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Table III.

P2z receptor ligation promotes 86Rb+ release from macrophages

Stimulus86Rb+ (% Released)a
None 10b 
40 μM ATP 17.5 
100 μM ATP 21 
1 mM ATP 81 
5 mM ATP 94 
200 μM benzoyl benzoic-ATP 46 
1 mM benzoyl benzoic-ATP 95 
5 mM UTP 21 
Stimulus86Rb+ (% Released)a
None 10b 
40 μM ATP 17.5 
100 μM ATP 21 
1 mM ATP 81 
5 mM ATP 94 
200 μM benzoyl benzoic-ATP 46 
1 mM benzoyl benzoic-ATP 95 
5 mM UTP 21 
a

LPS-activated, 86Rb+-loaded macrophages were incubated for 5 min in the presence of the indicated stimulus. At the conclusion of this incubation, cells and media were separated, and the percentage of the radioactive isotope recovered in the medium was determined.

b

The value for the control (none) is a mean of eight individual wells; other values are averages of duplicate wells.

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