong Ahn, Woong-Ryeon Park, Ping Gao, Michio Tomura, Cheung-Seog Park, Toshiyuki Hamaoka, Tsunetaka Ohta, Masashi Kurimoto, Hiromi Fujiwara
Journal: The Journal of Immunology
J Immunol (2002) 168 (3): 1146–1153.
https://doi.org/10.4049/jimmunol.168.3.1146
Published: 01 February 2002
View article titled, Synergy of IL-12 and IL-18 for IFN-γ Gene Expression: IL-12-Induced STAT4 Contributes to IFN-γ Promoter Activation by Up-Regulating the Binding Activity of IL-18-Induced Activator Protein 1
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A Mandatory Role for STAT4 in IL-12 Induction of Mouse T Cell CCR5

Masayuki Iwasaki, Takao Mukai, Chigusa Nakajima, Yi-Fu Yang, Ping Gao, Nobuya Yamaguchi, Michio Tomura, Hiromi Fujiwara, Toshiyuki Hamaoka
Journal: The Journal of Immunology
J Immunol (2001) 167 (12): 6877–6883.
https://doi.org/10.4049/jimmunol.167.12.6877
Published: 15 December 2001
View article titled, A Mandatory Role for STAT4 in IL-12 Induction of Mouse T Cell CCR5
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An Absolute Requirement for STAT4 and a Role for IFN-γ as an Amplifying Factor in IL-12 Induction of the Functional IL-18 Receptor Complex

Masakiyo Nakahira, Michio Tomura, Masayuki Iwasaki, Hyun-Jong Ahn, Yang Bian, Toshiyuki Hamaoka, Tsunetaka Ohta, Masashi Kurimoto, Hiromi Fujiwara
Journal: The Journal of Immunology
J Immunol (2001) 167 (3): 1306–1312.
https://doi.org/10.4049/jimmunol.167.3.1306
Published: 01 August 2001
View article titled, An Absolute Requirement for STAT4 and a Role for IFN-γ as an Amplifying Factor in IL-12 Induction of the Functional IL-18 Receptor Complex
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Serine 6 of Lck Tyrosine Kinase: A Critical Site for Lck Myristoylation, Membrane Localization, and Function in T Lymphocytes

Koubun Yasuda, Atsushi Kosugi, Fumie Hayashi, Shin-ichiroh Saitoh, Masakazu Nagafuku, Yoshiko Mori, Masato Ogata, Toshiyuki Hamaoka
Journal: The Journal of Immunology
J Immunol (2000) 165 (6): 3226–3231.
https://doi.org/10.4049/jimmunol.165.6.3226
Published: 15 September 2000
View article titled, Serine 6 of Lck Tyrosine Kinase: A Critical Site for Lck Myristoylation, Membrane Localization, and Function in T Lymphocytes
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CD5 Costimulation Up-Regulates the Signaling to Extracellular Signal-Regulated Kinase Activation in CD4+CD8+ Thymocytes and Supports Their Differentiation to the CD4 Lineage

Xu-Yu Zhou, Yumi Yashiro-Ohtani, Kazuhito Toyo-oka, Cheung-Seog Park, Xu-Guang Tai, Toshiyuki Hamaoka, Hiromi Fujiwara
Journal: The Journal of Immunology
J Immunol (2000) 164 (3): 1260–1268.
https://doi.org/10.4049/jimmunol.164.3.1260
Published: 01 February 2000
View article titled, CD5 Costimulation Up-Regulates the Signaling to Extracellular Signal-Regulated Kinase Activation in CD4<sup>+</sup>CD8<sup>+</sup> Thymocytes and Supports Their Differentiation to the CD4 Lineage
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Journal Articles

Non-CD28 Costimulatory Molecules Present in T Cell Rafts Induce T Cell Costimulation by Enhancing the Association of TCR with Rafts

Yumi Yashiro-Ohtani, Xu-Yu Zhou, Kazuhito Toyo-oka, Xu-Guang Tai, Cheung-Seog Park, Toshiyuki Hamaoka, Ryo Abe, Kensuke Miyake, Hiromi Fujiwara
Journal: The Journal of Immunology
J Immunol (2000) 164 (3): 1251–1259.
https://doi.org/10.4049/jimmunol.164.3.1251
Published: 01 February 2000
View article titled, Non-CD28 Costimulatory Molecules Present in T Cell Rafts Induce T Cell Costimulation by Enhancing the Association of TCR with Rafts
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Journal Articles

Direct Suppression of TCR-Mediated Activation of Extracellular Signal-Regulated Kinase by Leukocyte Protein Tyrosine Phosphatase, a Tyrosine-Specific Phosphatase

Masatsugu Oh-hora, Masato Ogata, Yoshiko Mori, Masaaki Adachi, Kohzoh Imai, Atsushi Kosugi, Toshiyuki Hamaoka
Journal: The Journal of Immunology
J Immunol (1999) 163 (3): 1282–1288.
https://doi.org/10.4049/jimmunol.163.3.1282
Published: 01 August 1999
View article titled, Direct Suppression of TCR-Mediated Activation of Extracellular Signal-Regulated Kinase by Leukocyte Protein Tyrosine Phosphatase, a Tyrosine-Specific Phosphatase
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Journal Articles

A Novel Function of Vα14+CD4+NKT Cells: Stimulation of IL-12 Production by Antigen-Presenting Cells in the Innate Immune System

Michio Tomura, Wen-Gong Yu, Hyun-Jong Ahn, Motozo Yamashita, Yi-Fu Yang, Shiro Ono, Toshiyuki Hamaoka, Tetsu Kawano, Masaru Taniguchi, Yasuhiko Koezuka, Hiromi Fujiwara
Journal: The Journal of Immunology
J Immunol (1999) 163 (1): 93–101.
https://doi.org/10.4049/jimmunol.163.1.93
Published: 01 July 1999
View article titled, A Novel Function of Vα14<sup>+</sup>CD4<sup>+</sup>NKT Cells: Stimulation of IL-12 Production by Antigen-Presenting Cells in the Innate Immune System
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Requirement for Distinct Janus Kinases and STAT Proteins in T Cell Proliferation Versus IFN-γ Production Following IL-12 Stimulation

Hyun-Jong Ahn, Michio Tomura, Wen-Gong Yu, Masayuki Iwasaki, Woong-Ryeon Park, Toshiyuki Hamaoka, Hiromi Fujiwara
Journal: The Journal of Immunology
J Immunol (1998) 161 (11): 5893–5900.
https://doi.org/10.4049/jimmunol.161.11.5893
Published: 01 December 1998
View article titled, Requirement for Distinct Janus Kinases and STAT Proteins in T Cell Proliferation Versus IFN-γ Production Following IL-12 Stimulation
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Differential Involvement of a Fas-CPP32-Like Protease Pathway in Apoptosis of TCR/CD9-Costimulated, Naive T Cells and TCR-Restimulated, Activated T Cells

Cheung-Seog Park, Yumi Yashiro, Xu-Guang Tai, Kazuhito Toyo-oka, Toshiyuki Hamaoka, Hideo Yagita, Ko Okumura, Steven Neben, Hiromi Fujiwara
Journal: The Journal of Immunology
J Immunol (1998) 160 (12): 5790–5796.
https://doi.org/10.4049/jimmunol.160.12.5790
Published: 15 June 1998
View article titled, Differential Involvement of a Fas-CPP32-Like Protease Pathway in Apoptosis of TCR/CD9-Costimulated, Naive T Cells and TCR-Restimulated, Activated T Cells
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A Critical Role for IL-18 in the Proliferation and Activation of NK1.1+CD3− Cells

Michio Tomura, Xu-Yu Zhou, Seiji Maruo, Hyun-Jong Ahn, Toshiyuki Hamaoka, Haruki Okamura, Kenji Nakanishi, Tadao Tanimoto, Masashi Kurimoto, Hiromi Fujiwara
Journal: The Journal of Immunology
J Immunol (1998) 160 (10): 4738–4746.
https://doi.org/10.4049/jimmunol.160.10.4738
Published: 15 May 1998
View article titled, A Critical Role for IL-18 in the Proliferation and Activation of NK1.1<sup>+</sup>CD3<sup>−</sup> Cells
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Differential Capacities of CD4+, CD8+, and CD4−CD8− T Cell Subsets to Express IL-18 Receptor and Produce IFN-γ in Response to IL-18

Michio Tomura, Seiji Maruo, Jie Mu, Xu-Yu Zhou, Hyun-Jong Ahn, Toshiyuki Hamaoka, Haruki Okamura, Kenji Nakanishi, Steven Clark, Masashi Kurimoto, Hiromi Fujiwara
Journal: The Journal of Immunology
J Immunol (1998) 160 (8): 3759–3765.
https://doi.org/10.4049/jimmunol.160.8.3759
Published: 15 April 1998
View article titled, Differential Capacities of CD4<sup>+</sup>, CD8<sup>+</sup>, and CD4<sup>−</sup>CD8<sup>−</sup> T Cell Subsets to Express IL-18 Receptor and Produce IFN-γ in Response to IL-18
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The Requirement of Ia-Positive Accessory Cells for the Induction of Hapten-Reactive Cytotoxic T Lymphocytes in vitro

Uki Yamashita, Toshiyuki Hamaoka
Journal: The Journal of Immunology
J Immunol (1979) 123 (6): 2637–2643.
https://doi.org/10.4049/jimmunol.123.6.2637
Published: 01 December 1979
View article titled, The Requirement of Ia-Positive Accessory Cells for the Induction of Hapten-Reactive Cytotoxic T Lymphocytes <em>in vitro</em>
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Immunologic Characterization of Tumor-Associated Transplantation Antigens on MM102 Mammary Tumor Eliciting Preferentially Helper T Cell Activity

Hiromi Fujiwara, Hisakazu Aoki, Tetsuo Tsuchida, Toshiyuki Hamaoka
Journal: The Journal of Immunology
J Immunol (1978) 121 (4): 1591–1595.
https://doi.org/10.4049/jimmunol.121.4.1591
Published: 01 October 1978
View article titled, Immunologic Characterization of Tumor-Associated Transplantation Antigens on MM102 Mammary Tumor Eliciting Preferentially Helper T Cell Activity
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Preventive Effect of Hapten-Reactive Thymus-Derived Helper Lymphocytes on the Tolerance Induction in Hapten-Specific Precursors of Antibody-Forming Cells

Toshiyuki Hamaoka, Tetsushi Inada, Uki Yamashita, Masayasu Kitagawa
Journal: The Journal of Immunology
J Immunol (1975) 114 (6): 1771–1778.
https://doi.org/10.4049/jimmunol.114.6.1771
Published: 01 June 1975
View article titled, Preventive Effect of Hapten-Reactive Thymus-Derived Helper Lymphocytes on the Tolerance Induction in Hapten-Specific Precursors of Antibody-Forming Cells
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Hapten-Specific IgE Antibody Responses in Mice: III. Establishment of Parameters for Generation of Helper T Cell Function Regulating the Primary and Secondary Responses of IgE and IgG B Lymphocytes

Toshiyuki Hamaoka, Peter E. Newburger, David H. Katz, Baruj Benacerraf
Journal: The Journal of Immunology
J Immunol (1974) 113 (3): 958–973.
https://doi.org/10.4049/jimmunol.113.3.958
Published: 01 September 1974
View article titled, Hapten-Specific IgE Antibody Responses in Mice: <subtitle>III. Establishment of Parameters for Generation of Helper T Cell Function Regulating the Primary and Secondary Responses of IgE and IgG B Lymphocytes</subtitle>
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Potentiation of Helper T Cell Function in IgE Antibody Responses by Bacterial Lipolysaccharide (LPS)

Peter E. Newburger, Toshiyuki Hamaoka, David H. Katz
Journal: The Journal of Immunology
J Immunol (1974) 113 (3): 824–829.
https://doi.org/10.4049/jimmunol.113.3.824
Published: 01 September 1974
View article titled, Potentiation of Helper T Cell Function in IgE Antibody Responses by Bacterial Lipolysaccharide (LPS)
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