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Tyler J. Curiel
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Journal Articles

Melanocyte PDL1 promotes early tumor progression in a novel autochthonous NRAS-mutant melanoma model

Carlos Oscar Ontiveros, Tiffany Chen, Clare Murray, Anand Kornepati, Yilun Deng, Paige Blinkiewicz, Haiyan Bai, Grace Crossland, Alvaro Souto-Padron, Harshita B. Gupta, Mary Jo Turk, Christin Burd, Tyler J Curiel
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 88.11.
https://doi.org/10.4049/jimmunol.210.Supp.88.11
Published: 01 May 2023
View article titled, Melanocyte PDL1 promotes early tumor progression in a novel autochthonous NRAS-mutant melanoma model
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Pharmacologic tumor PDL1 depletion as a novel approach to overcome treatment resistance

Clare Murray, Haiyan Bai, Carlos Oscar Ontiveros, Paige Blinkiewicz, Eva Galvan, Yilun Deng, Alvaro Souto-Padron, Tyler J Curiel
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 230.08.
https://doi.org/10.4049/jimmunol.210.Supp.230.08
Published: 01 May 2023
View article titled, Pharmacologic tumor PDL1 depletion as a novel approach to overcome treatment resistance
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Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T-cells

Carmen Maria Anadon Galindo, Xiaoqing Yu, kay Hanggi, Subir Biswas, Ricardo Chaurio, Gunjan Mandal, Alexandra Martin, Kyle K Payne, Pasquale P Innamarato, Carly M Harro, Jessica Mine, Kimberly Sprenger, Carla Cortina, John J Powers, Bradford A Perez, Chandler D Gatenbee, Sandhya Prabhakaran, Douglas Marchion, Mirjam H Heemskerk, Tyler J Curiel, Alexander R.A. Anderson, Robert M Wenham, Paulo C Rodriguez, Jose R Conejo-Garcia
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 63.04.
https://doi.org/10.4049/jimmunol.208.Supp.63.04
Published: 01 May 2022
View article titled, Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T-cells
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Journal Articles

Nitration of CCL2 disrupts the tumor-protective function of CCL2 in bladder cancer

Neelam Mukherjee, Niannian Ji, Zhen-Ju Shu, Tyler J Curiel, Robert S Svatek
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 121.01.
https://doi.org/10.4049/jimmunol.208.Supp.121.01
Published: 01 May 2022
View article titled, Nitration of CCL2 disrupts the tumor-protective function of CCL2 in bladder cancer
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PD-L1 plays a B cell-intrinsic role in suppressing the antibody response and anti-tumor immunity.

Christian Cervantes, Mustafa Khan, Maria Fernandez, Zexuan Liu, Zainab Hakeem, Suryavathi Viswanadhapalli, Harshita B. Gupta, Tyler J Curiel, Hui Yan, Ratna Vadlamudi, Zhenming Xu
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 112.11.
https://doi.org/10.4049/jimmunol.208.Supp.112.11
Published: 01 May 2022
View article titled, PD-L1 plays a B cell-intrinsic role in suppressing the antibody response and anti-tumor immunity.
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Journal Articles

Spontaneous class-switched antibody responses at endometrial cancer tumor bed drives superior patients’ outcome

GUNJAN MANDAL, Subir Biswas, Carmen M Anadon, Xiaoqing Yu, Chandler D Gatenbee, Sandhya Prabhakaran, Kyle K Payne, Ricardo A Chaurio, Alexandra Martin, Patrick Innamarato, Carlos Moran, John J Powers, Carly M Harro, Jessica A Mine, Kimberly B Sprenger, Kristen E Rigolizzo, Xuefeng Wang, Tyler J Curiel, Paulo C Rodriguez, Alexander R.A. Anderson, Ozlen Saglam, Jose R Conejo-Garcia
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 177.01.
https://doi.org/10.4049/jimmunol.208.Supp.177.01
Published: 01 May 2022
View article titled, Spontaneous class-switched antibody responses at endometrial cancer tumor bed drives superior patients’ outcome
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CD122-SELECTIVE IL-2 COMPLEXES TREAT OVARIAN CARCINOMAS, INDUCE TREG FRAGILITY AND PROMOTE T CELL STEM CELLS

Yilun Deng, Justin Michael Drerup, Xinyue Zhang, Ryan M Reyes, Jenny Mendez, Miro E Raeber, Myrna G Garcia, Alvaro S Pardon, Harshita B. Gupta, Onur Boyman, Tyler J Curiel
Journal: The Journal of Immunology
J Immunol (2021) 206 (1_Supplement): 57.17.
https://doi.org/10.4049/jimmunol.206.Supp.57.17
Published: 01 May 2021
View article titled, CD122-SELECTIVE IL-2 COMPLEXES TREAT OVARIAN CARCINOMAS, INDUCE TREG FRAGILITY AND PROMOTE T CELL STEM CELLS
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Intracellular PD-L1 regulates DNA damage checkpoints and suppresses Chk1 and PARP inhibitor synthetic lethality

Anand V Kornepati, Yilun Deng, Eloise Dray, Clare Murray, Suresh C Kari, Erica Osta, Zexuan Liu, Jacob Boyd, Alvaro Padron, Ryan Reyes, Harshita B. Gupta, Curtis A Clark, Rong Li, Weixing Zhao, Ratna Vadlamudi, Patrick Sung, Tyler J. Curiel
Journal: The Journal of Immunology
J Immunol (2021) 206 (1_Supplement): 67.15.
https://doi.org/10.4049/jimmunol.206.Supp.67.15
Published: 01 May 2021
View article titled, Intracellular PD-L1 regulates DNA damage checkpoints and suppresses Chk1 and PARP inhibitor synthetic lethality
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Journal Articles

Tumor cell-intrinsic PD-L1 signals promote DNA damage responses that mediate resistance to Chk1 and PARP inhibitors in vivo

Anand V Kornepati, Deyi Zhang, Alvaro S Padron, Jacob T Boyd, Yilun Deng, Erica G Osta, Ryan M Reyes, Hailian Shen, Juan Wang, Suresh Kari, Curtis A Clark, Yanfen Hu, Rong Li, Harshita B Gupta, Weixing Zhao, Tyler J Curiel
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 241.33.
https://doi.org/10.4049/jimmunol.204.Supp.241.33
Published: 01 May 2020
View article titled, Tumor cell-intrinsic PD-L1 signals promote DNA damage responses that mediate resistance to Chk1 and PARP inhibitors <em>in vivo</em>
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CD122-selective IL-2 complexes target γδ T and NK cells to reduce tumor-promoting Th17 effects and synergize with αPD-L1 to treat primary and metastatic bladder cancer

Ryan Michael Reyes, Yilun Deng, Deyi Zhang, Neelam Mukherjee, Niannian Ji, Karen Wheeler, Harshita B. Gupta, Myrna Garcia, Anand Kornepati, Robert S Svatek, Tyler J Curiel
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 88.14.
https://doi.org/10.4049/jimmunol.204.Supp.88.14
Published: 01 May 2020
View article titled, CD122-selective IL-2 complexes target γδ T and NK cells to reduce tumor-promoting Th17 effects and synergize with αPD-L1 to treat primary and metastatic bladder cancer
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CCL2/CCR2 signaling protects against bladder cancer growth in a T cell dependent manner

Neelam Mukherjee, Niannian Ji, Zhen-Ju Shu, Tyler J Curiel, Robert S Svatek
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 90.1.
https://doi.org/10.4049/jimmunol.204.Supp.90.1
Published: 01 May 2020
View article titled, CCL2/CCR2 signaling protects against bladder cancer growth in a T cell dependent manner
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Journal Articles

Adipocyte PD-L1 suppresses anti-tumor immune response and promotes breast cancer progression

Bogang Wu, Xiujie Sun, Harshita B. Gupta, Bin Yuan, Huai-Chin Chiang, Yanfen Hu, Tyler J Curiel, Rong Li
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 165.24.
https://doi.org/10.4049/jimmunol.204.Supp.165.24
Published: 01 May 2020
View article titled, Adipocyte PD-L1 suppresses anti-tumor immune response and promotes breast cancer progression
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Distinct responses to αPD-1, αPD-L1 and αPD-L2 immunotherapy in aged versus young hosts includes T-cell stem cell effects and PD-L2 expression differences

Myrna G Garcia, Alvaro S Padron, Yilun Deng, Aravind Kancharla, Ryan M Reyes, Harshita B Gupta, Tyler J Curiel
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 165.17.
https://doi.org/10.4049/jimmunol.204.Supp.165.17
Published: 01 May 2020
View article titled, Distinct responses to αPD-1, αPD-L1 and αPD-L2 immunotherapy in aged versus young hosts includes T-cell stem cell effects and PD-L2 expression differences
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Journal Articles

A phosphotyrosine switch controls antitumor activity of estrogen receptor b

Bin Yuan, Curtis A Clark, Jing Yang, Bogang Wu, Yanfen Hu, Tyler J Curiel, Rong Li
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 165.31.
https://doi.org/10.4049/jimmunol.204.Supp.165.31
Published: 01 May 2020
View article titled, A phosphotyrosine switch controls antitumor activity of estrogen receptor b
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Selective IL-2 receptor β (CD122) targeting improves αPD-L1 immunotherapy in a metastatic bladder cancer model

Ryan Michael Reyes, Deyi Zhang, Yilun Deng, Neelam Mukherjee, Niannian Ji, Harshita B Gupta, Robert S Svatek, Tyler J Curiel
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 136.14.
https://doi.org/10.4049/jimmunol.202.Supp.136.14
Published: 01 May 2019
View article titled, Selective IL-2 receptor β (CD122) targeting improves αPD-L1 immunotherapy in a metastatic bladder cancer model
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CD122-selective IL-2 complexes treat ovarian carcinomas and melanoma, alter Treg differentiation and induce more CD8+CXCR5+TCF-1+ stem T cells when combined with αPD-L1

Yilun Deng, Harshita B. Gupta, Justin Michael Drerup, Ryan Michael Reyes, Jenny Mendez, Xinyue Zhang, Alvaro S Padron, Myrna Garcia, Tyler J Curiel
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 136.15.
https://doi.org/10.4049/jimmunol.202.Supp.136.15
Published: 01 May 2019
View article titled, CD122-selective IL-2 complexes treat ovarian carcinomas and melanoma, alter Treg differentiation and induce more CD8+CXCR5+TCF-1+ stem T cells when combined with αPD-L1
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Surface and cytoplasmic tumor cell PD-L1 differentially mediate virulence in ovarian cancer and melanoma through mTOR activation

Heather Graham Hambright, Harshita B. Gupta, Alvaro S Padron, Ratna Vadlamudi, Yidong Chen, Pawel A Osmulski, Tyler J Curiel
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 195.5.
https://doi.org/10.4049/jimmunol.202.Supp.195.5
Published: 01 May 2019
View article titled, Surface and cytoplasmic tumor cell PD-L1 differentially mediate virulence in ovarian cancer and melanoma through mTOR activation
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Tumor-intrinsic PD-L1 reduces actin cytoskeleton polymerization to promote mTORC1 signals driving tumor stemness

Suresh Chandra Kari, Aravind Kancharla, Harshita B. Gupta, April Risinger, Tyler J Curiel
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 137.8.
https://doi.org/10.4049/jimmunol.202.Supp.137.8
Published: 01 May 2019
View article titled, Tumor-intrinsic PD-L1 reduces actin cytoskeleton polymerization to promote mTORC1 signals driving tumor stemness
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Tumor-intrinsic PD-L1 regulates tumor initiating cell virulence and stemness genes, and TCF1+ stem-like T cells through Raptor in ovarian cancer, which correlates with survival in high grade serous ovarian cancer

Harshita B. Gupta, Clare E Murray, June Deng, Tabrez AS Mohammad, Xinyue Zhang, Bogang Wu, Curtis A Clark, Gangadhara Sareddy, Yidong Chen, Ratna Vadlamudi, Rong Li, Tyler J Curiel
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 195.29.
https://doi.org/10.4049/jimmunol.202.Supp.195.29
Published: 01 May 2019
View article titled, Tumor-intrinsic PD-L1 regulates tumor initiating cell virulence and stemness genes, and TCF1<sup>+</sup> stem-like T cells through Raptor in ovarian cancer, which correlates with survival in high grade serous ovarian cancer
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Cell-intrinsic programmed death ligand-1 (PD-L1) inhibits cytotoxic chemo, promotes DNA damage repair, and enhances ATM/ATR signaling following exposure to DNA damaging agents in bladder, melanoma, and ovarian cancer cells

Anand V Kornepati, Deyi Zhang, Heather G. Hambright, Suresh C. Kari, Yilun Deng, Curtis A. Clark, Harshita B. Gupta, Rekha Chakravarty, Yanfen Hu, Rong Li, Tyler J. Curiel
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 195.17.
https://doi.org/10.4049/jimmunol.202.Supp.195.17
Published: 01 May 2019
View article titled, Cell-intrinsic programmed death ligand-1 (PD-L1) inhibits cytotoxic chemo, promotes DNA damage repair, and enhances ATM/ATR signaling following exposure to DNA damaging agents in bladder, melanoma, and ovarian cancer cells
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