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Yuko Ohta
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Journal Articles

An Ancient MHC-Linked Gene Encodes a Nonrearranging Shark Antibody, UrIg, Convergent with IgG

Free
Martin F. Flajnik, Robyn Stanfield, Elena N. Pokidysheva, Sergei P. Boudko, Ian Wilson, Yuko Ohta
Journal: The Journal of Immunology
J Immunol (2023) 211 (6): 1042–1051.
https://doi.org/10.4049/jimmunol.2300361
Published: 04 August 2023
View articletitled, An Ancient MHC-Linked Gene Encodes a Nonrearranging Shark Antibody, UrIg, Convergent with IgG
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Includes: Supplementary data
Journal Articles

A Highly Complex, MHC-Linked, 350 Million-Year-Old Shark Nonclassical Class I Lineage

Free
Tereza Almeida, Yuko Ohta, Arnaud Gaigher, Antonio Muñoz-Mérida, Fabiana Neves, L. Filipe C. Castro, André M. Machado, Pedro J. Esteves, Ana Veríssimo, Martin F. Flajnik
Journal: The Journal of Immunology
J Immunol (2021) 207 (3): 824–836.
https://doi.org/10.4049/jimmunol.2000851
Published: 01 August 2021
View articletitled, A Highly Complex, MHC-Linked, 350 Million-Year-Old Shark Nonclassical Class I Lineage
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Journal Articles

An Ancient, MHC-Linked, Nonclassical Class I Lineage in Cartilaginous Fish

Free
Tereza Almeida, Pedro J. Esteves, Martin F. Flajnik, Yuko Ohta, Ana Veríssimo
Journal: The Journal of Immunology
J Immunol (2020) 204 (4): 892–902.
https://doi.org/10.4049/jimmunol.1901025
Published: 15 February 2020
View articletitled, An Ancient, MHC-Linked, Nonclassical Class I Lineage in Cartilaginous Fish
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Includes: Supplementary data
Journal Articles

Inferring the “Primordial Immune Complex”: Origins of MHC Class I and Antigen Receptors Revealed by Comparative Genomics

Free
Yuko Ohta, Masanori Kasahara, Timothy D. O’Connor, Martin F. Flajnik
Journal: The Journal of Immunology
J Immunol (2019) 203 (7): 1882–1896.
https://doi.org/10.4049/jimmunol.1900597
Published: 01 October 2019
View articletitled, Inferring the “Primordial Immune Complex”: Origins of MHC Class I and Antigen Receptors Revealed by Comparative Genomics
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Includes: Supplementary data
Journal Articles

Ancient Use of Ig Variable Domains Contributes Significantly to the TCRδ Repertoire

Free
Thaddeus C. Deiss, Breanna Breaux, Jeannine A. Ott, Rebecca A. Daniel, Patricia L. Chen, Caitlin D. Castro, Yuko Ohta, Martin F. Flajnik, Michael F. Criscitiello
Journal: The Journal of Immunology
J Immunol (2019) 203 (5): 1265–1275.
https://doi.org/10.4049/jimmunol.1900369
Published: 01 September 2019
View articletitled, Ancient Use of Ig Variable Domains Contributes Significantly to the TCRδ Repertoire
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Includes: Supplementary data
Journal Articles

Haptoglobin Is a Divergent MASP Family Member That Neofunctionalized To Recycle Hemoglobin via CD163 in Mammals

Free
Anthony K. Redmond, Yuko Ohta, Michael F. Criscitiello, Daniel J. Macqueen, Martin F. Flajnik, Helen Dooley
Journal: The Journal of Immunology
J Immunol (2018) 201 (8): 2483–2491.
https://doi.org/10.4049/jimmunol.1800508
Published: 15 October 2018
View articletitled, Haptoglobin Is a Divergent MASP Family Member That Neofunctionalized To Recycle Hemoglobin via CD163 in Mammals
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Includes: Supplementary data
Journal Articles

Evidence for Ig Light Chain Isotype Exclusion in Shark B Lymphocytes Suggests Ordered Mechanisms

Open Access
Anna Iacoangeli, Anita Lui, Ashley Haines, Yuko Ohta, Martin Flajnik, Ellen Hsu
Journal: The Journal of Immunology
J Immunol (2017) 199 (5): 1875–1885.
https://doi.org/10.4049/jimmunol.1700762
Published: 01 September 2017
View articletitled, Evidence for Ig Light Chain Isotype Exclusion in Shark B Lymphocytes Suggests Ordered Mechanisms
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Journal Articles

Biased Immunoglobulin Light Chain Gene Usage in the Shark

Free
Anna Iacoangeli, Anita Lui, Ushma Naik, Yuko Ohta, Martin Flajnik, Ellen Hsu
Journal: The Journal of Immunology
J Immunol (2015) 195 (8): 3992–4000.
https://doi.org/10.4049/jimmunol.1501426
Published: 15 October 2015
View articletitled, Biased Immunoglobulin Light Chain Gene Usage in the Shark
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Includes: Supplementary data
Journal Articles

B cell immunogenetics in the T cell receptor repertoire generation of shark (P6069)

Free
Michael Criscitiello, Jeannine Eubanks, Patricia Chen, Caitlin Castro, Andrea Wallace, Yuko Ohta, Martin Flajnik
Journal: The Journal of Immunology
J Immunol (2013) 190 (1_Supplement): 141.18.
https://doi.org/10.4049/jimmunol.190.Supp.141.18
Published: 01 May 2013
View articletitled, B cell immunogenetics in the T cell receptor repertoire generation of shark (P6069)
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Journal Articles

Ontogenic analysis of Xenopus γδ T cells: expressed T cell receptor (TCR) γ and δ chains and IL-17 family members (160.8)

Free
Shawn Jackson, Ada Undieh, Harold Steiner, Zuly Parra, Robert Miller, Yuko Ohta, Martin Flajnik
Journal: The Journal of Immunology
J Immunol (2012) 188 (1_Supplement): 160.8.
https://doi.org/10.4049/jimmunol.188.Supp.160.8
Published: 01 May 2012
View articletitled, Ontogenic analysis of Xenopus γδ T cells: expressed T cell receptor (TCR) γ and δ chains and IL-17 family members (160.8)
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Journal Articles

The Multiple Shark Ig H Chain Genes Rearrange and Hypermutate Autonomously

Free
Catherine Zhu, Wendy Feng, Jeremy Weedon, Pauline Hua, Dimitre Stefanov, Yuko Ohta, Martin F. Flajnik, Ellen Hsu
Journal: The Journal of Immunology
J Immunol (2011) 187 (5): 2492–2501.
https://doi.org/10.4049/jimmunol.1101671
Published: 01 September 2011
View articletitled, The Multiple Shark Ig H Chain Genes Rearrange and Hypermutate Autonomously
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Includes: Supplementary data
Journal Articles

Evolution of the T cell receptor: expression of non-conventional TCRδ chains in Xenopus (170.7)

Free
Shawn Jackson, Ada Undieh, Harold Steiner, Zuly Parra, Robert Miller, Yuko Ohta, Martin Flajnik
Journal: The Journal of Immunology
J Immunol (2011) 186 (1_Supplement): 170.7.
https://doi.org/10.4049/jimmunol.186.Supp.170.7
Published: 01 April 2011
View articletitled, Evolution of the T cell receptor: expression of non-conventional TCRδ chains in Xenopus (170.7)
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Journal Articles

Primordial Linkage of β2-Microglobulin to the MHC

Free
Yuko Ohta, Takashi Shiina, Rebecca L. Lohr, Kazuyoshi Hosomichi, Toni I. Pollin, Edward J. Heist, Shingo Suzuki, Hidetoshi Inoko, Martin F. Flajnik
Journal: The Journal of Immunology
J Immunol (2011) 186 (6): 3563–3571.
https://doi.org/10.4049/jimmunol.1003933
Published: 15 March 2011
View articletitled, Primordial Linkage of β2-Microglobulin to the MHC
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Includes: Supplementary data
Journal Articles

Remarkable Conservation of Distinct Nonclassical MHC Class I Lineages in Divergent Amphibian Species

Free
Ana Goyos, Jessica Sowa, Yuko Ohta, Jacques Robert
Journal: The Journal of Immunology
J Immunol (2011) 186 (1): 372–381.
https://doi.org/10.4049/jimmunol.1001467
Published: 01 January 2011
View articletitled, Remarkable Conservation of Distinct Nonclassical MHC Class I Lineages in Divergent Amphibian Species
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Includes: Supplementary data
Journal Articles

Evolutionarily Conserved TCR Binding Sites, Identification of T Cells in Primary Lymphoid Tissues, and Surprising Trans-Rearrangements in Nurse Shark

Free
Michael F. Criscitiello, Yuko Ohta, Mark Saltis, E. Churchill McKinney, Martin F. Flajnik
Journal: The Journal of Immunology
J Immunol (2010) 184 (12): 6950–6960.
https://doi.org/10.4049/jimmunol.0902774
Published: 15 June 2010
View articletitled, Evolutionarily Conserved TCR Binding Sites, Identification of T Cells in Primary Lymphoid Tissues, and Surprising Trans-Rearrangements in Nurse Shark
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Includes: Supplementary data
Journal Articles

Blimp1 is not required for all Ig secretion and J-chain expression in nurse shark plasma cells (36.11)

Free
Caitlin Doremus, Helen Dooley, Yuko Ohta, Martin Flajnik
Journal: The Journal of Immunology
J Immunol (2010) 184 (1_Supplement): 36.11.
https://doi.org/10.4049/jimmunol.184.Supp.36.11
Published: 01 April 2010
View articletitled, Blimp1 is not required for all Ig secretion and J-chain expression in nurse shark plasma cells (36.11)
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Journal Articles

The Evolution of Multiple Isotypic IgM Heavy Chain Genes in the Shark

Free
Victor Lee, Jing Li Huang, Ming Fai Lui, Karolina Malecek, Yuko Ohta, Arne Mooers, Ellen Hsu
Journal: The Journal of Immunology
J Immunol (2008) 180 (11): 7461–7470.
https://doi.org/10.4049/jimmunol.180.11.7461
Published: 01 June 2008
View articletitled, The Evolution of Multiple Isotypic IgM Heavy Chain Genes in the Shark
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Journal Articles

Ancestral Organization of the MHC Revealed in the Amphibian Xenopus

Free
Yuko Ohta, Wilfried Goetz, M. Zulfiquer Hossain, Masaru Nonaka, Martin F. Flajnik
Journal: The Journal of Immunology
J Immunol (2006) 176 (6): 3674–3685.
https://doi.org/10.4049/jimmunol.176.6.3674
Published: 15 March 2006
View articletitled, Ancestral Organization of the MHC Revealed in the Amphibian Xenopus
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Journal Articles

Somatic Hypermutation and Junctional Diversification at Ig Heavy Chain Loci in the Nurse Shark

Free
Karolina Malecek, Julie Brandman, Jennie E. Brodsky, Yuko Ohta, Martin F. Flajnik, Ellen Hsu
Journal: The Journal of Immunology
J Immunol (2005) 175 (12): 8105–8115.
https://doi.org/10.4049/jimmunol.175.12.8105
Published: 15 December 2005
View articletitled, Somatic Hypermutation and Junctional Diversification at Ig Heavy Chain Loci in the Nurse Shark
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Journal Articles

Homologs of CD83 from Elasmobranch and Teleost Fish

Free
Yuko Ohta, Eric Landis, Thomas Boulay, Ruth B. Phillips, Bertrand Collet, Chris J. Secombes, Martin F. Flajnik, John D. Hansen
Journal: The Journal of Immunology
J Immunol (2004) 173 (7): 4553–4560.
https://doi.org/10.4049/jimmunol.173.7.4553
Published: 01 October 2004
View articletitled, Homologs of CD83 from Elasmobranch and Teleost Fish
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