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Journal Articles

Multi-modal single-cell sequencing of circulating mononuclear cells deconvolutes outcome-specific immune responses in trauma patients

Tianmeng Chen, Julia Hughes, Alyssa Gregory, Julia Cornoy, Wei Chen, Richard Duerr, Timothy Billiar
Journal: The Journal of Immunology
J Immunol (2024) 212 (1_Supplement): 0667_7479.
https://doi.org/10.4049/jimmunol.212.supp.0667.7479
Published: 01 May 2024
View articletitled, Multi-modal single-cell sequencing of circulating mononuclear cells deconvolutes outcome-specific immune responses in trauma patients
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Journal Articles

Autocrine pro-inflammatory IL-10 initiates lung-specific Th2 responses to inhaled allergen to induce allergic asthma

Kun He, Zhongli Xu, William A MacDonald, Anuradha Ray, Wei Chen, Bart N Lambrecht, Amanda Poholek
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 67.16.
https://doi.org/10.4049/jimmunol.210.Supp.67.16
Published: 01 May 2023
View articletitled, Autocrine pro-inflammatory IL-10 initiates lung-specific Th2 responses to inhaled allergen to induce allergic asthma
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Journal Articles

Heterotypic Influenza Infections Mitigate Susceptibility to Secondary Bacterial Infection

Ellyse M. Cipolla, Molin Yue, Kara L. Nickolich, Brydie R. Huckestein, Danielle Antos, Wei Chen, John F. Alcorn
Journal: The Journal of Immunology
J Immunol (2022) 209 (4): 760–771.
https://doi.org/10.4049/jimmunol.2200261
Published: 15 August 2022
View articletitled, Heterotypic Influenza Infections Mitigate Susceptibility to Secondary Bacterial Infection
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Includes: Supplementary data
Journal Articles

Single cell RNA sequencing reveals novel inflammatory mechanisms of human acute respiratory distress syndrome

Brian R Rosborough, Jie Chen, Yale Jiang, Georgios Kitsios, Bryan McVerry, Janet S Lee, Anuradha Ray, Wei Chen, Prabir Ray
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 69.19.
https://doi.org/10.4049/jimmunol.204.Supp.69.19
Published: 01 May 2020
View articletitled, Single cell RNA sequencing reveals novel inflammatory mechanisms of human acute respiratory distress syndrome
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Journal Articles

Simultaneous analysis of gene expression and T cell repertoire in peripheral blood mononuclear cells from patients with cystic fibrosis at the single cell level

Annabel Ferguson, Jaidi Luo, Xiaojing An, Joseph M Pilewski, Wei Chen, Kong Chen
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 182.31.
https://doi.org/10.4049/jimmunol.202.Supp.182.31
Published: 01 May 2019
View articletitled, Simultaneous analysis of gene expression and T cell repertoire in peripheral blood mononuclear cells from patients with cystic fibrosis at the single cell level
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Journal Articles

IRAK-M Associates with Susceptibility to Adult-Onset Asthma and Promotes Chronic Airway Inflammation

Yi Liu, Mingqiang Zhang, Lili Lou, Lun Li, Youming Zhang, Wei Chen, Weixun Zhou, Yan Bai, Jinming Gao
Journal: The Journal of Immunology
J Immunol (2019) 202 (3): 899–911.
https://doi.org/10.4049/jimmunol.1800712
Published: 01 February 2019
View articletitled, IRAK-M Associates with Susceptibility to Adult-Onset Asthma and Promotes Chronic Airway Inflammation
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Includes: Supplementary data
Journal Articles

Therapeutic Effects of Monoclonal Antibody against Dengue Virus NS1 in a STAT1 Knockout Mouse Model of Dengue Infection

Shu-Wen Wan, Pei-Wei Chen, Chin-Yu Chen, Yen-Chung Lai, Ya-Ting Chu, Chia-Yi Hung, Han Lee, Hsuan Franziska Wu, Yung-Chun Chuang, Jessica Lin, Chih-Peng Chang, Shuying Wang, Ching-Chuan Liu, Tzong-Shiann Ho, Chiou-Feng Lin, Chien-Kuo Lee, Betty A. Wu-Hsieh, Robert Anderson, Trai-Ming Yeh, Yee-Shin Lin
Journal: The Journal of Immunology
J Immunol (2017) 199 (8): 2834–2844.
https://doi.org/10.4049/jimmunol.1601523
Published: 15 October 2017
View articletitled, Therapeutic Effects of Monoclonal Antibody against Dengue Virus NS1 in a STAT1 Knockout Mouse Model of Dengue Infection
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Includes: Supplementary data
Journal Articles

AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality

Hongbo Zhang, Jiadi Luo, John F. Alcorn, Kong Chen, Songqing Fan, Joseph Pilewski, Aizhong Liu, Wei Chen, Jay K. Kolls, Jieru Wang
Journal: The Journal of Immunology
J Immunol (2017) 198 (11): 4383–4393.
https://doi.org/10.4049/jimmunol.1600714
Published: 01 June 2017
View articletitled, AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality
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Includes: Supplementary data
Journal Articles

Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10

Alexandra Zanin-Zhorov, Jonathan M. Weiss, Alissa Trzeciak, Wei Chen, Jingya Zhang, Melanie S. Nyuydzefe, Carmen Arencibia, Seetharam Polimera, Olivier Schueller, Judilyn Fuentes-Duculan, Kathleen M. Bonifacio, Norma Kunjravia, Inna Cueto, Jennifer Soung, Roy M. Fleischmann, Alan Kivitz, Mark Lebwohl, Margarita Nunez, Johnnie Woodson, Shondra L. Smith, Robert F. West, Mark Berger, James G. Krueger, John L. Ryan, Samuel D. Waksal
Journal: The Journal of Immunology
J Immunol (2017) 198 (10): 3809–3814.
https://doi.org/10.4049/jimmunol.1602142
Published: 15 May 2017
View articletitled, Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10
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Includes: Supplementary data
Journal Articles

Selective oral ROCK2 inhibitor reduces clinical scores in patients with Psoriasis Vulgaris and normalizes skin pathology via concurrent regulation of IL-17 and IL-10 levels

Alexandra Zanin-Zhorov, Jonathan M Weiss, Alyssa Trzeciak, Wei Chen, Jingya Zhang, Melanie Nyuydzefe, Carmen Arencibia, Seetharam Polimera, Judilyn Fuentes-Duculan, Kathleen Bonifacio, Norma Kunjravia, Inna Cueto, Mark Berger, James Krueger, John L Ryan, Samuel D Waksal
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 197.3.
https://doi.org/10.4049/jimmunol.198.Supp.197.3
Published: 01 May 2017
View articletitled, Selective oral ROCK2 inhibitor reduces clinical scores in patients with Psoriasis Vulgaris and normalizes skin pathology via concurrent regulation of IL-17 and IL-10 levels
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Journal Articles

ROCK2, but not ROCK1 interacts with STAT3 to regulate TH17/TFH gene transcription

Wei Chen, Melanie S. Nyuydzefe, Jonathan M. Weiss, Jingya Zhang, Sam D. Waksal, Alexandra Zanin-Zhorov
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 223.7.
https://doi.org/10.4049/jimmunol.198.Supp.223.7
Published: 01 May 2017
View articletitled, ROCK2, but not ROCK1 interacts with STAT3 to regulate TH17/TFH gene transcription
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Journal Articles

T Cells Infiltrating Diseased Liver Express Ligands for the NKG2D Stress Surveillance System

Wei-Chen Huang, Nicholas J. Easom, Xin-Zi Tang, Upkar S. Gill, Harsimran Singh, Francis Robertson, Chiwen Chang, John Trowsdale, Brian R. Davidson, William M. Rosenberg, Giuseppe Fusai, Antoine Toubert, Patrick T. Kennedy, Dimitra Peppa, Mala K. Maini
Journal: The Journal of Immunology
J Immunol (2017) 198 (3): 1172–1182.
https://doi.org/10.4049/jimmunol.1601313
Published: 01 February 2017
View articletitled, T Cells Infiltrating Diseased Liver Express Ligands for the NKG2D Stress Surveillance System
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Includes: Supplementary data
Journal Articles

Imprinting of Skin/Inflammation Homing in CD4+ T Cells Is Controlled by DNA Methylation within the Fucosyltransferase 7 Gene

Matthias Pink, Boris A. Ratsch, Maibritt Mardahl, Pawel Durek, Julia K. Polansky, Martin Karl, Ria Baumgrass, Stefan Wallner, Cristina Cadenas, Kathrin Gianmoena, Stefan Floess, Wei Chen, Karl Nordstroem, Sascha Tierling, Sven Olek, Jörn Walter, Alf Hamann, Uta Syrbe
Journal: The Journal of Immunology
J Immunol (2016) 197 (8): 3406–3414.
https://doi.org/10.4049/jimmunol.1502434
Published: 15 October 2016
View articletitled, Imprinting of Skin/Inflammation Homing in CD4+ T Cells Is Controlled by DNA Methylation within the Fucosyltransferase 7 Gene
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Includes: Supplementary data
Journal Articles

Towards a non-allergenic peptide mix containing the T cell epitopes of the clinically most relevant house dust mite allergens for tolerance induction

Huey-Jy Huang, Mirela Curin, Srinita Banerjee, Kuan-Wei Chen, Tetiana Garmatiuk, Yvonne Resch, Raffaela Campana, Margarete Focke-Tejkl, Rudolf Valenta, Susanne Vrtala
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 192.5.
https://doi.org/10.4049/jimmunol.196.Supp.192.5
Published: 01 May 2016
View articletitled, Towards a non-allergenic peptide mix containing the T cell epitopes of the clinically most relevant house dust mite allergens for tolerance induction
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Journal Articles

MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3

Kai Guan, Congwen Wei, Zirui Zheng, Ting Song, Feixiang Wu, Yanhong Zhang, Ye Cao, Shengli Ma, Wei Chen, Quanbin Xu, Weiwei Xia, Jun Gu, Xiang He, Hui Zhong
Journal: The Journal of Immunology
J Immunol (2015) 194 (10): 4880–4890.
https://doi.org/10.4049/jimmunol.1402851
Published: 15 May 2015
View articletitled, MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3
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Includes: Supplementary data
Journal Articles

Increasing intestinal reactive oxygen species reverses diabetes-induced inflammation (MUC2P.928)

Lee-Wei Chen, Ying-Ying Wu, Pei-Hsuan Chen, Ching-Mei Hsu
Journal: The Journal of Immunology
J Immunol (2015) 194 (1_Supplement): 65.11.
https://doi.org/10.4049/jimmunol.194.Supp.65.11
Published: 01 May 2015
View articletitled, Increasing intestinal reactive oxygen species reverses diabetes-induced inflammation (MUC2P.928)
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Journal Articles

ROCK2 signaling is required for development and function of T follicular helper cells (HUM3P.247)

Jonathan Weiss, Wei Chen, melanie Nyuydzefe, Ryan Flynn, James Tonra, Suzana Marusic, Bruce Blazar, Samuel Waksal, Alexandra Zanin-Zhorov
Journal: The Journal of Immunology
J Immunol (2015) 194 (1_Supplement): 121.7.
https://doi.org/10.4049/jimmunol.194.Supp.121.7
Published: 01 May 2015
View articletitled, ROCK2 signaling is required for development and function of T follicular helper cells (HUM3P.247)
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Journal Articles

Selective ROCK2 inhibitor reverses experimental chronic graft-versus-host disease via concurrent regulation of STAT3/STAT5 phosphorylation (TRAN1P.933)

Alexandra Zanin-Zhorov, Ryan Flynn, Leo Luznik, melanie Nyuydzefe, Angela Panoskaltsis-Mortari, Jing Du, Katelyn Goodman, Jonathan Weiss, Wei Chen, Jonathan Serody, Kelli MacDonald, Geoffrey Hill, John O'Shea, Samuel Waksal, Bruce Blazar
Journal: The Journal of Immunology
J Immunol (2015) 194 (1_Supplement): 140.15.
https://doi.org/10.4049/jimmunol.194.Supp.140.15
Published: 01 May 2015
View articletitled, Selective ROCK2 inhibitor reverses experimental chronic graft-versus-host disease via concurrent regulation of STAT3/STAT5 phosphorylation (TRAN1P.933)
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Journal Articles

Calpain-1 Contributes to IgE-Mediated Mast Cell Activation

Zhengli Wu, Xiaochun Chen, Fang Liu, Wei Chen, Ping Wu, Adam J. Wieschhaus, Athar H. Chishti, Paul A. Roche, Wei-Min Chen, Tong-Jun Lin
Journal: The Journal of Immunology
J Immunol (2014) 192 (11): 5130–5139.
https://doi.org/10.4049/jimmunol.1301677
Published: 01 June 2014
View articletitled, Calpain-1 Contributes to IgE-Mediated Mast Cell Activation
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Includes: Supplementary data
Journal Articles

Structural mechanism of TCR-pMHC catch bond revealed by molecular dynamics, mutagenesis, and single-molecule kinetics analyses (IRM10P.752)

Baoyu Liu, Wei Chen, Ryan Martinez, Jizhong Lou, Cheng Zhu, Brian Evavold
Journal: The Journal of Immunology
J Immunol (2014) 192 (1_Supplement): 129.19.
https://doi.org/10.4049/jimmunol.192.Supp.129.19
Published: 01 May 2014
View articletitled, Structural mechanism of TCR-pMHC catch bond revealed by molecular dynamics, mutagenesis, and single-molecule kinetics analyses (IRM10P.752)
Add to Citation Manager for Structural mechanism of TCR-pMHC catch bond revealed by molecular dynamics, mutagenesis, and single-molecule kinetics analyses (IRM10P.752)