American Association of Immunologists

Table II.

Blind test of the predictive power of the DRB1*0401 algorithm

Selection Criteria	No. of Peptides
		Binding affinity^a				Total	χ²(p)
		High	Intermediate	Negative		Total	χ²(p)
None	3	11	36	50	—^b
P1-P6	3	9	28	40	0.177 (NS)
0.734^c	3	8	7	18	10.28 (<0.01)
2.617^d	3	4	2	9	16.36 (<0.005)

Selection Criteria	No. of Peptides
		Binding affinity^a				Total	χ²(p)
		High	Intermediate	Negative		Total	χ²(p)
None	3	11	36	50	—^b
P1-P6	3	9	28	40	0.177 (NS)
0.734^c	3	8	7	18	10.28 (<0.01)
2.617^d	3	4	2	9	16.36 (<0.005)

High binding corresponds to an IC₅₀ ≤100 nM, intermediate binding corresponds to an IC₅₀ in the 100 to 1000 nM range, and negative binding refers to affinity >1000 nM.

Not applicable.

Algorithm score that predicts 90% of all binders.

Algorithm score that predicts 75% of all binders.

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