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IL-10 neutralization suppresses intestinal anaphylaxis and MC responses in ...
Published: 18 June 2024
FIGURE 1. IL-10 neutralization suppresses intestinal anaphylaxis and MC responses in allergic mice. BALB/c mice were immunized and challenged with OVA as depicted in ( A ). Some mice were injected with anti–IL-10 prior to each OVA challenge. One hour later, mice were sacrificed and various indices of food allergy were measured, including ( B ) serum OVA-IgE levels, ( C ) percent of animals exhibiting diarrhea, ( D ) chloroacetate esterase (CAE)+ MCs in the jejunum, and ( E ) serum mMCP-1 levels. ( F ) Histological images of MCs in the jejunum are shown (original magnification ×40). Data are representative of more than three experiments; n = 5–7 mice/group. *p < 0.05, **p < 0.01, ***p < 0.001 (t test). More about this image found in IL-10 neutralization suppresses intestinal anaphylaxis and MC responses in ...
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Attenuation of small intestinal Th2 cytokine expression in mice treated wit...
Published: 18 June 2024
FIGURE 2. Attenuation of small intestinal Th2 cytokine expression in mice treated with anti – IL-10. Mice were sensitized and challenged with OVA and some mice were treated with anti–IL-10 as shown in Fig. 1A . ( A–F ) Jejunal tissue was collected and mRNA expression for various Th2 cytokine genes was assessed as shown. Data are representative of two experiments; n = 5–7 mice/group. *p < 0.05, **p < 0.01 (t test). More about this image found in Attenuation of small intestinal Th2 cytokine expression in mice treated wit...
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Systemic Th2 responses are decreased in mice treated with anti – IL-10.   M...
Published: 18 June 2024
FIGURE 3. Systemic Th2 responses are decreased in mice treated with anti – IL-10. Mice were sensitized and challenged with OVA and some mice were treated with anti–IL-10 as shown in Fig. 1A . ( A–E ) Spleen cells were collected and cultured with OVA for 96 h as described in Materials and Methods. Cytokines were then evaluated in supernatants. Data are representative of two experiments; n = 5–7 mice/group. *p < 0.05, **p < 0.01, ***p < 0.001 (t test). More about this image found in Systemic Th2 responses are decreased in mice treated with anti – IL-10. M...
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Reduced MCs and lymphocyte populations in IL-10 – neutralized mice.   Mice ...
Published: 18 June 2024
FIGURE 4. Reduced MCs and lymphocyte populations in IL-10 – neutralized mice. Mice were sensitized and challenged with OVA and some mice were treated with anti–IL-10 as shown in Fig. 1A . ( A – F ) Flow cytometry was performed on spleen cells from experimental mice and various leukocyte populations were evaluated. (A) CD4 T cells, (B) CD8 T cells, (C) B cells, (D and E) MCs, and (F) total Tregs gated on CD4 T cells are shown. Data are representative of two experiments; n = 5–7 mice/group. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 (t test). More about this image found in Reduced MCs and lymphocyte populations in IL-10 – neutralized mice. Mice ...
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IL-10 blockade has partly suppressive effects in mice with established food...
Published: 18 June 2024
FIGURE 5. IL-10 blockade has partly suppressive effects in mice with established food allergy. Mice were sensitized and challenged with OVA and some mice were injected with anti–IL-10 prior to the final challenge with OVA. Serum was obtained from allergic mice after the fifth OVA challenge and prior to anti–IL-10 treatment and then subsequently after anti–IL-10 treatment and final challenge with OVA. ( A and B ) Serum OVA-IgE and mMCP-1 levels in the same mice before and after anti–IL-10 administration; purple circles represent mice with five OVA challenges, and green circles represent the same mice after anti–IL-10 and a sixth challenge. ( C – I ) Mice treated with anti–IL-10 (green circles) were compared with a separate group of mice that received six OVA challenges but no anti–IL-10 (light blue circles). (C) Percent of mice exhibiting allergic diarrhea, (D) jejunal MCs (original magnification ×40), and (E–I) cytokine secretion by spleen cells after OVA stimulation are shown. *p < 0.05 (t test). More about this image found in IL-10 blockade has partly suppressive effects in mice with established food...