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V H Engelhard
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Journal Articles

Perforin-dependent cytotoxic activity and lymphokine secretion by CD4+ T cells are regulated by CD8+ T cells.

N S Williams, V H Engelhard
Journal: The Journal of Immunology
J Immunol (1997) 159 (5): 2091–2099.
DOI: https://doi.org/10.4049/jimmunol.159.5.2091
Published: 01 September 1997
View article titled, Perforin-dependent cytotoxic activity and lymphokine secretion by CD4+ T cells are regulated by CD8+ T cells.
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A naturally processed peptide presented by HLA-A*0201 is expressed at low abundance and recognized by an alloreactive CD8+ cytotoxic T cell with apparent high affinity.

W Wang, P H Gulden, R A Pierce, J Shabanowitz, S T Man, D F Hunt, V H Engelhard, J A Shabanowitz
Journal: The Journal of Immunology
J Immunol (1997) 158 (12): 5797–5804.
DOI: https://doi.org/10.4049/jimmunol.158.12.5797
Published: 15 June 1997
View article titled, A naturally processed peptide presented by HLA-A*0201 is expressed at low abundance and recognized by an alloreactive CD8+ cytotoxic T cell with apparent high affinity.
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Journal Articles

Differential contact of disparate class I/peptide complexes as the basis for epitope cross-recognition by a single T cell receptor.

D J Loftus, Y Chen, D G Covell, V H Engelhard, E Appella
Journal: The Journal of Immunology
J Immunol (1997) 158 (8): 3651–3658.
DOI: https://doi.org/10.4049/jimmunol.158.8.3651
Published: 15 April 1997
View article titled, Differential contact of disparate class I/peptide complexes as the basis for epitope cross-recognition by a single T cell receptor.
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Journal Articles

Shared epitopes for HLA-A3-restricted melanoma-reactive human CTL include a naturally processed epitope from Pmel-17/gp100.

J C Skipper, D J Kittlesen, R C Hendrickson, D D Deacon, N L Harthun, S N Wagner, D F Hunt, V H Engelhard, C L Slingluff, Jr
Journal: The Journal of Immunology
J Immunol (1996) 157 (11): 5027–5033.
DOI: https://doi.org/10.4049/jimmunol.157.11.5027
Published: 01 December 1996
View article titled, Shared epitopes for HLA-A3-restricted melanoma-reactive human CTL include a naturally processed epitope from Pmel-17/gp100.
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Probing HLA-B7 conformational shifts induced by peptide-binding groove mutations and bound peptide with anti-HLA monoclonal antibodies.

K D Smith, B E Mace, A Valenzuela, J L Vigna, J A McCutcheon, J A Barbosa, E Huczko, V H Engelhard, C T Lutz
Journal: The Journal of Immunology
J Immunol (1996) 157 (6): 2470–2478.
DOI: https://doi.org/10.4049/jimmunol.157.6.2470
Published: 15 September 1996
View article titled, Probing HLA-B7 conformational shifts induced by peptide-binding groove mutations and bound peptide with anti-HLA monoclonal antibodies.
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Journal Articles

Importance of MHC class 1 alpha2 and alpha3 domains in the recognition of self and non-self MHC molecules.

M H Newberg, D H Smith, S B Haertel, D R Vining, E Lacy, V H Engelhard
Journal: The Journal of Immunology
J Immunol (1996) 156 (7): 2473–2480.
DOI: https://doi.org/10.4049/jimmunol.156.7.2473
Published: 01 April 1996
View article titled, Importance of MHC class 1 alpha2 and alpha3 domains in the recognition of self and non-self MHC molecules.
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Journal Articles

Identification of a population of CD4+ CTL that utilizes a perforin- rather than a Fas ligand-dependent cytotoxic mechanism.

N S Williams, V H Engelhard
Journal: The Journal of Immunology
J Immunol (1996) 156 (1): 153–159.
DOI: https://doi.org/10.4049/jimmunol.156.1.153
Published: 01 January 1996
View article titled, Identification of a population of CD4+ CTL that utilizes a perforin- rather than a Fas ligand-dependent cytotoxic mechanism.
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Journal Articles

CTL responses of HLA-A2.1-transgenic mice specific for hepatitis C viral peptides predict epitopes for CTL of humans carrying HLA-A2.1.

M Shirai, T Arichi, M Nishioka, T Nomura, K Ikeda, K Kawanishi, V H Engelhard, S M Feinstone, J A Berzofsky
Journal: The Journal of Immunology
J Immunol (1995) 154 (6): 2733–2742.
DOI: https://doi.org/10.4049/jimmunol.154.6.2733
Published: 15 March 1995
View article titled, CTL responses of HLA-A2.1-transgenic mice specific for hepatitis C viral peptides predict epitopes for CTL of humans carrying HLA-A2.1.
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Journal Articles

Several HLA alleles share overlapping peptide specificities.

J Sidney, M F del Guercio, S Southwood, V H Engelhard, E Appella, H G Rammensee, K Falk, O Rötzschke, M Takiguchi, R T Kubo
Journal: The Journal of Immunology
J Immunol (1995) 154 (1): 247–259.
DOI: https://doi.org/10.4049/jimmunol.154.1.247
Published: 01 January 1995
View article titled, Several HLA alleles share overlapping peptide specificities.
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Journal Articles

Diversity and dominance among TCR recognizing HLA-A2.1+ influenza matrix peptide in human MHC class I transgenic mice.

S Man, J P Ridge, V H Engelhard
Journal: The Journal of Immunology
J Immunol (1994) 153 (10): 4458–4467.
DOI: https://doi.org/10.4049/jimmunol.153.10.4458
Published: 15 November 1994
View article titled, Diversity and dominance among TCR recognizing HLA-A2.1+ influenza matrix peptide in human MHC class I transgenic mice.
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Journal Articles

Inhibition of T cell activation by a monoclonal antibody reactive against the alpha 3 domain of human MHC class I molecules.

D M Smith, J A Bluestone, D R Jeyarajah, M H Newberg, V H Engelhard, J R Thistlethwaite, Jr, E S Woodle
Journal: The Journal of Immunology
J Immunol (1994) 153 (3): 1054–1067.
DOI: https://doi.org/10.4049/jimmunol.153.3.1054
Published: 01 August 1994
View article titled, Inhibition of T cell activation by a monoclonal antibody reactive against the alpha 3 domain of human MHC class I molecules.
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Journal Articles

Association of human class I MHC alleles with the adenovirus E3/19K protein.

D C Beier, J H Cox, D R Vining, P Cresswell, V H Engelhard
Journal: The Journal of Immunology
J Immunol (1994) 152 (8): 3862–3872.
DOI: https://doi.org/10.4049/jimmunol.152.8.3862
Published: 15 April 1994
View article titled, Association of human class I MHC alleles with the adenovirus E3/19K protein.
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Journal Articles

Naturally processed peptides longer than nine amino acid residues bind to the class I MHC molecule HLA-A2.1 with high affinity and in different conformations.

Y Chen, J Sidney, S Southwood, A L Cox, K Sakaguchi, R A Henderson, E Appella, D F Hunt, A Sette, V H Engelhard
Journal: The Journal of Immunology
J Immunol (1994) 152 (6): 2874–2881.
DOI: https://doi.org/10.4049/jimmunol.152.6.2874
Published: 15 March 1994
View article titled, Naturally processed peptides longer than nine amino acid residues bind to the class I MHC molecule HLA-A2.1 with high affinity and in different conformations.
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Journal Articles

Characteristics of endogenous peptides eluted from the class I MHC molecule HLA-B7 determined by mass spectrometry and computer modeling.

E L Huczko, W M Bodnar, D Benjamin, K Sakaguchi, N Z Zhu, J Shabanowitz, R A Henderson, E Appella, D F Hunt, V H Engelhard
Journal: The Journal of Immunology
J Immunol (1993) 151 (5): 2572–2587.
DOI: https://doi.org/10.4049/jimmunol.151.5.2572
Published: 01 September 1993
View article titled, Characteristics of endogenous peptides eluted from the class I MHC molecule HLA-B7 determined by mass spectrometry and computer modeling.
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Journal Articles

Recognition of human melanoma cells by HLA-A2.1-restricted cytotoxic T lymphocytes is mediated by at least six shared peptide epitopes.

C L Slingluff, Jr, A L Cox, R A Henderson, D F Hunt, V H Engelhard
Journal: The Journal of Immunology
J Immunol (1993) 150 (7): 2955–2963.
DOI: https://doi.org/10.4049/jimmunol.150.7.2955
Published: 01 April 1993
View article titled, Recognition of human melanoma cells by HLA-A2.1-restricted cytotoxic T lymphocytes is mediated by at least six shared peptide epitopes.
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Journal Articles

Species specificity in the interaction of CD8 with the alpha 3 domain of MHC class I molecules.

M H Newberg, J P Ridge, D R Vining, R D Salter, V H Engelhard
Journal: The Journal of Immunology
J Immunol (1992) 149 (1): 136–142.
DOI: https://doi.org/10.4049/jimmunol.149.1.136
Published: 01 July 1992
View article titled, Species specificity in the interaction of CD8 with the alpha 3 domain of MHC class I molecules.
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Role of endogenous peptides in murine allogenic cytotoxic T cell responses assessed using transfectants of the antigen-processing mutant 174xCEM.T2.

D B Crumpacker, J Alexander, P Cresswell, V H Engelhard
Journal: The Journal of Immunology
J Immunol (1992) 148 (10): 3004–3011.
DOI: https://doi.org/10.4049/jimmunol.148.10.3004
Published: 15 May 1992
View article titled, Role of endogenous peptides in murine allogenic cytotoxic T cell responses assessed using transfectants of the antigen-processing mutant 174xCEM.T2.
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Journal Articles

Three intracellular signals for cytotoxic T lymphocyte-mediated killing. Independent roles for protein kinase C, Ca2+ influx, and Ca2+ release from internal stores.

D M Haverstick, V H Engelhard, L S Gray
Journal: The Journal of Immunology
J Immunol (1991) 146 (10): 3306–3313.
DOI: https://doi.org/10.4049/jimmunol.146.10.3306
Published: 15 May 1991
View article titled, Three intracellular signals for cytotoxic T lymphocyte-mediated killing. Independent roles for protein kinase C, Ca2+ influx, and Ca2+ release from internal stores.
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Journal Articles

Influenza A-specific, HLA-A2.1-restricted cytotoxic T lymphocytes from HLA-A2.1 transgenic mice recognize fragments of the M1 protein.

V H Engelhard, E Lacy, J P Ridge
Journal: The Journal of Immunology
J Immunol (1991) 146 (4): 1226–1232.
DOI: https://doi.org/10.4049/jimmunol.146.4.1226
Published: 15 February 1991
View article titled, Influenza A-specific, HLA-A2.1-restricted cytotoxic T lymphocytes from HLA-A2.1 transgenic mice recognize fragments of the M1 protein.
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Cytotoxic activity and lymphokine production of T cell receptor (TCR)-alpha beta+ and TCR-gamma delta+ cytotoxic T lymphocyte (CTL) clones recognizing HLA-A2 and HLA-A2 mutants. Recognition of TCR-gamma delta+ CTL clones is affected by mutations at positions 152 and 156.

H Spits, X Paliard, V H Engelhard, J E de Vries
Journal: The Journal of Immunology
J Immunol (1990) 144 (11): 4156–4162.
DOI: https://doi.org/10.4049/jimmunol.144.11.4156
Published: 01 June 1990
View article titled, Cytotoxic activity and lymphokine production of T cell receptor (TCR)-alpha beta+ and TCR-gamma delta+ cytotoxic T lymphocyte (CTL) clones recognizing HLA-A2 and HLA-A2 mutants. Recognition of TCR-gamma delta+ CTL clones is affected by mutations at positions 152 and 156.
Click here to open pdf in another window PDF for Cytotoxic activity and lymphokine production of T cell receptor (TCR)-alpha beta+ and TCR-gamma delta+ cytotoxic T lymphocyte (CTL) clones recognizing HLA-A2 and HLA-A2 mutants. Recognition of TCR-gamma delta+ CTL clones is affected by mutations at positions 152 and 156.
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