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Cellular Therapies and Vaccines for Cancer
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Journal Articles

Unraveling tumor-specific iNKT cell plasticity

Filippo Cortesi, Leonie Konczalla, Tabea M Sturmheit, Francesco Siracusa, Nicola Gagliani
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.23.
https://doi.org/10.4049/jimmunol.204.Supp.239.23
Published: 01 May 2020
View article titled, Unraveling tumor-specific iNKT cell plasticity
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Modulating extracellular TCR-CD3 interaction to identify new immunotherapy targets against cancer

Michelle Krogsgaard, Aswin Natarajan, Yogambigai Velmurugu, Zhou Yuan, Chenghao Ge, Vidushan Nadarajah, Timothy Cardozo, William C. Bracken, Cheng Zhu
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.22.
https://doi.org/10.4049/jimmunol.204.Supp.239.22
Published: 01 May 2020
View article titled, Modulating extracellular TCR-CD3 interaction to identify new immunotherapy targets against cancer
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Mechanisms of “Peptide Alarm Therapy”: Can antiviral memory T cells directly kill cancer cells in an MHC Class I-dependent way?

Noah Veis Gavil, Vineet Joag, Pamela C. Rosato, David Masopust
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.12.
https://doi.org/10.4049/jimmunol.204.Supp.239.12
Published: 01 May 2020
View article titled, Mechanisms of “Peptide Alarm Therapy”: Can antiviral memory T cells directly kill cancer cells in an MHC Class I-dependent way?
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High affinity oligoclonal TCRs define effective adoptive T-cell therapy targeting mutant KRAS-G12D

Malcolm John Wyness Sim, Jinghua Lu, Matthew Spencer, Francis Hopkins, Eric Tran, Steven A Rosenberg, Eric O Long, Peter Daopin Sun
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.11.
https://doi.org/10.4049/jimmunol.204.Supp.239.11
Published: 01 May 2020
View article titled, High affinity oligoclonal TCRs define effective adoptive T-cell therapy targeting mutant KRAS-G12D
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Anaplastic lymphoma kinase fusions as a target for TCR-directed cellular therapies

James M Heather, Matthew J Spindler, Mark Cobbold, Justin F Gainor, David S Johnson, Aaron N Hata
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.10.
https://doi.org/10.4049/jimmunol.204.Supp.239.10
Published: 01 May 2020
View article titled, Anaplastic lymphoma kinase fusions as a target for TCR-directed cellular therapies
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CRS free T cell therapy: T cell membrane anchored and tumor targeted IL12 (ATTIL12)-T cell therapy eliminates large tumors, overcomes heterogeneity, and avoids adverse effects

Jiemiao Hu, Wendong Zhang, Xueqing Xia, Qing Yang, Yuhui Chen, Natalie W Fowlkes, John Andrew Livingston, Zhongting Zhang, Kris M Mahadeo, Jonathan B Gill, Gianpietro Dotti, Scott Kopetz, Richard Gorlick, Shulin Li
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.1.
https://doi.org/10.4049/jimmunol.204.Supp.239.1
Published: 01 May 2020
View article titled, CRS free T cell therapy: T cell membrane anchored and tumor targeted IL12 (ATTIL12)-T cell therapy eliminates large tumors, overcomes heterogeneity, and avoids adverse effects
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Journal Articles

Bispecific anti-CD22 T-cell engager efficiently promotes cell-mediated cytotoxicity of lymphoma, leukemia and sarcoma targets

Gustavo A Barisone, Daniel P Vang, William J Murphy, Joseph Tuscano
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.27.
https://doi.org/10.4049/jimmunol.204.Supp.239.27
Published: 01 May 2020
View article titled, Bispecific anti-CD22 T-cell engager efficiently promotes cell-mediated cytotoxicity of lymphoma, leukemia and sarcoma targets
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Establishment and Preclinical Therapy of Patient-derived Hepatocellular Carcinoma Xenograft Model

yuwei wu, Zhigang Tian, Rui Sun
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.2.
https://doi.org/10.4049/jimmunol.204.Supp.239.2
Published: 01 May 2020
View article titled, Establishment and Preclinical Therapy of Patient-derived Hepatocellular Carcinoma Xenograft Model
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Unbiased analysis of all possible neoepitopes of MC38-FABF tumor reveals a new universe of cancer neoepitopes with unexpected properties

Mariam M George, Cory A Brennick, Marmar M Moussa, Adam T Hagymasi, Sahar Al Seesi, Tatiana V Shcheglova, Ryan P Englander, Grant L.J Keller, Jeremy L Balsbaugh, Brian M Baker, Ion I. Mandoiu, Pramod K Srivastava
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.18.
https://doi.org/10.4049/jimmunol.204.Supp.239.18
Published: 01 May 2020
View article titled, Unbiased analysis of all possible neoepitopes of MC38-FABF tumor reveals a new universe of cancer neoepitopes with unexpected properties
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Journal Articles

Modular Antigen-Specific T Cell Suppression Assay for In Vitro Drug Screening

Eden Kleiman, Gloria Sierra, Pirouz Daftarian
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.17.
https://doi.org/10.4049/jimmunol.204.Supp.239.17
Published: 01 May 2020
View article titled, Modular Antigen-Specific T Cell Suppression Assay for In Vitro Drug Screening
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Engineering Chimeric Antigen Receptor T cells Against Immune Checkpoint Inhibitors PD-1/PD-L1 for Treating Pancreatic Cancer

Chao Lien Liu, Ming Huei Fan, Carol H. Miao, Yi Jen Liao
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.15.
https://doi.org/10.4049/jimmunol.204.Supp.239.15
Published: 01 May 2020
View article titled, Engineering Chimeric Antigen Receptor T cells Against Immune Checkpoint Inhibitors PD-1/PD-L1 for Treating Pancreatic Cancer
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Journal Articles

Identification of T cells specific for DNAJB1-PRKACA fusion neoantigens in fibrolamellar carcinoma

Allison M Kirk, Jeremy Chase Crawford, Anthony E Zamora, Kaity Allen, Xiaoyu Zhang, Scott E Strome, Paul G Thomas
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.14.
https://doi.org/10.4049/jimmunol.204.Supp.239.14
Published: 01 May 2020
View article titled, Identification of T cells specific for <em>DNAJB1-PRKACA</em> fusion neoantigens in fibrolamellar carcinoma
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Journal Articles

Synthetic MyD88 co-stimulation in donor CD8+ T cells enhances T cell activation, function, and tumor control in experimental hematopoietic cell transplant

Nicholas G Ciavattone, Long Wu, Rachel O’Neill, Eduardo Davila, Xuefang Cao
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.13.
https://doi.org/10.4049/jimmunol.204.Supp.239.13
Published: 01 May 2020
View article titled, Synthetic MyD88 co-stimulation in donor CD8+ T cells enhances T cell activation, function, and tumor control in experimental hematopoietic cell transplant
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Enhancing ADCC by human natural killer cells to improve tumor cell killing

Kristin M Snyder, Robert Hullsiek, Hemant Kumar Mishra, Kate J Dixon, Daniel C Mendez, Yunfang Li, Allison Rogich, Jianming Wu, Bruce Walcheck
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.26.
https://doi.org/10.4049/jimmunol.204.Supp.239.26
Published: 01 May 2020
View article titled, Enhancing ADCC by human natural killer cells to improve tumor cell killing
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Treatment of CEA-positive solid tumors with anti-CEA chimeric antigen receptor T-cells in CEA transgenic mice

Seung Cha, Paul J Yazaki, Christine Brown, John Shively
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.25.
https://doi.org/10.4049/jimmunol.204.Supp.239.25
Published: 01 May 2020
View article titled, Treatment of CEA-positive solid tumors with anti-CEA chimeric antigen receptor T-cells in CEA transgenic mice
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Super2-expressing CAR T cells generate improved anti-tumor responses against solid tumors

Rachel A Brog, Prathna Kumar, Charles Sentman, Yina Huang
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.8.
https://doi.org/10.4049/jimmunol.204.Supp.239.8
Published: 01 May 2020
View article titled, Super2-expressing CAR T cells generate improved anti-tumor responses against solid tumors
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THERAPEUTIC EFFECTS OF TRAIL-SECRETING MESENCHYMAL STEM CELLS WITH FOCUSED ULTRASOUND-INDUCED TEMPORARILY OPENING OF BLOOD-BRAIN BARRIERS IN THE BRAIN TUMOR

Sang In Park, Ho Yong Jung, Eui-Jin Lee, Lee-So Maeng
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.39.
https://doi.org/10.4049/jimmunol.204.Supp.239.39
Published: 01 May 2020
View article titled, THERAPEUTIC EFFECTS OF TRAIL-SECRETING MESENCHYMAL STEM CELLS WITH FOCUSED ULTRASOUND-INDUCED TEMPORARILY OPENING OF BLOOD-BRAIN BARRIERS IN THE BRAIN TUMOR
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Metformin reduces PD-L1 expression in the tumor and enhances the efficacy of vaccine generated CD8 T cells in a murine model of triple negative breast cancer

Luis E Munoz, Haley Lei Huang, Rohini Neha Guin, Ramireddy Bommireddy, Periasamy Selvaraj
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.33.
https://doi.org/10.4049/jimmunol.204.Supp.239.33
Published: 01 May 2020
View article titled, Metformin reduces PD-L1 expression in the tumor and enhances the efficacy of vaccine generated CD8 T cells in a murine model of triple negative breast cancer
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Inhibition of TET (Ten-Eleven Translocation) enzymes enhances systemic anti-tumor immune responses in T cells

Hyungseok Seo, Chao Yang, Wade Zhang, Patrick Hogan, Anjana Rao
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.3.
https://doi.org/10.4049/jimmunol.204.Supp.239.3
Published: 01 May 2020
View article titled, Inhibition of TET (Ten-Eleven Translocation) enzymes enhances systemic anti-tumor immune responses in T cells
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Heteroclitic peptide cancer vaccine counters MHC-I skewing in mutant calreticulin-positive myeloproliferative neoplasms

Mathieu Gigoux, Roberta Zappasodi, Joseph J Park, Stephane Pourpe, Arnab Ghosh, Cansu Cimen Bozkus, Levi M.B. Mangarin, David Redmond, Svena Verma, Sara Schad, William Duke, Matthew Leventhal, Max Jan, Vincent Ho, Gabriella Hobbs, Trine Alma Knudsen, Vibe Skov, Lasse Kjær, Thomas Stauffer Larsen, Dennis Lund Hansen, R Coleman Lindsley, Hans Hasselbalch, Jacob H Grauslund, Mads H Andersen, Morten O Holmström, Timothy Chan, Raajit Rampal, Omar Abdel-Wahab, Nina Bhardwaj, Jedd D Wolchok, Ann Mullally, Taha Merghoub
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 239.34.
https://doi.org/10.4049/jimmunol.204.Supp.239.34
Published: 01 May 2020
View article titled, Heteroclitic peptide cancer vaccine counters MHC-I skewing in mutant calreticulin-positive myeloproliferative neoplasms
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