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Journal Articles

Complement receptor 2 as a novel therapeutic target to suppress germinal center-derived autoantibody production in a SLE mouse model

Ajitanuj Rattan, Danni Y. Zhu, V. Michael Holers, Brigitte T. Huber, Michael C. Carroll
Journal: The Journal of Immunology
J Immunol (2024) 212 (1_Supplement): 1405_4789.
https://doi.org/10.4049/jimmunol.212.supp.1405.4789
Published: 01 May 2024
View article titled, Complement receptor 2 as a novel therapeutic target to suppress germinal center-derived autoantibody production in a SLE mouse model
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Female but Not Male Mice Deficient in Soluble IgM Are Susceptible to Chemically Induced Glomerular Injury

Russell Whelan, Andrew Feemster, Jennifer Laskowski, Brandon Renner, Liudmila Kulik, Felix Poppelaars, Cameron Lee, V. Michael Holers, Joshua M. Thurman
Journal: The Journal of Immunology
J Immunol (2023) 211 (8): 1240–1248.
https://doi.org/10.4049/jimmunol.2200292
Published: 08 September 2023
View article titled, Female but Not Male Mice Deficient in Soluble IgM Are Susceptible to Chemically Induced Glomerular Injury
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Includes: Supplementary data
Journal Articles

Clonally Expanded Cytotoxic CD8 +T cells Target Citrullinated Antigens In ACPA+ Rheumatoid Arthritis

Jae Seung Moon, Shady Younis, Orr Sharpe, Navin L. Rao, Julie A. Carman, Eddie A James, Jane H Buckner, Kevin D. Deane, V Michael Holers, Laura T. Donlin, Mark M Davis, William H Robinson
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 78.05.
https://doi.org/10.4049/jimmunol.210.Supp.78.05
Published: 01 May 2023
View article titled, Clonally Expanded Cytotoxic CD8 <sup>+</sup>T cells Target Citrullinated Antigens In ACPA+ Rheumatoid Arthritis
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Journal Articles

Complement: The Road Less Traveled

Claudia Kemper, Viviana P. Ferreira, Jeanne T. Paz, V. Michael Holers, Michail S. Lionakis, Jessy J. Alexander
Journal: The Journal of Immunology
J Immunol (2023) 210 (2): 119–125.
https://doi.org/10.4049/jimmunol.2200540
Published: 15 January 2023
View article titled, Complement: The Road Less Traveled
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Journal Articles

Analysis of Complement Gene Expression, Clinical Associations, and Biodistribution of Complement Proteins in the Synovium of Early Rheumatoid Arthritis Patients Reveals Unique Pathophysiologic Features

Nirmal K. Banda, Kevin D. Deane, Elizabeth A. Bemis, Colin Strickland, Jennifer Seifert, Kimberly Jordan, Katriona Goldman, B. Paul Morgan, Larry W. Moreland, Myles J. Lewis, Costantino Pitzalis, V. Michael Holers
Journal: The Journal of Immunology
J Immunol (2022) 208 (11): 2482–2496.
https://doi.org/10.4049/jimmunol.2101170
Published: 01 June 2022
View article titled, Analysis of Complement Gene Expression, Clinical Associations, and Biodistribution of Complement Proteins in the Synovium of Early Rheumatoid Arthritis Patients Reveals Unique Pathophysiologic Features
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Includes: Supplementary data
Journal Articles

A Snap Shot of Complement Gene Expression and Presence of Complement Proteins in Synovial Biopsies from Early Rheumatoid Arthritis Patients

Nirmal K Banda, Kevin D Deane, Jennifer Seifert, Colin Strickland, Elizabeth Bemis, Kimberly Jordan, Kationa Goldmann, Accelerating Medicines Partnership (AMP) RA/SLE Network, B. Paul Morgan, Myles J Lewis, Costantino Pitzalis, Larry W Moreland, V. Michael Holers
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 108.03.
https://doi.org/10.4049/jimmunol.208.Supp.108.03
Published: 01 May 2022
View article titled, A Snap Shot of Complement Gene Expression and Presence of Complement Proteins in Synovial Biopsies from Early Rheumatoid Arthritis Patients
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Journal Articles

Administration of 3,3-dimethyl-1-butanol is immunomodulatory in collagen induced arthritis murine model independent of TMA lyase activity

Sabrina Fechtner, Brendan Allen, Meagan E Chriswell, Widian K Jubair, M. Aaron Vroljik, V. Michael Holers, Kristine A Kuhn
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 170.39.
https://doi.org/10.4049/jimmunol.208.Supp.170.39
Published: 01 May 2022
View article titled, Administration of 3,3-dimethyl-1-butanol is immunomodulatory in collagen induced arthritis murine model independent of TMA lyase activity
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Journal Articles

Dual IgA/IgG family plasmablast-derived mAbs from peripheral blood of individuals at risk for rheumatoid arthritis are polyreactive to autoantigens and intestinal bacteria

Meagan Chriswell, Michelle Bloom, Jennifer A Seifert, Marie Feser, M. Kristen Demoruelle, Kevin D. Deane, Jill M. Norris, William H Robinson, V. Michael Holers, Kristine A Kuhn
Journal: The Journal of Immunology
J Immunol (2021) 206 (1_Supplement): 52.01.
https://doi.org/10.4049/jimmunol.206.Supp.52.01
Published: 01 May 2021
View article titled, Dual IgA/IgG family plasmablast-derived mAbs from peripheral blood of individuals at risk for rheumatoid arthritis are polyreactive to autoantigens and intestinal bacteria
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Journal Articles

Targeting the Immune Complex–Bound Complement C3d Ligand as a Novel Therapy for Lupus

Liudmila Kulik, Jennifer Laskowski, Brandon Renner, Rachel Woolaver, Lian Zhang, Taras Lyubchenko, Zhiying You, Joshua M. Thurman, V. Michael Holers
Journal: The Journal of Immunology
J Immunol (2019) 203 (12): 3136–3147.
https://doi.org/10.4049/jimmunol.1900620
Published: 15 December 2019
View article titled, Targeting the Immune Complex–Bound Complement C3d Ligand as a Novel Therapy for Lupus
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Journal Articles

Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity

Panos Stathopoulos, Anne Chastre, Patrick Waters, Sarosh Irani, Miriam L. Fichtner, Erik S. Benotti, Joel M. Guthridge, Jennifer Seifert, Richard J. Nowak, Jane H. Buckner, V. Michael Holers, Judith A. James, David A. Hafler, Kevin C. O’Connor
Journal: The Journal of Immunology
J Immunol (2019) 202 (8): 2210–2219.
https://doi.org/10.4049/jimmunol.1801295
Published: 15 April 2019
View article titled, Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity
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Includes: Supplementary data
Journal Articles

Modulation of the Alternative Pathway of Complement by Murine Factor H–Related Proteins

Alexandra H. Antonioli, Janice White, Frances Crawford, Brandon Renner, Kevin J. Marchbank, Jonathan P. Hannan, Joshua M. Thurman, Philippa Marrack, V. Michael Holers
Journal: The Journal of Immunology
J Immunol (2018) 200 (1): 316–326.
https://doi.org/10.4049/jimmunol.1602017
Published: 01 January 2018
View article titled, Modulation of the Alternative Pathway of Complement by Murine Factor H–Related Proteins
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Includes: Supplementary data
Journal Articles

Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein–Associated Serine Protease 2

Nirmal K. Banda, Sumitra Acharya, Robert I. Scheinman, Gaurav Mehta, Minoru Takahashi, Yuichi Endo, Wuding Zhou, Conrad A. Farrar, Steven H. Sacks, Teizo Fujita, Hideharu Sekine, V. Michael Holers
Journal: The Journal of Immunology
J Immunol (2017) 199 (5): 1835–1845.
https://doi.org/10.4049/jimmunol.1700119
Published: 01 September 2017
View article titled, Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein–Associated Serine Protease 2
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Includes: Supplementary data
Journal Articles

Mannan-Binding Lectin–Associated Serine Protease 1/3 Cleavage of Pro–Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference–Mediated Gene Silencing

Nirmal K. Banda, Sumitra Acharya, Robert I. Scheinman, Gaurav Mehta, Marilyne Coulombe, Minoru Takahashi, Hideharu Sekine, Steffen Thiel, Teizo Fujita, V. Michael Holers
Journal: The Journal of Immunology
J Immunol (2016) 197 (9): 3680–3694.
https://doi.org/10.4049/jimmunol.1600719
Published: 01 November 2016
View article titled, Mannan-Binding Lectin–Associated Serine Protease 1/3 Cleavage of Pro–Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference–Mediated Gene Silencing
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Includes: Supplementary data
Journal Articles

Complement mannan-binding lectin associated serine proteases 1 and 3 generated by allo-liver transplantation cleave in vivo pro-Factor D generated by the adipose tissue into active Factor D

Nirmal K Banda, Sumitra Acharya, Robert I. Scheinman, Gaurav Mehta, Minoru Takahashi, Steffen Thiel, Hideharu Sekine, Teizo Fujita, V Michael Holers
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 124.30.
https://doi.org/10.4049/jimmunol.196.Supp.124.30
Published: 01 May 2016
View article titled, Complement mannan-binding lectin associated serine proteases 1 and 3 generated by allo-liver transplantation cleave in vivo pro-Factor D generated by the adipose tissue into active Factor D
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Journal Articles

Annexin A2 Enhances Complement Activation by Inhibiting Factor H

Brandon Renner, Hua Hua Tong, Jennifer Laskowski, Karen Jonscher, Lindsey Goetz, Rachel Woolaver, Jonathan Hannan, Yong Xing Li, Dennis Hourcade, Matthew C. Pickering, V. Michael Holers, Joshua M. Thurman
Journal: The Journal of Immunology
J Immunol (2016) 196 (3): 1355–1365.
https://doi.org/10.4049/jimmunol.1500793
Published: 01 February 2016
View article titled, Annexin A2 Enhances Complement Activation by Inhibiting Factor H
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Journal Articles

A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA

Gaurav Mehta, Robert I. Scheinman, V. Michael Holers, Nirmal K. Banda
Journal: The Journal of Immunology
J Immunol (2015) 194 (11): 5446–5454.
https://doi.org/10.4049/jimmunol.1403012
Published: 01 June 2015
View article titled, A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA
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Includes: Supplementary data
Journal Articles

Essential Role for the Lectin Pathway in Collagen Antibody–Induced Arthritis Revealed through Use of Adenovirus Programming Complement Inhibitor MAp44 Expression

Nirmal K. Banda, Gaurav Mehta, Troels R. Kjaer, Minoru Takahashi, Jerome Schaack, Thomas E. Morrison, Steffen Thiel, William P. Arend, V. Michael Holers
Journal: The Journal of Immunology
J Immunol (2014) 193 (5): 2455–2468.
https://doi.org/10.4049/jimmunol.1400752
Published: 01 September 2014
View article titled, Essential Role for the Lectin Pathway in Collagen Antibody–Induced Arthritis Revealed through Use of Adenovirus Programming Complement Inhibitor MAp44 Expression
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Includes: Supplementary data
Journal Articles

Roles of Adipocytes and Fibroblasts in Activation of the Alternative Pathway of Complement in Inflammatory Arthritis in Mice

William P. Arend, Gaurav Mehta, Alexandra H. Antonioli, Minoru Takahashi, Kazue Takahashi, Gregory L. Stahl, V. Michael Holers, Nirmal K. Banda
Journal: The Journal of Immunology
J Immunol (2013) 190 (12): 6423–6433.
https://doi.org/10.4049/jimmunol.1300580
Published: 15 June 2013
View article titled, Roles of Adipocytes and Fibroblasts in Activation of the Alternative Pathway of Complement in Inflammatory Arthritis in Mice
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Includes: Supplementary data
Journal Articles

Essential Role of Surface-Bound Complement Factor H in Controlling Immune Complex–Induced Arthritis

Nirmal K. Banda, Gaurav Mehta, Viviana P. Ferreira, Claudio Cortes, Matthew C. Pickering, Michael K. Pangburn, William P. Arend, V. Michael Holers
Journal: The Journal of Immunology
J Immunol (2013) 190 (7): 3560–3569.
https://doi.org/10.4049/jimmunol.1203271
Published: 01 April 2013
View article titled, Essential Role of Surface-Bound Complement Factor H in Controlling Immune Complex–Induced Arthritis
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Includes: Supplementary data
Journal Articles

A Citrullinated Fibrinogen-Specific T Cell Line Enhances Autoimmune Arthritis in a Mouse Model of Rheumatoid Arthritis

Kristen N. Cordova, Van C. Willis, Kathryn Haskins, V. Michael Holers
Journal: The Journal of Immunology
J Immunol (2013) 190 (4): 1457–1465.
https://doi.org/10.4049/jimmunol.1201517
Published: 15 February 2013
View article titled, A Citrullinated Fibrinogen-Specific T Cell Line Enhances Autoimmune Arthritis in a Mouse Model of Rheumatoid Arthritis
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Includes: Supplementary data